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  1. Article ; Online: Understanding the role of chronopharmacology for drug optimization: what do we know?

    Fujimura, Akio / Ushijima, Kentaro

    Expert review of clinical pharmacology

    2023  Volume 16, Issue 7, Page(s) 655–668

    Abstract: Introduction: Circadian rhythm influences the pharmacokinetics and pharmacodynamics of a number of drugs and affects their therapeutic efficacy and toxicity depending on the time of day they are administered. Chronopharmacology is a method for ... ...

    Abstract Introduction: Circadian rhythm influences the pharmacokinetics and pharmacodynamics of a number of drugs and affects their therapeutic efficacy and toxicity depending on the time of day they are administered. Chronopharmacology is a method for incorporating knowledge about circadian rhythm into pharmacotherapy. Chronotherapy, which is the clinical application of chronopharmacology, is particularly relevant when the risk and/or severity of symptoms of a disease change in a predictable manner over time. Chronotherapy has potential benefits in the treatment of many diseases.
    Areas covered: Although a considerable amount of knowledge about chronopharmacology and chronotherapy has been accumulated, its therapeutic application in clinical practice remains limited in terms of therapy optimization. Resolution of these issues will improve our ability to deliver adequate drug treatment.
    Expert opinion: We propose four approaches for promoting chronotherapy-based drug treatment in clinical practice: targeting drug development and regulatory authorities; education about chronotherapy; drug information for both health professionals and consumers; and a chronotherapy network.
    MeSH term(s) Humans ; Circadian Rhythm ; Chronotherapy/methods
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Journal Article ; Review
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2023.2233438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Chronotherapy of hypertension].

    Fujimura, Akio

    Nihon rinsho. Japanese journal of clinical medicine

    2015  Volume 73, Issue 11, Page(s) 1846–1850

    Abstract: Blunted blood pressure (BP) decline during night-time leads to the higher risk of cardiovascular events in hypertensive patients. Therefore, to improve the prognosis of the patients, it is essential for properly controlling BP during night-time sleep as ... ...

    Abstract Blunted blood pressure (BP) decline during night-time leads to the higher risk of cardiovascular events in hypertensive patients. Therefore, to improve the prognosis of the patients, it is essential for properly controlling BP during night-time sleep as well as day-time activity. In addition, the dosing-time dependent changes are observed in the pharmacokinetics and pharmacodynamics of some antihypertensive drugs. Thus, the efficacy and toxicity of drugs might be affected by their dosing-time. Chronotherapy is the therapeutic application of chronopharmacology and chronotoxicology to enhance the effectiveness and tolerance of drugs by determining optical dosing-time of drugs from a circadian perspective. In this article, chronotherapy of angiotensin-converting enzyme inhibitor, Ca channel blocker, α1 blocker, diuretics and angiotensin II receptor blocker will be discussed.
    MeSH term(s) Antihypertensive Agents/therapeutic use ; Blood Pressure ; Calcium Channel Blockers/therapeutic use ; Chronotherapy ; Circadian Clocks ; Humans ; Hypertension/therapy
    Chemical Substances Antihypertensive Agents ; Calcium Channel Blockers
    Language Japanese
    Publishing date 2015-11
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 429: Show issues Location:
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  3. Article ; Online: COVID-19 infection at nighttime.

    Fujimura, Akio / Ushijima, Kentaro / Smolensky, Michael H

    Chronobiology international

    2020  Volume 37, Issue 5, Page(s) 726–727

    MeSH term(s) Betacoronavirus/pathogenicity ; COVID-19 ; Circadian Rhythm/physiology ; Coronavirus Infections/virology ; Humans ; Pandemics ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Virus Diseases/etiology
    Keywords covid19
    Language English
    Publishing date 2020-06-08
    Publishing country England
    Document type Letter
    ZDB-ID 998996-1
    ISSN 1525-6073 ; 0742-0528
    ISSN (online) 1525-6073
    ISSN 0742-0528
    DOI 10.1080/07420528.2020.1767642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Programs for continuing medical education: B session: 4. Chronotherapy in medicine--dosing-time dependent effect and safety of drugs].

    Fujimura, Akio

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2013  Volume 102, Issue 3, Page(s) 664–668

    MeSH term(s) Circadian Clocks/physiology ; Drug Administration Schedule ; Drug Therapy/methods ; Education, Medical, Continuing ; Humans ; Time Factors ; Treatment Outcome
    Language Japanese
    Publishing date 2013-05-21
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    DOI 10.2169/naika.102.664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Edoxaban Dosing Time Affects Blood Coagulation Inhibition in Rats.

    Nagata, Naoto / Kawasumi, Muneo / Fujimura, Akio / Ando, Hitoshi

    TH open : companion journal to thrombosis and haemostasis

    2021  Volume 5, Issue 2, Page(s) e107–e112

    Abstract: Coagulation-fibrinolytic system activity shows daily rhythmicity, with hypercoagulability in the morning and hypocoagulability in the evening. Consequently, the efficacy of anticoagulants may be influenced by their dosing time. Edoxaban, a selective ... ...

