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Book: Richard Brautigan

Foster, Edward Halsey / Brautigan, Richard

(Twayne's United States authors series ; 439)

1983

Author's details	by Edward Halsey Foster
Series title	Twayne's United States authors series ; 439
Language	English
Size	142 S, Ill
Publisher	Twayne
Publishing place	Boston, Mass
Document type	Book
Note	Mit Bibliogr
ISBN	0805773789 ; 9780805773781
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: The Impact of Race and Ethnicity on Surgical Risk and Outcomes Following Palatoplasty: An Analysis of the NSQIP Pediatric Database.

Halsey, Jordan N / Asti, Lindsey / Kirschner, Richard E

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2022 Volume 60, Issue 6, Page(s) 663–670

Abstract: Objective: To determine how race and ethnicity affect palatoplasty 30-day outcomes.: Design: Retrospective review.: Patients/setting: The 2012 to 2019 National Surgical Quality Improvement Program (NSQIP) Pediatric database was used to identify ... ...

Abstract	Objective: To determine how race and ethnicity affect palatoplasty 30-day outcomes. Design: Retrospective review. Patients/setting: The 2012 to 2019 National Surgical Quality Improvement Program (NSQIP) Pediatric database was used to identify patients ≤ 2 years who underwent primary palatoplasty. We compared demographics, comorbidities, and 30-day outcomes among different racial and ethnic groups. Logistic regression was used to determine independent risk factors for adverse events. Main outcome measures: Increased risk for adverse events and postoperative surgical outcomes, including complications, readmission, and prolonged length of stay. Results: A total of 8537 patients were identified in the database. African-American patients had the highest proportion of premature infants and infants with a BMI < 15% at the time of repair. Asian patients underwent palatoplasty at a later age compared to other races (12.7 months vs 11.7-12.1 months). Postoperatively, the odds of a complication were significantly higher in Asian patients (aOR = 1.73, 95% CI: 1.17-2.57) and other/unknown patients (aOR = 1.40, 95% CI: 1.05-1.86), but not among African American (aOR = 1.02, 95% CI: 0.70-1.47) or Hispanic (aOR = 0.93, 95% CI: 0.69-1.26) patients. Other/unknown patients were more likely to require postoperative ventilation (aOR = 2.34, 95% CI: 1.38-3.95). The odds of readmission were highest in Asian and other/unknown patients. African American, Hispanic, and other/unknown patients were more likely than Caucasian patients to be hospitalized > 2 days postoperatively. Conclusion: This study highlights ethnic differences in presentation and 30-day outcomes following palatoplasty. Further evaluation of disparities in cleft care should be performed to improve healthcare access and surgical outcomes.
MeSH term(s)	Infant ; Humans ; Child ; Ethnicity ; Quality Improvement ; Length of Stay ; Cleft Palate/surgery ; Retrospective Studies ; Postoperative Complications/epidemiology
Language	English
Publishing date	2022-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1069409-2
ISSN	1545-1569 ; 0009-8701 ; 1055-6656
ISSN (online)	1545-1569
ISSN	0009-8701 ; 1055-6656
DOI	10.1177/10556656221078154
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Article ; Online: Role of elastic fiber degradation in disease pathogenesis.

Halsey, Gregory / Sinha, Dipasha / Dhital, Saphala / Wang, Xiaoying / Vyavahare, Naren

Biochimica et biophysica acta. Molecular basis of disease

2023 Volume 1869, Issue 5, Page(s) 166706

Abstract: ... thoroughly studied in elastic fiber rich tissues such as the vasculature and the lungs, even tissues ...

