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  1. Article ; Online: Identification of the Chemical Constituents of an Anti-Arthritic Chinese Medicine Wen Luo Yin by Liquid Chromatography Coupled with Mass Spectrometry.

    Guan, Huanyu / Luo, Xiaomei / Chang, Xiaoyan / Su, Meifeng / Li, Zhuangzhuang / Li, Pengfei / Wang, Xiaoming / Shi, Yue

    Molecules (Basel, Switzerland)

    2019  Volume 24, Issue 2

    Abstract: Wen Luo Yin (WLY), a well-known traditional Chinese medicine formulation, has been used ...

    Abstract Wen Luo Yin (WLY), a well-known traditional Chinese medicine formulation, has been used as a complementary therapy for the treatment of rheumatoid arthritis in clinical settings. However, the chemical constituents of WLY remain unclear. In this study, a high-performance liquid chromatography coupled with tandem mass spectrometry method was established to separate and comprehensively identify the chemical constituents of WLY. The analytes were eluted with a mobile phase of acetonitrile and 0.1% aqueous acetic acid. Mass detection was performed in both positive and negative ion mode. The MS/MS fragmentation pathways were proposed for the identification of the components. A total of 42 compounds including sesquiterpenes, alkaloids, biflavonoids, polyacetylenes, phenylpropanoids and acetylenic phenols were identified unambiguously or tentatively according to their retention times and mass behavior with those of authentic standards or literature data. The identification and structural elucidation of chemical constituents may provide important information for quality control and pharmacological research of WLY.
    MeSH term(s) Alkaloids/isolation & purification ; Biflavonoids/isolation & purification ; Chromatography, Liquid/methods ; Drugs, Chinese Herbal/analysis ; Phenols/isolation & purification ; Sesquiterpenes/isolation & purification ; Tandem Mass Spectrometry/methods
    Chemical Substances Alkaloids ; Biflavonoids ; Drugs, Chinese Herbal ; Phenols ; Sesquiterpenes ; wen luo yin
    Language English
    Publishing date 2019-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules24020233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  2. Article ; Online: UHPLC-MS-based metabolomics and chemoinformatics study reveals the neuroprotective effect and chemical characteristic in Parkinson's disease mice after oral administration of Wen-Shen-Yang-Gan decoction.

    Zhu, Guoxue / Wang, Wang / Chen, Chang / Tang, Lili / Liang, Yan / Zhang, Zhennian / Lu, Yan / Zhao, Yang

    Aging

    2021  Volume 13, Issue 15, Page(s) 19510–19528

    Abstract: ... Traditional Chinese medicine (TCM) has been utilized to treat the dysfunction of the autonomic nervous system. Wen-Shen-Yang ...

    Abstract Parkinson's disease (PD), the typical neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN). However, no therapeutic agent used currently could slow down neuronal cell loss so as to decelerate or halt the progression of PD. Traditional Chinese medicine (TCM) has been utilized to treat the dysfunction of the autonomic nervous system. Wen-Shen-Yang-Gan decoction (WSYGD) has a good effect on the clinical treatment of PD with constipation. However, it is not clear which ingredients and what mechanism are responsible for the therapeutic effect. In this study, the pharmacodynamic study of WSYGD in PD mice was applied. Concurrently, a novel method for the identification of metabolic profiles of WSYGD has been developed. Finally, we found that WSYGD could protect the PD mice induced by rotenone. The underlying mechanism of the protective effect may be related to the reduction of the DA neurons apoptosis via reducing inflammatory reaction. By virtue of UPLC-MS and chemoinformatics method, 35 prototype compounds and 27 metabolites were filtered out and tentatively characterized. In conclusion, this study provides an insight into the metabolism of WSYGD
    MeSH term(s) Administration, Oral ; Animals ; Antiparkinson Agents/isolation & purification ; Antiparkinson Agents/pharmacology ; Cheminformatics/methods ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/pathology ; Male ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Multivariate Analysis ; Neuroprotective Agents/isolation & purification ; Neuroprotective Agents/pharmacology ; Parkinson Disease/drug therapy ; Parkinson Disease/pathology ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Rotenone ; Substantia Nigra/drug effects ; Substantia Nigra/pathology ; Tandem Mass Spectrometry
    Chemical Substances Antiparkinson Agents ; Neuroprotective Agents ; Plant Extracts ; Rotenone (03L9OT429T)
    Language English
    Publishing date 2021-08-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.203361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Identification of the Chemical Constituents of an Anti-Arthritic Chinese Medicine Wen Luo Yin by Liquid Chromatography Coupled with Mass Spectrometry

    Huanyu Guan / Xiaomei Luo / Xiaoyan Chang / Meifeng Su / Zhuangzhuang Li / Pengfei Li / Xiaoming Wang / Yue Shi

    Molecules, Vol 24, Iss 2, p

    2019  Volume 233

    Abstract: Wen Luo Yin (WLY), a well-known traditional Chinese medicine formulation, has been used ...

