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Article ; Online: Correction to: Development of the Italian clinical practice guidelines for the treatment of diabetic foot syndrome: design and methodological aspects.

Monami, Matteo / Scatena, Alessia / Miranda, Cesare / Monge, Luca / De Cassai, Alessandro / Volpe, Antonio / Tramonta, Rodolfo / Medea, Gerardo / Bordieri, Corrado / Falcone, Marco / Stefanon, Laura / Bernetti, Andrea / Cappella, Cristina / Gargiulo, Mauro / Lorenzoni, Valentina / Scevola, Germano / Stabile, Eugenio / Ragghianti, Benedetta / Silverii, Giovanni Antonio /

da Ros, Roberto / Meloni, Marco / Giurato, Laura / Murdolo, Giuseppe / Bianchini, Eleonora / Gaggia, Francesco / Gauna, Carlotta / Romeo, Francesco / Apicella, Matteo / Mantuano, Michele / Uccioli, Luigi / Vermigli, Cristiana

Acta diabetologica

2024

Language	English
Publishing date	2024-04-02
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	1097676-0
ISSN	1432-5233 ; 0940-5429
ISSN (online)	1432-5233
ISSN	0940-5429
DOI	10.1007/s00592-024-02263-8
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Article ; Online: Use of ICEsat-2 and Sentinel-2 Open Data for the Derivation of Bathymetry in Shallow Waters

Massimo Bernardis / Roberto Nardini / Lorenza Apicella / Maurizio Demarte / Matteo Guideri / Bianca Federici / Alfonso Quarati / Monica De Martino

Remote Sensing, Vol 15, Iss 2944, p

Case Studies in Sardinia and in the Venice Lagoon

2023 Volume 2944

Abstract: Despite the high accuracy of conventional acoustic hydrographic systems, measurement of the seabed along coastal belts is still a complex problem due to the limitations arising from shallow water. In addition to traditional echo sounders, airborne LiDAR ... ...

Abstract	Despite the high accuracy of conventional acoustic hydrographic systems, measurement of the seabed along coastal belts is still a complex problem due to the limitations arising from shallow water. In addition to traditional echo sounders, airborne LiDAR also suffers from high application costs, low efficiency, and limited coverage. On the other hand, remote sensing offers a practical alternative for the extraction of depth information, providing fast, reproducible, low-cost mapping over large areas to optimize and minimize fieldwork. Satellite-derived bathymetry (SDB) techniques have proven to be a promising alternative to supply shallow-water bathymetry data. However, this methodology is still limited since it usually requires in situ observations as control points for multispectral imagery calibration and bathymetric validation. In this context, this paper illustrates the potential for bathymetric derivation conducted entirely from open satellite data, without relying on in situ data collected using traditional methods. The SDB was performed using multispectral images from Sentinel-2 and bathymetric data collected by NASA’s ICESat-2 on two areas of relevant interest. To assess outcomes’ reliability, bathymetries extracted from ICESat-2 and derived from Sentinel-2 were compared with the updated and reliable data from the BathyDataBase of the Italian Hydrographic Institute.
Keywords	satellite-derived bathymetry ; ICESat-2 ; Sentinel-2 ; shallow water ; Stumpf method ; Science ; Q
Subject code	550
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bypass surgery versus endovascular revascularization for occlusive infrainguinal peripheral artery disease: a meta-analysis of randomized controlled trials for the development of the Italian Guidelines for the treatment of diabetic foot syndrome.

Scatena, Alessia / Apicella, Matteo / Mantuano, Michele / Liistro, Francesco / Ventoruzzo, Giorgio / Petruzzi, Pasquale / Miranda, Cesare / Monge, Luca / Ragghianti, Benedetta / Silverii, Antonio / Ferraro, Isabella / Uccioli, Luigi / Vermigli, Cristiana / Mannucci, Edoardo / Scevola, Germano / Stabile, Eugenio / Gargiulo, Mauro / Monami, Matteo

Acta diabetologica

2023 Volume 61, Issue 1, Page(s) 19–28

Abstract: To report a review and meta-analysis of all randomized controlled trials (RCTs) comparing bypass surgery (BS) and endovascular treatment (ET) in infrainguinal peripheral arterial disease (PAD) for several endpoints, such as major and minor amputation, ... ...

