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Article: Psychological predictors of protective behaviours during the Covid-19 pandemic: Theory of planned behaviour and risk perception.

Trifiletti, Elena / Shamloo, Soraya E / Faccini, Martina / Zaka, Agustina

Journal of community & applied social psychology

2021 Volume 32, Issue 3, Page(s) 382–397

Abstract: The Covid-19 outbreak was declared a public health emergency by the World Health Organization in January 2020. As a consequence, several protective measures were urged by national governments in order to limit the spread of the pandemic. Drawing on the ... ...

Abstract	The Covid-19 outbreak was declared a public health emergency by the World Health Organization in January 2020. As a consequence, several protective measures were urged by national governments in order to limit the spread of the pandemic. Drawing on the literature on health behaviours, in the present study, we investigated the psychological factors (i.e., attitudes, social norms, perceived behavioural control, intentions, and risk perception) that were associated with two highly recommended behaviours: frequent hand washing and social distancing (i.e., staying at home except for essential reasons). The study employed a correlational design with a follow-up. A questionnaire including measures of psychological predictors was administered via social media to a sample of 403 adults residing in Italy during the lockdown. Self-reported behaviours were assessed one week later. Findings showed that attitudes, social norms, perceived behavioural control were significantly related to hand washing and social distancing through intentions. Risk perception was a significant predictor of social distancing but not of hand washing. These findings suggest that intervention and communication strategies aimed at encouraging preventive measures during the Covid-19 pandemic should be organized taking into account multiple factors which partially differ depending on the type of behaviour considered. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
Language	English
Publishing date	2021-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2001638-4
ISSN	1099-1298 ; 1052-9284
ISSN (online)	1099-1298
ISSN	1052-9284
DOI	10.1002/casp.2509
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Predicting global QoL after orthotopic neobladder or ileal conduit diversion: nomogram development.

Siracusano, Salvatore / Zaka, Agustina / Zaffuto, Emanuele / Porcaro, Antonio Benito / Colombo, Renzo / Talamini, Renato / Romantini, Federico / Montorsi, Francesco / Lonardi, Cristina

Frontiers in oncology

2023 Volume 13, Page(s) 1055140

Abstract: Introduction: Quality of life (QoL) outcomes in patients undergoing radical cystectomy (RC) with orthotopic neobladder (ONB) or ileal conduit (IC) have been extensively investigated. However, a general lack of consensus on QoL's predictive factors ... ...

Abstract	Introduction: Quality of life (QoL) outcomes in patients undergoing radical cystectomy (RC) with orthotopic neobladder (ONB) or ileal conduit (IC) have been extensively investigated. However, a general lack of consensus on QoL's predictive factors exists. The aim of the study was to develop a nomogram using preoperative parameters to predict global QoL outcome in patients with localized muscle-invasive bladder cancer (MIBC) undergoing RC with ONB or IC urinary diversion (UD). Methods: A cohort of 319 patients who underwent RC and ONB or IC were retrospectively enrolled. Multivariable linear regression analyses were used to predict the global QoL score of the European Organisation for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30), according to the patient characteristics and UD. A nomogram was developed and internally validated. Results: Patients' data in the two study groups significantly differed with regard to comorbidity profiles (chronic cardiac failure, p < 0.001; chronic kidney disease, p < 0.01; hypertension, p < 0.03; diabetic disease, p = 0.02; chronic arthritis, p = 0.02). A multivariable model that included patient age at surgery, UD, chronic cardiac disease, and peripheral vascular disease represented the basis for the nomogram. The calibration plot of the prediction model showed a systematic overestimation of the predicted global QoL score over the observed scores, with a slight underestimation for observed global QoL scores between 57 and 72. After performing leave-one-out cross-validation, the root mean square error (RMSE) emerged as 24.0. Discussion/conclusion: A novel nomogram based completely on known preoperative factors was developed for patients with MIBC undergoing RC to predict a mid-term QoL outcome.
Language	English
Publishing date	2023-05-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1055140
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Article: Quality of Life in Female Patients Following Ileal Neobladder and Ileal Conduit: Where Are We?

