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  1. Article ; Online: COVID-19 outbreak: the gold rush and the responsibilities of the scientific community.

    Pezzani, M D

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2020  Volume 26, Issue 9, Page(s) 1123–1124

    MeSH term(s) Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Clinical Trials as Topic ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Evidence-Based Medicine ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Publishing ; SARS-CoV-2
    Chemical Substances Antiviral Agents
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2020.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 284: Show issues

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  3. Article ; Online: COVID-19 outbreak

    Pezzani, M.D.

    Clinical Microbiology and Infection

    the gold rush and the responsibilities of the scientific community

    2020  Volume 26, Issue 9, Page(s) 1123–1124

    Keywords Microbiology (medical) ; Infectious Diseases ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2020.05.002
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 284: Show issues

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  4. Article: SBIDDS Syndrome: A New Spoke of the Epigenetic Machinery Wheel.

    Aleo, Sebastiano / Pezzani, Lidia / Milani, Donatella / Pezzoli, Laura / Marchisio, Paola / Iascone, Maria

    Molecular syndromology

    2022  Volume 13, Issue 6, Page(s) 543–550

    Abstract: Introduction: Mendelian disorders of the epigenetic machinery are a growing group of disorders exhibiting several overlapping clinical features that are probably due to common abnormalities at the epigenomic level, which lead to downstream convergence ... ...

    Abstract Introduction: Mendelian disorders of the epigenetic machinery are a growing group of disorders exhibiting several overlapping clinical features that are probably due to common abnormalities at the epigenomic level, which lead to downstream convergence at the transcriptomic level.
    Case presentation: Here, we report a new case of short stature, brachydactyly, intellectual developmental disability, and seizures (SBIDDS) syndrome with a severe ocular phenotype and hypogonadism.
    Conclusion: Similarities and connections with other mendelian disorders of the epigenetic machinery are highlighted, confirming SBIDDS' enrolment as a new spoke of the epigenetic machinery wheel.
    Language English
    Publishing date 2022-06-07
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2546218-0
    ISSN 1661-8777 ; 1661-8769
    ISSN (online) 1661-8777
    ISSN 1661-8769
    DOI 10.1159/000524844
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Criteria and methodologies for determining the causes of swelling of canned tomatoes in tinplate containers.

    Squitieri, Giuseppe / Pirone, Giuseppe / La Pietra, Liliana / Cannavacciuolo, Mariarosaria / Pezzani, Aldo / Ferrari, Giovanna / Castaldo, Domenico / Balestrieri, Maria Luisa / Cautela, Domenico

    Comprehensive reviews in food science and food safety

    2022  Volume 22, Issue 1, Page(s) 408–429

    Abstract: This review provides the current laboratory criteria for the detection and evaluation of the possible causes of alteration of non-concentrated industrial derivatives of tomatoes (peeled tomatoes, pulps, purees, sauces, and fillets), packaged in coated or ...

    Abstract This review provides the current laboratory criteria for the detection and evaluation of the possible causes of alteration of non-concentrated industrial derivatives of tomatoes (peeled tomatoes, pulps, purees, sauces, and fillets), packaged in coated or uncoated tinplate cans. We discuss how the product alterations are typically the consequence of technological errors either in the can production, or in the storage process, or in the product sterilization. The described procedures include the quantitative determination of the distribution of gases (H
    MeSH term(s) Solanum lycopersicum ; Food Preservation/methods ; Food Packaging ; Food Contamination/analysis ; Food
    Language English
    Publishing date 2022-12-05
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2185829-9
    ISSN 1541-4337 ; 1541-4337
    ISSN (online) 1541-4337
    ISSN 1541-4337
    DOI 10.1111/1541-4337.13073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy.

