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  1. Article ; Online: Is Nosocomial SARS-CoV-2 Still Worth Preventing?

    Klompas, Michael / Baker, Meghan A / Rhee, Chanu

    JAMA network open

    2023  Volume 6, Issue 11, Page(s) e2344704

    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.44704
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  2. Article ; Online: Strategic Masking to Protect Patients from All Respiratory Viral Infections.

    Klompas, Michael / Baker, Meghan A / Rhee, Chanu / Baden, Lindsey R

    The New England journal of medicine

    2023  Volume 389, Issue 1, Page(s) 4–6

    MeSH term(s) Humans ; Respiratory Tract Infections/prevention & control ; Virus Diseases/prevention & control ; Masks
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMp2306223
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  3. Article ; Online: Coronavirus Disease 2019's Challenges to Infection Control Dogma Regarding Respiratory Virus Transmission.

    Klompas, Michael / Baker, Meghan A / Rhee, Chanu

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 75, Issue 1, Page(s) e102–e104

    MeSH term(s) COVID-19 ; Humans ; Infection Control ; SARS-CoV-2
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac204
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  4. Article ; Online: Prevention of SARS-CoV-2 and respiratory viral infections in healthcare settings: current and emerging concepts.

    Rhee, Chanu / Baker, Meghan A / Klompas, Michael

    Current opinion in infectious diseases

    2022  Volume 35, Issue 4, Page(s) 353–362

    Abstract: Purpose of review: COVID-19 has catalyzed a wealth of new data on the science of respiratory pathogen transmission and revealed opportunities to enhance infection prevention practices in healthcare settings.: Recent findings: New data refute the ... ...

    Abstract Purpose of review: COVID-19 has catalyzed a wealth of new data on the science of respiratory pathogen transmission and revealed opportunities to enhance infection prevention practices in healthcare settings.
    Recent findings: New data refute the traditional division between droplet vs airborne transmission and clarify the central role of aerosols in spreading all respiratory viruses, including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), even in the absence of so-called 'aerosol-generating procedures' (AGPs). Indeed, most AGPs generate fewer aerosols than talking, labored breathing, or coughing. Risk factors for transmission include high viral loads, symptoms, proximity, prolonged exposure, lack of masking, and poor ventilation. Testing all patients on admission and thereafter can identify early occult infections and prevent hospital-based clusters. Additional prevention strategies include universal masking, encouraging universal vaccination, preferential use of N95 respirators when community rates are high, improving native ventilation, utilizing portable high-efficiency particulate air filters when ventilation is limited, and minimizing room sharing when possible.
    Summary: Multifaceted infection prevention programs that include universal testing, masking, vaccination, and enhanced ventilation can minimize nosocomial SARS-CoV-2 infections in patients and workplace infections in healthcare personnel. Extending these insights to other respiratory viruses may further increase the safety of healthcare and ready hospitals for novel respiratory viruses that may emerge in the future.
    MeSH term(s) Aerosols ; COVID-19/prevention & control ; Delivery of Health Care ; Health Personnel ; Humans ; SARS-CoV-2
    Chemical Substances Aerosols
    Language English
    Publishing date 2022-07-05
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000839
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  5. Article ; Online: Survey of coronavirus disease 2019 (COVID-19) infection control policies at leading US academic hospitals in the context of the initial pandemic surge of the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) omicron variant.

    Rhee, Chanu / Baker, Meghan A / Klompas, Michael

    Infection control and hospital epidemiology

    2022  Volume 44, Issue 4, Page(s) 597–603

    Abstract: Objective: To assess coronavirus disease 2019 (COVID-19) infection policies at leading US medical centers in the context of the initial wave of the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) omicron variant.: Design: Electronic survey ... ...

