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Article ; Online: Novel risk factor for valganciclovir toxicity-NUDT15 genetic variant.

Shingare, Ashay / Dhope, Nikhil / Bahadur, Madan M

Transplant infectious disease : an official journal of the Transplantation Society

2022 Volume 24, Issue 2, Page(s) e13799

MeSH term(s)	Azathioprine ; Humans ; Leukopenia ; Pyrophosphatases/genetics ; Risk Factors ; Valganciclovir/adverse effects
Chemical Substances	Pyrophosphatases (EC 3.6.1.-) ; Valganciclovir (GCU97FKN3R) ; Azathioprine (MRK240IY2L)
Language	English
Publishing date	2022-02-04
Publishing country	Denmark
Document type	Letter
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.13799
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Article: Efficacy of Casirivimab/Imdevimab in Kidney Transplant Recipients Admitted with Mild-to-Moderate COVID-19: A Case Series.

Rajmane, Siddhavinayak Suryakant / Patil, Ashwin Arunkumar / Dash, Choudhary Sudhiranjan / Bahadur, Madan M / Shingare, Ashay / Deshpande, Rushi Vijaykumar

Indian journal of nephrology

2023 Volume 33, Issue 5, Page(s) 371–372

Language	English
Publishing date	2023-06-05
Publishing country	India
Document type	Journal Article
ZDB-ID	2134388-3
ISSN	1998-3662 ; 0971-4065
ISSN (online)	1998-3662
ISSN	0971-4065
DOI	10.4103/ijn.ijn_300_22
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Article ; Online: COVID-19 in recent kidney transplant recipients.

Shingare, Ashay / Bahadur, Madan M / Raina, Shailesh

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2020 Volume 20, Issue 11, Page(s) 3206–3209

Abstract: As the coronavirus disease 2019 (COVID-19) pandemic spread across the globe, transplant programs suffered a setback. We report the first experience of COVID-19 infection within 1 month of living donor kidney transplant (LDKT). We describe 2 LDKT ... ...

Abstract	As the coronavirus disease 2019 (COVID-19) pandemic spread across the globe, transplant programs suffered a setback. We report the first experience of COVID-19 infection within 1 month of living donor kidney transplant (LDKT). We describe 2 LDKT recipients who were detected positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at day 19 and day 7 posttransplant. They had minimal symptoms at diagnosis and did not develop any respiratory complications or allograft dysfunction. Immunosuppression was de-escalated; however, nasopharyngeal swab real-time reverse transcription polymerase chain reaction (rRT-PCR) remained positive for SARS-CoV-2 for a prolonged time. Younger age, absence of other comorbidities, and lower dose of anti-thymocyte globulin (ATG) used as induction possibly contributed to good outcome in our recent LDKT recipients compared with earlier published cases of recent deceased donor kidney transplant recipients with COVID-19.
MeSH term(s)	Adult ; COVID-19/epidemiology ; Comorbidity ; Graft Rejection/prevention & control ; Humans ; Immunosuppression Therapy/methods ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/methods ; Male ; Middle Aged ; Pandemics ; Transplant Recipients
Keywords	covid19
Language	English
Publishing date	2020-06-28
Publishing country	United States
Document type	Case Reports
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.16120
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Article ; Online: COVID‐19 in recent kidney transplant recipients

Shingare, Ashay / Bahadur, Madan M. / Raina, Shailesh

American Journal of Transplantation ; ISSN 1600-6135 1600-6143

2020

Keywords	Immunology and Allergy ; Pharmacology (medical) ; Transplantation ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
DOI	10.1111/ajt.16120
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: COVID-19 in recent kidney transplant recipients

Shingare, Ashay / Bahadur, Madan M / Raina, Shailesh

Am. j. transplant

Abstract	As the coronavirus disease 2019 (COVID-19) pandemic spread across the globe, transplant programs suffered a setback. We report the first experience of COVID-19 infection within 1 month of living donor kidney transplant (LDKT). We describe 2 LDKT recipients who were detected positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection at day 19 and day 7 posttransplant. They had minimal symptoms at diagnosis and did not develop any respiratory complications or allograft dysfunction. Immunosuppression was de-escalated; however, nasopharyngeal swab real-time reverse transcription polymerase chain reaction (rRT-PCR) remained positive for SARS-CoV-2 for a prolonged time. Younger age, absence of other comorbidities, and lower dose of anti-thymocyte globulin (ATG) used as induction possibly contributed to good outcome in our recent LDKT recipients compared with earlier published cases of recent deceased donor kidney transplant recipients with COVID-19.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #591954
Database	COVID19

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Article: Study of patient characteristics/profile and factors determining the (immediate) outcome in spontaneous subarachnoid hemorrhage.

