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  1. Article ; Online: Upper Limb Casting Application Post-Botulinum Toxin Injection for Elbow Spasticity: A Guided Casting Protocol.

    Wortley, Kate / Carda, Stefano / Ganzert, Carl / Farag, Jordan / Reebye, Rajiv

    American journal of physical medicine & rehabilitation

    2024  

    Abstract: Abstract: Casting is an effective adjunctive treatment which increases the effects of botulinum toxin on patients with spasticity. The evidence for casting as an adjunctive therapy post-botulinum toxin has been well documented in the literature. However, ...

    Abstract Abstract: Casting is an effective adjunctive treatment which increases the effects of botulinum toxin on patients with spasticity. The evidence for casting as an adjunctive therapy post-botulinum toxin has been well documented in the literature. However, standardized casting protocols are lacking, with no published descriptions of upper limb casting application post-botulinum toxin injection for spasticity. In this paper we will describe our experience regarding the application of upper limb casting as an adjunctive therapy for elbow spasticity, detailing indications, contraindications and description of our protocol (materials required and technique).
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000002487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intrathecal baclofen as an effective treatment for generalized dystonia in Wilson's disease.

    Grana, Elisa / Peschi, Livia / Carda, Stefano

    European journal of physical and rehabilitation medicine

    2023  Volume 59, Issue 5, Page(s) 653–655

    MeSH term(s) Humans ; Hepatolenticular Degeneration/complications ; Hepatolenticular Degeneration/drug therapy ; Dystonia/drug therapy ; Dystonia/etiology ; Baclofen/therapeutic use ; Treatment Outcome
    Chemical Substances Baclofen (H789N3FKE8)
    Language English
    Publishing date 2023-09-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2426908-6
    ISSN 1973-9095 ; 1973-9087
    ISSN (online) 1973-9095
    ISSN 1973-9087
    DOI 10.23736/S1973-9087.23.07960-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Botulinum Toxin for Pain Relief in Cancer Patients: A Systematic Review of Randomized Controlled Trials.

    Lippi, Lorenzo / de Sire, Alessandro / Turco, Alessio / Ferrillo, Martina / Kesikburun, Serdar / Baricich, Alessio / Carda, Stefano / Invernizzi, Marco

    Toxins

    2024  Volume 16, Issue 3

    Abstract: Cancer pain is one of the most disabling symptoms complained by cancer patients, with a crucial impact on physical and psychological well-being. Botulinum neurotoxins (BoNTs) type A and B have emerged as potential interventions for chronic pain; however, ...

    Abstract Cancer pain is one of the most disabling symptoms complained by cancer patients, with a crucial impact on physical and psychological well-being. Botulinum neurotoxins (BoNTs) type A and B have emerged as potential interventions for chronic pain; however, their role in these patients is still debated. Thus, this systematic review of randomized controlled trials aimed at assessing the effects of BoNT treatment for cancer pain to guide physicians in an evidence-based approach integrating BoNT in cancer care. Out of 5824 records, 10 RCTs satisfied our eligibility criteria and were included in the present work for a total of 413 subjects with several cancer types (breast, head and neck, esophageal, and thoracic/gastric cancers). While some studies demonstrated significant pain reduction and improved quality of life post-BoNT-A injections, outcomes across different cancer types were inconclusive. Additionally, several effects were observed in functioning, dysphagia, salivary outcomes, esophageal strictures, gastric emptying, and expansions. This review emphasizes the need for further standardized research to conclusively establish the efficacy of BoNT in comprehensive cancer pain management.
    MeSH term(s) Humans ; Pain Management ; Cancer Pain ; Quality of Life ; Randomized Controlled Trials as Topic ; Stomach Neoplasms ; Chronic Pain
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins16030153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A practical guide to botulinum neurotoxin treatment of shoulder spasticity 1: Anatomy, physiology, and goal setting.

    Jacinto, Jorge / Camões-Barbosa, Alexandre / Carda, Stefano / Hoad, Damon / Wissel, Jörg

    Frontiers in neurology

    2022  Volume 13, Page(s) 1004629

    Abstract: Botulinum neurotoxin type A (BoNT-A) is a first-line treatment option for post-stroke spasticity, reducing pain and involuntary movements and helping to restore function. BoNT-A is frequently injected into the arm, wrist, hand and/or finger muscles, but ... ...

