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  1. Article: Pattern of drug resistant

    Ansarin, Khalil / Sahebi, Leyla

    Iranian journal of microbiology

    2022  Volume 14, Issue 3, Page(s) 285–290

    Abstract: Background and objectives: Drug-resistant tuberculosis (Tb) is a major public health issue across the world. Therefore, it is crucial to determine its pattern in different regions of the world. The aim of this study was to review the prevalence of drug ... ...

    Abstract Background and objectives: Drug-resistant tuberculosis (Tb) is a major public health issue across the world. Therefore, it is crucial to determine its pattern in different regions of the world. The aim of this study was to review the prevalence of drug resistant TB in the west and northwest of Iran.
    Materials and methods: A systematic literature search was performed to identify studies (2010 to 2021) in Google Scholar, PubMed, Thomson Reuters, Scientific Information Database (SID), Cochrane Library, and Medical Library (MedLib) databases. The patterns of any drug-resistant
    Results: In this review, 7 studies met the eligibility criteria for a meta-analysis. The pooled proportion of any drug resistant TB was 13% (CI 95%: 9.0, 17.0) (43.0% in re-treatment group). The pooled prevalence of any drug resistant TB was more than 1.5 times higher in men compared to women (15% vs. 9.0%). The pooled prevalence (%) of resistance to INH, RMP, SMP, EMB and MDR-TB was 11.0%, 12.0%, 13.0%, 6.0%, and 6.0%, respectively. Kermanshah Province (a province in the west of Iran) showed a high prevalence of any type of drug resistance and MDR-TB (15.9% and 20.0%, respectively).
    Conclusion: It seems that the western provinces of Iran have a different pattern of drug resistance compared to the northwestern provinces. Considering the extent of Iran and the neighboring countries, it is recommended that the pattern of tuberculosis drug resistance be reviewed separately in different provinces or regions of Iran. Drug resistance in the re-treatment group was more than three times that of all patients with TB drug resistance. The burden of drug resistance reduces significantly with better control and management of TB drug treatment and preventing re-infection.
    Language English
    Publishing date 2022-12-21
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2652849-6
    ISSN 2008-4447 ; 2008-3289
    ISSN (online) 2008-4447
    ISSN 2008-3289
    DOI 10.18502/ijm.v14i3.9754
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  2. Article ; Online: The cross-talk between leptin and circadian rhythm signaling proteins in physiological processes: a systematic review.

    Ansarin, Atefeh / Mahdavi, Aida Malek / Javadivala, Zeinab / Shanehbandi, Dariush / Zarredar, Habib / Ansarin, Khalil

    Molecular biology reports

    2023  Volume 50, Issue 12, Page(s) 10427–10443

    Abstract: Background: Today, modern lifestyles and disrupted sleep patterns cause circadian clock rhythm impairments that are associated with altered leptin levels, which subsequently affect a wide range of physiological processes and have significant health ... ...

    Abstract Background: Today, modern lifestyles and disrupted sleep patterns cause circadian clock rhythm impairments that are associated with altered leptin levels, which subsequently affect a wide range of physiological processes and have significant health burdens on societies. Nevertheless, there has been no systematic review of circadian clock genes and proteins, leptin, and related signaling pathways.
    Methods: Accordingly, we systematically reviewed circadian clock proteins, leptin, and molecular mechanisms between them by searching Pubmed, Scopus, ProQuest, Web of Sciences, and Google Scholar until September 2022. After considering the inclusion and exclusion criteria, 20 animal studies were selected. The risk of bias was assessed in each study.
    Results: The results clarified the reciprocal interconnected relationship between circadian clock genes and leptin. Circadian clock genes regulate leptin expression and signaling via different mechanisms, such as CLOCK-BMAL1 heterodimers, which increase the expression of PPARs. PPARs induce the expression of C/EBPα, a key factor in upregulating leptin expression. CLOCK-BMAL1 also induces the expression of Per1 and Rev-erb genes. PER1 activates mTORC1 and mTORC1 enhances the expression of C/EBPα. In addition, REV-ERBs activate the leptin signaling pathway. Also, leptin controls the expression of circadian clock genes by triggering the AMPK and ERK/MAPK signaling pathways, which regulate the activity of PPARs. Moreover, the roles of these molecular mechanisms are elucidated in different physiological processes and organs.
    Conclusions: Crosstalk between circadian clock genes and leptin and their affecting elements should be considered in the selection of new therapeutic targets for related disorders, especially obesity and metabolic impairments.
    MeSH term(s) Animals ; ARNTL Transcription Factors ; Circadian Clocks/genetics ; Circadian Rhythm/genetics ; Circadian Rhythm Signaling Peptides and Proteins ; Leptin/genetics ; Mechanistic Target of Rapamycin Complex 1 ; Nuclear Receptor Subfamily 1, Group D, Member 1/genetics ; Nuclear Receptor Subfamily 1, Group D, Member 1/metabolism ; Peroxisome Proliferator-Activated Receptors ; Humans
    Chemical Substances ARNTL Transcription Factors ; Circadian Rhythm Signaling Peptides and Proteins ; Leptin ; Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; Nuclear Receptor Subfamily 1, Group D, Member 1 ; Peroxisome Proliferator-Activated Receptors ; LEP protein, human
    Language English
    Publishing date 2023-10-24
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-023-08887-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
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  3. Article ; Online: Carcinogenic and non-carcinogenic risk of exposure to metal fume in different types of welding processes.