Shingare, Ashay / Nadkar, Milind Y / Singh, Raminder

The Journal of the Association of Physicians of India

2011 Volume 59, Page(s) 505–508

Abstract: Aims and objectives: The aims of the study were to delineate the risk factors, type and location of underlying pathology, outcome and the determinants of outcome in patients with spontaneous subarachnoid hemorrhage.: Material and methods: Forty ... ...

Abstract	Aims and objectives: The aims of the study were to delineate the risk factors, type and location of underlying pathology, outcome and the determinants of outcome in patients with spontaneous subarachnoid hemorrhage. Material and methods: Forty consecutive patients with spontaneous subarachnoid hemorrhage on neuroimaging scan were recruited over a period of 1 year. Risk factors profile, site and type of pathology seen on angiography were assessed in all patients. Patient outcome at the end of hospital stay was assessed using the Glasgow Outcome Scale (GOS) and was analysed with respect to demographic factors, premorbid risk factors, initial WFNS scoring, neuroimaging findings and complications during in-hospital stay. Results: Of the total 40 patients in the study, 43% were males and 57% were females. The mean age in study group was 49.63 yrs (SD 13.12). Fifty percent patients were hypertensive, 22.5% were smokers and alcohol intake was reported by 17.5%. Saccular aneurysms were seen in 80% patients and arteriovenous malformations in 7.5%. Aneurysms were more common in the anterior circulation than in the posterior circulation. Poor outcome was associated with higher age, hyponatremia, higher World Federation of Neurosurgeons (WFNS) grade on admission, presence of vasospasm on angiography, fever any time during the course in hospital and requirement of ventilatory support. Conclusion: Gender, site of aneurysmal bleeding (anterior/posterior circulation) and procedure performed (coiling/clipping) do not influence the immediate outcome of patients with subarachnoid hemorrhage. Further studies on Indian subset of patients are necessary to determine the patient characteristics and factors influencing the long-term outcome in spontaneous subarachnoid hemorrhage.
MeSH term(s)	Adult ; Age Distribution ; Age Factors ; Aged ; Angiography ; Female ; Glasgow Coma Scale ; Glasgow Outcome Scale ; Humans ; Intracranial Aneurysm/complications ; Intracranial Aneurysm/surgery ; Length of Stay ; Male ; Middle Aged ; Prognosis ; Risk Factors ; Sex Distribution ; Subarachnoid Hemorrhage/diagnosis ; Subarachnoid Hemorrhage/etiology ; Subarachnoid Hemorrhage/surgery ; Treatment Outcome ; Vasospasm, Intracranial/etiology ; Vasospasm, Intracranial/physiopathology
Language	English
Publishing date	2011-08
Publishing country	India
Document type	Journal Article
ZDB-ID	800766-4
ISSN	0004-5772
ISSN	0004-5772
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Article ; Online: A Multicenter Retrospective Cohort Study on Management Protocols and Clinical Outcomes After ABO-incompatible Kidney Transplantation in India.

Kute, Vivek B / Pathak, Vivek / Ray, Deepak S / Bhalla, Anil K / Godara, Suraj M / Narayanan, Sajith / Hegde, Umapati / Das, Pratik / Jha, Pranaw Kumar / Kher, Vijay / Dalal, Sonal / Bahadur, Madan M / Gang, Sishir / Sinha, Vijay Kumar / Patel, Himanshu V / Deshpande, Rushi / Mali, Manish / Sharma, Ashish / Das, Sushree Sashmita /

Transplantation

2023 Volume 108, Issue 2, Page(s) 545–555

Abstract: Background: There is no robust evidence-based data for ABO-incompatible kidney transplantation (ABOiKT) from emerging countries.: Methods: Data from 1759 living donor ABOiKT and 33 157 ABO-compatible kidney transplantations (ABOcKT) performed in ... ...