Siracusano, Salvatore / Zaka, Agustina / Romantini, Federico / Porcaro, Antonio Benito / Vicentini, Carlo / Lonardi, Cristina

Journal of clinical medicine

2021 Volume 10, Issue 14

Abstract: Women undergoing a radical cystectomy (RC) followed by a urinary diversion (UD) for bladder cancer (BC), experience a substantial reduction in health-related quality of life (HRQOL). At present, studies comparing long-term QOL outcomes for different UD ... ...

Abstract	Women undergoing a radical cystectomy (RC) followed by a urinary diversion (UD) for bladder cancer (BC), experience a substantial reduction in health-related quality of life (HRQOL). At present, studies comparing long-term QOL outcomes for different UD methods in female patients are lacking. We summarize the current state of the QoL assessment in female patients after an RC.
Language	English
Publishing date	2021-07-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10143042
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Article ; Online: COVID-19 pandemic as a watershed moment: A call for systematic psychological health care for frontline medical staff.

Zaka, Agustina / Shamloo, Soraya E / Fiorente, Pasquale / Tafuri, Alessandro

Journal of health psychology

2020 Volume 25, Issue 7, Page(s) 883–887

Abstract: The COVID-19 pandemic is producing a huge health care burden with millions of cases and thousands of deaths. The coronavirus' high virulence and contagiousness and the frequent sudden onset of illness is overwhelming critical care and frontline ... ...

Abstract	The COVID-19 pandemic is producing a huge health care burden with millions of cases and thousands of deaths. The coronavirus' high virulence and contagiousness and the frequent sudden onset of illness is overwhelming critical care and frontline healthcare staff. Frontline professionals are exposed to unprecedented levels of intensive existential threat requiring systematic, specialized psychological intervention and support. New psychological services need to be urgently implemented to manage the mental healthcare needs of frontline medical staff working with patients with COVID-19. The COVID-19 pandemic is a watershed moment: health care systems universally require a step-change to improve our preparedness for future pandemics.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Civil Defense ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Humans ; Medical Staff/psychology ; Mental Health ; Mental Health Services ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-05
Publishing country	England
Document type	Editorial
ZDB-ID	2021897-7
ISSN	1461-7277 ; 1359-1053
ISSN (online)	1461-7277
ISSN	1359-1053
DOI	10.1177/1359105320925148
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Article ; Online: Quality of Life in Female Patients Following Ileal Neobladder and Ileal Conduit

Salvatore Siracusano / Agustina Zaka / Federico Romantini / Antonio Benito Porcaro / Carlo Vicentini / Cristina Lonardi

Journal of Clinical Medicine, Vol 10, Iss 3042, p

Where Are We?

2021 Volume 3042

Abstract	Women undergoing a radical cystectomy (RC) followed by a urinary diversion (UD) for bladder cancer (BC), experience a substantial reduction in health-related quality of life (HRQOL). At present, studies comparing long-term QOL outcomes for different UD methods in female patients are lacking. We summarize the current state of the QoL assessment in female patients after an RC.
Keywords	female ; muscle-invasive bladder cancer ; quality of life ; Medicine ; R
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: COVID-19 pandemic as a watershed moment

Zaka, Agustina / Shamloo, Soraya E / Fiorente, Pasquale / Tafuri, Alessandro

Journal of Health Psychology

A call for systematic psychological health care for frontline medical staff

2020 Volume 25, Issue 7, Page(s) 883–887

Abstract: The COVID-19 pandemic is producing a huge health care burden with millions of cases and thousands of deaths. The coronavirus’ high virulence and contagiousness and the frequent sudden onset of illness is overwhelming critical care and frontline ... ...