Abstract	To report a review and meta-analysis of all randomized controlled trials (RCTs) comparing bypass surgery (BS) and endovascular treatment (ET) in infrainguinal peripheral arterial disease (PAD) for several endpoints, such as major and minor amputation, major adverse limb events (MALEs), ulcer healing, time to healing, and all-cause mortality to support the development of the Italian Guidelines for the Treatment of Diabetic Foot Syndrome (DFS). A MEDLINE and EMBASE search was performed to identify RCTs, published since 1991 up to June 21, 2023, enrolling patients with lower limb ischemia due to atherosclerotic disease (Rutherford I-VI). Any surgical BS or ET was allowed, irrespective of the approach, route, or graft employed, from iliac to below-the-knee district. Primary endpoint was major amputation rate. Secondary endpoints were amputation-free survival major adverse limb events (MALEs), minor amputation rate, all-cause mortality, ulcer healing rate, time to healing, pain, transcutaneous oxygen pressure (T
MeSH term(s)	Humans ; Diabetic Foot/surgery ; Diabetic Foot/complications ; Ulcer/complications ; Randomized Controlled Trials as Topic ; Peripheral Arterial Disease/complications ; Peripheral Arterial Disease/surgery ; Pain/complications ; Italy/epidemiology ; Ischemia/etiology ; Ischemia/surgery ; Treatment Outcome ; Retrospective Studies ; Risk Factors ; Diabetes Mellitus
Language	English
Publishing date	2023-10-04
Publishing country	Germany
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	1097676-0
ISSN	1432-5233 ; 0940-5429
ISSN (online)	1432-5233
ISSN	0940-5429
DOI	10.1007/s00592-023-02185-x
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Article ; Online: COVID-19 in people with diabetes: understanding the reasons for worse outcomes.

Apicella, Matteo / Campopiano, Maria Cristina / Mantuano, Michele / Mazoni, Laura / Coppelli, Alberto / Del Prato, Stefano

The lancet. Diabetes & endocrinology

2020 Volume 8, Issue 9, Page(s) 782–792

Abstract: Since the initial COVID-19 outbreak in China, much attention has focused on people with diabetes because of poor prognosis in those with the infection. Initial reports were mainly on people with type 2 diabetes, although recent surveys have shown that ... ...

Abstract	Since the initial COVID-19 outbreak in China, much attention has focused on people with diabetes because of poor prognosis in those with the infection. Initial reports were mainly on people with type 2 diabetes, although recent surveys have shown that individuals with type 1 diabetes are also at risk of severe COVID-19. The reason for worse prognosis in people with diabetes is likely to be multifactorial, thus reflecting the syndromic nature of diabetes. Age, sex, ethnicity, comorbidities such as hypertension and cardiovascular disease, obesity, and a pro-inflammatory and pro-coagulative state all probably contribute to the risk of worse outcomes. Glucose-lowering agents and anti-viral treatments can modulate the risk, but limitations to their use and potential interactions with COVID-19 treatments should be carefully assessed. Finally, severe acute respiratory syndrome coronavirus 2 infection itself might represent a worsening factor for people with diabetes, as it can precipitate acute metabolic complications through direct negative effects on β-cell function. These effects on β-cell function might also cause diabetic ketoacidosis in individuals with diabetes, hyperglycaemia at hospital admission in individuals with unknown history of diabetes, and potentially new-onset diabetes.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/therapy ; Coronavirus Infections/blood ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/therapy ; Humans ; Hyperglycemia/blood ; Hyperglycemia/epidemiology ; Hyperglycemia/therapy ; Hypertension/blood ; Hypertension/epidemiology ; Hypertension/therapy ; Obesity/blood ; Obesity/epidemiology ; Obesity/therapy ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Treatment Outcome
Keywords	covid19
Language	English
Publishing date	2020-07-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	2213-8595
ISSN (online)	2213-8595
DOI	10.1016/S2213-8587(20)30238-2
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Article ; Online: Effect of a multidisciplinary team approach in patients with diabetic foot ulcers on major adverse limb events (MALEs): systematic review and meta-analysis for the development of the Italian guidelines for the treatment of diabetic foot syndrome.