    Soltanpour, Zahra / Rasoulzadeh, Yahya / Ansarin, Khalil / Seyedrezazadeh, Ensiyeh / Mohammadian, Yousef

    Environmental science and pollution research international

    2023  Volume 30, Issue 35, Page(s) 83728–83734

    Abstract: The international agency for cancer research (IARC) has classified welding fumes as definitive carcinogens. The aim of the present study was to assess health risk due to exposure to welding fumes in different welding types. In this study, exposure to ... ...

    Abstract The international agency for cancer research (IARC) has classified welding fumes as definitive carcinogens. The aim of the present study was to assess health risk due to exposure to welding fumes in different welding types. In this study, exposure to fumes of iron (Fe), chromium (Cr), and nickel (Ni) in the breathing zone air of 31 welder engaged in arc, argon and CO
    MeSH term(s) Humans ; Air Pollutants, Occupational/analysis ; Carcinogens ; Welding/methods ; Argon ; Carbon Dioxide ; Chromium/analysis ; Gases ; Carcinogenesis ; Nickel/analysis ; Occupational Exposure/analysis
    Chemical Substances Air Pollutants, Occupational ; Carcinogens ; Argon (67XQY1V3KH) ; Carbon Dioxide (142M471B3J) ; Chromium (0R0008Q3JB) ; Gases ; Nickel (7OV03QG267)
    Language English
    Publishing date 2023-06-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-28258-6
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  4. Article: Phosphorylation Modulates Survivin Function in Behcet's Disease.

    Pahlavan, Yasamin / Samadi, Naser / Ansarin, Khalil / Khabbazi, Alireza

    Advanced pharmaceutical bulletin

    2020  Volume 10, Issue 2, Page(s) 278–283

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2020-02-18
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 3018440-X
    ISSN 2251-7308 ; 2228-5881
    ISSN (online) 2251-7308
    ISSN 2228-5881
    DOI 10.34172/apb.2020.033
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  5. Article ; Online: Single-Center Experience of Pulmonary Endarterectomy for Chronic Thromboembolic Pulmonary Hypertension: The Results from the Tabriz University Medical Sciences (TUMS) CTEPH Program.

    Parvizi, Rezayat / Bilehjani, Eisa / Mahmoudian, Babak / Koohi, Ata / Shojaan, Hooriah / Ansarin, Khalil / Rashidi, Farid

    The Thoracic and cardiovascular surgeon

    2023  Volume 71, Issue 5, Page(s) 407–412

    Abstract: Introduction: Pulmonary endarterectomy (PEA) remains the preferred and potentially curative option for patients with chronic thromboembolic pulmonary hypertension (CTEPH). This study aimed to report the results of PEA for CTEPH in a tertiary center in ... ...

