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  1. Book ; Online: Climate Adaptation Modelling

    Kondrup, Claus / Mercogliano, Paola / Bosello, Francesco / Mysiak, Jaroslav / Scoccimarro, Enrico / Rizzo, Angela / Ebrey, Rhian / Ruiter, Marleen de / Jeuken, Ad / Watkiss, Paul

    (Springer Climate)

    2022  

    Author's details edited by Claus Kondrup, Paola Mercogliano, Francesco Bosello, Jaroslav Mysiak, Enrico Scoccimarro, Angela Rizzo, Rhian Ebrey, Marleen de Ruiter, Ad Jeuken, Paul Watkiss
    Series title Springer Climate
    Keywords Climatology ; Natural disasters ; Ecology—Methodology ; Bioclimatology ; Earth sciences ; Geography
    Subject code 551.6
    Language English
    Size 1 Online-Ressource (XVII, 238 p. 49 illus., 46 illus. in color)
    Edition 1st ed. 2022
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT021216945
    ISBN 978-3-030-86211-4 ; 9783030862107 ; 9783030862121 ; 9783030862138 ; 3-030-86211-9 ; 3030862100 ; 3030862127 ; 3030862135
    DOI 10.1007/978-3-030-86211-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Climate Adaptation Modelling

    Kondrup, Claus / Mercogliano, Paola / Bosello, Francesco / Mysiak, Jaroslav / Scoccimarro, Enrico / Rizzo, Angela / Ebrey, Rhian / Ruiter, Marleen de / Jeuken, Ad / Watkiss, Paul

    (Springer Climate)

    2022  

    Series title Springer Climate
    Keywords Meteorology & climatology ; Natural disasters ; Ecological science, the Biosphere ; Mathematics & science ; Climate change ; Climate adaptation ; Climate modelling ; Hazard assessment ; Rapid analysis ; Climate-Change Policy ; Climate-Change Adaptation ; Climate-Change Impacts ; Climate Change Management
    Language English
    Size 1 electronic resource (238 pages)
    Publisher Springer Nature
    Publishing place Cham
    Document type Book ; Online
    Note English
    HBZ-ID HT030379277
    ISBN 9783030862114 ; 3030862119
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: The Use of Microbial Modifying Therapies to Prevent Psoriasis Exacerbation and Associated Cardiovascular Comorbidity.

    Reali, Eva / Caliceti, Cristiana / Lorenzini, Antonello / Rizzo, Paola

    Inflammation

    2023  Volume 47, Issue 1, Page(s) 13–29

    Abstract: Psoriasis has emerged as a systemic disease characterized by skin and joint manifestations as well as systemic inflammation and cardiovascular comorbidities. Many progresses have been made in the comprehension of the immunological mechanisms involved in ... ...

    Abstract Psoriasis has emerged as a systemic disease characterized by skin and joint manifestations as well as systemic inflammation and cardiovascular comorbidities. Many progresses have been made in the comprehension of the immunological mechanisms involved in the exacerbation of psoriatic plaques, and initial studies have investigated the mechanisms that lead to extracutaneous disease manifestations, including endothelial disfunction and cardiovascular disease. In the past decade, the involvement of gut dysbiosis in the development of pathologies with inflammatory and autoimmune basis has clearly emerged. More recently, a major role for the skin microbiota in establishing the immunological tolerance in early life and as a source of antigens leading to cross-reactive responses towards self-antigens in adult life has also been evidenced. Gut microbiota can indeed be involved in shaping the immune and inflammatory response at systemic level and in fueling inflammation in the cutaneous and vascular compartments. Here, we summarized the microbiota-mediated mechanisms that, in the skin and gut, may promote and modulate local or systemic inflammation involved in psoriatic disease and endothelial dysfunction. We also analyze the emerging strategies for correcting dysbiosis or modulating skin and gut microbiota composition to integrate systemically existing pharmacological therapies for psoriatic disease. The possibility of merging systemic treatment and tailored microbial modifying therapies could increase the efficacy of the current treatments and potentially lower the effect on patient's life quality.
    MeSH term(s) Adult ; Humans ; Dysbiosis/pathology ; Psoriasis/drug therapy ; Psoriasis/pathology ; Comorbidity ; Skin/pathology ; Inflammation
    Language English
    Publishing date 2023-11-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 434408-x
    ISSN 1573-2576 ; 0360-3997
    ISSN (online) 1573-2576
    ISSN 0360-3997
    DOI 10.1007/s10753-023-01915-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1401: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Scleral fixation of the Smaller-Incision New-Generation Implantable Miniature Telescope (SING IMT ™) using GoreTex suture.

