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Book ; Online: VACCELERATE Webinar - Influence of age on the effectiveness and duration of protection of anti-COVID-19 vaccines

Barral-Netto, Manoel

2022

Abstract: ... analyzes lack the power to evaluate its role in subgroups within the elderly age group. Prof. Barral-Netto ... In this webinar, Prof. Barral-Netto reports if the tested vaccines have been effective in protecting against ...

Title variant	Influence of age on the effectiveness and duration of protection of Vaxzevria and CoronaVac vaccines : a population-based study
Institution	VACCELERATE
Author's details	with Prof. Manoel Barral-Netto, LIB and LEITV Laboratories, Instituto Goncalo Moniz, Fiocruz, Salvador & Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil ; Moderator: Zoi D. Pana ; VACCELERATE
Abstract	Aging influences COVID-19 severity and response to vaccination, but previous vaccine effectiveness analyzes lack the power to evaluate its role in subgroups within the elderly age group. Prof. Barral-Netto and his team analyzed the impact of age on viral vector and inactivated virus vaccines' effectiveness, the main platforms used in low- and middle-income countries. They report a retrospective longitudinal study of nearly 76 million Brazilian vaccinees from January 18 to July 24, 2021, evaluating documented infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19-related hospitalization, ICU admission, and death. In this webinar, Prof. Barral-Netto reports if the tested vaccines have been effective in protecting against infection, hospitalization and death and how vaccine effectiveness varies in different age groups. He will also include other aspects such as waning, the impact of variants and tell if he recommends further booster vaccination in elders.
Keywords	COVID-19
Subject	Coronavirus-Krankheit-2019 ; Corona virus disease 2019 ; Coronavirus disease 2019 ; 2019-nCoV acute respiratory disease ; Wuhan pneumonia ; COVID-19-Infektion ; Coronavirus-SARS-CoV-2-Infektion ; SARS-CoV-2-Infektion
Subject code	610
Language	English
Size	1 Online-Ressource (1 Videodatei, Lauflänge: 00:47:27)
Publisher	VACCELERATE
Publishing place	Cologe
Publishing country	Germany
Document type	Book ; Online
HBZ-ID	HT021395588
DOI	10.4126/FRL01-006433864
Database	Repository for Life Sciences

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Article: Manuelle Behandlung des M. supraspinatus

Barral, Jean-Pierre / Croibier, Alain

Osteopathische Medizin

2014 Volume 15, Issue 1, Page(s) 16

Language	German
Document type	Article
ZDB-ID	2041875-9
ISSN	1615-9071
Database	Current Contents Medicine

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Article ; Online: Protective Effect of Oral BCG and Inactivated Mycobacterium bovis Vaccines in European Badgers (Meles meles) Experimentally Infected With M. bovis

Ana Balseiro / José Miguel Prieto / Vega Álvarez / Sandrine Lesellier / Dipesh Davé / Francisco J. Salguero / Iker A. Sevilla / José Antonio Infantes-Lorenzo / Joseba M. Garrido / Hans Adriaensen / Ramón A. Juste / Marta Barral

Frontiers in Veterinary Science, Vol

2020 Volume 7

Abstract: ... oral vaccines against TB in a badger model: the live-attenuated M. bovis bacillus Calmette-Guérin BCG ... unvaccinated controls (n = 12). All badgers were experimentally infected with M. bovis (103 CFU ...

Abstract	In Europe, badgers (Meles meles) are recognized as major tuberculosis (TB) reservoir hosts with the potential to transmit infection to associated cattle herds. Recent studies in Spain have demonstrated that vaccination with a heat-inactivated Mycobacterium bovis vaccine (HIMB) successfully protects captive wild boar and red deer against progressive disease. The aim of this study was to evaluate the efficacy of two oral vaccines against TB in a badger model: the live-attenuated M. bovis bacillus Calmette-Guérin BCG vaccine (Danish strain) and a HIMB vaccine. Twenty-four badgers were separated in three treatment groups: oral vaccinated with live BCG (108 CFU, n = 5), oral vaccinated with HIMB (107 CFU, n = 7), and unvaccinated controls (n = 12). All badgers were experimentally infected with M. bovis (103 CFU) by the endobronchial route targeting the right middle lung lobe. Throughout the study, clinical, immunological, pathological, and bacteriological parameters of infection were measured. Both vaccines conferred protection against experimental TB in badger, as measured by a reduction of the severity and lesion volumes. Based on these data, HIMB vaccination appears to be a promising TB oral vaccine candidate for badgers in endemic countries.
Keywords	tuberculosis ; badger ; BCG vaccine ; Mycobacterium bovis heat-inactivated (HIMB) vaccine ; efficacy ; Veterinary medicine ; SF600-1100
Subject code	630
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Local Lung Immune Response to Mycobacterium bovis Challenge after BCG and M. bovis Heat-Inactivated Vaccination in European Badger ( Meles meles )