    Abstract Botulinum neurotoxin type A (BoNT-A) is a first-line treatment option for post-stroke spasticity, reducing pain and involuntary movements and helping to restore function. BoNT-A is frequently injected into the arm, wrist, hand and/or finger muscles, but less often into the shoulder muscles, despite clinical trials demonstrating improvements in pain and function after shoulder BoNT-A injection. In part 1 of this two-part practical guide, we present an experts' consensus on the use of BoNT-A injections in the multi-pattern treatment of shoulder spasticity to increase awareness of shoulder muscle injection with BoNT-A, alongside the more commonly injected upper limb muscles. Expert consensus was obtained from five European experts with a cumulative experience of more than 100 years of BoNT-A use in post-stroke spasticity. A patient-centered approach was proposed by the expert consensus: to identify which activities are limited by the spastic shoulder and consider treating the muscles that are involved in hindering those activities. Two patterns of shoulder spasticity were identified: for Pattern A (adduction, elevation, flexion and internal rotation of the shoulder), the expert panel recommended injecting the pectoralis major, teres major and subscapularis muscles; in most cases injecting only the pectoralis major and the teres major is sufficient for the first injection cycle; for Pattern B (abduction or adduction, extension and internal rotation of the shoulder), the panel recommended injecting the posterior part of the deltoid, the teres major and the latissimus dorsi in most cases. It is important to consider the local guidelines and product labels, as well as discussions within the multidisciplinary, multiprofessional team when deciding to inject shoulder muscles with BoNT-A. The choice of shoulder muscles for BoNT-A injection can be based on spastic pattern, but ideally should also firstly consider the functional limitation and patient expectations in order to establish better patient-centered treatment goals. These recommendations will be of benefit for clinicians who may not be experienced in evaluating and treating spastic shoulders.
    Language English
    Publishing date 2022-10-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.1004629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Selecting Goals and Target Muscles for Botulinum Toxin A Injection Using the Goal Oriented Facilitated Approach to Spasticity Treatment (GO-FAST) Tool.

    Jacinto, Jorge / Balbert, Alexander / Bensmail, Djamel / Carda, Stefano / Draulans, Nathalie / Deltombe, Thierry / Ketchum, Nicholas / Molteni, Franco / Reebye, Rajiv

    Toxins

    2023  Volume 15, Issue 12

    Abstract: The objective of this article is to introduce the GO-FAST Tool (developed by the Toxnet group) to clinicians working in the field of neurological rehabilitation, specifically post-stroke spasticity management. The concepts utilized in the Tool and ... ...

    Abstract The objective of this article is to introduce the GO-FAST Tool (developed by the Toxnet group) to clinicians working in the field of neurological rehabilitation, specifically post-stroke spasticity management. The concepts utilized in the Tool and described in this article can be broadly grouped into five topics: the principles of patient-centred goal-setting; an algorithm for setting SMART (specific, measurable, attainable, realistic, and timed) treatment goals; goal-related target muscles and botulinum toxin type A dose determinants; goal attainment follow-up, scoring, and interpretation; and the multimodal approach to spasticity management. The Tool can enhance clinical practice by providing guided assistance with goal-setting and target muscle selection for botulinum toxin type A treatment. It also provides support with the follow-up evaluation of goal attainment and calculation of treatment success. The Tool is designed to be used by clinicians with varying levels of expertise in the field of neurological rehabilitation and post-stroke spasticity management, from those who are new to the field to those with many years of experience. A case study is presented in the Results Section of the article to illustrate the utility of the Tool in setting SMART treatment goals in the management of patients with post-stroke spasticity.
    MeSH term(s) Humans ; Botulinum Toxins, Type A/therapeutic use ; Neuromuscular Agents/therapeutic use ; Goals ; Upper Extremity ; Muscle Spasticity/drug therapy ; Muscle Spasticity/rehabilitation ; Stroke/complications ; Stroke/drug therapy ; Treatment Outcome ; Muscles
    Chemical Substances Botulinum Toxins, Type A (EC 3.4.24.69) ; Neuromuscular Agents
    Language English
    Publishing date 2023-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins15120676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Prise en charge de la spasticité : une évaluation interprofessionnelle.

    Carda, Stefano / Vuadens, Philippe / Van Den Keybus, Katrien / Diserens, Karin

    Revue medicale suisse

    2020  Volume 16, Issue 692, Page(s) 904–906

    Abstract: Spasticity is a common sign of central nervous system lesions and its management is difficult because it is usually associated with other symptoms of upper motoneuron syndrome (paresis, spastic dystonia, contractures, …). We propose an interprofessional ... ...

