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Article: Bright-light distractions and visual performance.

Williamson, Craig A / Morganti, Jari J / Smithson, Hannah E

2023 Volume 14, Page(s) 1088975

Abstract: Visual distractions pose a significant risk to transportation safety, with laser attacks against aircraft pilots being a common example. This study used a research-grade High Dynamic Range (HDR) display to produce bright-light distractions for 12 ... ...

Abstract	Visual distractions pose a significant risk to transportation safety, with laser attacks against aircraft pilots being a common example. This study used a research-grade High Dynamic Range (HDR) display to produce bright-light distractions for 12 volunteer participants performing a combined visual task across central and peripheral visual fields. The visual scene had an average luminance of 10 cd∙m
Language	English
Publishing date	2023-04-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1088975
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Article: Liquid biopsy for brain metastases and leptomeningeal disease in patients with breast cancer.

Morganti, Stefania / Parsons, Heather A / Lin, Nancy U / Grinshpun, Albert

NPJ breast cancer

2023 Volume 9, Issue 1, Page(s) 43

Abstract: A significant subset of patients with metastatic breast cancer develops brain metastasis. As efficacy of systemic therapies has improved and patients live longer with metastatic breast cancer, the incidence of breast cancer brain metastases has increased. ...

Abstract	A significant subset of patients with metastatic breast cancer develops brain metastasis. As efficacy of systemic therapies has improved and patients live longer with metastatic breast cancer, the incidence of breast cancer brain metastases has increased. Brain metastases pose a clinical challenge in diagnosis, treatment, and monitoring across all breast cancer subtypes, and better tools are needed. Liquid biopsy, which enables minimally invasive sampling of a patient's cancer, has the potential to shed light on intra-cranial tumor biology and to improve patient care by enabling therapy tailoring. Here we review current evidence for the clinical validity of liquid biopsy in patients with breast cancer brain metastases, with a focus on circulating tumor cells and circulating tumor DNA.
Language	English
Publishing date	2023-05-24
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2374-4677
ISSN	2374-4677
DOI	10.1038/s41523-023-00550-1
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Article ; Online: Dexamethasone induces p21

Ricci, Anastasia / Biancucci, Federica / Morganti, Gianluca / Magnani, Mauro / Menotta, Michele

FEBS open bio

2023 Volume 13, Issue 8, Page(s) 1459–1468

Abstract: Ataxia-Telangiectasia (A-T) is a very rare autosomal recessive multisystemic disorder which to date is still uncurable. The use of glucocorticoid analogs, such as dexamethasone (dex), can improve neurological symptoms in patients, but the molecular ... ...

Abstract	Ataxia-Telangiectasia (A-T) is a very rare autosomal recessive multisystemic disorder which to date is still uncurable. The use of glucocorticoid analogs, such as dexamethasone (dex), can improve neurological symptoms in patients, but the molecular mechanism of action of these analogs remains unclear. Here, we report the effects of dex in regulating the interaction between Lamin A/C and HDAC2 in WT and A-T cells. Upon administration of dex to A-T cells, we first observed that the accumulation of HDAC2 on the CDKN1A promoter did not exert a repressive role on p21
MeSH term(s)	Humans ; Ataxia Telangiectasia/drug therapy ; Ataxia Telangiectasia/genetics ; Lamin Type A/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Glucocorticoids ; Dexamethasone/pharmacology ; Histone Deacetylase 2/genetics ; Histone Deacetylase 2/metabolism
Chemical Substances	Lamin Type A ; Cyclin-Dependent Kinase Inhibitor p21 ; Glucocorticoids ; Dexamethasone (7S5I7G3JQL) ; HDAC2 protein, human (EC 3.5.1.98) ; Histone Deacetylase 2 (EC 3.5.1.98)
Language	English
Publishing date	2023-07-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2651702-4
ISSN	2211-5463 ; 2211-5463
ISSN (online)	2211-5463
ISSN	2211-5463
DOI	10.1002/2211-5463.13663
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Article ; Online: Current progress toward isogeometric modeling of the heart biophysics.

Torre, Michele / Morganti, Simone / Pasqualini, Francesco S / Reali, Alessandro

Biophysics reviews

2023 Volume 4, Issue 4, Page(s) 41301

Abstract: In this paper, we review a powerful methodology to solve complex numerical simulations, known as isogeometric analysis, with a focus on applications to the biophysical modeling of the heart. We focus on the hemodynamics, modeling of the valves, cardiac ... ...