Cristina Blanco Vázquez / Miguel Prieto / Marta Barral / Ramón Antonio Juste / Sandrine Lesellier / Francisco Javier Salguero / Dipesh Davé / Ileana Zorhaya Martínez / María Gracia de Garnica García / Rosa Casais / Ana Balseiro

Pathogens, Vol 9, Iss 456, p

2020 Volume 456

Abstract: ... with live intra-bronchial Mycobacterium bovis in captive badgers: the live-attenuated M. bovis BCG vaccine ... Danish strain) and a heat-inactivated M. bovis (HIMB) vaccine. With the objective of increasing ... from control (non-vaccinated), BCG vaccinated and HIMB-vaccinated experimentally infected badgers with M. bovis ...

Abstract	Tuberculosis (TB) vaccination could be used as a key part of integrated strategies for the disease’s control if an effective and safe vaccine under field conditions is obtained. Recent studies in Spain have evaluated the protective efficacy of two oral vaccines against experimental challenge with live intra-bronchial Mycobacterium bovis in captive badgers: the live-attenuated M. bovis BCG vaccine (Danish strain) and a heat-inactivated M. bovis (HIMB) vaccine. With the objective of increasing the knowledge of the cellular development progress of infection and generating further tools to discriminate between mild and severe TB lesions between and within animals, the immunopathology of tuberculous lesions was studied to characterize the local immune response (cell type profile) within lung granulomas from control (non-vaccinated), BCG vaccinated and HIMB-vaccinated experimentally infected badgers with M. bovis . Four immunohistochemical protocols, for the specific detection of macrophages, T lymphocytes, B lymphocytes and plasma cells within TB granulomas in formalin fixed sections of the right middle lung lobe (lobe targeted for the M. bovis delivery), were performed. Immunolabelled sections were scanned and five randomly selected areas were analyzed with digital image analysis software. The results were expressed as the proportion of the positively immunolabelled area within the total area of the selected site. Data was analyzed using the statistical analysis software (SAS). In the three treatment groups, macrophages were the most abundant inflammatory cells within the granulomas, followed by B lymphocytes and plasma cells. T lymphocyes were absent in those granulomas. This would suggest a predominance of a non-specific innate response mediated by phagocytic cells over an adaptative humoral immune response. The proportion of macrophages and plasma cells was higher in BCG and HIMB-vaccinated badgers, respectively, suggesting the establishment of an adaptative humoral response in HIMB-vaccinated badgers. The lower ...
Keywords	tuberculosis ; badger ; BCG vaccine ; Mycobacterium bovis heat-inactivated (HIMB) vaccine ; immunohistochemistry ; granuloma ; Medicine ; R
Subject code	630
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Local Lung Immune Response to Mycobacterium bovis Challenge after BCG and M. bovis Heat-Inactivated Vaccination in European Badger (Meles meles)

Blanco Vázquez, Cristina / Prieto, Miguel / Barral, Marta / Juste, Ramón Antonio / Lesellier, Sandrine / Salguero, Francisco Javier / Davé, Dipesh / Martínez, Ileana Zorhaya / de Garnica García, María Gracia / Casais, Rosa / Balseiro, Ana