Abstract	Elastin is a crucial extracellular matrix protein that provides structural integrity to tissues. Crosslinked elastin and associated microfibrils, named elastic fiber, contribute to biomechanics by providing the elasticity required for proper function. During aging and disease, elastic fiber can be progressively degraded and since there is little elastin synthesis in adults, degraded elastic fiber is not regenerated. There is substantial evidence linking loss or damage of elastic fibers to the clinical manifestation and pathogenesis of a variety of diseases. Disruption of elastic fiber networks by hereditary mutations, aging, or pathogenic stimuli results in systemic ailments associated with the production of elastin degradation products, inflammatory responses, and abnormal physiology. Due to its longevity, unique mechanical properties, and widespread distribution in the body, elastic fiber plays a central role in homeostasis of various physiological systems. While pathogenesis related to elastic fiber degradation has been more thoroughly studied in elastic fiber rich tissues such as the vasculature and the lungs, even tissues containing relatively small quantities of elastic fibers such as the eyes or joints may be severely impacted by elastin degradation. Elastic fiber degradation is a common observation in certain hereditary, age, and specific risk factor exposure induced diseases representing a converging point of pathological clinical phenotypes which may also help explain the appearance of co-morbidities. In this review, we will first cover the role of elastic fiber degradation in the manifestation of hereditary diseases then individually explore the structural role and degradation effects of elastic fibers in various tissues and organ systems. Overall, stabilizing elastic fiber structures and repairing lost elastin may be effective strategies to reverse the effects of these diseases.
MeSH term(s)	Elastin/genetics ; Elastic Tissue/metabolism ; Extracellular Matrix/metabolism ; Extracellular Matrix Proteins/metabolism ; Lung/metabolism
Chemical Substances	Elastin (9007-58-3) ; Extracellular Matrix Proteins
Language	English
Publishing date	2023-03-29
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	60-7
ISSN	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-260X ; 1879-2596 ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbadis.2023.166706
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Article ; Online: Biologics in Acute Burn Injury.

Kogan, Samuel / Halsey, Jordan / Agag, Richard L

Annals of plastic surgery

2019 Volume 83, Issue 1, Page(s) 26–33

Abstract: There have been significant advances in the care of burns over the past decade. As a result of the improved survival of burn patients, attention has shifted to the optimized management of their wounds. Traditionally, autografts have been described as the ...

Abstract	There have been significant advances in the care of burns over the past decade. As a result of the improved survival of burn patients, attention has shifted to the optimized management of their wounds. Traditionally, autografts have been described as the gold standard treatment in cases of deep second- and third-degree burn wounds; however, they are limited especially in large surface area burns. As such, advancements have been made in the development of biologic dressings, which attempt to mimic the function of the lost epidermis and/or dermis. The ideal biologic dressing is nontoxic, lacks antigenicity, is immunologically compatible, and is sterile. Additionally, easy storage conditions, long shelf lives, and reasonable costs are key determinants of whether biologic dressings may truly be widely used in the clinical setting. Biologic dressings serve an important role as skin substitutes in the setting of acute burn injury. This review aims to summarize the multitude of available biologic dressings and their applications. METHODS: The PubMed and Google Scholar databases were searched for the following terms either alone or in combination: "burn injury," "biologic membrane," "skin substitutes," "biosynthetic dressings," and "acellular membrane."
MeSH term(s)	Biological Dressings ; Biological Products/administration & dosage ; Burns/diagnosis ; Burns/therapy ; Female ; Humans ; Injury Severity Score ; Male ; Prognosis ; Skin Transplantation/adverse effects ; Skin Transplantation/methods ; Skin, Artificial ; Transplantation, Autologous/methods ; Wound Healing/physiology
Chemical Substances	Biological Products
Language	English
Publishing date	2019-06-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	423835-7
ISSN	1536-3708 ; 0148-7043
ISSN (online)	1536-3708
ISSN	0148-7043
DOI	10.1097/SAP.0000000000001915
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Article ; Online: Radiographic imaging modalities for perinatal brachial plexus palsy: a systematic review.

Girard, Alisa O / Suresh, Visakha / Lopez, Christopher D / Seal, Stella M / Tuffaha, Sami H / Redett, Richard J / Halsey, Jordan N

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2022 Volume 38, Issue 7, Page(s) 1241–1258

Abstract: Purpose: Perinatal brachial plexus palsy (PBPP) has a wide spectrum of clinical symptoms that can range from incomplete paresis of the affected extremity to flaccid arm paralysis. Although there is a high rate of spontaneous recovery within the first ... ...

