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  1. Article ; Online: Diagnosis of Autism.

    Cirillo, Nicola

    JAMA

    2024  Volume 331, Issue 3, Page(s) 259

    MeSH term(s) Humans ; Autistic Disorder/diagnosis
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.24155
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  2. Article ; Online: Considerations in Early Autism Diagnosis.

    Cirillo, Nicola

    JAMA pediatrics

    2024  Volume 178, Issue 4, Page(s) 416–417

    MeSH term(s) Humans ; Child ; Autistic Disorder/diagnosis ; Developmental Disabilities/diagnosis ; Early Diagnosis ; Autism Spectrum Disorder/diagnosis
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2023.6434
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  3. Article: Precursor Lesions, Overdiagnosis, and Oral Cancer: A Critical Review.

    Cirillo, Nicola

    Cancers

    2024  Volume 16, Issue 8

    Abstract: Despite the profession placing great emphasis on oral potentially malignant disorders (OPMDs) as a gateway for early recognition and consequently better outcomes for oral cancer, the death rates for lip and oral cavity cancer have remained stagnant for ... ...

    Abstract Despite the profession placing great emphasis on oral potentially malignant disorders (OPMDs) as a gateway for early recognition and consequently better outcomes for oral cancer, the death rates for lip and oral cavity cancer have remained stagnant for three decades. Evidence shows that only a small fraction of oral cancers are in fact preceded by OPMDs, and that most OPMDs have an annual transformation rate of less than 1%. As OPMDs encompass a very heterogeneous group of oral conditions, it could be argued that only patients with oral mucosal diseases bearing a substantial risk of malignant transformation warrant close surveillance and treatment, these include proliferative leukoplakia, erythroplakia, non-homogeneous leukoplakia, as well as diseases presenting with severe dysplasia at biopsy. In this narrative review, I discuss the intricate epidemiology of the malignancies that we colloquially refer to as oral cancer, explore the limitations of focusing on OPMDs to reduce the incidence and mortality of oral cavity cancer, and argue that a
    Language English
    Publishing date 2024-04-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16081550
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  4. Article ; Online: Biosynthesis of glucocorticoids in tumors.

    Cirillo, Nicola

    The Journal of clinical investigation

    2023  Volume 133, Issue 21

    MeSH term(s) Humans ; Glucocorticoids/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/genetics ; Endocrinology
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI174686
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  5. Article ; Online: The Hyaluronan/CD44 Axis: A Double-Edged Sword in Cancer.

    Cirillo, Nicola

    International journal of molecular sciences

    2023  Volume 24, Issue 21

    Abstract: Hyaluronic acid (HA) receptor CD44 is widely used for identifying cancer stem cells and its activation promotes stemness. Recent evidence shows that overexpression of CD44 is associated with poor prognosis in most human cancers and mediates therapy ... ...

    Abstract Hyaluronic acid (HA) receptor CD44 is widely used for identifying cancer stem cells and its activation promotes stemness. Recent evidence shows that overexpression of CD44 is associated with poor prognosis in most human cancers and mediates therapy resistance. For these reasons, in recent years, CD44 has become a treatment target in precision oncology, often via HA-conjugated antineoplastic drugs. Importantly, HA molecules of different sizes have a dual effect and, therefore, may enhance or attenuate the CD44-mediated signaling pathways, as they compete with endogenous HA for binding to the receptors. The magnitude of these effects could be crucial for cancer progression, as well as for driving the inflammatory response in the tumor microenvironment. The increasingly common use of HA-conjugated drugs in oncology, as well as HA-based compounds as adjuvants in cancer treatment, adds further complexity to the understanding of the net effect of hyaluronan-CD44 activation in cancers. In this review, I focus on the significance of CD44 in malignancy and discuss the dichotomous function of the hyaluronan/CD44 axis in cancer progression.
    MeSH term(s) Humans ; Neoplasms/metabolism ; Hyaluronic Acid/chemistry ; Precision Medicine ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/chemistry ; Signal Transduction ; Hyaluronan Receptors/metabolism ; Tumor Microenvironment
    Chemical Substances Hyaluronic Acid (9004-61-9) ; Antineoplastic Agents ; Hyaluronan Receptors ; CD44 protein, human
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242115812
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  6. Article ; Online: Biosynthesis of glucocorticoids in tumors

    Nicola Cirillo

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Volume 21

    Keywords Endocrinology ; Oncology ; Medicine ; R
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The Hyaluronan/CD44 Axis

    Nicola Cirillo

    International Journal of Molecular Sciences, Vol 24, Iss 21, p

    A Double-Edged Sword in Cancer

    2023  Volume 15812

    Abstract: Hyaluronic acid (HA) receptor CD44 is widely used for identifying cancer stem cells and its activation promotes stemness. Recent evidence shows that overexpression of CD44 is associated with poor prognosis in most human cancers and mediates therapy ... ...

