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  1. Article: Idiopathic interstitial pneumonia in a patient with von Hippel-Lindau syndrome: a first case.

    Morlacchi, Letizia Corinna / Zanini, Umberto / Gramegna, Andrea / Faverio, Paola / Blasi, Francesco / Luppi, Fabrizio

    ERJ open research

    2023  Volume 9, Issue 6

    Abstract: Although the mechanisms are not known, this is a case of progressive interstitial lung involvement, with a NSIP radiological pattern, evolving in pulmonary fibrosis in a patient with von Hippel-Lindau syndrome, without extrapulmonary fibrosis. ...

    Abstract Although the mechanisms are not known, this is a case of progressive interstitial lung involvement, with a NSIP radiological pattern, evolving in pulmonary fibrosis in a patient with von Hippel-Lindau syndrome, without extrapulmonary fibrosis.
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00504-2023
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  2. Article ; Online: Idiopathic interstitial pneumonia in a patient with von Hippel–Lindau syndrome

    Letizia Corinna Morlacchi / Umberto Zanini / Andrea Gramegna / Paola Faverio / Francesco Blasi / Fabrizio Luppi

    ERJ Open Research, Vol 9, Iss

    a first case

    2023  Volume 6

    Keywords Medicine ; R
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Telemonitoring: An opportunity in cystic fibrosis lung transplant recipients.

    Corinna Morlacchi, Letizia / Privitera, Emilia / Rossetti, Valeria / Santambrogio, Martina / Bellofiore, Angela / Rosso, Lorenzo / Palleschi, Alessandro / Nosotti, Mario / Blasi, Francesco

    Heliyon

    2023  Volume 9, Issue 10, Page(s) e19931

    Abstract: Introduction: Telemedicine has been successfully employed in a wide range of conditions, such as such as chronic lung disease and COVID-19. This study evaluate the role of telemonitoring for the early diagnosis of acute lung allograft dysfunction in ... ...

    Abstract Introduction: Telemedicine has been successfully employed in a wide range of conditions, such as such as chronic lung disease and COVID-19. This study evaluate the role of telemonitoring for the early diagnosis of acute lung allograft dysfunction in cystic fibrosis adults who underwent lung transplant (LuTx). Quality of life and functional level achieved during a 12 months follow up were assessed.
    Methods: Patients were randomized into two groups; control group received traditional hospital-based follow-up, whereas patients in the intervention group received, on top of standard care, a telemonitoring device, with a pulse oximeter and a spirometer integrated. Telemonitoring data were digitally transmitted to our centre.
    Results: Sixteen patients were enrolled in each group. No statistically significant difference was found between the two groups in terms of incidence of allograft dysfunction, time from onset of symptoms to diagnosis and time of occurrence from LuTx. Moreover, both groups achieved similar quality of life and functional level. With reference to the telemonitoring group: 1) hospital reported data were consistent with those being remotely registered; 2) adherence to telemonitoring decreased during the follow up; 3) the majority of patients reported a high degree of satisfaction.
    Conclusion: The COVID19 pandemic highlighted the necessity to investigate alternative practices to treat chronically ill individuals. Telemonitoring is a valuable tool to improve quality care to LuTx recipients.
    Language English
    Publishing date 2023-09-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e19931
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  4. Article ; Online: Microbial Inflammatory Networks in Bronchiectasis Exacerbators With Pseudomonas aeruginosa.

