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Article ; Online: Application of nanotized formulation in the control of snail intermediate hosts of schistosomes.

Oyeyemi, Oyetunde T

2021 Volume 220, Page(s) 105945

Abstract: Schistosomiasis continues to pose significant public health problems in many developing countries. Mass drug administration (MDA) is the most adopted control option but there is increasing evidence for the development of praziquantel-resistant ... ...

Abstract	Schistosomiasis continues to pose significant public health problems in many developing countries. Mass drug administration (MDA) is the most adopted control option but there is increasing evidence for the development of praziquantel-resistant Schistosoma strains. This shortcoming has necessitated the search for other effective methods for the control of schistosomiasis. The breaking of Schistosoma transmission cycles through the application of molluscicides into snail infested freshwater bodies has yielded positive outcomes when integrated with MDA in some countries. However, few of such effective molluscicides are currently available, and where available, their application is restricted due to toxicity concerns. Some nanotized particles with molluscicidal activities against the different stages of snail intermediate hosts of schistosomes have been reported. Importantly, the curcumin-nisin nanoparticle synthesized by our group was very effective and it showed no significant toxicity in a mouse model and brine shrimps. This, therefore, offers the possibility of developing a molluscicide that is not only safe for man but also is environmentally friendly. This paper reviews nanoparticles with molluscicidal potential. The methods of their formulation, activities, probable mechanisms of actions, and their toxicity profiles are discussed. More research should be made in this field as it offers great potential for the development of new molluscicides.
MeSH term(s)	Animals ; Curcumin/chemistry ; Curcumin/pharmacology ; Drug Compounding ; Humans ; Mice ; Molluscacides/chemistry ; Molluscacides/pharmacology ; Nanoparticles/chemistry ; Nisin/chemistry ; Nisin/pharmacology ; Schistosomiasis/prevention & control ; Schistosomiasis/transmission ; Snails/drug effects ; Snails/physiology
Chemical Substances	Molluscacides ; Nisin (1414-45-5) ; nisin A (EN8XKG133D) ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2021-05-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2021.105945
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Soil-transmitted helminthiasis (STH) endemicity and performance of preventive chemotherapy intervention programme in Nigeria (in year 2021).

Oyeyemi, Oyetunde T / Okunlola, Oluyemi A

Scientific reports

2023 Volume 13, Issue 1, Page(s) 10155

Abstract: Preventive chemotherapy (PC) is an important tool to address transmission and reduce morbidities associated with soil-transmitted helminths (STHs). The aim of the study is to assess the PC implementation programme coverage and relate the same to the ... ...

Abstract	Preventive chemotherapy (PC) is an important tool to address transmission and reduce morbidities associated with soil-transmitted helminths (STHs). The aim of the study is to assess the PC implementation programme coverage and relate the same to the endemicity of STH in Nigeria. The secondary data collected by the World Health Organization (WHO) through the expanded special project for elimination of neglected tropical diseases (ESPEN) and made available at the ESPEN portal was used for the study. The PC implementation coverage and frequency of treatment were evaluated and related to STH endemicity levels in Nigeria. STH was actively transmitted in all six geopolitical zones of Nigeria. The southern part of Nigeria was more endemic compared with northern Nigeria. There was no PC intervention in preschoolers and effective PC coverage (19.3%) fell below the WHO ≥ 75% PC coverage index benchmark in school children. The percentages of children that harbour low, moderate, and high STH infections were 41.5, 41.6, and 13.4%, respectively. Multiple treatments did not necessarily reduce the endemicity of STH on certain occasions. STH continues to be a public health threat in Nigeria. The current treatment strategies should be reviewed to accommodate preschoolers in PC implementation programmes. Treatment should be integrated with the WASH programme in order to achieve a lasting impact.
MeSH term(s)	Child ; Animals ; Humans ; Nigeria/epidemiology ; Soil/parasitology ; Prevalence ; Helminthiasis/drug therapy ; Helminthiasis/epidemiology ; Helminthiasis/prevention & control ; Helminths
Chemical Substances	Soil
Language	English
Publishing date	2023-06-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-37402-8
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Article ; Online: Schistosomiasis Control in Nigeria: Moving Round the Circle?

Oyeyemi, Oyetunde T

Annals of global health

2020 Volume 86, Issue 1, Page(s) 74

Abstract: Background: Schistosomiasis has continued to plague low-resource areas of the Nigerian population. Mass drug administration (MDA) has been the only adopted interventional program for decades. However, it appears this effort does not culminate in ... ...