Meloni, Marco / Giurato, Laura / Monge, Luca / Miranda, Cesare / Scatena, Alessia / Ragghianti, Benedetta / Silverii, Giovanni Antonio / Vermigli, Cristiana / De Cassai, Alessandro / Volpe, Antonio / Tramonta, Rodolfo / Medea, Gerardo / Bordieri, Corrado / Falcone, Marco / Stefanon, Laura / Bernetti, Andrea / Cappella, Cristina / Gargiulo, Mauro / Lorenzoni, Valentina /

Scevola, Germano / Stabile, Eugenio / Da Ros, Roberto / Murdolo, Giuseppe / Bianchini, Eleonora / Gaggia, Francesco / Gauna, Carlotta / Romeo, Francesco / Apicella, Matteo / Mantuano, Michele / Monami, Matteo / Uccioli, Luigi

Acta diabetologica

2024

Abstract: The treatment of patients with diabetic foot ulcers (DFUs) is extremely complex, requiring a comprehensive approach that involves a variety of different healthcare professionals. Several studies have shown that a multidisciplinary team (MDT) approach is ... ...

Abstract	The treatment of patients with diabetic foot ulcers (DFUs) is extremely complex, requiring a comprehensive approach that involves a variety of different healthcare professionals. Several studies have shown that a multidisciplinary team (MDT) approach is useful to achieve good clinical outcomes, reducing major and minor amputation and increasing the chance of healing. Despite this, the multidisciplinary approach is not always a recognized treatment strategy. The aim of this meta-analysis was to assess the effects of an MDT approach on major adverse limb events, healing, time-to-heal, all-cause mortality, and other clinical outcomes in patients with active DFUs. The present meta-analysis was performed for the purpose of developing Italian guidelines for the treatment of diabetic foot with the support of the Italian Society of Diabetology (Società Italiana di Diabetologia, SID) and the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD). The study was performed using the Grading of Recommendations Assessment, Development, and Evaluation approach. All randomized clinical trials and observational studies, with a duration of at least 26 weeks, which compared the MDT approach with any other organizational strategy in the management of patients with DFUs were considered. Animal studies were excluded. A search of Medline and Embase databases was performed up until the May 1st, 2023. Patients managed by an MDT were reported to have better outcomes in terms of healing, minor and major amputation, and survival in comparison with those managed using other approaches. No data were found on quality of life, returning-to-walking, and emergency admission. Authors concluded that the MDT may be effective in improving outcomes in patients with DFUs.
Language	English
Publishing date	2024-03-10
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1097676-0
ISSN	1432-5233 ; 0940-5429
ISSN (online)	1432-5233
ISSN	0940-5429
DOI	10.1007/s00592-024-02246-9
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Zs.A 611: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: [A case of severe metformin-associated lactic acidosis treated with CVVHDF and regional anticoagulation with sodium citrate].

Ferrario, Matteo / Apicella, Antonio / Della Morte, Mauro / Beretta, Enrico

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

2018 Volume 35, Issue 5

Abstract: Metformin is an antidiabetic drug; used to treat type II diabetes mellitus, metformin associated lactic acidosis has an incidence of 2-9 cases / 100,000 patients / year with high mortality (30%). We have had the case of a 75-year-old woman with metabolic ...

