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  1. Article ; Online: Medication use evaluations as a research tool.

    Schiller, Daryl S

    Pharmacotherapy

    2014  Volume 34 Suppl 1, Page(s) 3S–4S

    MeSH term(s) Drug Utilization Review/methods ; Humans ; Pharmacists ; Quality Improvement
    Language English
    Publishing date 2014-12
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 603158-4
    ISSN 1875-9114 ; 0277-0008
    ISSN (online) 1875-9114
    ISSN 0277-0008
    DOI 10.1002/phar.1515
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    Zs.A 1738: Show issues Location:
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    Zs.MO 585: Show issues

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  2. Article ; Online: Withdrawn as duplicate: COVID-19 pandemic planning, response, and lessons learned at a community hospital.

    Schiller, Daryl S / Fulman, Magda / Champagne, Jennifer / Awad, Nirvana

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2020  Volume 79, Issue 9, Page(s) e154

    Keywords covid19
    Language English
    Publishing date 2020-09-29
    Publishing country England
    Document type Retraction of Publication
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxaa298
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    Zs.A 419: Show issues Location:
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  3. Article ; Online: Impact of hydroxychloroquine on disease progression and ICU admissions in patients with SARS-CoV-2 infection.

    Awad, Nirvana / Schiller, Daryl S / Fulman, Magda / Chak, Azfar

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2021  Volume 78, Issue 8, Page(s) 689–696

    Abstract: Purpose: To evaluate whether use of hydroxychloroquine was associated with a reduced likelihood of intensive care unit (ICU) admission in patients with coronavirus disease 2019 (COVID-19) in the early weeks of the pandemic.: Methods: A retrospective, ...

    Abstract Purpose: To evaluate whether use of hydroxychloroquine was associated with a reduced likelihood of intensive care unit (ICU) admission in patients with coronavirus disease 2019 (COVID-19) in the early weeks of the pandemic.
    Methods: A retrospective, observational cohort study was conducted to determine selected treatment outcomes in 336 patients hospitalized with COVID-19 at an acute care community hospital in the Hudson Valley region of New York from March 20 to April 20, 2020. Eligibility included admission to the hospital, a laboratory-confirmed diagnosis of SARS-CoV-2 infection, and no need for intubation or intensive care at admission. The median (interquartile range) ages of patients who received hydroxychloroquine (n = 188) and those who did not (n = 148) were 68 (58-82) and 64 (51-73) years, respectively. In a multivariable model that included age, gender, obesity, diabetes, and hydroxychloroquine use, patients who received hydroxychloroquine were significantly more likely than those not treated with the drug to be transferred to an ICU (odds ratio, [OR], 8.1; 95% confidence interval [CI]: 3.8-17) and significantly more likely to be intubated (OR, 7.99; 95% CI, 3.76-16.91); these associations were not influenced by disease severity. In-hospital mortality did not differ significantly with disease severity between those who did and those who did not receive hydroxychloroquine.
    Conclusion: Hydroxychloroquine use was significantly associated with increased risks of ICU admission and intubation in patients with mild, moderate, and severe symptoms of COVID-19. There were no significant between-group differences in mortality with use vs nonuse of hydroxychloroquine.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/drug therapy ; COVID-19/mortality ; Cohort Studies ; Disease Progression ; Female ; Humans ; Hydroxychloroquine/administration & dosage ; Hydroxychloroquine/therapeutic use ; Intensive Care Units ; Length of Stay ; Male ; Middle Aged ; New York ; Patient Admission ; Retrospective Studies ; SARS-CoV-2 ; Survival Analysis ; Young Adult
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2021-03-17
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxab056
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  4. Article ; Online: COVID-19 pandemic planning, response, and lessons learned at a community hospital.

    Schiller, Daryl S / Fulman, Magda / Champagne, Jennifer / Awad, Nirvana

    publication RETRACTED

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2020  Volume 77, Issue 17, Page(s) 1371–1374

    MeSH term(s) COVID-19 ; Civil Defense ; Coronavirus Infections ; Health Planning ; Hospitals, Community/organization & administration ; Humans ; Medication Systems, Hospital/organization & administration ; Off-Label Use ; Pandemics ; Personnel Staffing and Scheduling ; Pharmacists ; Pharmacy Service, Hospital/organization & administration ; Pneumonia, Viral
    Keywords covid19
    Language English
    Publishing date 2020-05-11
    Publishing country England
    Document type Journal Article ; Retracted Publication
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxaa179
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  6. Article ; Online: COVID-19 pandemic planning, response, and lessons learned at a community hospital

    Schiller, Daryl S / Fulman, Magda / Champagne, Jennifer / Awad, Nirvana

    American Journal of Health-System Pharmacy ; ISSN 1079-2082 1535-2900

    2020  

    Keywords Health Policy ; Pharmacology ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    DOI 10.1093/ajhp/zxaa298
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: COVID-19 pandemic planning, response, and lessons learned at a community hospital

    Schiller, Daryl S / Fulman, Magda / Champagne, Jennifer / Awad, Nirvana

    American Journal of Health-System Pharmacy

    2020  Volume 77, Issue 17, Page(s) 1371–1374

    Keywords Health Policy ; Pharmacology ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1224627-x
    ISSN 1079-2082
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxaa179
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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  8. Article ; Online: Long-Term Efficacy of Oral Vancomycin Prophylaxis for the Prevention of

    Knight, Emmanuel M / Schiller, Daryl S / Fulman, Magda K / Rastogi, Rupangi

    Journal of pharmacy practice

    2019  Volume 33, Issue 5, Page(s) 633–639

    Abstract: Background: Limited evidence suggests that prophylactic oral vancomycin may be beneficial in preventing : Objective: To evaluate the long-term efficacy of oral vancomycin prophylaxis (OVP) in preventing CDI recurrence in subjects who require ... ...