    Abstract Wen Luo Yin (WLY), a well-known traditional Chinese medicine formulation, has been used as a complementary therapy for the treatment of rheumatoid arthritis in clinical settings. However, the chemical constituents of WLY remain unclear. In this study, a high-performance liquid chromatography coupled with tandem mass spectrometry method was established to separate and comprehensively identify the chemical constituents of WLY. The analytes were eluted with a mobile phase of acetonitrile and 0.1% aqueous acetic acid. Mass detection was performed in both positive and negative ion mode. The MS/MS fragmentation pathways were proposed for the identification of the components. A total of 42 compounds including sesquiterpenes, alkaloids, biflavonoids, polyacetylenes, phenylpropanoids and acetylenic phenols were identified unambiguously or tentatively according to their retention times and mass behavior with those of authentic standards or literature data. The identification and structural elucidation of chemical constituents may provide important information for quality control and pharmacological research of WLY.
    Keywords Wen Luo Yin ; chemical profiling ; mass spectrometry ; liquid chromatography ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Multi-criteria analysis via the VIKOR method for prioritizing land-use restraint strategies in the Tseng-Wen reservoir watershed.

    Chang, Chia-Ling / Hsu, Chung-Hsin

    Journal of environmental management

    2009  Volume 90, Issue 11, Page(s) 3226–3230

    Abstract: ... of this study was to establish the priority ranking of land-use restrictions in the Tseng-Wen reservoir ...

    Abstract It is important to adopt proper water and soil conservation and land-use planning in a watershed for lowering adverse impacts on reservoir water quality. Although reservoir watersheds occupy a large amount of land in Taiwan, high population density has exerted development pressures on such land. Therefore, the priority ranking of land-use restrictions for the subdivisions with different degrees of environmental vulnerability is necessary in watershed management. Since there are several criteria for evaluating the potential environmental impact from the subdivisions, multi-criteria analysis was applied as a technique for solving these problems in this study. The VIKOR method was applied to determine the best feasible solution according to the selected criteria, including geographical and meteorological factors. The objective of this study was to establish the priority ranking of land-use restrictions in the Tseng-Wen reservoir wastershed in southern Taiwan. The results show that subdivisions close to the outlet or reservoir area should have the priority of land-use restrictions.
    MeSH term(s) Conservation of Natural Resources ; Environmental Monitoring/methods ; Taiwan ; Water Supply
    Language English
    Publishing date 2009-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2009.04.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7556: Show issues

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  5. Article: Discussion on "capital forebearance, ex ante life insurance guaranty schemes, and interest rate uncertainty," by Ya-Wen Hwang, Shih-Chieh Chang, and Yang-Che Wu, volume 19(2)

    Wang, Xiao / Chang, Shih-Chieh / Hwang, Ya-Wen / Wu, Yang-Che

    North American actuarial journal Vol. 20, No. 1 , p. 88-93

    2016  Volume 20, Issue 1, Page(s) 88–93

    Author's details Xiao Wang
    Language English
    Publisher Taylor & Francis
    Publishing place Philadelphia, Pa
    Document type Article
    ZDB-ID 1380138-7
    ISSN 1092-0277
    Database ECONomics Information System

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  6. Article: Multi-criteria analysis via the VIKOR method for prioritizing land-use restraint strategies in the Tseng-Wen reservoir water

    Chang, Chia-Ling / Hsu, Chung-Hsin

    Journal of environmental management. 2009 Aug., v. 90, issue 11

    2009  

    Abstract: ... of this study was to establish the priority ranking of land-use restrictions in the Tseng-Wen reservoir ...

    Abstract It is important to adopt proper water and soil conservation and land-use planning in a watershed for lowering adverse impacts on reservoir water quality. Although reservoir watersheds occupy a large amount of land in Taiwan, high population density has exerted development pressures on such land. Therefore, the priority ranking of land-use restrictions for the subdivisions with different degrees of environmental vulnerability is necessary in watershed management. Since there are several criteria for evaluating the potential environmental impact from the subdivisions, multi-criteria analysis was applied as a technique for solving these problems in this study. The VIKOR method was applied to determine the best feasible solution according to the selected criteria, including geographical and meteorological factors. The objective of this study was to establish the priority ranking of land-use restrictions in the Tseng-Wen reservoir wastershed in southern Taiwan. The results show that subdivisions close to the outlet or reservoir area should have the priority of land-use restrictions.
    Keywords reservoirs ; watersheds ; watershed management ; land use ; decision support systems ; equations ; Taiwan
    Language English
    Dates of publication 2009-08
    Size p. 3226-3230.
    Document type Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2009.04.020
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 7556: Show issues

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  7. Article: Wen-pi-tang-Hab-Wu-ling-san, an oriental herbal prescription, attenuates epithelial-mesenchymal transdifferentiation stimulated by TGF-beta1 in kidney cells.