    Gramegna, Andrea / Narayana, Jayanth Kumar / Amati, Francesco / Stainer, Anna / Wu, Benjamin / Morlacchi, Letizia Corinna / Segal, Leopoldo N / Tsaneva-Atanasova, Krasimira / Marchisio, Paola / Chotirmall, Sanjay H / Blasi, Francesco / Aliberti, Stefano

    Chest

    2023  Volume 164, Issue 1, Page(s) 65–68

    MeSH term(s) Humans ; Pseudomonas aeruginosa ; Bronchiectasis/drug therapy ; Pseudomonas Infections/complications ; Pseudomonas Infections/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Sputum
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.02.014
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  5. Article ; Online: Telemonitoring

    Letizia Corinna Morlacchi / Emilia Privitera / Valeria Rossetti / Martina Santambrogio / Angela Bellofiore / Lorenzo Rosso / Alessandro Palleschi / Mario Nosotti / Francesco Blasi

    Heliyon, Vol 9, Iss 10, Pp e19931- (2023)

    An opportunity in cystic fibrosis lung transplant recipients

    2023  

    Abstract: Introduction: Telemedicine has been successfully employed in a wide range of conditions, such as such as chronic lung disease and COVID-19. This study evaluate the role of telemonitoring for the early diagnosis of acute lung allograft dysfunction in ... ...

    Abstract Introduction: Telemedicine has been successfully employed in a wide range of conditions, such as such as chronic lung disease and COVID-19. This study evaluate the role of telemonitoring for the early diagnosis of acute lung allograft dysfunction in cystic fibrosis adults who underwent lung transplant (LuTx). Quality of life and functional level achieved during a 12 months follow up were assessed. Methods: Patients were randomized into two groups; control group received traditional hospital-based follow-up, whereas patients in the intervention group received, on top of standard care, a telemonitoring device, with a pulse oximeter and a spirometer integrated. Telemonitoring data were digitally transmitted to our centre. Results: Sixteen patients were enrolled in each group. No statistically significant difference was found between the two groups in terms of incidence of allograft dysfunction, time from onset of symptoms to diagnosis and time of occurrence from LuTx. Moreover, both groups achieved similar quality of life and functional level. With reference to the telemonitoring group: 1) hospital reported data were consistent with those being remotely registered; 2) adherence to telemonitoring decreased during the follow up; 3) the majority of patients reported a high degree of satisfaction. Conclusion: The COVID19 pandemic highlighted the necessity to investigate alternative practices to treat chronically ill individuals. Telemonitoring is a valuable tool to improve quality care to LuTx recipients.
    Keywords Telemedicine ; Telemonitoring ; Lung transplant ; Cystic fibrosis ; Adherence ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Infections after lung transplantation.

    Nosotti, Mario / Tarsia, Paolo / Morlacchi, Letizia Corinna

    Journal of thoracic disease

    2018  Volume 10, Issue 6, Page(s) 3849–3868

    Abstract: The good clinical result of lung transplantation is constantly undermined by the high incidence of infection, which negatively impacts on function and survival. Moreover, infections may also have immunological interactions that play a role in the acute ... ...

    Abstract The good clinical result of lung transplantation is constantly undermined by the high incidence of infection, which negatively impacts on function and survival. Moreover, infections may also have immunological interactions that play a role in the acute rejection and in the development of chronic lung allograft dysfunction. There is a temporal sequence in the types of infection that affects lung allograft: in the first postoperative month bacteria are the most frequent cause of infection; following this phase, cytomegalovirus and Pneumocystis carinii are common. Fungal infections are particularly feared due to their association with bronchial complication and high mortality. Scrupulous postoperative surveillance is mandatory for the successful management of lung transplantation patients with respect to early detection and treatment of infections. This paper is aimed to address clinicians in the management of the major infectious complications that affect the lung transplant population.
    Keywords covid19
    Language English
    Publishing date 2018-06-27
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.05.204
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  7. Article ; Online: PD-1 expression in transbronchial biopsies of lung transplant recipients is a possible early predictor of rejection.

    Righi, Ilaria / Vaira, Valentina / Morlacchi, Letizia Corinna / Croci, Giorgio Alberto / Rossetti, Valeria / Blasi, Francesco / Ferrero, Stefano / Nosotti, Mario / Rosso, Lorenzo / Clerici, Mario

    Frontiers in immunology

    2023  Volume 13, Page(s) 1024021

    Abstract: Introduction: Chronic lung allograft dysfunction (CLAD) is the main cause of the reduced survival of lung transplanted (LTx) patients. The possible role of immune checkpoint molecules in establishing tolerance has been scarcely investigated in the ... ...