Abstract	In this paper, we review a powerful methodology to solve complex numerical simulations, known as isogeometric analysis, with a focus on applications to the biophysical modeling of the heart. We focus on the hemodynamics, modeling of the valves, cardiac tissue mechanics, and on the simulation of medical devices and treatments. For every topic, we provide an overview of the methods employed to solve the specific numerical issue entailed by the simulation. We try to cover the complete process, starting from the creation of the geometrical model up to the analysis and post-processing, highlighting the advantages and disadvantages of the methodology.
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2688-4089
ISSN (online)	2688-4089
DOI	10.1063/5.0152690
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Article ; Online: Fluorescence-Based Evaluation of Bacterial Load in Perilesional Skin: A Comparison Between Short Stretch Bandage and Zinc Oxide Bandage.

Michelucci, Alessandra / Salvia, Giorgia / Janowska, Agata / Granieri, Giammarco / Morganti, Riccardo / Dini, Valentina / Romanelli, Marco

The international journal of lower extremity wounds

2023 , Page(s) 15347346231206449

Abstract: Bacterial proliferation plays a well-known role in delayed tissue healing. To date, the presence of microorganisms on the wound bed can be detected by skin swabs or skin biopsies. A novel noninvasive fluorescence imaging device has recently allowed real- ... ...

Abstract	Bacterial proliferation plays a well-known role in delayed tissue healing. To date, the presence of microorganisms on the wound bed can be detected by skin swabs or skin biopsies. A novel noninvasive fluorescence imaging device has recently allowed real-time detection of bacteria in different types of wounds through endogenous autofluorescence. The fluorescence signals detected by the device provide health workers with a visual indication of the presence, load, and distribution of bacteria. The aim of our study was to evaluate the level of bacterial colonization in perilesional skin of patients affected by venous leg ulcers treated with 2 different types of bandages: short stretch bandage and zinc oxide bandage. We conducted a monocentric prospective study, enrolling 30 patients with venous leg ulcers, divided into 2 groups: group A was treated with short stretch bandage and group B with zinc oxide bandage. A complete patient's assessment was performed once a week for 3 weeks. Levels of potentially harmful bacteria in perilesional skin were detected using a fluorescent device by 2 experienced operators on the frames taken at individual injuries, while pain was evaluated with the Numerical Rating Scale. After 3 weeks, we observed a reduction in the bacterial colonization levels of the perilesional skin by 68.67% for group A and 85.54% for group B. All the patients had a statistically significant reduction in bacterial load (
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171119-7
ISSN	1552-6941 ; 1534-7346
ISSN (online)	1552-6941
ISSN	1534-7346
DOI	10.1177/15347346231206449
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Article ; Online: Efficacy of a topical formulation containing eprinomectin, esafoxolaner and praziquantel (NexGard

Di Cesare, Angela / Morganti, Giulia / Vignoli, Massimo / Colombo, Mariasole / Veronesi, Fabrizia / Bufalari, Antonello / Tielemans, Eric / Beugnet, Frederic / Traversa, Donato

Parasite (Paris, France)

2024 Volume 31, Page(s) 2

Abstract: Feline pulmonary capillariosis is a significant disorder due to its distribution and clinical impact. This study evaluated the safety and efficacy of two administrations 28 days apart of a topical solution containing esafoxolaner, eprinomectin and ... ...

Title translation	Efficacité d’une formulation topique contenant de l’éprinomectine, de l’esafoxolaner et du praziquantel (NexGard
Abstract	Feline pulmonary capillariosis is a significant disorder due to its distribution and clinical impact. This study evaluated the safety and efficacy of two administrations 28 days apart of a topical solution containing esafoxolaner, eprinomectin and praziquantel (NexGard
MeSH term(s)	Animals ; Cats ; Praziquantel/therapeutic use ; Ivermectin/therapeutic use ; Nematode Infections/veterinary ; Enoplida Infections ; Cat Diseases/drug therapy ; Treatment Outcome
Chemical Substances	Praziquantel (6490C9U457) ; eprinomectin (75KP30FD8O) ; Ivermectin (70288-86-7)
Language	English
Publishing date	2024-02-04
Publishing country	France
Document type	Journal Article
ZDB-ID	1187629-3
ISSN	1776-1042 ; 1252-607X
ISSN (online)	1776-1042
ISSN	1252-607X
DOI	10.1051/parasite/2024005
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Zs.A 3965: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: Parasagittal Meningiomas: the impact of sinus opening and grade of resection on clinical outcome and recurrence in a consecutive series of patients.