Abstract	The COVID-19 pandemic is producing a huge health care burden with millions of cases and thousands of deaths. The coronavirus’ high virulence and contagiousness and the frequent sudden onset of illness is overwhelming critical care and frontline healthcare staff. Frontline professionals are exposed to unprecedented levels of intensive existential threat requiring systematic, specialized psychological intervention and support. New psychological services need to be urgently implemented to manage the mental healthcare needs of frontline medical staff working with patients with COVID-19. The COVID-19 pandemic is a watershed moment: health care systems universally require a step-change to improve our preparedness for future pandemics.
Keywords	Applied Psychology ; covid19
Language	English
Publisher	SAGE Publications
Publishing country	us
Document type	Article ; Online
ZDB-ID	2021897-7
ISSN	1461-7277 ; 1359-1053
ISSN (online)	1461-7277
ISSN	1359-1053
DOI	10.1177/1359105320925148
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: COVID-19 pandemic as a watershed moment: A call for systematic psychological health care for frontline medical staff

Zaka, Agustina / Shamloo, Soraya E / Fiorente, Pasquale / Tafuri, Alessandro

J Health Psychol

Abstract	The COVID-19 pandemic is producing a huge health care burden with millions of cases and thousands of deaths. The coronavirus' high virulence and contagiousness and the frequent sudden onset of illness is overwhelming critical care and frontline healthcare staff. Frontline professionals are exposed to unprecedented levels of intensive existential threat requiring systematic, specialized psychological intervention and support. New psychological services need to be urgently implemented to manage the mental healthcare needs of frontline medical staff working with patients with COVID-19. The COVID-19 pandemic is a watershed moment: health care systems universally require a step-change to improve our preparedness for future pandemics.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #186607
Database	COVID19

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Article: Quality-of-Life Outcomes in Female Patients With Ileal Conduit or Orthotopic Neobladder Urinary Diversion: 6-Month Results of a Multicenter Prospective Study.

Frontiers in oncology

2022 Volume 12, Page(s) 855546

Abstract: Radical cystectomy (RC) often affects patients' life as this surgery is a traumatic and invasive event for the patients, with drawbacks on their daily, social, working, and sex life. Such changes in the quality of life (QoL) of patients are commonly ... ...

Abstract	Radical cystectomy (RC) often affects patients' life as this surgery is a traumatic and invasive event for the patients, with drawbacks on their daily, social, working, and sex life. Such changes in the quality of life (QoL) of patients are commonly studied through retrospective clinical evaluations and rarely with longitudinal studies. To date, studies focusing on functional outcomes, sexual function, and health-related QoL for female patients are lacking. We evaluated 37 patients using EORTC QLQ-C30 (QLQ-30) and Short-Form 36 (SF-36) questionnaires, before and after surgery, at 3 and 6 months of follow-up. The mean values for the emotional functioning in QLQ-C30 as well as the mental health in SF-36 were significantly higher in the ONB group compared to the IC group at 3 months of follow-up. These differences were not significant at 6 months of follow-up. At 6 months of follow-up, the ONB group showed a higher mean score in the physical and role functioning than the IC group. Although there was a statistically significant age difference at baseline of the two groups, none of the results are correlated with age, as demonstrated by Spearman's analysis. The ONB seems to represent the most advantageous solution compared to the IC in terms of QOL at the 6-month follow-up.
Language	English
Publishing date	2022-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.855546
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Article: Treatment of low doses curcumin could modulate Th17/Treg balance specifically on CD4+ T cell cultures of systemic lupus erythematosus patients.

Handono, Kusworini / Pratama, Mirza Zaka / Endharti, Agustina Tri / Kalim, Handono

Central-European journal of immunology

2016 Volume 40, Issue 4, Page(s) 461–469

Abstract: Introduction: The balance between T helper 17 (Th17) and regulatory T cells (Treg) is a new paradigm in the pathogenesis of systemic lupus erythematosus (SLE). Currently, there are no drugs that able to modulate Th17/Treg balance specifically in SLE. ... ...