    Abstract Introduction: Chronic lung allograft dysfunction (CLAD) is the main cause of the reduced survival of lung transplanted (LTx) patients. The possible role of immune checkpoint molecules in establishing tolerance has been scarcely investigated in the setting of lung transplantation.
    Methods: We conducted a retrospective, observational pilot study on a consecutive series of transbronchial cryobiopsies (TCB) obtained from 24 patients during LTx follow-up focusing on PD-1, one of the most investigated immune checkpoint molecules.
    Results: Results showed that PD-1-expressing T lymphocytes were present in all TCB with a histological diagnosis of acute rejection (AR; 9/9), but not in most (11/15) of the TCB not resulting in a diagnosis of AR (p=0.0006). Notably, the presence of PD-1-expressing T lymphocytes in TCB resulted in a 10-times higher risk of developing chronic lung allograft dysfunction (CLAD), the main cause of the reduced survival of lung transplanted patients, thus being associated with a clearly worst clinical outcome.
    Discussion: Results of this pilot study indicate a central role of PD-1 in the development of AR and its evolution towards CLAD and suggest that the evaluation of PD-1-expressing lymphocytes in TCB could offer a prognostic advantage in monitoring the onset of AR in patients who underwent lung transplantation.
    MeSH term(s) Humans ; Programmed Cell Death 1 Receptor ; Transplant Recipients ; Retrospective Studies ; Immune Checkpoint Proteins ; Pilot Projects ; Graft Rejection/diagnosis ; Graft Rejection/etiology ; Lung/pathology ; Lung Transplantation/adverse effects ; Biopsy
    Chemical Substances Programmed Cell Death 1 Receptor ; Immune Checkpoint Proteins
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1024021
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  8. Article: Bone Disease in Long-Term Lung Transplant Survivors.

    Grassi, Giorgia / Cairoli, Elisa / Gentile, Lucrezia Maria Silvana / Chiodini, Iacopo / Zampogna, Marta / Ghielmetti, Alberto / Morlacchi, Letizia Corinna / Rossetti, Valeria / Rosso, Lorenzo / Righi, Ilaria / Nosotti, Mario / Arosio, Maura / Blasi, Francesco / Eller Vainicher, Cristina

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 4

    Abstract: Background: During the first two years after lung transplantation (LTx), the incidence of fragility fractures (FX) is estimated to be 15-50% and it is lower in patients with cystic fibrosis (CF) as compared with other end-stage lung diseases (nCF). The ... ...

    Abstract Background: During the first two years after lung transplantation (LTx), the incidence of fragility fractures (FX) is estimated to be 15-50% and it is lower in patients with cystic fibrosis (CF) as compared with other end-stage lung diseases (nCF). The aim of our study is to compare the skeletal outcomes, after the first 2 years post-LTx, in long-term survivors with CF and nCF.
    Materials and methods: We evaluated the FX rate, the changes in bone mineral density (BMD) and trabecular bone score (TBS) in 68 patients (38 CF and 30 nCF) who underwent LTx in our center and with a follow-up after LTx longer than 5 years (7.3 ± 2.0 years).
    Results: After the second year post-LTx: (i) the FX rate was lower than during the first two years post-LTx (4.4 vs. 20.6%,
    Conclusions: After the second year post-LTx, the skeletal complications become less frequent and have similar incidence in patients with CF and nCF.
    Language English
    Publishing date 2023-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13040928
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  9. Article ; Online: Hemodynamic failure and graft dysfunction after lung transplant: A possible clinical continuum with immediate and long-term consequences.