    Savastano, Alfonso / Sammarco, Leonardo Andrea / Francione, Giuseppe / Sasso, Paola / Rizzo, Stanislao

    Retinal cases & brief reports

    2024  

    Abstract: Purpose: In this case report we describe a surgical technique for scleral fixation of the Smaller-Incision New-Generation Implantable Miniature Telescope (SING-IMT). Using this surgical technique, patient's eye which receive surgery for the SING-IMT, ... ...

    Abstract Purpose: In this case report we describe a surgical technique for scleral fixation of the Smaller-Incision New-Generation Implantable Miniature Telescope (SING-IMT). Using this surgical technique, patient's eye which receive surgery for the SING-IMT, could still have a safe SING IMT implant despite the anatomical conditions of the capsular bag or in cases of intraoperative complications.
    Methods: The surgery was performed at Policlinico A. Gemelli, Rome, Italy. The patient's eye underwent a first surgery for artificial intraocular lens (IOL) explant and SING-IMT implant at the same time. We observed SING IMT dislocation into the vitreous chamber 90 days after surgery. We therefore carried out a 23-gauge vitrectomy and after SING IMT recovery from the vitreous chamber, we fixed one of its haptic to the sclera using a 8.0 GoreTex suture.
    Conclusion: Scleral fixation of SING-IMT haptics might be useful in eyes with dislocated or not stable SING IMT. We believe that reporting our experience can help surgeons to fix SING IMT in complicated cases where a capsular bag rupture o disinsertion (like our case) can cause SING IMT decentration or worse its drop into the vitreous chamber. We speculate that GoreTex suture could assure firm fixation of the SING IMT and could reduce the risk of recurrent dislocations.
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000001572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Skin erythematous migrant lesions consistent with histologically confirmed dermal arteriolar thrombosis connected to APS.

    Suardi, Silvia / Croce, Jacopo / Colato, Chiara / Rizzo, Paola Chiara / Friso, Simonetta / Pizzolo, Francesca

    Lupus

    2024  Volume 33, Issue 5, Page(s) 532–535

    Abstract: Antiphospholipid syndrome (APS) is an acquired thrombophilic disorder related to the presence of antiphospholipid antibodies (LAC, anticardiolipin, anti Beta2-glycoprotein) known to cause venous and arterial thrombosis and recurrent pregnancy loss. Skin ... ...

    Abstract Antiphospholipid syndrome (APS) is an acquired thrombophilic disorder related to the presence of antiphospholipid antibodies (LAC, anticardiolipin, anti Beta2-glycoprotein) known to cause venous and arterial thrombosis and recurrent pregnancy loss. Skin disorder is a frequent finding usually due to vascular thrombosis involving the dermal layer and can be either localized or widespread causing necrosis and ulceration of the skin, without histological evidence of vasculitis. We present a case of a woman with APS with both arterial and venous thrombotic involvement associated with an atypical dermatological manifestation histologically consistent with a pauci-inflammatory intermediate-deep dermal arteriolar platelet-mediated thrombosis that appeared despite anticoagulation with warfarin and responding to the addition of antiplatelet therapy.
    MeSH term(s) Pregnancy ; Female ; Humans ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Transients and Migrants ; Lupus Erythematosus, Systemic/complications ; Thrombosis/complications ; Erythema
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1154407-7
    ISSN 1477-0962 ; 0961-2033
    ISSN (online) 1477-0962
    ISSN 0961-2033
    DOI 10.1177/09612033241238270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3717: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The Critical Impact of Sphingolipid Metabolism in Breast Cancer Progression and Drug Response.

