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Article: Acute Psychotic Episode Induced by Antimicrobial Treatment.

Arain, Savera I / Al Shakhori, Majed / Thorakkattil, Shabeer A / Amin, Omer

2023 Volume 2023, Page(s) 9996763

Abstract: Psychosis is an abnormal state of mind that leads to losing touch with reality. Symptoms may include delusions and hallucinations, amongst other features. Psychosis is known to increase the risk of other health conditions and may have serious adverse ... ...

Abstract	Psychosis is an abnormal state of mind that leads to losing touch with reality. Symptoms may include delusions and hallucinations, amongst other features. Psychosis is known to increase the risk of other health conditions and may have serious adverse outcomes. This is a case report of a 26-year-old woman with no previous psychiatric history who presented with symptoms and signs suggestive of acute psychosis shortly after starting a postprocedural combination of antimicrobials. The patient's family decided to stop the antimicrobials as they observed an escalation of the psychotic symptoms with the ongoing use of antibiotics. The patient was subsequently brought to the emergency service (EMS) department, and she was admitted to the behavioral health unit. The treatment team managed to stabilize the patient with several interventions, including the administration of antianxiety and antipsychotic medications along with psychosocial intervention. The symptoms of psychosis resolved within 3-4 days, and she was discharged home. Even though transient psychotic episodes have been reported previously with antibiotics, this case emphasizes the increased need for vigilance and reporting in patients receiving antimicrobials.
Language	English
Publishing date	2023-04-01
Publishing country	United States
Document type	Case Reports
ZDB-ID	2629914-8
ISSN	2090-6838 ; 2090-682X
ISSN (online)	2090-6838
ISSN	2090-682X
DOI	10.1155/2023/9996763
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A patient-centered ambulatory care pharmacy design to abate the real-world patient counseling challenges.

Thorakkattil, Shabeer Ali / Parakkal, Sainul Abideen / Arain, Savera / AlDobayan, Zakariya

Exploratory research in clinical and social pharmacy

2023 Volume 9, Page(s) 100248

Abstract: Patient counseling is an important tool to help both healthcare providers and patients in achieving the desired health outcomes. It is one of the significant and well-established roles for pharmacists in the health care system, enabling them to develop a ...

Abstract	Patient counseling is an important tool to help both healthcare providers and patients in achieving the desired health outcomes. It is one of the significant and well-established roles for pharmacists in the health care system, enabling them to develop a pharmacist-patient collaborative relationship to ensure medication compliance, improved adherence to the prescribed medication regimen and prevention of adverse drug events. Delivering effective and efficient patient counseling is often hindered by numerous personal and system-related challenges. Therefore, efforts to overcome these challenges necessitate developing and incorporating various tools and methods to establish an integrated patient-centered pharmacy design. This article demonstrates the development of one such integrated model in the Johns Hopkins Aramco Healthcare ambulatory care pharmacy setting. It includes components such as electronic health records, patient portal communication systems, telehealth models (both telephonic and virtual), physical redesign of the pharmacy layout, enhanced pharmacy website, and utilizing robotic dispensing systems to deliver more efficient and interactive patient counseling. The goal of implementing the innovative patient-centered pharmacy design and integration of the telehealth model was to mitigate many of the barriers faced by the pharmacist in the traditional system during patient counseling. This new integrated model provides an example for other healthcare organizations to improve patient counseling effectiveness and provide excellent patient-centered care.
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Journal Article
ISSN	2667-2766
ISSN (online)	2667-2766
DOI	10.1016/j.rcsop.2023.100248
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Article: Exacerbation of Mania due to Metronidazole in a Bipolar Disorder Patient.

AlShakori, Majed / Arain, Savera I / Thorakkattil, Shabeer A / Abdulkader, Syed

Case reports in psychiatry

2022 Volume 2022, Page(s) 3748101

Abstract: Bipolar disorder is a mental health disorder where the patient experiences extreme shifts in mood marked by depression, mania, or hypomania. It affects their overall daily life activities and sleep patterns. This case report is of a 74-year-old female ... ...