Abstract	Purpose: Perinatal brachial plexus palsy (PBPP) has a wide spectrum of clinical symptoms that can range from incomplete paresis of the affected extremity to flaccid arm paralysis. Although there is a high rate of spontaneous recovery within the first two years of life, it remains challenging to determine which patients will benefit most from surgical intervention. The diagnostic and predictive use of various imaging modalities has been described in the literature, but there is little consensus on approach or algorithm. The anatomic, pathophysiological, and neurodevelopmental characteristics of the neonatal and infant patient population affected by PBPP necessitate thoughtful consideration prior to selecting an imaging modality. Methods: A systematic review was conducted using six databases. Two reviewers independently screened articles published through October 2021. Results: Literature search produced 10,329 publications, and 22 articles were included in the final analysis. These studies included 479 patients. Mean age at time of imaging ranged from 2.1 to 12.8 months and investigated imaging modalities included MRI (18 studies), ultrasound (4 studies), CT myelography (4 studies), and X-ray myelography (1 study). Imaging outcomes were compared against surgical findings (16 studies) or clinical examination (6 studies), and 87.5% of patients underwent surgery. Conclusion: This systematic review addresses the relative strengths and challenges of common radiologic imaging options. MRI is the most sensitive and specific for identifying preganglionic nerve injuries such as pseudomeningoceles and rootlet avulsion, the latter of which has the poorest prognosis in this patient population and often dictates the need for surgical intervention.
MeSH term(s)	Brachial Plexus/diagnostic imaging ; Brachial Plexus/surgery ; Brachial Plexus Neuropathies/surgery ; Humans ; Infant ; Infant, Newborn ; Myelography/methods ; Paralysis ; Sensitivity and Specificity
Language	English
Publishing date	2022-05-10
Publishing country	Germany
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-022-05538-z
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Article ; Online: Interleukin-1 blockade with anakinra in acute leukaemia patients with severe COVID-19 pneumonia appears safe and may result in clinical improvement.

Day, James W / Fox, Thomas A / Halsey, Richard / Carpenter, Ben / Kottaridis, Panagiotis D

British journal of haematology

2020 Volume 190, Issue 2, Page(s) e80–e83

MeSH term(s)	Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Humans ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Interleukin-1/antagonists & inhibitors ; Leukemia/drug therapy ; Male ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
Chemical Substances	Interleukin 1 Receptor Antagonist Protein ; Interleukin-1
Keywords	covid19
Language	English
Publishing date	2020-06-10
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.16873
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Article ; Online: Calcium Supplements and Risk of CVD: A Meta-Analysis of Randomized Trials.

Huo, Xiqian / Clarke, Robert / Halsey, Jim / Jackson, Rebecca / Lehman, Amy / Prince, Richard / Lewis, Joshua / Baron, John A / Kroger, Heikki / Sund, Reijo / Armitage, Jane

Current developments in nutrition

2023 Volume 7, Issue 3, Page(s) 100046

Abstract: Background: Vitamin D supplements may only be beneficial for the prevention of osteoporotic fractures when administered with calcium and in individuals with low blood levels of 25(OH)D, but possible hazards of calcium supplements on CVD cannot be ... ...

Abstract	Background: Vitamin D supplements may only be beneficial for the prevention of osteoporotic fractures when administered with calcium and in individuals with low blood levels of 25(OH)D, but possible hazards of calcium supplements on CVD cannot be excluded. Objectives: We conducted a meta-analysis of all placebo-controlled randomized trials assessing the effects of calcium supplements alone or with vitamin D on CHD, stroke, and all-cause mortality. Methods: A meta-analysis of 11 trials included 7 comparisons of calcium alone compared with control ( Results: Among trials of calcium alone (mean daily dose 1 g), calcium was not significantly associated with any excess risk of MI (RR, 1.15; 95% CI: 0.88, 1.51; Conclusions: This meta-analysis demonstrated that calcium supplements were not associated with any significant hazard for CHD, stroke, or all-cause mortality and excluded excess risks above 0.3%-0.5% per year for CHD or stroke. Further trials of calcium and vitamin D are required in individuals with low blood levels of 25(OH)D for the prevention of fracture and other disease outcomes.
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article
ISSN	2475-2991
ISSN (online)	2475-2991
DOI	10.1016/j.cdnut.2023.100046
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Article ; Online: Scoliosis Research Society survey: brace management in adolescent idiopathic scoliosis.

Halsey, Matthew / Dolan, Lori A / Hostin, Richard A / Adobor, Raphael D / Dayer, Romain / Dema, Eugenio / Letaif, Olavo B

Spine deformity

2021 Volume 9, Issue 3, Page(s) 697–702

Abstract: Purpose: While the Scoliosis Research Society (SRS) has established criteria for brace initiation in adolescent idiopathic scoliosis (AIS), there are no recommendations concerning other management issues. As the BrAIST study reinforced the utility of ... ...