Abstract	Metformin is an antidiabetic drug; used to treat type II diabetes mellitus, metformin associated lactic acidosis has an incidence of 2-9 cases / 100,000 patients / year with high mortality (30%). We have had the case of a 75-year-old woman with metabolic acidosis as a result of metformin assumption, treated by renal replacement therapy (CRRT) with continuous veno-venous hemodiafiltration (CVVHDF). Results: after a short treatment period there was a reduction in Lactates (from 16.8 mmol/L to 12.6 mmol/L) and a progressive improvement of acidosis. In 72 hours the recovery of diuresis and subsequent suspension of CRRT was achieved. Conclusion: CRRT, in addition to ensuring support for renal failure and volume correction, allowed a rapid recovery from metformin-associated lactic acidosis.
MeSH term(s)	Acidosis, Lactic/chemically induced ; Acidosis, Lactic/complications ; Acidosis, Lactic/drug therapy ; Aged ; Anticoagulants/therapeutic use ; Bronchial Spasm/etiology ; Combined Modality Therapy ; Female ; Furosemide/therapeutic use ; Hemodiafiltration ; Humans ; Hypoglycemic Agents/adverse effects ; Hypotension/etiology ; Metformin/adverse effects ; Piperacillin, Tazobactam Drug Combination/therapeutic use ; Sodium Bicarbonate/therapeutic use ; Sodium Citrate/therapeutic use
Chemical Substances	Anticoagulants ; Hypoglycemic Agents ; Piperacillin, Tazobactam Drug Combination (157044-21-8) ; Sodium Citrate (1Q73Q2JULR) ; Furosemide (7LXU5N7ZO5) ; Sodium Bicarbonate (8MDF5V39QO) ; Metformin (9100L32L2N)
Language	Italian
Publishing date	2018-10-10
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	1237110-5
ISSN	1724-5990 ; 0393-5590
ISSN (online)	1724-5990
ISSN	0393-5590
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Article ; Online: COVID-19 in people with diabetes

Apicella, Matteo / Campopiano, Maria Cristina / Mantuano, Michele / Mazoni, Laura / Coppelli, Alberto / Del Prato, Stefano

The Lancet Diabetes & Endocrinology

understanding the reasons for worse outcomes

2020 Volume 8, Issue 9, Page(s) 782–792

Keywords	Internal Medicine ; Endocrinology, Diabetes and Metabolism ; Endocrinology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ISSN	2213-8587
DOI	10.1016/s2213-8587(20)30238-2
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Development of the Italian clinical practice guidelines for the treatment of diabetic foot syndrome: design and methodological aspects.

Acta diabetologica

2023 Volume 60, Issue 11, Page(s) 1449–1469

Abstract: Aims: Diabetic foot syndrome (DFS) and its complications are a growing public health concern. The Italian Society of Diabetology (SID) and the Italian Association of Clinical Diabetologists (AMD), in collaboration with other scientific societies, will ... ...

Abstract	Aims: Diabetic foot syndrome (DFS) and its complications are a growing public health concern. The Italian Society of Diabetology (SID) and the Italian Association of Clinical Diabetologists (AMD), in collaboration with other scientific societies, will develop the first Italian guidelines for the treatment of DFS. Methods: The creation of SID/AMD Guidelines is based on an extended work made by 19 panelists and 12 members of the Evidence Review Team. Grading of Recommendations, Assessment, Development and Evaluations (GRADE) methodology has been used to decide aims, reference population, and target health professionals. Clinical questions have been created using PICO (Patient, Intervention, Comparison, Outcome) conceptual framework. The definition of questions has been performed using a two-step web-based Delphi methodology, a structured technique aimed at obtaining by repeated rounds of questionnaires a consensus opinion from a panel of experts in areas wherein evidence is scarce or conflicting, and opinion is important. Results: The mean age of panelists (26.3% women) was 53.7 ± 10.6 years. The panel proposed 34 questions. A consensus was immediately reached for all the proposed questions, 32 were approved and 2 were rejected. Conclusions: The areas covered by clinical questions included diagnosis of ischemia and infection, treatment of ischemic, neuropathic, and infected ulcers, prevention of foot ulceration, organization and education issues, and surgical management. The PICO presented in this paper are designed to provide indications for healthcare professionals in charge of diabetic foot treatment and prevention, primarily based on clinical needs of people with diabetic foot syndrome and considering the existing organization of health care.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Middle Aged ; Consensus ; Diabetes Mellitus ; Diabetic Foot/etiology ; Diabetic Foot/therapy ; Diabetic Foot/diagnosis ; Italy/epidemiology ; Surveys and Questionnaires ; Practice Guidelines as Topic
Language	English
Publishing date	2023-07-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1097676-0
ISSN	1432-5233 ; 0940-5429
ISSN (online)	1432-5233
ISSN	0940-5429
DOI	10.1007/s00592-023-02150-8
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Article ; Online: Guida pratica alla prevenzione e gestione dell’infezione da COVID-19 nelle persone con diabete