Abstract	Bipolar disorder is a mental health disorder where the patient experiences extreme shifts in mood marked by depression, mania, or hypomania. It affects their overall daily life activities and sleep patterns. This case report is of a 74-year-old female patient with bipolar disorder who experienced a manic episode after initiation of antibiotics to treat gallbladder perforation with abscess formation. The patient's past medical history included Parkinson's disease, diabetes mellitus, bipolar disorder, and acalculous cholecystitis. The patient required hospitalization for a cholecystostomy tube insertion for drainage. During hospitalization, the patient was started on empiric treatment with broad-spectrum antibiotics, including piperacillin/tazobactam and metronidazole. The patient remained stable during the inpatient stay and was discharged home one week later. She was prescribed cefuroxime and metronidazole to complete a 2-week duration of antibiotics. However, upon discharge, she developed manic symptoms, including lack of need to sleep, excessive talking, and severe agitation. Upon assessment, the psychiatric team decided to hold metronidazole as it has an adverse effect of mania as evidenced in drug information resources. The patient started to show immediate recovery from the symptoms with complete resolution of manic symptoms on the 3
Language	English
Publishing date	2022-06-02
Publishing country	United States
Document type	Case Reports
ZDB-ID	2629914-8
ISSN	2090-6838 ; 2090-682X
ISSN (online)	2090-6838
ISSN	2090-682X
DOI	10.1155/2022/3748101
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Article: Implementation of Pharmacist-led Telepsychiatry Services: Challenges and Opportunities in the Midst of COVID-19.

Arain, Savera / Al Shakori, Majed / Thorakkattil, Shabeer Ali / Mohiuddin, Syed Iqbal / Al-Ghamdi, Fuad

Journal of technology in behavioral science

2022 Volume 7, Issue 4, Page(s) 468–476

Abstract: Over the last few decades, healthcare systems worldwide have seen many transformations, and one of the most significant transformations is the adoption of telemedicine. Its rapid and wide adoption has created an entirely different set of healthcare ... ...

Abstract	Over the last few decades, healthcare systems worldwide have seen many transformations, and one of the most significant transformations is the adoption of telemedicine. Its rapid and wide adoption has created an entirely different set of healthcare experiences. The healthcare field has vastly benefited from integrating technology and patient care. Johns Hopkins Aramco Healthcare (JHAH) has implemented several telehealth models as a response measure to overcome challenges in access to patient care due to the COVID-19 pandemic. This article describes the implementation of pharmacist-led telepsychiatry services utilized to provide several psychiatric services such as counseling patients, ensuring the appropriateness of medications prescribed, conducting therapeutic drug monitoring, and making clinical interventions to ensure a safe and effective therapy. By utilizing this newly integrated telepsychiatry model, pharmacists have continued to remain an integral part of improving patients' health outcomes and overall patient experience for psychiatric patients.
Language	English
Publishing date	2022-07-26
Publishing country	Switzerland
Document type	Journal Article
ISSN	2366-5963
ISSN	2366-5963
DOI	10.1007/s41347-022-00266-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 pandemic: Response plan by the Johns Hopkins Aramco Healthcare inpatient pharmacy department.

Arain, Savera / Thalapparambath, Rajesh / Al Ghamdi, Fuad Hamed

Research in social & administrative pharmacy : RSAP

2020 Volume 17, Issue 1, Page(s) 2009–2011

Abstract: The coronavirus disease 2019 (COVID-19) is an ongoing pandemic having caused a major health care crises across the globe. Pharmacy professionals are considered vital in preparation for optimal response to the COVID-19 pandemic. Therefore, in response to ... ...