Pathogens. 2020 June 09, v. 9, no. 6

2020

Abstract	Tuberculosis (TB) vaccination could be used as a key part of integrated strategies for the disease’s control if an effective and safe vaccine under field conditions is obtained. Recent studies in Spain have evaluated the protective efficacy of two oral vaccines against experimental challenge with live intra-bronchial Mycobacterium bovis in captive badgers: the live-attenuated M. bovis BCG vaccine (Danish strain) and a heat-inactivated M. bovis (HIMB) vaccine. With the objective of increasing the knowledge of the cellular development progress of infection and generating further tools to discriminate between mild and severe TB lesions between and within animals, the immunopathology of tuberculous lesions was studied to characterize the local immune response (cell type profile) within lung granulomas from control (non-vaccinated), BCG vaccinated and HIMB-vaccinated experimentally infected badgers with M. bovis. Four immunohistochemical protocols, for the specific detection of macrophages, T lymphocytes, B lymphocytes and plasma cells within TB granulomas in formalin fixed sections of the right middle lung lobe (lobe targeted for the M. bovis delivery), were performed. Immunolabelled sections were scanned and five randomly selected areas were analyzed with digital image analysis software. The results were expressed as the proportion of the positively immunolabelled area within the total area of the selected site. Data was analyzed using the statistical analysis software (SAS). In the three treatment groups, macrophages were the most abundant inflammatory cells within the granulomas, followed by B lymphocytes and plasma cells. T lymphocyes were absent in those granulomas. This would suggest a predominance of a non-specific innate response mediated by phagocytic cells over an adaptative humoral immune response. The proportion of macrophages and plasma cells was higher in BCG and HIMB-vaccinated badgers, respectively, suggesting the establishment of an adaptative humoral response in HIMB-vaccinated badgers. The lower bacterial load at the lung level, as well as the volume of lesions in lungs using magnetic resonance imaging in badgers with the HIMB vaccine in relation with local immune response presented, must be highlighted, since it would be an advantage in favor of its use under field conditions in terms of reducing TB transmission and environmental contamination.
Keywords	BCG vaccine ; Meles meles ; Mycobacterium bovis ; T-lymphocytes ; area ; badgers ; computer software ; detection ; digital images ; edible vaccines ; formalin ; granuloma ; humoral immunity ; image analysis ; immune response ; immunohistochemistry ; immunopathology ; infection ; knowledge ; live vaccines ; lungs ; macrophages ; magnetic resonance imaging ; microbial load ; pathogens ; plasma cells ; pollution ; protocols ; statistical analysis ; tuberculosis ; vaccination ; volume ; Spain
Language	English
Dates of publication	2020-0609
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens9060456
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Construção de conhecimento no curso da pandemia de COVID-19 : aspectos biomédicos, clínico-assistenciais, epidemiológicos e sociais

Barral-Netto, Manoel / Barreto, Maurício L. / Pinto Junior, Elzo Pereira / Aragão, Erika

2020

Keywords	Infectious & contagious diseases ; Infectious and contagious diseases
Size	1 electronic resource (257 pages)
Publisher	Editora da Universidade Federal da Bahia
Document type	Book ; Online
Note	Portuguese ; Open Access
HBZ-ID	HT021232897
ISBN	9786556302447 ; 6556302449
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Microtubule specialization by +TIP networks: from mechanisms to functional implications.

Meier, Sandro M / Steinmetz, Michel O / Barral, Yves

Trends in biochemical sciences

2024 Volume 49, Issue 4, Page(s) 318–332

Abstract: To fulfill their actual cellular role, individual microtubules become functionally specialized through a broad range of mechanisms. The 'search and capture' model posits that microtubule dynamics and functions are specified by cellular targets that they ... ...

Abstract	To fulfill their actual cellular role, individual microtubules become functionally specialized through a broad range of mechanisms. The 'search and capture' model posits that microtubule dynamics and functions are specified by cellular targets that they capture (i.e., a posteriori), independently of the microtubule-organizing center (MTOC) they emerge from. However, work in budding yeast indicates that MTOCs may impart a functional identity to the microtubules they nucleate, a priori. Key effectors in this process are microtubule plus-end tracking proteins (+TIPs), which track microtubule tips to regulate their dynamics and facilitate their targeted interactions. In this review, we discuss potential mechanisms of a priori microtubule specialization, focusing on recent findings indicating that +TIP networks may undergo liquid biomolecular condensation in different cell types.
MeSH term(s)	Microtubule-Associated Proteins/metabolism ; Microtubules/metabolism
Chemical Substances	Microtubule-Associated Proteins
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	194216-5
ISSN	1362-4326 ; 0968-0004 ; 0376-5067
ISSN (online)	1362-4326
ISSN	0968-0004 ; 0376-5067
DOI	10.1016/j.tibs.2024.01.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Inhibitory control expertise through sports practice: A scoping review.

Simonet, Marie / Beltrami, Debra / Barral, Jérôme

Journal of sports sciences

2023 Volume 41, Issue 7, Page(s) 616–630

Abstract: The stopping of a planned motor response is called motor inhibitory control (IC) and allows humans to produce appropriate goal-directed behaviour. The ever-changing environment of many sports requires athletes to rapidly adapt to unpredictable situations ...