    Abstract Introduction: Pulmonary endarterectomy (PEA) remains the preferred and potentially curative option for patients with chronic thromboembolic pulmonary hypertension (CTEPH). This study aimed to report the results of PEA for CTEPH in a tertiary center in Tabriz, Iran.
    Methods: We analyzed the results of 42 CTEPH patients undergoing PEA, who were enrolled in the Tabriz University of Medical Sciences (TUMS-CTEPH) from January 2016 to October 2020. The main outcome measures included the New York Heart Association (NYHA) functional classification, the 6-Minute Walk Distance, hemodynamic measures in right heart catheterization, morbidity, and mortality.
    Results: There was a significant improvement in the NYHA function class (2.6 ± 0.5 vs 1.1 ± 0.34), mean pulmonary arterial pressure (47.1 ± 13 vs 27.9 ± 8 mm Hg), cardiac output (4.3 ± 1.06 vs 5.9 ± 1.2 L/min), and pulmonary vascular resistance (709.4 ± 297.5 vs 214 ± 77 dyn s/cm
    Conclusion: This is the first single-center report of PEA from Iran. Post-PEA and 1-year survival were acceptable as a referral center. PEA can be performed safe with low mortality. Greater awareness of PEA and patients' access to experienced CTEPH centers are important issues.
    MeSH term(s) Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/surgery ; Pulmonary Artery/surgery ; Pulmonary Embolism/complications ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/surgery ; Universities ; Treatment Outcome ; Chronic Disease ; Endarterectomy/adverse effects
    Language English
    Publishing date 2023-01-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 800050-5
    ISSN 1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
    ISSN (online) 1439-1902
    ISSN 0171-6425 ; 0946-4778 ; 0172-6137
    DOI 10.1055/s-0042-1760204
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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.186: Show issues Location:
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  6. Article: Conservative Management of a Delayed Benign Gastrobronchial Fistula: A 20-Year Follow-up.

    Shoja, Mohammadali M / Ansarin, Khalil

    Cureus

    2019  Volume 11, Issue 8, Page(s) e5444

    Abstract: We describe a case of gastrobronchial fistula (GBF) following a thoracoabdominal gunshot wound in a previously healthy young man. Despite initial surgery, the patient suffered recurrent hemoptysis, and a GBF was diagnosed 18 months after initial ... ...

    Abstract We describe a case of gastrobronchial fistula (GBF) following a thoracoabdominal gunshot wound in a previously healthy young man. Despite initial surgery, the patient suffered recurrent hemoptysis, and a GBF was diagnosed 18 months after initial presentation. The patient was treated with oral proton pump inhibitors for a prolonged period with the resolution of the fistula. During a follow-up 20 years later, no recurrence of the fistula was noted. The importance of early diagnosis of such fistulae cannot be overstated. This report provides a testimony to the feasibility of the conservative approaches in managing delayed, benign, and post-traumatic GBF.
    Language English
    Publishing date 2019-08-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.5444
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  7. Article ; Online: Female-biased association of

    Aftabi, Younes / Gilani, Neda / Ansarin, Atefeh / Amiri-Sadeghan, Amir / Bakhtiyari, Nasim / Seyyedi, Maryam / Faramarzi, Elnaz / Sharifi, Akbar / Ansarin, Khalil / Seyedrezazadeh, Ensiyeh

    Canadian journal of physiology and pharmacology

    2023  Volume 101, Issue 4, Page(s) 200–213

    Abstract: The nitric oxide (NO) pathway contributes to the pathogeneses of metabolic syndrome (MetS) and asthma. ...

    Abstract The nitric oxide (NO) pathway contributes to the pathogeneses of metabolic syndrome (MetS) and asthma.
    MeSH term(s) Male ; Humans ; Female ; Metabolic Syndrome/complications ; Metabolic Syndrome/genetics ; Genotype ; Metabolic Diseases ; Alleles ; Nitric Oxide Synthase Type II/genetics ; Asthma/complications ; Asthma/genetics ; Polymorphism, Single Nucleotide ; Genetic Predisposition to Disease
    Chemical Substances Nitric Oxide Synthase Type II (EC 1.14.13.39) ; NOS2 protein, human (EC 1.14.13.39)
    Language English
    Publishing date 2023-01-30
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 127527-6
    ISSN 1205-7541 ; 0008-4212
    ISSN (online) 1205-7541
    ISSN 0008-4212
    DOI 10.1139/cjpp-2022-0334
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    Zs.A 589: Show issues Location:
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  8. Article ; Online: Male-biased association of endothelial nitric oxide synthase Asp298Glu substitution (

    Aftabi, Younes / Amiri-Sadeghan, Amir / Gilani, Neda / Zahedi, Tahereh / Khodayari, Mohamad Taghi / Faramarzi, Elnaz / Seyedrezazadeh, Ensiyeh / Ansarin, Khalil

    The Journal of asthma : official journal of the Association for the Care of Asthma

    2023  Volume 60, Issue 10, Page(s) 1895–1906

    Abstract: Objective: The nitric-oxide pathway plays a crucial role in the pathogeneses of asthma and : Methods: We investigated the association of : Results: GT genotype (OR: Conclusions: ... ...