Abstract	The coronavirus disease 2019 (COVID-19) is an ongoing pandemic having caused a major health care crises across the globe. Pharmacy professionals are considered vital in preparation for optimal response to the COVID-19 pandemic. Therefore, in response to the estimated potential impact of COVID-19 on Johns Hopkins Aramco Healthcare (joint venture between Saudi Aramco and Johns Hopkins Medicine International), several initiatives were taken by the hospital's inpatient pharmacy department with focus on infection control, staffing, meeting clinical operational challenges, ethics, increased utilization of automation, and maintenance of employee wellness to prepare for this challenge. The plan implemented by the inpatient pharmacy department was prepared while incorporating information and recommendations from leading pharmacy organizations, ministry of health, institute's experience in battling another similar coronavirus (the Middle East respiratory syndrome-coronavirus) previously, and updated scientific research. The key focus areas include development of an institutionalized COVID-19 protocol, measures to improve infection control when handling and dispensing medications, modified staffing plan, system changes in peri-operative areas, keeping pharmacy professionals updated about new and scientific researches, increased utilization of automation, clinical interventions by pharmacist ensuring appropriate utilization of medications while monitoring for drug-drug interactions, adverse drug event prevention, and preparing for handling drug shortages. By implementing a robust plan, pharmacy professionals continue to show that they are an integral member of inter-professional health care teams.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/therapy ; Hospitalization/trends ; Humans ; Infection Control/methods ; Infection Control/trends ; Pandemics ; Pharmacists/trends ; Pharmacy Service, Hospital/methods ; Pharmacy Service, Hospital/trends ; Saudi Arabia/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-05-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2192059-X
ISSN	1934-8150 ; 1551-7411
ISSN (online)	1934-8150
ISSN	1551-7411
DOI	10.1016/j.sapharm.2020.05.016
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 pandemic

Arain, Savera / Thalapparambath, Rajesh / Al Ghamdi, Fuad Hamed

Research in Social and Administrative Pharmacy ; ISSN 1551-7411

Response plan by the Johns Hopkins Aramco Healthcare inpatient pharmacy department

2020

Keywords	Pharmaceutical Science ; Pharmacy ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.1016/j.sapharm.2020.05.016
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: COVID-19 pandemic: Response plan by the Johns Hopkins Aramco Healthcare inpatient pharmacy department

Arain, Savera / Thalapparambath, Rajesh / Al Ghamdi, Fuad Hamed

Res. soc. adm. pharm

Abstract: The coronavirus disease 2019 (COVID-19) is an ongoing pandemic having caused a major health care crises across the globe.Pharmacy professionals are considered vital in preparation for optimal response to the COVID-19 pandemic. Therefore, in response to ... ...

Abstract	The coronavirus disease 2019 (COVID-19) is an ongoing pandemic having caused a major health care crises across the globe.Pharmacy professionals are considered vital in preparation for optimal response to the COVID-19 pandemic. Therefore, in response to the estimated potential impact of COVID-19 on Johns Hopkins Aramco Healthcare (joint venture between Saudi Aramco and Johns Hopkins Medicine International), several initiatives were taken by the hospital's inpatient pharmacy department with focus on infection control, staffing, meeting clinical operational challenges, ethics, increased utilization of automation, and maintenance of employee wellness to prepare for this challenge. The plan implemented by the inpatient pharmacy department was prepared while incorporating information and recommendations from leading pharmacy organizations, ministry of health, institute's experience in battling another similar coronavirus (the Middle East respiratory syndrome-coronavirus) previously, and updated scientific research. The key focus areas include development of an institutionalized COVID-19 protocol, measures to improve infection control when handling and dispensing medications, modified staffing plan, system changes in peri-operative areas, keeping pharmacy professionals updated about new and scientific researches, increased utilization of automation, clinical interventions by pharmacist ensuring appropriate utilization of medications while monitoring for drug-drug interactions, adverse drug event prevention, and preparing for handling drug shortages. By implementing a robust plan, pharmacy professionals continue to show that they are an integral member of inter-professional health care teams.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #291083
Database	COVID19

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Article: Drug Utilization Evaluation and Impact of Pharmacist Interventions on Optimization of Piperacillin/Tazobactam Use: A Retrospective Analysis and Prospective Audit.

Arain, Savera / Khalawi, Fahad / Parakkal, Sainul Abideen / AlHamad, Hassan S / Thorakkattil, Shabeer Ali / Alghashmari, Faisal Fahad J / AlHarbi, Bader / Bakhashwain, Nujud / Alzawad, Weaam Mustafa / AlHomoud, Ali

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 7

Abstract: 1) Background: Piperacillin/tazobactam is a broad-spectrum antimicrobial encompassing most Gram-positive and Gram-negative aerobic and anaerobic bacteria. The inappropriate use of such broad-spectrum antibiotics is an important contributor to the rising ...