    Sharifi-Rad, Javad / Seidel, Veronique / Izabela, Michalak / Monserrat-Mequida, Margalida / Sureda, Antoni / Ormazabal, Valeska / Zuniga, Felipe A / Mangalpady, Shivaprasad Shetty / Pezzani, Raffaele / Ydyrys, Alibek / Tussupbekova, Gulmira / Martorell, Miquel / Calina, Daniela / Cho, William C

    Cell communication and signaling : CCS

    2023  Volume 21, Issue 1, Page(s) 89

    Abstract: Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. ...

    Abstract Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. Video Abstract.
    MeSH term(s) Humans ; NF-E2-Related Factor 2/metabolism ; Neoplasms/drug therapy ; Antineoplastic Agents/pharmacology ; Oxidative Stress ; Antioxidants/metabolism ; Phenols/pharmacology ; Phenols/therapeutic use
    Chemical Substances NF-E2-Related Factor 2 ; Antineoplastic Agents ; Antioxidants ; Phenols
    Language English
    Publishing date 2023-05-01
    Publishing country England
    Document type Video-Audio Media ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-023-01109-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Double somatic mosaicism in Cornelia de Lange syndrome.

    Pezzani, Lidia / Pezzoli, Laura / Rosina, Erica / Scatigno, Agnese / Cereda, Anna / Lucca, Camilla / Bellini, Matteo / Marchetti, Daniela / Maino, Marzia / Mangili, Giovanna / Selicorni, Angelo / Iascone, Maria

    American journal of medical genetics. Part A

    2023  Volume 194, Issue 5, Page(s) e63512

    Abstract: Post-zygotic mosaicism is a well-known biological phenomenon characterized by the presence of genetically distinct lineages of cells in the same individual due to post-zygotic de novo mutational events. It has been identified in about 13% of Cornelia de ... ...

    Abstract Post-zygotic mosaicism is a well-known biological phenomenon characterized by the presence of genetically distinct lineages of cells in the same individual due to post-zygotic de novo mutational events. It has been identified in about 13% of Cornelia de Lange (CdLS) syndrome patients with a molecular diagnosis, an unusual high frequency. Here, we report the case of a patient affected by classic CdLS harboring post-zygotic mosaicism for two different likely pathogenic variants at the same nucleotide position in NIPBL. Double somatic mosaicism has never been reported in CdLS and only rarely recognized in human diseases. Possible pathogenetic mechanisms are discussed.
    MeSH term(s) Humans ; De Lange Syndrome/diagnosis ; De Lange Syndrome/genetics ; Cell Cycle Proteins/genetics ; Mosaicism ; Phenotype
    Chemical Substances Cell Cycle Proteins ; NIPBL protein, human
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2108614-X
    ISSN 1552-4833 ; 0148-7299 ; 1552-4825
    ISSN (online) 1552-4833
    ISSN 0148-7299 ; 1552-4825
    DOI 10.1002/ajmg.a.63512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1376/A: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Rock around DYRK1A: Ethnic diversity, clinical challenges.

    Moroni, Alice / Pezzani, Lidia / Alfei, Enrico / Scatigno, Agnese / Cereda, Anna / Marzaroli, Michela / Guuva, Claudia / Gabbiadini, Sara / Pezzoli, Laura / Marchetti, Daniela / Spaccini, Luigina / Iascone, Maria

    American journal of medical genetics. Part A

    2023  Volume 191, Issue 5, Page(s) 1459–1464

    Abstract: DYRK1A-related intellectual disability is a recently described syndrome characterized by microcephaly, global developmental delay, impaired speech development, and distinctive facial features, which let to define it as a recognizable syndrome. Here we ... ...