    Corsetto, Paola Antonia / Zava, Stefania / Rizzo, Angela Maria / Colombo, Irma

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Breast cancer is the second leading cause of cancer-related death in women in the world, and its management includes a combination of surgery, radiation therapy, chemotherapy, and immunotherapy, whose effectiveness depends largely, but not exclusively, ... ...

    Abstract Breast cancer is the second leading cause of cancer-related death in women in the world, and its management includes a combination of surgery, radiation therapy, chemotherapy, and immunotherapy, whose effectiveness depends largely, but not exclusively, on the molecular subtype (Luminal A, Luminal B, HER2+ and Triple Negative). All breast cancer subtypes are accompanied by peculiar and substantial changes in sphingolipid metabolism. Alterations in sphingolipid metabolite levels, such as ceramides, dihydroceramide, sphingosine, sphingosine-1-phosphate, and sphingomyelin, as well as in their biosynthetic and catabolic enzymatic pathways, have emerged as molecular mechanisms by which breast cancer cells grow, respond to or escape therapeutic interventions and could take on diagnostic and prognostic value. In this review, we summarize the current landscape around two main themes: 1. sphingolipid metabolites, enzymes and transport proteins that have been found dysregulated in human breast cancer cells and/or tissues; 2. sphingolipid-driven mechanisms that allow breast cancer cells to respond to or evade therapies. Having a complete picture of the impact of the sphingolipid metabolism in the development and progression of breast cancer may provide an effective means to improve and personalize treatments and reduce associated drug resistance.
    MeSH term(s) Female ; Humans ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Ceramides/metabolism ; Sphingolipids/metabolism ; Sphingomyelins ; Lipid Metabolism
    Chemical Substances Ceramides ; Sphingolipids ; Sphingomyelins
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Segregation of Benzoic Acid in Polymer Crystalline Cavities.

    Cozzolino, Antonietta / Monaco, Guglielmo / Rizzo, Paola / Guerra, Gaetano

    Polymers

    2022  Volume 15, Issue 1

    Abstract: Benzoic acid (BA) and its derivatives are very attractive because of their pharmacological properties, such as antioxidant, radical-regulating, antiviral, antitumor, anti-inflammatory, antimicrobial and antifungal. Syndiotactic polystyrene (sPS) and poly( ...

    Abstract Benzoic acid (BA) and its derivatives are very attractive because of their pharmacological properties, such as antioxidant, radical-regulating, antiviral, antitumor, anti-inflammatory, antimicrobial and antifungal. Syndiotactic polystyrene (sPS) and poly(2,6-dimethyl-1,4-phenylene)oxide (PPO) films exhibiting co-crystalline phases with BA were prepared and characterized by WAXD, FTIR and polarized FTIR measurements. The FTIR measurements clearly showed that BA was present mainly as a dimer in the crystalline channels of the ε form of sPS as well as in the α form of PPO, as generally occurs not only in the solid state but also in organic dilute solutions. BA was instead present as isolated molecules in the crystalline cavities of the δ form of sPS. In fact, the FTIR spectra of BA guest molecules exhibited vibrational peaks close to those of BA in its vapor phase. Hence, the nanoporous-crystalline δ form of sPS not only avoids additive aggregation but also leads to the separation of dimeric molecules and the segregation of monomeric BA.
    Language English
    Publishing date 2022-12-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15010177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Critical Impact of Sphingolipid Metabolism in Breast Cancer Progression and Drug Response

    Paola Antonia Corsetto / Stefania Zava / Angela Maria Rizzo / Irma Colombo

    International Journal of Molecular Sciences, Vol 24, Iss 2107, p

    2023  Volume 2107

    Abstract: Breast cancer is the second leading cause of cancer-related death in women in the world, and its management includes a combination of surgery, radiation therapy, chemotherapy, and immunotherapy, whose effectiveness depends largely, but not exclusively, ... ...