Abstract	Background: There is no robust evidence-based data for ABO-incompatible kidney transplantation (ABOiKT) from emerging countries. Methods: Data from 1759 living donor ABOiKT and 33 157 ABO-compatible kidney transplantations (ABOcKT) performed in India between March 5, 2011, and July 2, 2022, were included in this retrospective, multicenter (n = 25) study. The primary outcomes included management protocols, mortality, graft loss, and biopsy-proven acute rejection (BPAR). Results: Protocol included rituximab 100 (232 [13.18%]), 200 (877 [49.85%]), and 500 mg (569 [32.34%]); immunoadsorption (IA) (145 [8.24%]), IVIG (663 [37.69%]), and no induction 200 (11.37%). Mortality, graft loss, and BPAR were reported in 167 (9.49%), 136 (7.73%), and 228 (12.96%) patients, respectively, over a median follow-up of 36.3 mo. In cox proportional hazard model, mortality was higher with IA (hazard ratio [HR]: 2.53 [1.62-3.97]; P < 0.001), BPAR (HR: 1.83 [1.25-2.69]; P = 0.0020), and graft loss (HR: 1.66 [1.05-2.64]; P = 0.0310); improved graft survival was associated with IVIG (HR: 0.44 [0.26-0.72]; P = 0.0010); higher BPAR was reported with conventional tube method (HR: 3.22 [1.9-5.46]; P < 0.0001) and IA use (HR: 2 [1.37-2.92]; P < 0.0001), whereas lower BPAR was reported in the prepandemic era (HR: 0.61 [0.43-0.88]; P = 0.008). Primary outcomes were not associated with rituximab dosing or high preconditioning/presurgery anti-A/anti-B titers. Incidence of overall infection 306 (17.39%), cytomegalovirus 66 (3.75%), and BK virus polyoma virus 20 (1.13%) was low. In unmatched univariate analysis, the outcomes between ABOiKT and ABOcKT were comparable. Conclusions: Our largest multicenter study on ABOiKT provides insights into various protocols and management strategies with results comparable to those of ABOcKT.
MeSH term(s)	Humans ; Kidney Transplantation/methods ; Rituximab/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Retrospective Studies ; Immunoglobulins, Intravenous/therapeutic use ; Blood Group Incompatibility ; ABO Blood-Group System ; Graft Rejection/epidemiology ; Graft Rejection/prevention & control ; Graft Survival ; Living Donors ; Multicenter Studies as Topic
Chemical Substances	Rituximab (4F4X42SYQ6) ; Immunosuppressive Agents ; Immunoglobulins, Intravenous ; ABO Blood-Group System
Language	English
Publishing date	2023-08-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004789
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Article ; Online: Clinical Profile and Outcome of COVID-19 in 250 Kidney Transplant Recipients: A Multicenter Cohort Study From India.

Transplantation

2020 Volume 105, Issue 4, Page(s) 851–860

Abstract: Background: There is a scarcity of data on the consequences of coronavirus disease-19 (COVID-19) infections in kidney transplant recipients (KTRs) from emerging countries.: Methods: Here, we present a cohort study of 13 transplant centers in India ... ...