    Lee, Sang Il / Kim, Hyo Jung / Baek, Moon-Chang / Park, Kwon Moo / Park, Yongki / Yoon, Cheol Ho / Boo, Yong Chool

    Phytotherapy research : PTR

    2007  Volume 21, Issue 6, Page(s) 548–553

    Abstract: Wen-pi-tang-Hab-Wu-ling-san (WHW), an oriental herbal prescription, is currently used in oriental ...

    Abstract Wen-pi-tang-Hab-Wu-ling-san (WHW), an oriental herbal prescription, is currently used in oriental clinics for the treatment of chronic renal failure (CRF). While its effectiveness has been supported by a series of modern studies, the underlying mechanism remains poorly understood. CRF progression involves tubulointerstitial fibrosis where transforming growth factor-beta1 (TGF-beta1) plays a critical role by inducing epithelial-mesenchymal transdifferentiation (EMT). This study examined whether WHW extract attenuated the TGF-beta1-induced EMT in Madin-Darby canine kidney cells. When the cells were stimulated by TGF-beta1 (2.5 ng/mL), they exhibited an elongated, spindle-shaped appearance but this morphological change was significantly suppressed by WHW extract (1 mg/mL). The WHW extract did not show notable cytotoxicity and even mitigated the cytotoxic effects of TGF-beta1. It inhibited the expression of alpha-smooth muscle actin (alpha-SMA), a marker of EMT, but not the secretion of matrix metalloproteinases stimulated by TGF-beta1. The WHW extract also inhibited the phosphorylation of Smad2 that mediates TGF-beta1 signaling leading to alpha-SMA expression. The present study suggests that WHW extract may provide renal protective effects through modulation of the TGF-beta1/Smad2/alpha-SMA pathway involved in fibrosis.
    MeSH term(s) Actins/metabolism ; Animals ; Blotting, Western ; Cell Differentiation/drug effects ; Cell Line ; Cell Survival/drug effects ; Chromatography, High Pressure Liquid ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Kidney/cytology ; Kidney/drug effects ; Kidney/metabolism ; Kidney Failure, Chronic/drug therapy ; Medicine, Chinese Traditional ; Phosphorylation/drug effects ; Plant Extracts/pharmacology ; Smad2 Protein/metabolism ; Transforming Growth Factor beta1/pharmacology
    Chemical Substances Actins ; Drugs, Chinese Herbal ; Plant Extracts ; Smad2 Protein ; Transforming Growth Factor beta1
    Language English
    Publishing date 2007-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.2106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3092: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Book: Yang chi wen ta

    Hsiung, Cho / Chang, Hsien-jen

    (Yang chih chi shu tsʻung shu)

    1983  

    Title translation Questions and answers on raising chickens.
    Author's details Hsiung Cho, Chang Hsien-jen pien hsieh
    Series title Yang chih chi shu tsʻung shu
    Keywords Chickens/Breeding. ; Chickens/Feeding and feeds.
    Language Chinese
    Size 2, 6, 122 p. :, ill. ;, 18 cm.
    Edition Ti 1 pan.
    Publisher Chiang-hsi jen min chʻu pan she ; Chiang-hsi sheng Hsin hua shu tien fa hsing
    Publishing place Nan-chʻang
    Document type Book
    Database NAL-Catalogue (AGRICOLA)

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  9. Book: Pao wen chu she

    Chang, Yung-chʻun

    1982  

    Title translation Heat preserved pig pens.
    Author's details Chang Yung-ch'un pien chu
    Keywords Swine/Housing/Heating and ventilation.
    Language Chinese
    Size 67 p. :, ill. ;, 26 cm.
    Edition Ti 1 pan.
    Publisher Hei-lung-chiang k'o hsüeh ch'i shu ch'u pan she ; Hei-lung-chiang sheng hsin hua shu tien fa hsing
    Publishing place Ha-erh-pin
    Document type Book
    Database NAL-Catalogue (AGRICOLA)

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  10. Book: Fei liao shih yung 300 wen

    Pʻang, Chʻeng-chang / Ting, Yü-chih / Yeh, Wen-chiang

    (Nung yeh shih yung chi shu wen ta tsʻung shu)

    1991  

    Title translation Fertilizer application, 300 questions.
    Author's details Pʻang Chʻeng-chang, Ting Yü-chih, Yeh Wen-chiang pien chu
    Series title Nung yeh shih yung chi shu wen ta tsʻung shu
    Keywords Fertilizers
    Language Chinese
    Size 2, 15, 217 p. ;, 19 cm.
    Edition Ti 1 pan.
    Publisher Kuang-hsi kʻo hsüeh chi shu chʻu pan she ; Kuang-hsi hsin hua shu tien fa hsing
    Publishing place Nan-ning shih
    Document type Book
    ISBN 7805655030 ; 9787805655031
    Database NAL-Catalogue (AGRICOLA)

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