Petrella, Giandomenico / Piazza, Amedeo / Fava, Arianna / Gorgoglione, Nicola / De Angelis, Michelangelo / Vangelista, Tommaso / Morganti, Riccardo / di Russo, Paolo / Esposito, Vincenzo

World neurosurgery

2024

Abstract: Background: Surgical management of parasagittal meningiomas (PMs) still remains controversial in literature. The need to pursue a resection as radical as possible along with the high risk of venous injuries contribute to making the sinus opening a ... ...

Abstract	Background: Surgical management of parasagittal meningiomas (PMs) still remains controversial in literature. The need to pursue a resection as radical as possible along with the high risk of venous injuries contribute to making the sinus opening a widely argued choice. The aim of our study was to analyze factors affecting the risk of recurrence and to assess clinical outcome of patients that underwent surgical resection of PMs with conservative or aggressive management of the intrasinusal portion. Methods: A single institution retrospective review of all patients with PM surgically treated from January 2013 and March 2021 was conducted. Results: Among 56 patients, sinus was opened in 32 patients (57%) while conservative approach was used in 24 patients (43%). The sinus opening was found to be a predictive factor of radical resection (Simpson grade, SG I+II) (P = ,007). The SG resulted being the only predictive factor of recurrence (P < 0,001). The radical-resection group (SG I+II) showed a recurrence-free survival (RFS) at 72 months about 90% vs 30% in the non-radical group (SG III+IV) (log-rank test, 14,21; P < ,001). Aggressive management of the sinus and radical resection were not found to be related to permanent deficit (P = 0,214; P = 0,254) or worsening of the KPS (P = ,822; P = 0,933), respectively. Conclusion: Removal of the intrasinusal portion of the tumor using standard procedures is not associated with a higher risk of permanent deficit or worsening of the KPS, while reducing the risk of recurrence.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2024.04.030
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Article: Twenty years of emotional-behavioral problems of community adolescents living in Italy measured through the Achenbach system of empirically based assessment (ASEBA): a systematic review and meta-analysis.

Pace, Cecilia Serena / Muzi, Stefania / Frigerio, Alessandra / Morganti, Wanda / Bianchi, Victoria / Rogier, Guyonne

Frontiers in psychiatry

2023 Volume 14, Page(s) 1161917

Abstract: Background: This is a systematic review and meta-analysis of emotional and behavioral problems among Italian community adolescents in the last 20 years, as assessed through the ASEBA questionnaires CBCL 6-18, YSR 11-18 and TRF 6-18. Research questions ... ...

Abstract	Background: This is a systematic review and meta-analysis of emotional and behavioral problems among Italian community adolescents in the last 20 years, as assessed through the ASEBA questionnaires CBCL 6-18, YSR 11-18 and TRF 6-18. Research questions address: (1) pooled means of problems' scores in questionnaires scales; (2-3) variations in scores according to sociodemographic and time-related factors, and studies' quality; (4) trends in research with ASEBA instruments along with other outcomes, e.g., psychopathological symptoms. Methods: A systematic literature review of Scopus, EBSCO, PubMed, Web of Science, and ProQuest databases using the PRISMA 2020 guidelines was conducted on November, 2021, and of grey literature on December, 2021. The quality of studies was assessed through the Newcastle-Ottawa Scale. Results: Forty-four studies were eligible for the systematic review, of which 34 were included for meta-analysis. Results showed that: (1) emotional-behavioral problems were higher when assessed by the CBCL and lower when assessed by the YSR compared to normative data; (2) there were no gender and age differences, except for higher scores of Anxious/Depression symptoms, in girls. (3) internalizing and attention problems increased over the last two decades. (4) major trends of Italian research investigate adolescents' emotional behavioral problems concerning attachment, comorbid symptoms, especially internet addictions, and eating disorders. Discussion: Despite some limitations (e.g., low-medium quality of most studies, no data on the TRF, under-representation of some geographical areas, some search-related choices), these data provides Italian practitioners and international researchers of some parameter to evaluate Italian adolescents emotional-behavioral problems. Registered on PROSPERO N. CRD42022299999.
Language	English
Publishing date	2023-12-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1161917
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Article ; Online: New human ATM variants are able to regain ATM functions in ataxia telangiectasia disease.

Ricci, Anastasia / Biancucci, Federica / Morganti, Gianluca / Magnani, Mauro / Menotta, Michele

Cellular and molecular life sciences : CMLS

2022 Volume 79, Issue 12, Page(s) 601

Abstract: Ataxia telangiectasia is a rare neurodegenerative disease caused by biallelic mutations in the ataxia telangiectasia mutated gene. No cure is currently available for these patients but positive effects on neurologic features in AT patients have been ... ...

