Result 1 - 10 of total 744
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| Keywords | covid19 |
|---|---|
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #548494 |
| Database | COVID19 |
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Journal of vascular and interventional radiology : JVIR
2023 Volume 34, Issue 11, Page(s) 2028–2030
| MeSH term(s) | Male ; Humans ; Prostate/blood supply ; Embolization, Therapeutic ; Prostatic Hyperplasia/complications ; Prostatic Hyperplasia/diagnostic imaging ; Prostatic Hyperplasia/therapy ; Hematuria/etiology ; Hematuria/therapy ; Arteries |
|---|---|
| Language | English |
| Publishing date | 2023-08-01 |
| Publishing country | United States |
| Document type | Letter |
| ZDB-ID | 1137756-2 |
| ISSN | 1535-7732 ; 1051-0443 |
| ISSN (online) | 1535-7732 |
| ISSN | 1051-0443 |
| DOI | 10.1016/j.jvir.2023.07.029 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 3720: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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2024 Volume 15, Issue 1, Page(s) 605
Abstract: Theoretical models have successfully predicted the evolution of poultry pathogen virulence in industrialized farm contexts of broiler chicken populations. Whether there are ecological factors specific to more traditional rural farming that affect ... ...
| Abstract | Theoretical models have successfully predicted the evolution of poultry pathogen virulence in industrialized farm contexts of broiler chicken populations. Whether there are ecological factors specific to more traditional rural farming that affect virulence is an open question. Within non-industrialized farming networks, live bird markets are known to be hotspots of transmission, but whether they could shift selection pressures on the evolution of poultry pathogen virulence has not been addressed. Here, we revisit predictions for the evolution of virulence for viral poultry pathogens, such as Newcastle's disease virus, Marek's disease virus, and influenza virus, H5N1, using a compartmental model that represents transmission in rural markets. We show that both the higher turnover rate and higher environmental persistence in markets relative to farms could select for higher optimal virulence strategies. In contrast to theoretical results modeling industrialized poultry farms, we find that cleaning could also select for decreased virulence in the live poultry market setting. Additionally, we predict that more virulent strategies selected in markets could circulate solely within poultry located in markets. Thus, we recommend the close monitoring of markets not only as hotspots of transmission, but as potential sources of more virulent strains of poultry pathogens. |
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| MeSH term(s) | Animals ; Poultry ; Chickens ; Influenza A Virus, H5N1 Subtype ; Farms ; Epidemiological Models ; Influenza in Birds |
| Language | English |
| Publishing date | 2024-01-19 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2553671-0 |
| ISSN | 2041-1723 ; 2041-1723 |
| ISSN (online) | 2041-1723 |
| ISSN | 2041-1723 |
| DOI | 10.1038/s41467-024-44777-3 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Journal of Clinical and Diagnostic Research, Vol 17, Iss 10, Pp 32-
A Retrospective Observational Study
2023 Volume 35
Abstract: Introduction: The Fontan operation is a surgical technique used to treat cyanotic heart diseases with single ventricle physiology. Although it has undergone several modifications since its inception in 1971, it is still associated with significant ... ...
| Abstract | Introduction: The Fontan operation is a surgical technique used to treat cyanotic heart diseases with single ventricle physiology. Although it has undergone several modifications since its inception in 1971, it is still associated with significant morbidity and mortality. Aim: To examine the outcomes of the Fontan operation and identify various risk factors associated with it. Materials and Methods: This retrospective observational study was conducted at the Postgraduate Institute of Medical Education and Research (PGIMER) in Chandigarh, India from January 2014 to December 2017. All patients who underwent the Fontan operation at PGIMER were included in the study. The study analysed outcomes such as survival, arrhythmias, neurological complications, heart failure, cirrhosis, and Protein Losing Enteropathy (PLE) following the Fontan operation. Various risk factors that could potentially influence the outcome of the Fontan operation were assessed, including preoperative, intraoperative, and postoperative factors. Statistical analysis was performed using Statistical Package for the Social Sciences (SPSS) software, version 25.0. The Chi-square test was utilised to determine predictors of survival and other longterm outcomes, with a p-value of <0.05 considered statistically significant. Results: A total of 35 patients underwent the Fontan operation during the study period and completed five years of follow-up. Out of these, 28 were known to be alive at the last contact. There were six early deaths (less than one year). The overall oneyear and five-year survival rates from the time of the operation were 29 (83%) and 28 (80%), respectively. Graft thrombosis/ thromboembolism was observed in three cases (8.6%) and neurological complications in three cases (8.6%) during the early postoperative period. Arrhythmias in 6 cases (14%) were the most common late postoperative complication. Conclusion: The Fontan procedure is currently the best available palliative treatment for cyanotic heart diseases with single ventricle ... |
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| Keywords | fontan operation ; pulmonary artery pressure ; protein losing enteropathy ; Medicine ; R |
| Subject code | 610 |
| Language | English |
| Publishing date | 2023-10-01T00:00:00Z |
| Publisher | JCDR Research and Publications Private Limited |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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Pacing and clinical electrophysiology : PACE
2024
Abstract: Introduction: Concomitant left bundle branch area pacing (LBBAP) with atrioventricular (AV) nodal ablation is emerging as a viable management option in atrial fibrillation refractory to medical management. Its viability in patients with pulmonary ... ...