    Scaravilli, Vittorio / Guzzardella, Amedeo / Madotto, Fabiana / Morlacchi, Letizia Corinna / Bosone, Marco / Bonetti, Claudia / Musso, Valeria / Rossetti, Valeria / Russo, Filippo Maria / Sorbo, Lorenzo Del / Blasi, Francesco / Nosotti, Mario / Zanella, Alberto / Grasselli, Giacomo

    Clinical transplantation

    2023  Volume 37, Issue 12, Page(s) e15122

    Abstract: Introduction: The postoperative hemodynamic management after lung transplant (LUTX) is guided by limited evidence. We aimed to describe and evaluate risk factors and outcomes of postoperative vasoactive support of LUTX recipients.: Methods: In a ... ...

    Abstract Introduction: The postoperative hemodynamic management after lung transplant (LUTX) is guided by limited evidence. We aimed to describe and evaluate risk factors and outcomes of postoperative vasoactive support of LUTX recipients.
    Methods: In a single-center retrospective analysis of consecutive adult LUTX, two cohorts were identified: (1) patients needing prolonged vasoactive support (>12 h from ICU admission) (VASO+); (2) or not (VASO-). Postoperative hemodynamic characteristics were thoroughly analyzed. Risk factors and outcomes of VASO+ versus VASO- cohorts were assessed by multivariate logistic regression and propensity score matching.
    Results: One hundred and thirty-eight patients were included (86 (62%) VASO+ versus 52 (38%) VASO-). Vasopressors (epinephrine, norepinephrine, dopamine) were used in the first postoperative days (vasoactive inotropic score at 12 h: 6 [4-12]), while inodilators (dobutamine, levosimendan) later. Length of vasoactive support was 3 [2-4] days. Independent predictors of vasoactive use were: LUTX indication different from cystic fibrosis (p = .003), higher Oto score (p = .020), longer cold ischemia time (p = .031), but not preoperative cardiac catheterization. VASO+ patients showed concomitant hemodynamic and graft impairment, with longer mechanical ventilation (p = .010), higher primary graft dysfunction (PGD) grade at 72 h (PGD grade > 0 65% vs. 31%, p = .004, OR 4.2 [1.54-11.2]), longer ICU (p < .001) and hospital stay (p = .013). Levosimendan as a second-line inodilator appeared safe.
    Conclusions: Vasoactive support is frequently necessary after LUTX, especially in recipients of grafts of lesser quality. Postoperative hemodynamic dysfunction requiring vasopressor support and graft dysfunction may represent a clinical continuum with immediate and long-term consequences. Further studies may elucidate if this represents a possible treatable condition.
    MeSH term(s) Adult ; Humans ; Retrospective Studies ; Simendan/pharmacology ; Lung Transplantation/adverse effects ; Norepinephrine ; Vasoconstrictor Agents/therapeutic use ; Hemodynamics ; Primary Graft Dysfunction/etiology
    Chemical Substances Simendan (349552KRHK) ; Norepinephrine (X4W3ENH1CV) ; Vasoconstrictor Agents
    Language English
    Publishing date 2023-09-11
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.15122
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2204: Show issues Location:
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  10. Article ; Online: Safety of mRNA-based vaccines against SARS-CoV-2 in people with cystic fibrosis aged 12 years and over.

    Alicandro, Gianfranco / Daccó, Valeria / Cariani, Lisa / Contarini, Martina / Morlacchi, Letizia Corinna / Rosazza, Chiara / Sciarrabba, Calogero Sathya / Ferraro, Federica / Lanfranchi, Chiara / Orena, Beatrice Silvia / Gramegna, Andrea / Blasi, Francesco / Colombo, Carla

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

    2022  Volume 21, Issue 3, Page(s) e173–e175

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Cystic Fibrosis ; Humans ; RNA, Messenger ; SARS-CoV-2 ; mRNA Vaccines
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger ; mRNA Vaccines
    Language English
    Publishing date 2022-02-16
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2084724-5
    ISSN 1873-5010 ; 1569-1993
    ISSN (online) 1873-5010
    ISSN 1569-1993
    DOI 10.1016/j.jcf.2022.02.009
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