    Abstract Breast cancer is the second leading cause of cancer-related death in women in the world, and its management includes a combination of surgery, radiation therapy, chemotherapy, and immunotherapy, whose effectiveness depends largely, but not exclusively, on the molecular subtype (Luminal A, Luminal B, HER2+ and Triple Negative). All breast cancer subtypes are accompanied by peculiar and substantial changes in sphingolipid metabolism. Alterations in sphingolipid metabolite levels, such as ceramides, dihydroceramide, sphingosine, sphingosine-1-phosphate, and sphingomyelin, as well as in their biosynthetic and catabolic enzymatic pathways, have emerged as molecular mechanisms by which breast cancer cells grow, respond to or escape therapeutic interventions and could take on diagnostic and prognostic value. In this review, we summarize the current landscape around two main themes: 1. sphingolipid metabolites, enzymes and transport proteins that have been found dysregulated in human breast cancer cells and/or tissues; 2. sphingolipid-driven mechanisms that allow breast cancer cells to respond to or evade therapies. Having a complete picture of the impact of the sphingolipid metabolism in the development and progression of breast cancer may provide an effective means to improve and personalize treatments and reduce associated drug resistance.
    Keywords breast cancer ; sphingolipids ; lipids ; metabolism ; ceramide ; sphingomyelin ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610 ; 616
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Hydrogen Bonded Dimer of an Alcohol with the Derived Carboxylic Acid Triggering their Sorption by Nanoporous-crystalline PPO Films.

    Nagendra, Baku / Cozzolino, Antonietta / Acocella, Maria Rosaria / Daniel, Christophe / Rizzo, Paola / Guerra, Gaetano

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2023  Volume 29, Issue 55, Page(s) e202301441

    Abstract: Films exhibiting nanoporous-crystalline (NC) phases of poly(2,6-dimethyl-1,4-phenylene) oxide (PPO), which are highly effective to absorb apolar organic guest molecules, are also able to absorb polar molecules (like alcohols and carboxylic acids) but ... ...

    Abstract Films exhibiting nanoporous-crystalline (NC) phases of poly(2,6-dimethyl-1,4-phenylene) oxide (PPO), which are highly effective to absorb apolar organic guest molecules, are also able to absorb polar molecules (like alcohols and carboxylic acids) but only from concentrated organic solutions. NC PPO films, which do not absorb alcohols and carboxylic acids from diluted aqueous solutions, exhibits a huge uptake (even above 30 wt %) of benzyl alcohol (BAL) and benzoic acid (BA), if BA is obtained by spontaneous room temperature oxidation of BAL in aqueous solution. This phenomenon is rationalized by an easy uptake, mainly by the PPO intrahelical crystalline empty channels, of a BAL/BA 1/1 hydrogen-bonded dimer. This huge uptake of BAL/BA dimer by NC PPO films, which is also fast for films exhibiting the orientation of the crystalline helices perpendicular to the film plane (c
    Language English
    Publishing date 2023-08-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202301441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Dependence on Film Thickness of Guest-Induced

    Nagendra, Baku / Vignola, Emanuele / Daniel, Christophe / Rizzo, Paola / Guerra, Gaetano

    Polymers

    2021  Volume 13, Issue 24

    Abstract: For poly(2,6-dimethyl-1,4-phenylene)oxide (PPO) films exhibiting nanoporous-crystalline (NC) phases, ...

    Abstract For poly(2,6-dimethyl-1,4-phenylene)oxide (PPO) films exhibiting nanoporous-crystalline (NC) phases,
    Language English
    Publishing date 2021-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym13244384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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