    Title translation Spasticity management: an interprofessional evaluation.
    Abstract Spasticity is a common sign of central nervous system lesions and its management is difficult because it is usually associated with other symptoms of upper motoneuron syndrome (paresis, spastic dystonia, contractures, …). We propose an interprofessional evaluation, which demonstrates that a standardized evaluation, a common approach and a gait analysis improve the therapeutic decision.
    MeSH term(s) Central Nervous System/injuries ; Central Nervous System/physiopathology ; Gait Analysis ; Humans ; Muscle Spasticity/diagnosis ; Muscle Spasticity/physiopathology ; Muscle Spasticity/therapy
    Language French
    Publishing date 2020-05-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Neurorééducation en phases aiguë et postaiguë : qu’avons-nous appris de la première vague de Covid-19 ?

    Diserens, Karin / Carda, Stefano / Epiney, Jean-Benoît / Meyer, Ivo / Jöhr, Jane

    Revue medicale suisse

    2021  Volume 17, Issue 736, Page(s) 835–840

    Abstract: The majority of patients with Coronavirus disease 2019 (COVID-19) present mild to moderate illness and recover without hospitalization. Nevertheless, 5 % of cases require hospitalization in the intensive care unit, with 15 % of them showing severe ... ...

    Title translation Neurorehabilitation in the acute and post-acute phase: what did we learn from the first wave of COVID-19?
    Abstract The majority of patients with Coronavirus disease 2019 (COVID-19) present mild to moderate illness and recover without hospitalization. Nevertheless, 5 % of cases require hospitalization in the intensive care unit, with 15 % of them showing severe central and peripheral nervous system manifestations. These patients should be considered high risk patients and their management must include prevention of a potential accompanying cascade of negative factors. In order to optimize care, it is essential that signs of neurological damage are searched for as early as in intensive care so that appropriate neurorehabilitation can be started immediately and continued in a specific unit for patients with neurological sequelae at post-acute and outpatient phases.
    MeSH term(s) COVID-19 ; Critical Care ; Hospitalization ; Humans ; Neurological Rehabilitation ; SARS-CoV-2
    Language French
    Publishing date 2021-04-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Selecting Goals and Target Muscles for Botulinum Toxin A Injection Using the Goal Oriented Facilitated Approach to Spasticity Treatment (GO-FAST) Tool

    Jorge Jacinto / Alexander Balbert / Djamel Bensmail / Stefano Carda / Nathalie Draulans / Thierry Deltombe / Nicholas Ketchum / Franco Molteni / Rajiv Reebye

    Toxins, Vol 15, Iss 12, p

    2023  Volume 676

    Abstract: The objective of this article is to introduce the GO-FAST Tool (developed by the Toxnet group) to clinicians working in the field of neurological rehabilitation, specifically post-stroke spasticity management. The concepts utilized in the Tool and ... ...

    Abstract The objective of this article is to introduce the GO-FAST Tool (developed by the Toxnet group) to clinicians working in the field of neurological rehabilitation, specifically post-stroke spasticity management. The concepts utilized in the Tool and described in this article can be broadly grouped into five topics: the principles of patient-centred goal-setting; an algorithm for setting SMART (specific, measurable, attainable, realistic, and timed) treatment goals; goal-related target muscles and botulinum toxin type A dose determinants; goal attainment follow-up, scoring, and interpretation; and the multimodal approach to spasticity management. The Tool can enhance clinical practice by providing guided assistance with goal-setting and target muscle selection for botulinum toxin type A treatment. It also provides support with the follow-up evaluation of goal attainment and calculation of treatment success. The Tool is designed to be used by clinicians with varying levels of expertise in the field of neurological rehabilitation and post-stroke spasticity management, from those who are new to the field to those with many years of experience. A case study is presented in the Results Section of the article to illustrate the utility of the Tool in setting SMART treatment goals in the management of patients with post-stroke spasticity.
    Keywords GAS ; goal-setting ; GO-FAST ; SMART treatment goals ; Medicine ; R
    Subject code 650
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Multidimensional Effectiveness of Botulinum Toxin in Neuropathic Pain: A Systematic Review of Randomized Clinical Trials.

    Lippi, Lorenzo / de Sire, Alessandro / Folli, Arianna / D'Abrosca, Francesco / Grana, Elisa / Baricich, Alessio / Carda, Stefano / Invernizzi, Marco

    Toxins

    2022  Volume 14, Issue 5

    Abstract: Although botulinum toxin (BoNT) has been suggested as a treatment to counter neuropathic pain, no previous systematic reviews investigated the multidimensional effects of BoNT on pain relief and Health-Related Quality of Life (HR-QoL). The aim of this ... ...