Abstract	Background: There is a scarcity of data on the consequences of coronavirus disease-19 (COVID-19) infections in kidney transplant recipients (KTRs) from emerging countries. Methods: Here, we present a cohort study of 13 transplant centers in India including 250 KTR (226 living and 24 deceased donors) with polymerase chain reaction-confirmed COVID-19 positivity from March 23, 2020, until September 15, 2020. We detailed demographics, immunosuppression regimen, clinical profile, treatment, and outcomes. Results: Median age of transplant recipients was 43 years, and recipients presented at a median of 3.5 years after transplant. Most common comorbidities (94%) included arterial hypertension (84%) and diabetes (32%); presenting symptoms at the time of COVID-19 included fever (88%), cough (72%), and sputum production (52%). Clinical severity ranged from asymptomatic (6%), mild (60%), and moderate (20%) to severe (14%). Strategies to modify immunosuppressants included discontinuation of antimetabolites without changes in calcineurin inhibitors and steroids (60%). Risk factors for mortality included older age; dyspnea; severe disease; obesity; allograft dysfunction before COVID-19 infection; acute kidney injury; higher levels of inflammatory markers including C-reactive protein, interleukin-6 level, and procalcitonin; chest X-ray abnormality, and intensive care unit/ventilator requirements. Overall patient mortality was 11.6% (29 of 250), 14.5% (29 of 200) in hospitalized patients, 47% (25 of 53) in intensive care unit patients, and 96.7% (29 of 30) in patients requiring ventilation. KTRs with mild COVID-19 symptoms (n = 50) were managed as outpatients to optimize the utilization of scarce resources during the COVID-19 pandemic. Conclusions: Mortality rates in COVID-19-positive KTR appear to be higher than those in nonimmunosuppressed patients, and high mortality was noted among those requiring intensive care and those on ventilator.
MeSH term(s)	Adult ; Aged ; Antiviral Agents/therapeutic use ; COVID-19/complications ; COVID-19/epidemiology ; Cohort Studies ; Female ; Humans ; Immunosuppression Therapy/adverse effects ; Immunosuppression Therapy/methods ; India/epidemiology ; Kidney Transplantation/adverse effects ; Kidney Transplantation/mortality ; Male ; Middle Aged ; Multivariate Analysis ; Pandemics ; Proportional Hazards Models ; Retrospective Studies ; SARS-CoV-2 ; Transplant Recipients ; Treatment Outcome ; Young Adult ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2020-12-24
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000003593
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Article ; Online: A Multicenter Cohort Study From India of 75 Kidney Transplants in Recipients Recovered After COVID-19.

Kute, Vivek B / Ray, Deepak S / Yadav, Dinesh Kumar / Pathak, Vivek / Bhalla, Anil K / Godara, Suraj / Kumar, Anil / Guleria, Sandeep / Khullar, Dinesh / Thukral, Sharmila / Mondal, Rabi Ranjan Sow / Jain, Manish / Jha, Pranaw Kumar / Hegde, Umapati / Abraham M, Abi / Dalal, Sonal / Patel, Himanshu / Bahadur, Madan M / Shingare, Ashay /

Sharma, Ashish / Kumar Sharma, Raj / Anandh, Urmila / Gulati, Sanjeev / Gumber, Manoj / Siddini, Vishwanath / Deshpande, Rushi / Kaswan, Kamal / Varyani, Umesh / Kakde, Shailesh / Kenwar, Deepesh B / Shankar Meshram, Hari / Kher, Vijay

Transplantation

2021 Volume 105, Issue 7, Page(s) 1423–1432

Abstract: Background: There is limited current knowledge on feasibility and safety of kidney transplantation in coronavirus disease-19 (COVID-19) survivors.: Methods: We present a retrospective cohort study of 75 kidney transplants in patients who recovered ... ...

Abstract	Background: There is limited current knowledge on feasibility and safety of kidney transplantation in coronavirus disease-19 (COVID-19) survivors. Methods: We present a retrospective cohort study of 75 kidney transplants in patients who recovered from polymerase chain reaction (PCR)-confirmed COVID-19 performed across 22 transplant centers in India from July 3, 2020, to January 31, 2021. We detail demographics, clinical manifestations, immunosuppression regimen, laboratory findings, treatment, and outcomes. Patients with a previous diagnosis of COVID-19 were accepted after documenting 2 negative severe acute respiratory syndrome coronavirus 2 PCR tests, normal chest imaging with complete resolution of symptom for at least 28 d and significant social distancing for 14 d before surgery. Results: Clinical severity in patients ranged from asymptomatic (n = 17, 22.7%), mild (n = 36.48%), moderate (n = 15.20%), and severe (n = 7.9.3%) disease. Median duration between PCR positive to transplant was 60 d (overall) and increased significantly from asymptomatic, mild, moderate, and severe disease (49, 57, 83, 94 d, P 0.019), respectively. All recipients and donors were asymptomatic with normal creatinine after surgery at a median (interquartile range) follow-up of 81 (56-117) d without any complications relating to surgery or COVID-19. Patient and graft survival was 100%, and acute rejection was reported in 6.6%. Conclusions: Prospective kidney transplant recipients post-COVID-19 can be considered for transplantation after comprehensive donor and recipient screening before surgery using a combination of clinical, radiologic, and laboratory criteria, careful pretransplant evaluation, and individualized risk-benefit analysis. Further large-scale prospective studies with longer follow-up will better clarify our initial findings. To date, this remains the first and the largest study of kidney transplantation in COVID-19 survivors.
MeSH term(s)	Adult ; Aged ; COVID-19/complications ; COVID-19/diagnosis ; Donor Selection/methods ; Female ; Follow-Up Studies ; Humans ; India ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Male ; Middle Aged ; Patient Selection ; Retrospective Studies ; Survivors ; Treatment Outcome
Language	English
Publishing date	2021-05-04
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000003740
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Article ; Online: Management strategies and outcomes in renal transplant recipients recovering from COVID-19: A retrospective, multicentre, cohort study.