Abstract	Background: Schistosomiasis has continued to plague low-resource areas of the Nigerian population. Mass drug administration (MDA) has been the only adopted interventional program for decades. However, it appears this effort does not culminate in transmission and morbidity reduction. Purpose: To highlight the current situation of schistosomiasis in Nigeria, why MDA alone cannot achieve the expected result, identify research needs, and promotion of integrated control approach for schistosomiasis. Method: A viewpoint based on practices, research findings, and personal and professional experience in the field of schistosomiasis control. Conclusion: This viewpoint strongly advocates a commitment to the integrated control approach through the development of robust schistosomiasis control policy for the country. It stressed the need for research priorities in neglected areas of schistosomiasis that are germane for control of the disease. The government's willpower to implement important recommendations from research outcomes is important to achieve success.
MeSH term(s)	Animals ; Anthelmintics/therapeutic use ; Biomphalaria/parasitology ; Bulinus/parasitology ; Communicable Disease Control/methods ; Health Policy ; Humans ; Mass Drug Administration ; Molluscacides ; Nigeria ; Praziquantel/therapeutic use ; Research ; Schistosomiasis/drug therapy ; Schistosomiasis/prevention & control ; Schistosomiasis/transmission ; Schistosomiasis haematobia/drug therapy ; Schistosomiasis haematobia/prevention & control ; Schistosomiasis haematobia/transmission ; Schistosomiasis mansoni/drug therapy ; Schistosomiasis mansoni/prevention & control ; Schistosomiasis mansoni/transmission
Chemical Substances	Anthelmintics ; Molluscacides ; Praziquantel (6490C9U457)
Language	English
Publishing date	2020-07-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2821756-1
ISSN	2214-9996 ; 2214-9996
ISSN (online)	2214-9996
ISSN	2214-9996
DOI	10.5334/aogh.2930
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Article ; Online: Malaria transmission in Africa: Its relationship with yellow fever and measles.

Okunlola, Oluyemi A / Oyeyemi, Oyetunde T

PloS one

2022 Volume 17, Issue 5, Page(s) e0268080

Abstract: Background: Malaria has been strongly linked to the transmission and pathophysiology of some viral diseases. Malaria and vaccine-preventable diseases often co-exist in endemic countries but the implication of their co-existence on their transmission ... ...

Abstract	Background: Malaria has been strongly linked to the transmission and pathophysiology of some viral diseases. Malaria and vaccine-preventable diseases often co-exist in endemic countries but the implication of their co-existence on their transmission dynamics and control is poorly understood. The study aims to evaluate the relationships between the incidence of malaria and cases of measles and yellow fever in Africa. Methods: The malaria incidence, death due to malaria, measles and yellow fever data were sourced from the WHO database. Poisson and zero-inflated time-trend regression were used to model the relationships between malaria and the two vaccine-preventable diseases. P-values <0.05 were considered statistically significant. Results: A significant negative relationship existed between malaria incidence and measles cases (P<0.05), however, malaria showed a positive relationship with yellow fever (P<0.05). The relationships between death due to malaria and measles/yellow fever cases followed similar trends but with a higher level of statistical significance (P<0.001). Conclusions: Malaria varied negatively with measles cases but positively with yellow fever. The relationships observed in this study could be important for the management of malaria and the studied vaccine-preventable diseases. Increase vaccination coverage and/or malaria treatment could modulate the direction of these relationships.
MeSH term(s)	Africa/epidemiology ; Humans ; Malaria/complications ; Malaria/epidemiology ; Measles/epidemiology ; Measles/prevention & control ; Measles Vaccine/therapeutic use ; Vaccination ; Vaccine-Preventable Diseases ; Yellow Fever/epidemiology ; Yellow Fever Vaccine
Chemical Substances	Measles Vaccine ; Yellow Fever Vaccine
Language	English
Publishing date	2022-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0268080
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Article: Application of nanotized formulation in the control of snail intermediate hosts of schistosomes

Oyeyemi, Oyetunde T

Acta tropica. 2021 Aug., v. 220

2021

Abstract	Schistosomiasis continues to pose significant public health problems in many developing countries. Mass drug administration (MDA) is the most adopted control option but there is increasing evidence for the development of praziquantel-resistant Schistosoma strains. This shortcoming has necessitated the search for other effective methods for the control of schistosomiasis. The breaking of Schistosoma transmission cycles through the application of molluscicides into snail infested freshwater bodies has yielded positive outcomes when integrated with MDA in some countries. However, few of such effective molluscicides are currently available, and where available, their application is restricted due to toxicity concerns. Some nanotized particles with molluscicidal activities against the different stages of snail intermediate hosts of schistosomes have been reported. Importantly, the curcumin-nisin nanoparticle synthesized by our group was very effective and it showed no significant toxicity in a mouse model and brine shrimps. This, therefore, offers the possibility of developing a molluscicide that is not only safe for man but also is environmentally friendly. This paper reviews nanoparticles with molluscicidal potential. The methods of their formulation, activities, probable mechanisms of actions, and their toxicity profiles are discussed. More research should be made in this field as it offers great potential for the development of new molluscicides.
Keywords	Schistosoma ; drugs ; freshwater ; mice ; molluscicides ; public health ; schistosomiasis ; snails ; toxicity
Language	English
Dates of publication	2021-08
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2021.105945
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Soil-transmitted helminthiasis (STH) endemicity and performance of preventive chemotherapy intervention programme in Nigeria (in year 2021)