    Abstract Objective: To assess coronavirus disease 2019 (COVID-19) infection policies at leading US medical centers in the context of the initial wave of the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) omicron variant.
    Design: Electronic survey study eliciting hospital policies on masking, personal protective equipment, cohorting, airborne-infection isolation rooms (AIIRs), portable HEPA filters, and patient and employee testing.
    Setting and participants: "Hospital epidemiologists from U.S. News top 20 hospitals and 10 hospitals in the CDC Prevention Epicenters program."  As it is currently written, it implies all 30 hospitals are from the CDC Prevention Epicenters program, but that only applies to 10 hospitals.  Alternatively, we could just say "Hospital epidemiologists from 30 leading US hospitals."
    Methods: Survey results were reported using descriptive statistics.
    Results: Of 30 hospital epidemiologists surveyed, 23 (77%) completed the survey between February 15 and March 3, 2022. Among the responding hospitals, 18 (78%) used medical masks for universal masking and 5 (22%) used N95 respirators. 16 hospitals (70%) required universal eye protection. 22 hospitals (96%) used N95s for routine COVID-19 care and 1 (4%) reserved N95s for aerosol-generating procedures. 2 responding hospitals (9%) utilized dedicated COVID-19 wards; 8 (35%) used mixed COVID-19 and non-COVID-19 units; and 13 (57%) used both dedicated and mixed units. 4 hospitals (17%) used AIIRs for all COVID-19 patients, 10 (43%) prioritized AIIRs for aerosol-generating procedures, 3 (13%) used alternate risk-stratification criteria (not based on aerosol-generating procedures), and 6 (26%) did not routinely use AIIRs. 9 hospitals (39%) did not use portable HEPA filters, but 14 (61%) used them for various indications, most commonly as substitutes for AIIRs when unavailable or for specific high-risk areas or situations. 21 hospitals (91%) tested asymptomatic patients on admission, but postadmission testing strategies and preferred specimen sites varied substantially. 5 hospitals (22%) required regular testing of unvaccinated employees and 1 hospital (4%) reported mandatory weekly testing even for vaccinated employees during the SARS-CoV-2 omicron surge.
    Conclusions: COVID-19 infection control practices in leading hospitals vary substantially. Clearer public health guidance and transparency around hospital policies may facilitate more consistent national standards.
    MeSH term(s) Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Pandemics/prevention & control ; Respiratory Aerosols and Droplets ; Virus Diseases ; Infection Control/methods ; Hospitals
    Language English
    Publishing date 2022-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2022.155
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  6. Article ; Online: Impact of SARS-CoV-2 Prevention Measures on Non-SARS-CoV-2 Hospital-Onset Respiratory Viral Infections: An Incidence Trend Analysis From 2015-2023.

    Ehrenzeller, Selina / Chen, Tom / Vaidya, Vineeta / Rhee, Chanu / Baker, Meghan A / Klompas, Michael

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 12, Page(s) 1696–1699

    Abstract: We reviewed hospital-onset respiratory viral infections, 2015-2023, in one hospital to determine whether Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmission prevention measures prevented non-SARS-CoV-2 respiratory viral infections. ... ...

    Abstract We reviewed hospital-onset respiratory viral infections, 2015-2023, in one hospital to determine whether Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmission prevention measures prevented non-SARS-CoV-2 respiratory viral infections. Masking, employee symptom attestations, and screening patients and visitors for symptoms were associated with a 44%-53% reduction in hospital-onset influenza and respiratory syncytial virus (RSV), accounting for changes in community incidence.
    MeSH term(s) Humans ; SARS-CoV-2 ; Incidence ; COVID-19/epidemiology ; COVID-19/prevention & control ; Influenza, Human ; Hospitals ; Respiratory Syncytial Virus, Human ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus Infections/prevention & control ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/prevention & control
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad451
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  7. Article ; Online: Prison Visitation and Concerns about Reentry: Variations in Frequency and Quality of Visits are Associated with Reentry Concerns among People Incarcerated in Prison.