Abstract	Introduction: The balance between T helper 17 (Th17) and regulatory T cells (Treg) is a new paradigm in the pathogenesis of systemic lupus erythematosus (SLE). Currently, there are no drugs that able to modulate Th17/Treg balance specifically in SLE. Curcumin is a bioactive agent that has a specific action against hyperproliferative cells. However, its role in modulating Th17/Treg balance in SLE is still unknown. This research aimed to investigate the role of curcumin in modulating Th17/Treg balance on CD4+ T cell cultures of SLE patients. Material and methods: CD4+ T cells from SLE 6 untreated patients and 6 healthy subjects were collected, stimulated with Th17 differentiating factors, and curcumin 0.1 and 1 µg/ml was added on cultures. After 72 hours incubation, cells were harvested and measured for Th17 and Treg percentages using flow cytometry and interleukin-17A (IL-17A) and transforming growth factor-β1 (TGF-β1) levels using ELISA. Results: Administration of low doses of curcumin (0.1 and 1 µg/ml) could decrease Th17 percentages (p = 0.000 and p = 0.000 compared to control), reduce IL-17A productions (p = 0.000 and p = 0.000 compared to control), increase Treg percentages (p = 0.001 and p = 0.000 compared to control), and increase TGF-β1 productions (p = 0.001 and p = 0.000 compared to control) on CD4+ T cells of SLE patients. Interestingly, these effects were not reproduced on CD4+ T cells cultures of healthy subjects. Conclusions: These data suggest that curcumin can modulate Th17/Treg balance specifically on CD4+ T cells of SLE patients without affecting healthy subjects.
Language	English
Publishing date	2016-01-15
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1336421-2
ISSN	1644-4124 ; 1426-3912
ISSN (online)	1644-4124
ISSN	1426-3912
DOI	10.5114/ceji.2015.56970
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Article ; Online: Vitamin A improve Th17 and Treg regulation in systemic lupus erythematosus.

Handono, Kusworini / Firdausi, Sevita Nuril / Pratama, Mirza Zaka / Endharti, Agustina Tri / Kalim, Handono

Clinical rheumatology

2016 Volume 35, Issue 3, Page(s) 631–638

Abstract: The aim of this study was to determine the role of vitamin A in modulating T helper 17 (Th17) and regulatory T cell (Treg) balance in systemic lupus erythematosus (SLE) patients. Sixty-two female SLE patients and sixty-two female controls were measured ... ...

Abstract	The aim of this study was to determine the role of vitamin A in modulating T helper 17 (Th17) and regulatory T cell (Treg) balance in systemic lupus erythematosus (SLE) patients. Sixty-two female SLE patients and sixty-two female controls were measured for vitamin A levels from serum by enzyme-linked immunosorbent assay (ELISA) and percentages of Th17 and Treg from peripheral blood mononuclear cells (PBMC) by flow cytometry. We also performed an in vitro study to evaluate the effects of retinoic acid treatment (0, 0.1, 0.2, and 0.3 μg/ml) in modulating Th17/Treg balance in CD4(+) T cell culture from hypovitaminosis A SLE patients. Th17 and Treg percentages from cell cultures were measured by flow cytometry. Vitamin A levels in the SLE patients were lower compared to those in the healthy control (46.9 ± 43.4 vs. 75.6 ± 73.1 ng/ml, p = 0.015). Vitamin A levels also had a negative correlation to Th17 percentages in the SLE patients (p = 0.000, R = -0.642). Th17 percentages in the hypovitaminosis A SLE patients were higher compared to those SLE patients with normal vitamin A levels (10.9 ± 5.3 vs. 2.9 ± 2.2 %, p = 0.000). Treatment of 0.3 μg/ml of retinoic acid could increase Treg differentiation (33.9 ± 1.6 vs. 21.8 ± 1.1 %, p = 0.000) and decrease Th17 differentiation (27.2 ± 2.5 vs. 37.4 ± 1.3 %, p = 0.000). In conclusion, vitamin A has important roles in modulating Th17/Treg balance in the SLE patients shown by the significant decrease of vitamin A levels in the SLE patients which negatively correlate with Th17 population, and treatment of retinoic acid could decrease Th17 and increase Treg percentages in CD4(+) T cells cultures.
MeSH term(s)	Adult ; Female ; Flow Cytometry ; Humans ; Lupus Erythematosus, Systemic/blood ; Lupus Erythematosus, Systemic/immunology ; Lymphocyte Activation ; T-Lymphocytes, Regulatory/drug effects ; T-Lymphocytes, Regulatory/immunology ; Th17 Cells/drug effects ; Th17 Cells/immunology ; Tretinoin/pharmacology ; Vitamin A/blood ; Young Adult
Chemical Substances	Vitamin A (11103-57-4) ; Tretinoin (5688UTC01R)
Language	English
Publishing date	2016-03
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-016-3197-x
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