Abstract	The stopping of a planned motor response is called motor inhibitory control (IC) and allows humans to produce appropriate goal-directed behaviour. The ever-changing environment of many sports requires athletes to rapidly adapt to unpredictable situations in which split-second suppressions of planned or current actions are needed. In this scoping review, the approach of the PRISMA-ScR was used to determine whether sports practice develops IC and, if so, which sports factors are key to building IC expertise. The PubMed, Web of Science Core Collection, ScienceDirect and APA PsycNet Advanced Search databases were searched with predefined combinations of keywords. Twenty-six articles were selected and analysed. Most of the publications (
MeSH term(s)	Humans ; Athletes ; Sports
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	995528-8
ISSN	1466-447X ; 0264-0414
ISSN (online)	1466-447X
ISSN	0264-0414
DOI	10.1080/02640414.2023.2230713
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Perspectives of Cone-beam Computed Tomography in Interventional Radiology: Techniques for Planning, Guidance, and Monitoring.

Barral, Matthias / Chevallier, Olivier / Cornelis, Francois H

Techniques in vascular and interventional radiology

2023 Volume 26, Issue 3, Page(s) 100912

Abstract: Cone-beam computed tomography (CBCT) has emerged as a prominent imaging modality in interventional radiology that offers real-time visualization and precise guidance in various procedures. This article aims to provide an overview of the techniques used ... ...

Abstract	Cone-beam computed tomography (CBCT) has emerged as a prominent imaging modality in interventional radiology that offers real-time visualization and precise guidance in various procedures. This article aims to provide an overview of the techniques used to guide and monitor interventions that use CBCT. It discusses the advantages of CBCT, its current applications, and potential future CBCT-related developments in the field of interventional radiology.
MeSH term(s)	Humans ; Cone-Beam Computed Tomography/methods ; Radiology, Interventional/methods
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2170922-1
ISSN	1557-9808 ; 1089-2516
ISSN (online)	1557-9808
ISSN	1089-2516
DOI	10.1016/j.tvir.2023.100912
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hémoptysies sévères du patient d’onco-hématologie.

Parrot, A / Canellas, A / Barral, M / Gibelin, A / Cadranel, J

Revue des maladies respiratoires

2023 Volume 41, Issue 4, Page(s) 303–316

Abstract: In France, even though it occurs only exceptionally in cases of hemopathy, severe hemoptysis in cancer is the leading cause of hemoptysis. Without adequate treatment, in-hospital mortality exceeds 60%, even reaching 100% at 6 months. The management of ... ...

Title translation	Severe hemoptysis in the onco-hematology patient.
Abstract	In France, even though it occurs only exceptionally in cases of hemopathy, severe hemoptysis in cancer is the leading cause of hemoptysis. Without adequate treatment, in-hospital mortality exceeds 60%, even reaching 100% at 6 months. The management of severe hemoptysis should be discussed with the oncologist. Aside from situations of threatening hemoptysis, in which bronchoscopy should be performed immediately, CT angiography is an essential means of localizing the bleeding and determining the causes and the vascular mechanisms involved. In more than 90% of cases, hemoptysis is linked to systemic bronchial or non-bronchial hypervascularization, whereas in fewer than 5%, it is associated with pulmonary arterial origin or, exceptionally, with damage to the alveolar-capillary barrier. The most severely ill patients must be treated in intensive care in centers equipped with interventional radiology, thoracic surgery and, ideally, with interventional bronchoscopy. Interventional radiology is the first-line symptomatic treatment. In over 80% of cases, bronchial arteriography with embolization allows immediate control. Emergency surgery should be avoided, as it is associated with significant mortality. Appropriate and adequate care reduces hospital mortality to 30%, enabling patients to benefit from the most recent, survival-prolonging treatments.
MeSH term(s)	Humans ; Hemoptysis/diagnosis ; Hemoptysis/etiology ; Hemoptysis/therapy ; Embolization, Therapeutic/adverse effects ; Bronchoscopy/adverse effects ; Bronchi ; Hematology
Language	French
Publishing date	2023-12-27
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	605743-3
ISSN	1776-2588 ; 0301-0279 ; 0761-8425
ISSN (online)	1776-2588
ISSN	0301-0279 ; 0761-8425
DOI	10.1016/j.rmr.2023.11.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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