    Abstract DYRK1A-related intellectual disability is a recently described syndrome characterized by microcephaly, global developmental delay, impaired speech development, and distinctive facial features, which let to define it as a recognizable syndrome. Here we report four new patients of different ethnicity, broadening the clinical phenotype of the condition and highlighting how ethnic influences in the facial appearance could make it less recognizable.
    MeSH term(s) Humans ; Intellectual Disability/genetics ; Syndrome ; Microcephaly/genetics ; Phenotype ; Language Development Disorders
    Language English
    Publishing date 2023-02-11
    Publishing country United States
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2108614-X
    ISSN 1552-4833 ; 0148-7299 ; 1552-4825
    ISSN (online) 1552-4833
    ISSN 0148-7299 ; 1552-4825
    DOI 10.1002/ajmg.a.63140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1376/A: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Validation of miRNAs as diagnostic and prognostic biomarkers, and possible therapeutic targets in medullary thyroid cancers.

    Mondin, Alberto / Bertazza, Loris / Barollo, Susi / Pedron, Maria Chiara / Manso, Jacopo / Piva, Ilaria / Basso, Daniela / Merante Boschin, Isabella / Iacobone, Maurizio / Pezzani, Raffaele / Mian, Caterina / Censi, Simona

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1151583

    Abstract: Introduction: Medullary thyroid cancer (MTC) is a rare type of neuroendocrine tumor that produces a hormone called calcitonin (CT). Thyroidectomy is the preferred treatment for MTC, as chemotherapy has been shown to have limited effectiveness. Targeted ... ...

    Abstract Introduction: Medullary thyroid cancer (MTC) is a rare type of neuroendocrine tumor that produces a hormone called calcitonin (CT). Thyroidectomy is the preferred treatment for MTC, as chemotherapy has been shown to have limited effectiveness. Targeted therapy approaches are currently being used for patients with advanced, metastatic MTC. Several studies have identified microRNAs, including miR-21, as playing a role in the development of MTC. Programmed cell death 4 (PDCD4) is a tumor suppressor gene that is an important target of miR-21. Our previous research has shown that high levels of miR-21 are associated with low PDCD4 nuclear scores and high CT levels. The aim of this study was to investigate the potential of this pathway as a novel therapeutic target for MTC.
    Methods: We used a specific process to silence miR-21 in two human MTC cell lines. We studied the effect of this anti-miRNA process alone and in combination with cabozantinib and vandetanib, two drugs used in targeted therapy for MTC. We analyzed the effect of miR-21 silencing on cell viability, PDCD4 and CT expression, phosphorylation pathways, cell migration, cell cycle, and apoptosis.
    Results: Silencing miR-21 alone resulted in a reduction of cell viability and an increase in PDCD4 levels at both mRNA and protein levels. It also led to a reduction in CT expression at both mRNA and secretion levels. When combined with cabozantinib and vandetanib, miR-21 silencing did not affect cell cycle or migration but was able to enhance apoptosis.
    Conclusion: Silencing miR-21, although not showing synergistic activity with TKIs (tyrosine kinase inhibitors), represents a potential alternative worth exploring as a therapeutic target for MTC.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Prognosis ; Thyroid Neoplasms/diagnosis ; Thyroid Neoplasms/drug therapy ; Thyroid Neoplasms/genetics ; Piperidines/therapeutic use ; RNA, Messenger/genetics ; Biomarkers ; RNA-Binding Proteins/genetics ; Apoptosis Regulatory Proteins/genetics
    Chemical Substances MicroRNAs ; cabozantinib (1C39JW444G) ; Piperidines ; RNA, Messenger ; Biomarkers ; PDCD4 protein, human ; RNA-Binding Proteins ; Apoptosis Regulatory Proteins
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1151583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sisymbrium officinale, the Plant of Singers: A Review of Its Properties and Uses.

    Zorzan, Maira / Zucca, Paolo / Collazuol, Daniela / Peddio, Stefania / Rescigno, Antonio / Pezzani, Raffaele

    Planta medica

    2020  Volume 86, Issue 5, Page(s) 307–311

    Abstract: Sisymbrium ... ...

    Abstract Sisymbrium officinale
    MeSH term(s) Africa ; Brassicaceae ; Europe ; Seeds ; Singing
    Language English
    Publishing date 2020-02-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/a-1088-9928
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