Abstract	Ataxia telangiectasia is a rare neurodegenerative disease caused by biallelic mutations in the ataxia telangiectasia mutated gene. No cure is currently available for these patients but positive effects on neurologic features in AT patients have been achieved by dexamethasone administration through autologous erythrocytes (EryDex) in phase II and phase III clinical trials, leading us to explore the molecular mechanisms behind the drug action. During these investigations, new ATM variants, which originated from alternative splicing of ATM messenger, were discovered, and detected in vivo in the blood of AT patients treated with EryDex. Some of the new ATM variants, alongside an in silico designed one, were characterized and examined in AT fibroblast cell lines. ATM variants were capable of rescuing ATM activity in AT cells, particularly in the nuclear role of DNA DSBs recognition and repair, and in the cytoplasmic role of modulating autophagy, antioxidant capacity and mitochondria functionality, all of the features that are compromised in AT but essential for neuron survival. These outcomes are triggered by the kinase and further functional domains of the tested ATM variants, that are useful for restoring cellular functionality. The in silico designed ATM variant eliciting most of the functionality recover may be exploited in gene therapy or gene delivery for the treatment of AT patients.
MeSH term(s)	Humans ; Ataxia Telangiectasia/genetics ; Ataxia Telangiectasia/metabolism ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Neurodegenerative Diseases ; Cell Line ; Alternative Splicing
Chemical Substances	Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; ATM protein, human (EC 2.7.11.1)
Language	English
Publishing date	2022-11-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1358415-7
ISSN	1420-9071 ; 1420-682X
ISSN (online)	1420-9071
ISSN	1420-682X
DOI	10.1007/s00018-022-04625-3
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Zs.A 195: Show issues

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Article ; Online: Validation of the Italian version of a patient-reported outcome measure for Hereditary Spastic Paraplegia.

Diella, Eleonora / D'Angelo, Maria Grazia / Stefan, Cristina / Girardi, Giulia / Morganti, Roberta / Martinuzzi, Andrea / Biffi, Emilia

PloS one

2024 Volume 19, Issue 4, Page(s) e0301452

Abstract: Background and aim: Patient-reported outcome measures (PROMs) are recognized as valuable measures in the clinical setting. In 2018 we developed the Italian version of the "Hereditary Spastic Paraplegia-Self Notion and Perception Questionnaire" (HSP-SNAP) ...

Abstract	Background and aim: Patient-reported outcome measures (PROMs) are recognized as valuable measures in the clinical setting. In 2018 we developed the Italian version of the "Hereditary Spastic Paraplegia-Self Notion and Perception Questionnaire" (HSP-SNAP), a disease-specific questionnaire that collects personal perception on motor symptoms related to HSP such as stiffness, weakness, imbalance, reduced endurance, fatigue and pain. In this study our primary aim was to assess the questionnaire validity and reliability. Our secondary aim was to characterize the symptoms "perceived" by patients with HSP and compare them with those "perceived" by age-matched healthy subjects. Methods: The 12-item HSP-SNAP questionnaire was submitted to 20 external judges for comprehensibility and to 15 external judges for content validity assessment. We recruited 40 subjects with HSP and asked them to fill the questionnaire twice for test-retest procedure. They also completed the Medical Outcome Survey Short Form (SF-36) and were evaluated by the Spastic Paraplegia Rating Scale and the Six-Minute Walk Test. We also recruited 44 healthy subjects who completed the HSP-SNAP once to test score variability. Results: The HSP-SNAP content validity index was high (0.8±0.1) and the test-retest analysis showed high reliability (ICC = 0.94). The mean HSP-SNAP score (score range 0-48) of the HSP group was 22.2±7.8, which was significantly lower than healthy subjects (43.1±6.3). The most commonly perceived symptom was stiffness, followed by weakness and imbalance. Conclusion: Although HSP-SNAP does not investigate non-motor symptoms and we validated only its Italian version, it showed good validity and reliability and it could be used in combination with other objective outcome measures for clinical purposes or as endpoints for future clinical rehabilitation studies. Trial registration: Trial Registration: ClinicalTrial.gov, NCT04256681. Registered 3 February 2020.
MeSH term(s)	Humans ; Spastic Paraplegia, Hereditary/diagnosis ; Reproducibility of Results ; Paraplegia ; Patient Reported Outcome Measures ; Italy
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0301452
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