Abstract	(1) Background: Piperacillin/tazobactam is a broad-spectrum antimicrobial encompassing most Gram-positive and Gram-negative aerobic and anaerobic bacteria. The inappropriate use of such broad-spectrum antibiotics is an important contributor to the rising rates of antimicrobial drug resistance worldwide. Drug utilization evaluation studies and pharmacists' interventions are vital to assess, develop, and promote the rational use of antibiotics. This drug utilization study aimed to evaluate the current utilization practice of piperacillin/tazobactam in a hospital setting and assess the impact of pharmacist intervention in improving its appropriate use. (2) Methodology: In this study, we used a retrospective cohort and a prospective cohort, a cross-sectional, observational method. It included a retrospective (Cycle A/pre-intervention-CycA) phase followed by an educational interventional phase conducted by the pharmacists. During the 2 months of educational intervention, pharmacists used several methods, including workshops, lectures, oral presentations, and the development and reinforcement of clinical pathways to promote the judicious use of piperacillin/tazobactam. This was followed by a prospective (Cycle B/post-intervention-CycB) phase to improve piperacillin/tazobactam usage appropriateness. The appropriateness criteria for this drug utilization evaluation were established based on antimicrobial guidelines, the published literature, the institutional antibiogram, consultation from the antimicrobial stewardship committee, and the product monograph (Tazocin). The appropriateness of CycA and CycB patients was compared using the measurable elements, including indication and dose based on renal function, timely order for cultures, de-escalation, and use of extended infusion protocol. (3) Results: The study population comprised 100 patients in both CycA and CycB. The mean age of the patients was 66.28 ± 16.15 and 67.35 ± 17.98, and the ratios of men to women were found to be 49:51 and 61:39 in CycA and CycB, respectively. It was observed that inappropriate usage was high in CycA patients, and the appropriateness was improved in CycB patients. A total of 31% of inappropriate empirical broad-spectrum use was found in CycA, and it was reduced to 12% in CycB patients. The transition of appropriateness was observed in all measurable criteria, which includes the optimized dose according to the renal function (CycA = 49% to CycB = 94%), timely bacterial culture orders (CycA = 47% to CycB = 74%), prompt de-escalation (CycA = 31% to CycB = 53%), and adherence to extended infusion institutional guidelines (CycA = 34% to CycB = 86%). (4) Conclusions: The study highlighted important aspects of inappropriate piperacillin/tazobactam use. This can be considerably improved by proper education and timely interventions based on the pharmacists' vigilant approach. The study results emphasized the need for surveillance of piperacillin/tazobactam usage by conducting similar drug utilization evaluations and practice to improve quality and safety in healthcare organizations globally.
Language	English
Publishing date	2023-07-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12071192
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Article ; Online: The Pharmacist's Role in Managing COVID-19 in Chronic Kidney Disease Patients: A Review of Existing Strategies and Future Implications.

Karattuthodi, Mohammed Salim / Thorakkattil, Shabeer Ali / Abdulsalim, Suhaj / Sridhar, Sathvik Belagodu / Parakkal, Sainul Abideen / Arain, Savera / Madathil, Hafees / Karumbaru Kuzhiyil, Ajmal / Mohammed Ahmed Ageeli, Mamdouh / Unnikrishnan, Mazhuvanchery Kesavan

Pharmacy (Basel, Switzerland)

2022 Volume 10, Issue 4

Abstract: The global burden of the COVID-19 pandemic has not only disrupted healthcare delivery but has also compromised patients' access to healthcare on account of the scarcity of medications and trained healthcare professionals. COVID-19 has been particularly ... ...

Abstract	The global burden of the COVID-19 pandemic has not only disrupted healthcare delivery but has also compromised patients' access to healthcare on account of the scarcity of medications and trained healthcare professionals. COVID-19 has been particularly challenging for patient subpopulations constituting immunocompromised individuals, geriatric patients, and those afflicted by chronic ailments. Reports indicate that diminished kidney function in chronic kidney disease (CKD) renders patients highly susceptible to complications during COVID-19 treatment. Pharmacists, being medication experts, have a significant role in making treatment decisions during COVID-19 infection. This article describes pharmacists' interventions for monitoring and managing COVID-19 in patients with CKD. Given the massive increase in off-label use of medications to treat COVID-19, pharmacists can contribute substantially towards dosing decisions, reporting adverse medication events, and managing drug-drug interactions in COVID-19 patients suffering from CKD. In addition to traditional methods of delivering their services, the pharmacist should also adopt innovative tele-health systems to optimize patient care and ensure that patients receive safe and effective therapy during the pandemic.
Language	English
Publishing date	2022-08-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737194-3
ISSN	2226-4787 ; 2226-4787
ISSN (online)	2226-4787
ISSN	2226-4787
DOI	10.3390/pharmacy10040094
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Article ; Online: COSORE: A community database for continuous soil respiration and other soil-atmosphere greenhouse gas flux data.