    Abstract Background: Limited evidence suggests that prophylactic oral vancomycin may be beneficial in preventing
    Objective: To evaluate the long-term efficacy of oral vancomycin prophylaxis (OVP) in preventing CDI recurrence in subjects who require subsequent antibiotic exposure.
    Methods: A retrospective cohort study was conducted at a community hospital. A total of 91 subjects with a history of CDI between January 2013 and December 2015 who had a subsequent hospitalization requiring systemic antibiotics within 12 months were evaluated. Thirty-two subjects who received prophylaxis with oral vancomycin were compared to 59 subjects who did not receive prophylaxis.
    Results: CDI recurrence within 12 months was significantly lower in subjects receiving OVP compared to those who did not receive OVP (6.3% vs 28.8%; odds ratio [OR]: 0.16; 95% confidence interval [CI]: 0.04-0.77;
    Conclusion: Use of OVP in subjects with a history of CDI up to 12 months prior to subsequent antibiotic exposure appears to reduce the risk of CDI recurrence for up to 12 months.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Clostridioides difficile ; Clostridium Infections/drug therapy ; Clostridium Infections/epidemiology ; Clostridium Infections/prevention & control ; Humans ; Recurrence ; Retrospective Studies ; Vancomycin
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2019-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1027474-1
    ISSN 1531-1937 ; 0897-1900
    ISSN (online) 1531-1937
    ISSN 0897-1900
    DOI 10.1177/0897190019825994
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    Zs.A 2893: Show issues Location:
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  9. Article: Identification, management, and prevention of adverse effects associated with highly active antiretroviral therapy.

    Schiller, Daryl S

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2004  Volume 61, Issue 23, Page(s) 2507–2522

    Abstract: Purpose: The adverse effects associated with highly active antiretroviral therapy (HAART), as well as potential options available for management of these complications, are summarized.: Summary: Effective treatment of human immunodeficiency virus ( ... ...

    Abstract Purpose: The adverse effects associated with highly active antiretroviral therapy (HAART), as well as potential options available for management of these complications, are summarized.
    Summary: Effective treatment of human immunodeficiency virus (HIV) infection requires three or four drug regimens that are complicated and commonly associated with adverse effects. This makes compliance difficult and can result in treatment failures, development of resistance, and loss of future treatment options. In addition, some adverse effects may lead to an increase in morbidity and represent additional risk factors for future complications. Serious adverse events after the initiation of HAART are related to both patient and treatment characteristics. Most organ systems can be affected, depending on the drug or class of drugs being used; therefore, proper identification of adverse effects can be difficult. The most common adverse effects are gastrointestinal, neurologic, metabolic, and cardiovascular, although renal, dermatological, and hematologic events may also be encountered. Adverse-effect management has included treatment interruptions and therapeutic drug monitoring but most commonly involves switching to another drug or class of drugs. This requires a complete understanding of HAART regimens and their associated complications. HIV clinics that have employed clinical pharmacists have been able to successfully prevent or identify adverse effects through suggestions for effective treatment alternatives, medication counseling, and compliance education.
    Conclusion: The identification, management, and prevention of adverse events associated with HAART can be difficult but are integral components of effective treatment. Proper interventions are cost-effective and have resulted in improved quality of life for patients infected with HIV.
    MeSH term(s) Antiretroviral Therapy, Highly Active/adverse effects ; Antiretroviral Therapy, Highly Active/economics ; Costs and Cost Analysis ; Drug Information Services ; Drug Monitoring/methods ; Drug Resistance, Viral/drug effects ; HIV Infections/drug therapy ; HIV Infections/virology ; Humans ; Patient Compliance ; Patient Education as Topic/methods ; Pharmacists ; Professional Role ; Quality of Life
    Language English
    Publishing date 2004-09-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1224627-x
    ISSN 1079-2082
    ISSN 1079-2082
    DOI 10.1093/ajhp/61.23.2507
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  10. Article: Aerosolized Delivery of Antifungal Agents.

    Le, Jennifer / Schiller, Daryl S

    Current fungal infection reports

    2010  Volume 4, Issue 2, Page(s) 96–102

    Abstract: Pulmonary infections caused by Aspergillus species are associated with significant morbidity and mortality in immunocompromised patients. Although the treatment of pulmonary fungal infections requires the use of systemic agents, aerosolized delivery is ... ...

    Abstract Pulmonary infections caused by Aspergillus species are associated with significant morbidity and mortality in immunocompromised patients. Although the treatment of pulmonary fungal infections requires the use of systemic agents, aerosolized delivery is an attractive option in prevention because the drug can concentrate locally at the site of infection with minimal systemic exposure. Current clinical evidence for the use of aerosolized delivery in preventing fungal infections is limited to amphotericin B products, although itraconazole, voriconazole, and caspofungin are under investigation. Based on conflicting results from clinical trials that evaluated various amphotericin B formulations, the routine use of aerosolized delivery cannot be recommended. Further research with well-designed clinical trials is necessary to elucidate the therapeutic role and risks associated with aerosolized delivery of antifungal agents. This article provides an overview of aerosolized delivery systems, the intrapulmonary pharmacokinetic properties of aerosolized antifungal agents, and key findings from clinical studies.
    Language English
    Publishing date 2010-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2391647-3
    ISSN 1936-377X ; 1936-3761
    ISSN (online) 1936-377X
    ISSN 1936-3761
    DOI 10.1007/s12281-010-0011-0
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