Abstract	Purpose: While the Scoliosis Research Society (SRS) has established criteria for brace initiation in adolescent idiopathic scoliosis (AIS), there are no recommendations concerning other management issues. As the BrAIST study reinforced the utility of bracing, the SRS Non-Operative Management Committee decided to evaluate the consensus or discord in AIS brace management. Methods: 1200 SRS members were sent an online survey in 2017, which included 21 items concerning demographics, bracing indications, management, and monitoring. Free-text responses were analyzed and collated into common themes. Data were analyzed using Microsoft Excel 2013. Results: Of 218 respondents; 207 regularly evaluate and manage patients with AIS, and 205 currently prescribe bracing. 99% of respondents use bracing for AIS and the majority (89%) use the published SRS criteria, or a modified version, to initiate bracing. 85% do not use brace monitoring and 66% use both %-Cobb correction and fit criteria to evaluate brace adequacy. In contrast, other aspects of brace management demonstrated a high degree of practice variability. This was seen with a radiographic assessment of maturity level, hours prescribed, timing and frequency of radiographic evaluation, the use of nighttime bracing only, and the method and timing of brace discontinuation. Conclusion: Although there is consensus in brace management amongst SRS members with respect to brace initiation and evaluation of adequacy, there is striking variability in how bracing for AIS is used. This variability may impact the overall efficacy of brace treatment and may be decreased with more robust guidelines from the SRS. Level of evidence: III.
MeSH term(s)	Adolescent ; Braces ; Consensus ; Humans ; Kyphosis ; Scoliosis/diagnostic imaging ; Scoliosis/therapy ; Societies
Language	English
Publishing date	2021-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2717704-X
ISSN	2212-1358 ; 2212-134X ; 2212-1358
ISSN (online)	2212-1358 ; 2212-134X
ISSN	2212-1358
DOI	10.1007/s43390-020-00265-4
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Article ; Online: Comparison of genetic variation between rare and common congeners of Dipodomys with estimates of contemporary and historical effective population size.

Halsey, Michaela K / Stuhler, John D / Bayona-Vásquez, Natalia J / Platt, Roy N / Goetze, Jim R / Martin, Robert E / Matocha, Kenneth G / Bradley, Robert D / Stevens, Richard D / Ray, David A

PloS one

2022 Volume 17, Issue 9, Page(s) e0274554

Abstract: Species with low effective population sizes are at greater risk of extinction because of reduced genetic diversity. Such species are more vulnerable to chance events that decrease population sizes (e.g. demographic stochasticity). Dipodomys elator, ( ... ...

Abstract	Species with low effective population sizes are at greater risk of extinction because of reduced genetic diversity. Such species are more vulnerable to chance events that decrease population sizes (e.g. demographic stochasticity). Dipodomys elator, (Texas kangaroo rat) is a kangaroo rat that is classified as threatened in Texas and field surveys from the past 50 years indicate that the distribution of this species has decreased. This suggests geographic range reductions that could have caused population fluctuations, potentially impacting effective population size. Conversely, the more common and widespread D. ordii (Ord's kangaroo rat) is thought to exhibit relative geographic and demographic stability. We assessed the genetic variation of D. elator and D. ordii samples using 3RAD, a modified restriction site associated sequencing approach. We hypothesized that D. elator would show lower levels of nucleotide diversity, observed heterozygosity, and effective population size when compared to D. ordii. We were also interested in identifying population structure within contemporary samples of D. elator and detecting genetic variation between temporal samples to understand demographic dynamics. We analyzed up to 61,000 single nucleotide polymorphisms. We found that genetic variability and effective population size in contemporary D. elator populations is lower than that of D. ordii. There is slight, if any, population structure within contemporary D. elator samples, and we found low genetic differentiation between spatial or temporal historical samples. This indicates little change in nuclear genetic diversity over 30 years. Results suggest that genetic diversity of D. elator has remained stable despite reduced population size and/or abundance, which may indicate a metapopulation-like system, whose fluctuations might counteract species extinction.
MeSH term(s)	Animals ; Base Sequence ; Dipodomys/genetics ; Genetic Variation ; Population Density ; Texas
Language	English
Publishing date	2022-09-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0274554
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Article: Interleukin-1 blockade with anakinra in acute leukaemia patients with severe COVID-19 pneumonia appears safe and may result in clinical improvement

Day, James W / Fox, Thomas A / Halsey, Richard / Carpenter, Ben / Kottaridis, Panagiotis D

Br J Haematol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #327255
Database	COVID19

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