Oyetunde T. Oyeyemi / Oluyemi A. Okunlola

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 9

Abstract: Abstract Preventive chemotherapy (PC) is an important tool to address transmission and reduce morbidities associated with soil-transmitted helminths (STHs). The aim of the study is to assess the PC implementation programme coverage and relate the same to ...

Abstract	Abstract Preventive chemotherapy (PC) is an important tool to address transmission and reduce morbidities associated with soil-transmitted helminths (STHs). The aim of the study is to assess the PC implementation programme coverage and relate the same to the endemicity of STH in Nigeria. The secondary data collected by the World Health Organization (WHO) through the expanded special project for elimination of neglected tropical diseases (ESPEN) and made available at the ESPEN portal was used for the study. The PC implementation coverage and frequency of treatment were evaluated and related to STH endemicity levels in Nigeria. STH was actively transmitted in all six geopolitical zones of Nigeria. The southern part of Nigeria was more endemic compared with northern Nigeria. There was no PC intervention in preschoolers and effective PC coverage (19.3%) fell below the WHO ≥ 75% PC coverage index benchmark in school children. The percentages of children that harbour low, moderate, and high STH infections were 41.5, 41.6, and 13.4%, respectively. Multiple treatments did not necessarily reduce the endemicity of STH on certain occasions. STH continues to be a public health threat in Nigeria. The current treatment strategies should be reviewed to accommodate preschoolers in PC implementation programmes. Treatment should be integrated with the WASH programme in order to achieve a lasting impact.
Keywords	Medicine ; R ; Science ; Q
Subject code	360
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Schistosomiasis Control in Nigeria

Oyetunde T. Oyeyemi

Annals of Global Health, Vol 86, Iss

Moving Round the Circle?

2020 Volume 1

Abstract	Background: Schistosomiasis has continued to plague low-resource areas of the Nigerian population. Mass drug administration (MDA) has been the only adopted interventional program for decades. However, it appears this effort does not culminate in transmission and morbidity reduction. Purpose: To highlight the current situation of schistosomiasis in Nigeria, why MDA alone cannot achieve the expected result, identify research needs, and promotion of integrated control approach for schistosomiasis. Method: A viewpoint based on practices, research findings, and personal and professional experience in the field of schistosomiasis control. Conclusion: This viewpoint strongly advocates a commitment to the integrated control approach through the development of robust schistosomiasis control policy for the country. It stressed the need for research priorities in neglected areas of schistosomiasis that are germane for control of the disease. The government’s willpower to implement important recommendations from research outcomes is important to achieve success.
Keywords	Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Ubiquity Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neglected tropical disease (NTD) diagnostics: current development and operations to advance control.

Oyeyemi, Oyetunde T / Ogundahunsi, Olumide / Schunk, Mirjam / Fatem, Ramzy G / Shollenberger, Lisa M

Pathogens and global health

2024 Volume 118, Issue 1, Page(s) 1–24

Abstract: Neglected tropical diseases (NTDs) have become important public health threats that require multi-faceted control interventions. As late treatment and management of NTDs contribute significantly to the associated burdens, early diagnosis becomes an ... ...

Abstract	Neglected tropical diseases (NTDs) have become important public health threats that require multi-faceted control interventions. As late treatment and management of NTDs contribute significantly to the associated burdens, early diagnosis becomes an important component for surveillance and planning effective interventions. This review identifies common NTDs and highlights the progress in the development of diagnostics for these NTDs. Leveraging existing technologies to improve NTD diagnosis and improving current operational approaches for deployment of developed diagnostics are crucial to achieving the 2030 NTD elimination target. Point-of-care NTD (POC-NTD) diagnostic tools are recommended preferred diagnostic options in resource-constrained areas for mapping risk zones and monitoring treatment efficacy. However, few are currently available commercially. Technical training of remote health care workers on the use of POC-NTD diagnostics, and training of health workers on the psychosocial consequences of these diagnostics are critical in harnessing POC-NTD diagnostic potential. While the COVID-19 pandemic has challenged the possibility of achieving NTD elimination in 2030 due to the disruption of healthcare services and dwindling financial support for NTDs, the possible contribution of NTDs in exacerbating COVID-19 pandemic should motivate NTD health system strengthening.
MeSH term(s)	Humans ; Neglected Diseases/diagnosis ; Neglected Diseases/prevention & control ; Neglected Diseases/epidemiology ; Pandemics ; Public Health ; COVID-19/diagnosis ; COVID-19/epidemiology ; Tropical Medicine
Language	English
Publishing date	2024-01-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2625162-0
ISSN	2047-7732 ; 2047-7724
ISSN (online)	2047-7732
ISSN	2047-7724
DOI	10.1080/20477724.2023.2272095
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Article ; Online: Extant interspecific hybridization among trematodes within the Schistosoma haematobium species complex in Nigeria.