| Abstract | Introduction: Concomitant left bundle branch area pacing (LBBAP) with atrioventricular (AV) nodal ablation is emerging as a viable management option in atrial fibrillation refractory to medical management. Its viability in patients with pulmonary disease and atrial fibrillation is unknown. Methods and results: This is a retrospective, observational cohort study in consecutive patients who underwent concomitant LBBAP with AV nodal ablation with advanced pulmonary disease at the Cleveland Clinic Fairview Hospital between January 2019 and January 2023. Patient characteristics, comorbidities, and medication use were extracted via chart review. Rates of hospitalizations, medication use, and structural disease seen on echocardiography were compared before and after the procedure. There were 27 patients with group 3 pulmonary hypertension who underwent the procedure. In the 24 months preprocedure, there were 114 admissions for heart failure or atrial fibrillation compared to 9 admissions postprocedure (p < .001). Mean follow up was 17.3 ± 12.1 months. There were no significant complications or lead dislodgements. Echocardiographic characteristics were similar prior to and after pacemaker implantation. Use of medications for rate and rhythm control was common preprocedure, and was reduced dramatically postprocedure. Conclusion: This small, retrospective cohort study suggests concomitant LBBAP with AV nodal ablation may be safe and efficacious for management of atrial fibrillation in patients with advanced pulmonary disease. |
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| Language | English |
| Publishing date | 2024-04-20 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 424437-0 |
| ISSN | 1540-8159 ; 0147-8389 |
| ISSN (online) | 1540-8159 |
| ISSN | 0147-8389 |
| DOI | 10.1111/pace.14990 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1466: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 399: Show issues |
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2022 Volume 82, Issue 13, Page(s) 1273–1283
Abstract: Background: Previously we reported that arsenic and estrogen cause synergistic effects in the neoplastic transformation of human prostate epithelial cells. In addition to receptor-mediated pathways, DNA-reactive estrogen metabolites have also been shown ...
| Abstract | Background: Previously we reported that arsenic and estrogen cause synergistic effects in the neoplastic transformation of human prostate epithelial cells. In addition to receptor-mediated pathways, DNA-reactive estrogen metabolites have also been shown to play a critical role in mutagenicity and carcinogenicity. Both estrogen and arsenic are known prostate carcinogens, however, the effect of coexposure to these two chemicals on genes involved in estrogen metabolism is not known. Therefore, the objective of this study was to evaluate the role of arsenic and estrogen coexposure on the expression of estrogen receptors and estrogen metabolism-associated genes. Earlier, we also reported the synergistic effect of arsenic and estrogen on decreased expression of MBD4 genes that play an important role in DNA repair through its DNA glycosylase activity. To further understand the mechanism, the promoter methylation of this gene was also analyzed. Methods: Total RNA and protein were isolated from RWPE-1 human prostate epithelial cells that were coexposed to arsenic and estrogen for a chronic duration (6 months). The expression of estrogen receptors, estrogen metabolism associated phase I genes (CYP 1A1, 1A2, 3A4, and 1B1) and phase II gene catechol-O-methyltransferase (COMT), as well as antioxidant MnSOD, were analyzed either at the RNA level by quantitative reverse transcriptase-polymerase chain reaction or at the protein level by western blot. Promoter methylation of MBD4 was analyzed by pyrosequencing. Results: Expression of MnSOD and phase I genes that convert E Conclusions: These novel findings suggest that coexposure to arsenic and estrogen acts synergistically in the activation of not only the estrogen receptors but also the genes associated with genotoxic estrogen metabolism and epigenetic inactivation of DNA glycosylase MBD4. Together, these genetic and epigenetic aberrations provide the molecular basis for the potentiation of carcinogenicity of arsenic and estrogen coexposure in prostate epithelial cells. |
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| MeSH term(s) | Arsenic/metabolism ; Arsenic/toxicity ; Catechol O-Methyltransferase/genetics ; Catechol O-Methyltransferase/metabolism ; Catechol O-Methyltransferase/pharmacology ; DNA Damage/drug effects ; DNA Damage/genetics ; DNA Glycosylases/genetics ; DNA Glycosylases/metabolism ; DNA Glycosylases/pharmacology ; DNA Methylation ; Endodeoxyribonucleases/genetics ; Endodeoxyribonucleases/metabolism ; Endodeoxyribonucleases/pharmacology ; Environmental Exposure ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Estrogens/adverse effects ; Estrogens/pharmacology ; Humans ; Male ; Metabolic Networks and Pathways ; Prostate/drug effects ; Prostate/metabolism ; Prostate/pathology ; RNA ; Receptors, Estrogen/genetics ; Receptors, Estrogen/metabolism |