    Abstract Although botulinum toxin (BoNT) has been suggested as a treatment to counter neuropathic pain, no previous systematic reviews investigated the multidimensional effects of BoNT on pain relief and Health-Related Quality of Life (HR-QoL). The aim of this systematic review is to summarize the current evidence on the effectiveness of BoNT treatment for neuropathic pain, and to characterize its multidimensional effectiveness in order to guide physicians in clinical practice. Five databases were systematically searched up to 4 April 2022, to identify randomized controlled trials satisfying the following criteria: adults suffering from neuropathic pain, BoNT administration, any comparator, multidimensional assessment of pain as primary outcome, HR-QoL, physical function, anxiety and depression, and sleep quality as secondary outcomes. Twelve studies were included. The multidimensional pain scales used were short-form McGill Pain Questionnaire, Neuropathic pain scale, Neuropathic Pain Symptom Inventory, International SCI Pain Basic Data Set, West Haven-Yale Multidimensional Pain Inventory, Brief Pain Inventory, and Douleur Neuropathique 4. These scales highlighted the positive effects of BoNT administration. According to the Jadad scale, all the RCTs included were high-quality studies. BoNT administration might be effectively introduced in the comprehensive management of neuropathic pain. Further research should focus on optimal and cost-effective therapeutic protocols.
    MeSH term(s) Botulinum Toxins/therapeutic use ; Humans ; Neuralgia/drug therapy ; Pain Measurement ; Quality of Life ; Randomized Controlled Trials as Topic
    Chemical Substances Botulinum Toxins (EC 3.4.24.69)
    Language English
    Publishing date 2022-04-27
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins14050308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A practical guide to botulinum neurotoxin treatment of shoulder spasticity 2

    Wissel, Jörg / Camões-Barbosa, Alexandre / Carda, Stefano / Hoad, Damon / Jacinto, Jorge

    Frontiers in Psychology

    Injection techniques, outcome measurement scales, and case studies

    2022  

    Abstract: Introduction: Botulinum neurotoxin type A (BoNT-A) is a first-line treatment option for post-stroke spasticity, reducing pain and involuntary movements and helping to restore function. BoNT-A is frequently injected into the arm, the wrist, the hand, and/ ... ...

    Title translation Ein praktischer Leitfaden für die Botulinum-Neurotoxin-Behandlung der Schulterspastik 2: Injektionstechniken, Skalen zur Ergebnismessung und Fallstudien. (DeepL)
    Abstract Introduction: Botulinum neurotoxin type A (BoNT-A) is a first-line treatment option for post-stroke spasticity, reducing pain and involuntary movements and helping to restore function. BoNT-A is frequently injected into the arm, the wrist, the hand, and/or the finger muscles but less often into the shoulder muscles, despite clinical trials demonstrating improvements in pain and function after shoulder BoNT-A injection. Methods: In part 2 of this two-part practical guide, we present an experts' consensus on the choice of outcome measurement scales and goal-setting recommendations for BoNT-A in the treatment of shoulder spasticity to increase awareness of shoulder muscle injection with BoNT-A, alongside the more commonly injected upper limb muscles. Expert consensus was obtained from five European experts with a cumulative experience of more than 100 years of BoNT-A use in post-stroke spasticity. Case studies are included as examples of approaches taken in the treatment of shoulder spasticity. Results: Although the velocity-dependent increase in muscle tone is often a focus of patient assessment, it is only one component of spasticity and should be assessed as part of a wider range of measurements. For outcome measurement following BoNT-A injection in shoulder muscles, shoulder-specific scales are recommended. Other scales to be considered include Pain Numerical Rating and/or global functioning, as well as the quality of life and global perception of benefit scores. Goal setting is an essential part of the multidisciplinary management process for spasticity; goals should be patient-centric, realistic, and achievable; functional-focused goal statements and a mixture of short- (3-6 month) and long-term (9-18 month) goals are recommended. These can be grouped into symptomatic, passive function, active function, involuntary movement, and global mobility. Clinical evaluation tools, goal setting, and outcome expectations for the multipattern treatment of shoulder spasticity with BoNT-A should be defined by the whole multidisciplinary team, ensuring patient and caregiver involvement. Discussion: These recommendations will be of benefit to clinicians who may not be experienced in evaluating and treating spastic shoulders.
    Keywords Behandlungsleitlinien ; Botulinum Toxin ; Botulinumtoxin ; Goals ; Muscle Spasms ; Muskelspasmen ; Schulter ; Shoulder (Anatomy) ; Therapieerfolgskontrolle ; Treatment Effectiveness Evaluation ; Treatment Guidelines ; Ziele
    Language English
    Document type Article
    DOI 10.3389/fneur.2022.1022549
    Database PSYNDEX

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