Bond-Lamberty, Ben / Christianson, Danielle S / Malhotra, Avni / Pennington, Stephanie C / Sihi, Debjani / AghaKouchak, Amir / Anjileli, Hassan / Altaf Arain, M / Armesto, Juan J / Ashraf, Samaneh / Ataka, Mioko / Baldocchi, Dennis / Andrew Black, Thomas / Buchmann, Nina / Carbone, Mariah S / Chang, Shih-Chieh / Crill, Patrick / Curtis, Peter S / Davidson, Eric A /

Desai, Ankur R / Drake, John E / El-Madany, Tarek S / Gavazzi, Michael / Görres, Carolyn-Monika / Gough, Christopher M / Goulden, Michael / Gregg, Jillian / Gutiérrez Del Arroyo, Omar / He, Jin-Sheng / Hirano, Takashi / Hopple, Anya / Hughes, Holly / Järveoja, Järvi / Jassal, Rachhpal / Jian, Jinshi / Kan, Haiming / Kaye, Jason / Kominami, Yuji / Liang, Naishen / Lipson, David / Macdonald, Catriona A / Maseyk, Kadmiel / Mathes, Kayla / Mauritz, Marguerite / Mayes, Melanie A / McNulty, Steve / Miao, Guofang / Migliavacca, Mirco / Miller, Scott / Miniat, Chelcy F / Nietz, Jennifer G / Nilsson, Mats B / Noormets, Asko / Norouzi, Hamidreza / O'Connell, Christine S / Osborne, Bruce / Oyonarte, Cecilio / Pang, Zhuo / Peichl, Matthias / Pendall, Elise / Perez-Quezada, Jorge F / Phillips, Claire L / Phillips, Richard P / Raich, James W / Renchon, Alexandre A / Ruehr, Nadine K / Sánchez-Cañete, Enrique P / Saunders, Matthew / Savage, Kathleen E / Schrumpf, Marion / Scott, Russell L / Seibt, Ulli / Silver, Whendee L / Sun, Wu / Szutu, Daphne / Takagi, Kentaro / Takagi, Masahiro / Teramoto, Munemasa / Tjoelker, Mark G / Trumbore, Susan / Ueyama, Masahito / Vargas, Rodrigo / Varner, Ruth K / Verfaillie, Joseph / Vogel, Christoph / Wang, Jinsong / Winston, Greg / Wood, Tana E / Wu, Juying / Wutzler, Thomas / Zeng, Jiye / Zha, Tianshan / Zhang, Quan / Zou, Junliang

Global change biology

2020 Volume 26, Issue 12, Page(s) 7268–7283

Abstract: Globally, soils store two to three times as much carbon as currently resides in the atmosphere, and it is critical to understand how soil greenhouse gas (GHG) emissions and uptake will respond to ongoing climate change. In particular, the soil-to- ... ...

Abstract	Globally, soils store two to three times as much carbon as currently resides in the atmosphere, and it is critical to understand how soil greenhouse gas (GHG) emissions and uptake will respond to ongoing climate change. In particular, the soil-to-atmosphere CO
MeSH term(s)	Atmosphere ; Carbon Dioxide/analysis ; Ecosystem ; Greenhouse Gases/analysis ; Methane/analysis ; Nitrous Oxide/analysis ; Reproducibility of Results ; Respiration ; Soil
Chemical Substances	Greenhouse Gases ; Soil ; Carbon Dioxide (142M471B3J) ; Nitrous Oxide (K50XQU1029) ; Methane (OP0UW79H66)
Language	English
Publishing date	2020-10-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.15353
Database	MEDical Literature Analysis and Retrieval System OnLINE

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