| Chemical Substances | Estrogens ; Receptors, Estrogen ; RNA (63231-63-0) ; Catechol O-Methyltransferase (EC 2.1.1.6) ; Endodeoxyribonucleases (EC 3.1.-) ; MBD4 protein, human (EC 3.1.-) ; DNA Glycosylases (EC 3.2.2.-) ; Arsenic (N712M78A8G) |
| Language | English |
| Publishing date | 2022-06-23 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 604707-5 |
| ISSN | 1097-0045 ; 0270-4137 |
| ISSN (online) | 1097-0045 |
| ISSN | 0270-4137 |
| DOI | 10.1002/pros.24401 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1608: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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2024 , Page(s) 2692155241236600
Abstract: Objective: The Posterior Standing Overhead Arm Reach (SOAR) test has been previously reported as a reliable clinical measure of closed chain hip extension motion. The proposed Medial SOAR test expands on that testing approach to provide a similar ... ...
| Abstract | Objective: The Posterior Standing Overhead Arm Reach (SOAR) test has been previously reported as a reliable clinical measure of closed chain hip extension motion. The proposed Medial SOAR test expands on that testing approach to provide a similar measure of functional hip adduction motion. This was a preliminary intrarater and interrater reliability and validity study of the Medial SOAR test as a measure of functional hip adduction. Design: Cross-sectional. Setting: University motion analysis laboratory. Participants: Fifty hips were assessed in 25 (22 female) asymptomatic participants (mean age = 23.4 years, SD = 0.8). Main measures: Maximum hip adduction during the Medial SOAR test was measured with a standard goniometer independently by two examiners. The test was also performed using three-dimensional motion capture. The intrarater and interrater reliability of the goniometric measure was determined using intraclass correlation coefficients, and the relationship between measures obtained via goniometry and three-dimensional motion capture was assessed with Pearson correlations and Bland-Altman analysis. Results: Intrarater reliability (ICC Conclusions: Similar to the previously reported Posterior SOAR test, the Medial SOAR test demonstrated acceptable intrarater and interrater reliability, along with low-to-moderate associations with three-dimensional motion capture. The Medial SOAR test has the potential to provide a reliable and accurate assessment of closed chain hip adduction. |
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| Language | English |
| Publishing date | 2024-03-05 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 639276-3 |
| ISSN | 1477-0873 ; 0269-2155 |
| ISSN (online) | 1477-0873 |
| ISSN | 0269-2155 |
| DOI | 10.1177/02692155241236600 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 2297: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Journal of microbiology & biology education
2021 Volume 22, Issue 2
Abstract: CRISPR-Cas9 genome editing technology is widely used in scientific research and biotechnology. As this technology becomes a staple tool in life sciences research, it is increasingly important to incorporate it into biology curricula to train future ... ...
| Abstract | CRISPR-Cas9 genome editing technology is widely used in scientific research and biotechnology. As this technology becomes a staple tool in life sciences research, it is increasingly important to incorporate it into biology curricula to train future scientists. To demonstrate the molecular underpinnings and some limitations of CRISPR-based gene editing, we designed a laboratory module to accompany a discussion-based course on genome editing for college and advanced high school biology students. The laboratory module uses CRISPR-Cas9 to target and inactivate the |
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| Language | English |
| Publishing date | 2021-05-31 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 1935-7877 |
| ISSN | 1935-7877 |
| DOI | 10.1128/jmbe.00106-21 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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South Dakota medicine : the journal of the South Dakota State Medical Association
2021 Volume 73, Issue 11, Page(s) 540–541
| MeSH term(s) | Human Trafficking/prevention & control ; Humans |
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| Language | English |
| Publishing date | 2021-03-08 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2278073-7 |
| ISSN | 0038-3317 |
| ISSN | 0038-3317 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.B 205: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2019 Volume 11, Issue Suppl 15, Page(s) S1973–S1975
| Language | English |
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| Publishing date | 2019-10-14 |
| Publishing country | China |
| Document type | Editorial ; Comment |
| ZDB-ID | 2573571-8 |
| ISSN | 2077-6624 ; 2072-1439 |
| ISSN (online) | 2077-6624 |
| ISSN | 2072-1439 |
| DOI | 10.21037/jtd.2019.07.61 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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