    Abstract Coagulation-fibrinolytic system activity shows daily rhythmicity, with hypercoagulability in the morning and hypocoagulability in the evening. Consequently, the efficacy of anticoagulants may be influenced by their dosing time. Edoxaban, a selective inhibitor of the active form of coagulation factor X (FXa), is taken orally once daily, but the optimal dosing time is unknown. This study evaluated the dosing time-dependent effects of edoxaban on coagulation activity and thrombus formation in rats. Edoxaban (10 mg/kg) or vehicle was administered to Wistar rats at zeitgeber time (ZT)-2 (beginning of the light phase) or ZT14 (beginning of the dark phase), followed by blood collection at ZT4, ZT10, ZT16, or ZT22, to measure the activity of coagulation factors and edoxaban concentrations, or followed by inferior vena cava ligations at ZT4 or ZT16, to assess the efficacy of edoxaban against thrombus formation. Coagulation FX activity was high during the light phase, and a single dose of edoxaban administered at ZT2 inhibited FX activity and thrombus formation more potently compared with the same dose administered at ZT14. The inhibitory effects during the light phase could be attributed, at least in part, to the high blood concentration of edoxaban achieved by dosing at ZT2. Morning dosing of edoxaban leads to a high blood concentration of the drug during the morning hours and thus may better counteract the hypercoagulability and hypofibrinolytic activity characteristic of the morning hours. Optimizing the dosing time may contribute to improving the efficacy of edoxaban.
    Language English
    Publishing date 2021-04-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2901738-5
    ISSN 2512-9465 ; 2567-3459
    ISSN (online) 2512-9465
    ISSN 2567-3459
    DOI 10.1055/s-0041-1725041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Chronotherapy--present and future].

    Fujimura, Akio

    Nihon rinsho. Japanese journal of clinical medicine

    2013  Volume 71, Issue 12, Page(s) 2097–2101

    Abstract: Chronotherapy integrates chronoeffective and chronotoxic data to enhance an effectiveness and tolerance of a drug by choosing optimal dosing-time. Chronotherapy is already performed in several diseases such as hypertension, osteoporosis, dyslipidemia and ...

    Abstract Chronotherapy integrates chronoeffective and chronotoxic data to enhance an effectiveness and tolerance of a drug by choosing optimal dosing-time. Chronotherapy is already performed in several diseases such as hypertension, osteoporosis, dyslipidemia and malignant diseases, and improves the prognosis of these patients. However, it is still a new concept for physicians. Efforts are needed to take chronotherapy into dosage regimen by physicians, who have a major role in providing the benefits of chronotherapy to their patients. In addition, chronotherapy studies are not requested for drug evaluations by the regulatory authorities. However, preliminary screening of new drugs for their chronotherapeutic potential is a way of enhancing the research and development in pharmaceutical industries.
    MeSH term(s) Chronotherapy/methods ; Circadian Clocks ; Humans ; Hypertension/therapy ; Neoplasms/therapy ; Osteoporosis/therapy ; Prognosis
    Language Japanese
    Publishing date 2013-12
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Chronotherapy in the treatment of cardiovascular diseases.

    Fujimura, Akio

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2011  Volume 137, Issue 3, Page(s) 125–129

    MeSH term(s) Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/physiopathology ; Chronotherapy/methods ; Humans ; Hypertension/drug therapy ; Myocardial Infarction/drug therapy
    Language Japanese
    Publishing date 2011
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.137.125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 439: Show issues Location:
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  9. Book: Hayabusa Asteroid Sample catalogue

    Fujimura, Akio

    (Uchū Kōkū Kenkyū Kaihatsu Kikō tokubetsu shiryō = JAXA special publication : JAXA-SP ; 2012,12E)

    2013  

    Title variant Hayabusa Asteroid Sample catalogue 2011
    Author's details Japan Aerospace Exploration Agency
    Series title Uchū Kōkū Kenkyū Kaihatsu Kikō tokubetsu shiryō = JAXA special publication : JAXA-SP ; 2012,12E
    Language English
    Size 366 S., Ill., graph. Darst.
    Publisher Japan Aerospace Exploration Agency
    Publishing place Tokyo
    Document type Book
    Note Literaturverz. S. 47 - 50
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Article ; Online: Potential mechanism of hepatic lipid accumulation during a long-term rest phase restricted feeding in mice.

    Tsurudome, Yuya / Akamine, Takahiro / Horiguchi, Michiko / Wada, Yukiyo / Fujimura, Akio / Ushijima, Kentaro

    Chronobiology international

    2022  Volume 39, Issue 8, Page(s) 1132–1143

    Abstract: Eating during a rest phase disrupts the biological clock system and leads to obesity and metabolic diseases. Although a rest phase restricted feeding (RF) is reported to enhance hepatic lipid accumulation, the mechanism(s) of the phenomenon is still ... ...

    Abstract Eating during a rest phase disrupts the biological clock system and leads to obesity and metabolic diseases. Although a rest phase restricted feeding (RF) is reported to enhance hepatic lipid accumulation, the mechanism(s) of the phenomenon is still unknown. This study evaluated the potential involvement of the CD36-related transport of lipids into the liver in mice with the RF procedure. This study showed that hepatic lipid accumulation was more significant in the RF group compared with mice under an active phase restricted feeding (AF). The RF procedure also elevated the expression of CD36 mRNA and its protein on the cellular membrane throughout the day. The transcription factor profiling array revealed that the RF activated the proliferator-activated receptor-γ (PPARγ), one of the CD36 transcript enhancers. In the liver of RF mice, the expression of miR-27b-3p, which is known to interfere with PPARγ gene expression, significantly decreased. These results suggest that the RF procedure inhibits the expression of miR-27b-3p in the liver and subsequently elevates PPARγ activity. Activated PPARγ might lead to CD36 upregulation, which, in turn, stimulates the transport of lipids into the liver.
    MeSH term(s) Animals ; Circadian Rhythm ; Lipids ; Liver/metabolism ; Mice ; MicroRNAs/genetics ; PPAR gamma/metabolism
    Chemical Substances Lipids ; MicroRNAs ; PPAR gamma
    Language English
    Publishing date 2022-05-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 998996-1
    ISSN 1525-6073 ; 0742-0528
    ISSN (online) 1525-6073
    ISSN 0742-0528
    DOI 10.1080/07420528.2022.2077746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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