Apicella, Matteo / Campopiano, Maria Cristina / Mantuano, Michele / Mazoni, Laura / Del Prato, Stefano

L'Endocrinologo

Abstract: La pandemia di COVID-19 rappresenta un’enorme sfida per il sistema sanitario nazionale. Sulla base dei dati ad oggi disponibili è emerso che le persone con diabete mellito presentano un maggior rischio di complicanze e morte per COVID-19. Pertanto, ... ...

Abstract	La pandemia di COVID-19 rappresenta un’enorme sfida per il sistema sanitario nazionale. Sulla base dei dati ad oggi disponibili è emerso che le persone con diabete mellito presentano un maggior rischio di complicanze e morte per COVID-19. Pertanto, adottare misure preventive di igiene e di distanziamento sociale è cruciale, a maggior ragione in questa categoria di soggetti. A sostegno dei pazienti con diabete sono state intraprese molteplici iniziative al fine di garantire la continuità assistenziale, tra cui la proroga della validità dei piani terapeutici per i farmaci ipoglicemizzanti, le procedure per il rinnovo della patente di guida e l’attivazione di servizi di telemedicina. In caso di infezione da COVID-19 e sintomi lievi è possibile una gestione domiciliare della persona con diabete, raccomandando un attento monitoraggio glicemico. Il paziente diabetico che necessita di ospedalizzazione richiede una gestione multidisciplinare che includa il diabetologo, con l’obiettivo di mantenere un adeguato controllo glicemico in assenza di ipoglicemie. Le persone con diabete rappresentano un gruppo vulnerabile per il quale devono essere poste in atto strategie specifiche sia in termini di prevenzione che di trattamento. MATERIALE ELETTRONICO SUPPLEMENTARE: La versione elettronica di questo articolo (10.1007/s40619-020-00767-3) contiene materiale supplementare, disponibile per gli utenti autorizzati.
Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1007/s40619-020-00767-3
Database	COVID19

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Article: COVID-19 in people with diabetes: understanding the reasons for worse outcomes

Apicella, Matteo / Campopiano, Maria Cristina / Mantuano, Michele / Mazoni, Laura / Coppelli, Alberto / Del Prato, Stefano

Lancet Diabetes Endocrinol

Abstract	Since the initial COVID-19 outbreak in China, much attention has focused on people with diabetes because of poor prognosis in those with the infection. Initial reports were mainly on people with type 2 diabetes, although recent surveys have shown that individuals with type 1 diabetes are also at risk of severe COVID-19. The reason for worse prognosis in people with diabetes is likely to be multifactorial, thus reflecting the syndromic nature of diabetes. Age, sex, ethnicity, comorbidities such as hypertension and cardiovascular disease, obesity, and a pro-inflammatory and pro-coagulative state all probably contribute to the risk of worse outcomes. Glucose-lowering agents and anti-viral treatments can modulate the risk, but limitations to their use and potential interactions with COVID-19 treatments should be carefully assessed. Finally, severe acute respiratory syndrome coronavirus 2 infection itself might represent a worsening factor for people with diabetes, as it can precipitate acute metabolic complications through direct negative effects on ß-cell function. These effects on ß-cell function might also cause diabetic ketoacidosis in individuals with diabetes, hyperglycaemia at hospital admission in individuals with unknown history of diabetes, and potentially new-onset diabetes.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #651329
Database	COVID19

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