    Abstract Hyaluronic acid (HA) receptor CD44 is widely used for identifying cancer stem cells and its activation promotes stemness. Recent evidence shows that overexpression of CD44 is associated with poor prognosis in most human cancers and mediates therapy resistance. For these reasons, in recent years, CD44 has become a treatment target in precision oncology, often via HA-conjugated antineoplastic drugs. Importantly, HA molecules of different sizes have a dual effect and, therefore, may enhance or attenuate the CD44-mediated signaling pathways, as they compete with endogenous HA for binding to the receptors. The magnitude of these effects could be crucial for cancer progression, as well as for driving the inflammatory response in the tumor microenvironment. The increasingly common use of HA-conjugated drugs in oncology, as well as HA-based compounds as adjuvants in cancer treatment, adds further complexity to the understanding of the net effect of hyaluronan-CD44 activation in cancers. In this review, I focus on the significance of CD44 in malignancy and discuss the dichotomous function of the hyaluronan/CD44 axis in cancer progression.
    Keywords hyaluronic acid ; CD44 ; cancer stem cells ; chemoresistance ; carcinogenesis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Do health-care workers need a COVID-19 vaccine booster?

    Cirillo, Nicola

    The Lancet. Infectious diseases

    2021  Volume 22, Issue 1, Page(s) 20

    MeSH term(s) Adult ; Aged ; BNT162 Vaccine/immunology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/standards ; Global Health ; Health Personnel/statistics & numerical data ; Humans ; Immunization, Secondary/standards ; Middle Aged ; SARS-CoV-2/immunology ; Vaccination/legislation & jurisprudence ; Vaccination/standards
    Chemical Substances COVID-19 Vaccines ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-12-16
    Publishing country United States
    Document type Letter
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(21)00782-9
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    Zs.A 5743: Show issues Location:
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  9. Article ; Online: Taste alteration in COVID-19: Significant geographical differences exist in the prevalence of the symptom.

    Cirillo, Nicola

    Journal of infection and public health

    2021  Volume 14, Issue 8, Page(s) 1099–1105

    Abstract: Early detection of COVID-19 is important for reduction in the spread of the disease and gustatory disturbances (GD) are known to have a strong predictive value. In the present study, we aimed to map the geographical differences in the prevalence of GD in ...

    Abstract Early detection of COVID-19 is important for reduction in the spread of the disease and gustatory disturbances (GD) are known to have a strong predictive value. In the present study, we aimed to map the geographical differences in the prevalence of GD in individuals infected with SARS-CoV-2 during the first wave of COVID-19 in order to improve case identification and to facilitate prioritization. We undertook a rapid scoping review of articles published in the repository of the National Library of Medicine (MEDLINE/PubMed) and medRxiv from their inception until 3
    MeSH term(s) COVID-19 ; Europe/epidemiology ; Humans ; Middle East ; Prevalence ; SARS-CoV-2 ; Taste
    Language English
    Publishing date 2021-07-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2467587-8
    ISSN 1876-035X ; 1876-0341
    ISSN (online) 1876-035X
    ISSN 1876-0341
    DOI 10.1016/j.jiph.2021.07.002
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  10. Article: The Local Neuropeptide System of Keratinocytes.

    Cirillo, Nicola

    Biomedicines

    2021  Volume 9, Issue 12

    Abstract: Neuropeptides have been known for over 50 years as chemical signals in the brain. However, it is now well established that the synthesis of this class of peptides is not restricted to neurons. For example, human skin not only expresses several functional ...

    Abstract Neuropeptides have been known for over 50 years as chemical signals in the brain. However, it is now well established that the synthesis of this class of peptides is not restricted to neurons. For example, human skin not only expresses several functional receptors for neuropeptides but, also, can serve as a local source of neuroactive molecules such as corticotropin-releasing hormone, melanocortins, and β-endorphin. In contrast, an equivalent of the hypothalamic-pituitary axis in the oral mucosa has not been well characterized to date. In view of the differences in the morphology and function of oral mucosal and skin cells, in this review I surveyed the existing evidence for a local synthesis of hypothalamic-pituitary, opiate, neurohypophyseal, and neuroendocrine neuropeptides in both epidermal and oral keratinocytes.
    Language English
    Publishing date 2021-12-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9121854
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