Kute, Vivek B / Ray, Deepak S / Aziz, Feroz / Godara, Suraj M / Hegde, Umapati / KumarBT, Anil / Bhalla, Anil K / Yadav, Dinesh Kumar / Singh, Sarbpreet / Pathak, Vivek / Dalal, Sonal / Bahadur, Madan M / Anandh, Urmila / Abraham M, Abi / Siddini, Vishwanath / Das, Sushree Sashmita / Thukral, Sharmila / Krishnakumar, Arvind / Sharma, Ashish /

Kher, Vijay / Bansal, Shyam B / Shingare, Ashay / Narayanan, Ranjit / Patel, Himanshu / Gulati, Sanjeev / Kakde, Shailesh / Bansal, Dinesh / Guleria, Sandeep / Khullar, Dinesh / Gumber, Manoj R / Varyani, Umesh / Guditi, Swarnalatha / Khetan, Prakash / Dave, Rutul / Mishra, Vineet V / Tullius, Stefan G / Chauhan, Sanshriti / Meshram, Hari Shankar

EClinicalMedicine

2022 Volume 46, Page(s) 101359

Abstract: Background: There is an enormous knowledge gap on management strategies, clinical outcomes, and follow-up after kidney transplantation (KT) in recipients that have recovered from coronavirus disease (COVID-19).: Methods: We conducted a multi-center, ... ...

Abstract	Background: There is an enormous knowledge gap on management strategies, clinical outcomes, and follow-up after kidney transplantation (KT) in recipients that have recovered from coronavirus disease (COVID-19). Methods: We conducted a multi-center, retrospective analysis in 23 Indian transplant centres between June 26, 2020 to December 1, 2021 on KT recipients who recovered after COVID-19 infections. We analyzed clinical and biopsy-confirmed acute rejection (AR) incidence and used cox-proportional modeling to estimate multivariate-adjusted hazard ratios (HR) for predictors of AR. We also performed competing risk analysis. Additional outcome measures included graft loss, all-cause mortality, waiting time from a positive real-time polymerase test (RT-PCR) to KT, laboratory parameters, and quality of life in follow-up. Findings: Among 372 KT which included 38(10·21%) ABO-incompatible, 12(3·22%) sensitized, 64(17·20%) coexisting donors with COVID-19 history and 20 (5·37%) recipients with residual radiographic abnormalities, the incidence of AR was 34 (9·1%) with 1(0·26%) death censored graft loss, and 4(1·07%) all-cause mortality over a median (interquartile range) follow-up of 241 (106-350) days. In our cox hazard proportional analysis, absence of oxygen requirement during COVID-19 compared to oxygen need [HR = 0·14(0·03-0·59); Interpretation: Our findings support that the outcomes of KT after COVID-19 recovery are excellent with absence of COVID-19 sequelae during follow-up. Additionally, there does not seem to be a need for changes in the induction/immunosuppression regimen based on the severity of COVID-19. Funding: Sanofi.
Language	English
Publishing date	2022-03-25
Publishing country	England
Document type	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2022.101359
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