    Abstract Objective: The nitric-oxide pathway plays a crucial role in the pathogeneses of asthma and
    Methods: We investigated the association of
    Results: GT genotype (OR
    Conclusions: NOS3
    MeSH term(s) Humans ; Male ; Nitric Oxide Synthase Type III/genetics ; Polymorphism, Single Nucleotide ; Asthma/genetics ; Genotype ; Alleles ; Case-Control Studies ; Gene Frequency ; Genetic Predisposition to Disease
    Chemical Substances Nitric Oxide Synthase Type III (EC 1.14.13.39) ; NOS3 protein, human (EC 1.14.13.39)
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603816-5
    ISSN 1532-4303 ; 0277-0903
    ISSN (online) 1532-4303
    ISSN 0277-0903
    DOI 10.1080/02770903.2023.2196689
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    Zs.B 18: Show issues Location:
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  9. Article ; Online: Micronucleus assay of DNA damage among welders: Effects of welding processes.

    Soltanpour, Zahra / Rasoulzadeh, Yahya / Ansarin, Khalil / Seyedrezazadeh, Ensiyeh / Jafarpour, Mehdi / Mohammadian, Yousef / Khuniqi, Hakimeh Nazari

    Mutation research. Genetic toxicology and environmental mutagenesis

    2023  Volume 887, Page(s) 503598

    Abstract: Metal fumes, gases, noise, and radiation are hazardous occupational exposures that may be encountered by welders. We have evaluated DNA damage among welders; the buccal micronucleus cytome (BMCyt) assay was used. Thirty-four exposed welders (cases) and ... ...

    Abstract Metal fumes, gases, noise, and radiation are hazardous occupational exposures that may be encountered by welders. We have evaluated DNA damage among welders; the buccal micronucleus cytome (BMCyt) assay was used. Thirty-four exposed welders (cases) and an equal number of non-welders (controls) participated in this study. Cell types including basal, early and late differentiated cells with micronucleus (MN), dense chromatin, karyorrhectic, pyknotic, karyolitic, and binucleated cells (NBUD) were measured. Damage levels among, arc, argon, and CO
    MeSH term(s) Micronucleus Tests ; Welding ; Argon ; Carbon Dioxide ; Occupational Exposure/adverse effects ; Occupational Exposure/analysis ; DNA Damage
    Chemical Substances Argon (67XQY1V3KH) ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2023-02-10
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1879-3592
    ISSN (online) 1879-3592
    DOI 10.1016/j.mrgentox.2023.503598
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  10. Article ; Online: Sex-specific association of exposure to air pollutants and Nrf2 gene expression and inflammatory biomarkers in exhaled breath of healthy adolescents.

    Sabeti, Zahra / Ansarin, Atefeh / Ansarin, Khalil / Zafari, Venus / Seyedrezazadeh, Ensiyeh / Shakerkhatibi, Mohammad / Asghari-Jafarabadi, Mohammad / Dastgiri, Saeed / Zoroufchi Benis, Khaled / Sepehri, Maryam / Khamnian, Zhila

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 326, Page(s) 121463

    Abstract: Studies investigating the nuclear factor erythroid 2-related factor 2 (Nrf2) expression levels in the respiratory system of healthy subjects are scarce. Moreover, separate studies on the health-related outcomes of air pollution for each sex are limited. ... ...

    Abstract Studies investigating the nuclear factor erythroid 2-related factor 2 (Nrf2) expression levels in the respiratory system of healthy subjects are scarce. Moreover, separate studies on the health-related outcomes of air pollution for each sex are limited. The current panel study investigated sex-specific Nrf2 expression levels and related oxidative stress and inflammatory responses among healthy adolescents exposed to PM
    MeSH term(s) Adolescent ; Female ; Humans ; Male ; Air Pollutants/toxicity ; Air Pollutants/analysis ; Air Pollution/adverse effects ; Air Pollution/analysis ; Biomarkers/metabolism ; Gene Expression ; Interleukin-6 ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Particulate Matter/toxicity ; Particulate Matter/analysis ; Respiratory System/chemistry ; Tumor Necrosis Factor-alpha/genetics ; Environmental Exposure
    Chemical Substances Air Pollutants ; Biomarkers ; Interleukin-6 ; NF-E2-Related Factor 2 ; Particulate Matter ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2023-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.121463
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    Zs.A 2599: Show issues Location:
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