    Baker, Thomas / Mitchell, Meghan M / Gordon, Jill A

    International journal of offender therapy and comparative criminology

    2021  Volume 66, Issue 12, Page(s) 1263–1284

    Abstract: Prior studies suggest that visitation may have an impact on successful reentry. At the same time, the impact of visitation on incarcerated people's concerns about reentry has received little empirical attention. Understanding how factors such as ... ...

    Abstract Prior studies suggest that visitation may have an impact on successful reentry. At the same time, the impact of visitation on incarcerated people's concerns about reentry has received little empirical attention. Understanding how factors such as visitation affect concerns about reentry can provide correctional officials with policy directions on how to reduce strains and enhance successful reintegration. Further, while some studies have evaluated frequency of visitation far fewer have examined the impact of quality of visitation. Using a sample of males and females incarcerated in five correctional facilities (
    MeSH term(s) Employment ; Female ; Housing ; Humans ; Male ; Prisoners ; Prisons ; Recidivism
    Language English
    Publishing date 2021-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218274-9
    ISSN 1552-6933 ; 0306-624X
    ISSN (online) 1552-6933
    ISSN 0306-624X
    DOI 10.1177/0306624X211013516
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  8. Article ; Online: Concise syntheses of GB22, GB13, and himgaline by cross-coupling and complete reduction.

    Landwehr, Eleanor M / Baker, Meghan A / Oguma, Takuya / Burdge, Hannah E / Kawajiri, Takahiro / Shenvi, Ryan A

    Science (New York, N.Y.)

    2022  Volume 375, Issue 6586, Page(s) 1270–1274

    Abstract: Neuroactive metabolites from the bark ... ...

    Abstract Neuroactive metabolites from the bark of
    MeSH term(s) Alkaloids/chemical synthesis ; Alkaloids/chemistry ; Chemistry Techniques, Synthetic ; Heterocyclic Compounds/chemical synthesis ; Heterocyclic Compounds/chemistry ; Magnoliopsida ; Oxidation-Reduction ; Stereoisomerism ; Trees
    Chemical Substances Alkaloids ; Heterocyclic Compounds ; himgaline ; alkaloid GB22
    Language English
    Publishing date 2022-03-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abn8343
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  9. Article ; Online: Association of Omicron vs Wild-type SARS-CoV-2 Variants With Hospital-Onset SARS-CoV-2 Infections in a US Regional Hospital System.

    Klompas, Michael / Pandolfi, Michael C / Nisar, Ansa B / Baker, Meghan A / Rhee, Chanu

    JAMA

    2022  Volume 328, Issue 3, Page(s) 296–298

    MeSH term(s) COVID-19/genetics ; COVID-19/virology ; Hospitals/statistics & numerical data ; Humans ; SARS-CoV-2/genetics ; United States/epidemiology
    Language English
    Publishing date 2022-06-15
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.9609
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  10. Article ; Online: Olefin Hydroarylation via Ni/Co Dual Catalysis.

    Shevick, Sophie L / Baker, Meghan A / Shenvi, Ryan A

    Trends in chemistry

    2020  Volume 1, Issue 5, Page(s) 540–541

    Abstract: Cobalt/nickel dual-catalysis enables the branch-selective hydroarylation of olefins through a novel "cage-rebound" transmetalation pathway. This process allows for the rapid introduction of complexity by coupling readily available iodoarenes with ... ...

    Abstract Cobalt/nickel dual-catalysis enables the branch-selective hydroarylation of olefins through a novel "cage-rebound" transmetalation pathway. This process allows for the rapid introduction of complexity by coupling readily available iodoarenes with abundant and unbiased alkenes without the need for substrate prefunctionalization.
    Language English
    Publishing date 2020-07-28
    Publishing country United States
    Document type Journal Article
    ISSN 2589-5974
    ISSN (online) 2589-5974
    DOI 10.1016/j.trechm.2019.06.003
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