Ajakaye, Oluwaremilekun G / Enabulele, Elisha E / Balogun, Joshua B / Oyeyemi, Oyetunde T / Grigg, Michael E

PLoS neglected tropical diseases

2024 Volume 18, Issue 4, Page(s) e0011472

Abstract: Background: Natural interspecific hybridization between the human parasite (Schistosoma haematobium [Sh]) and bovine parasites (Schistosoma bovis [Sb], Schistosoma curassoni [Sc]) is increasingly reported in Africa. We developed a multi-locus PCR DNA- ... ...

Abstract	Background: Natural interspecific hybridization between the human parasite (Schistosoma haematobium [Sh]) and bovine parasites (Schistosoma bovis [Sb], Schistosoma curassoni [Sc]) is increasingly reported in Africa. We developed a multi-locus PCR DNA-Seq strategy that amplifies two unlinked nuclear (transITS, BF) and two linked organellar genome markers (CO1, ND5) to genotype S. haematobium eggs collected from infected people in Ile Oluji/Oke Igbo, Ondo State (an agrarian community) and Kachi, Jigawa State (a pastoral community) in Southwestern and Northern Nigeria, respectively. Principal findings: Out of a total of 219 urine samples collected, 57 were positive for schistosomes. All patients from Jigawa state possessed an Sh mitochondrial genome and were infected with a genetic profile consistent with an Sh x Sb hybrid based on sequences obtained at CO1, ND5, transITS and BF nuclear markers. Whereas samples collected from Ondo state were more varied. Mitonuclear discordance was observed in all 17 patients, worms possessed an Sb mitochondrial genome but one of four different genetic profiles at the nuclear markers, either admixed (heterozygous between Sh x Sc or Sh x Sb) at both markers (n = 10), Sh at BF and admixed at transITS (Sh x Sc) (n = 5), admixed (Sh x Sc) at BF and homozygous Sc at transITS (n = 1) or homozygous Sh at BF and homozygous Sc at transITS (n = 1). Significance: Previous work suggested that zoonotic transmission of S. bovis in pastoral communities, where humans and animals share a common water source, is a driving factor facilitating interspecific hybridization. However, our data showed that all samples were hybrids, with greater diversity identified in Southwestern Nigeria, a non-pastoral site. Further, one patient possessed an S. bovis mitochondrial genome but was homozygous for S. haematobium at BF and homozygous for S. curassoni at transITS supporting at least two separate backcrosses in its origin, suggesting that interspecific hybridization may be an ongoing process.
MeSH term(s)	Animals ; Nigeria/epidemiology ; Humans ; Hybridization, Genetic ; Schistosoma haematobium/genetics ; Schistosoma haematobium/isolation & purification ; Schistosoma haematobium/classification ; Schistosomiasis haematobia/parasitology ; Schistosomiasis haematobia/epidemiology ; Male ; Female ; Genotype ; DNA, Helminth/genetics ; Genome, Mitochondrial ; Adult
Chemical Substances	DNA, Helminth
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011472
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Vaccination compliance of selected childhood immunization programs and the socio-determinant factors in Nigeria.

Okunlola, Oluyemi A / Oyerinde, Olawunmi R / Fashina, Imisioluwa D / Oyeyemi, Oyetunde T

Journal of infection in developing countries

2023 Volume 17, Issue 10, Page(s) 1466–1473

Abstract: Introduction: Adherence to full vaccination is important in preventing childhood diseases. The aim of this study was to evaluate the level of compliance to full vaccination and identify the socio-cultural factors associated with full vaccination ... ...

Abstract	Introduction: Adherence to full vaccination is important in preventing childhood diseases. The aim of this study was to evaluate the level of compliance to full vaccination and identify the socio-cultural factors associated with full vaccination compliance in children. Methodology: The socioeconomic variables associated with each of the four binary dependent variables of whether or not a child is fully vaccinated against tetanus, BCG, measles, and pentavalent were determined using logistic regression. Results: While compliance to full tetanus and BCG vaccinations was > 60% at the national level, less than 50% and 10% full vaccination compliance were recorded for pentavalent and measles vaccinations, respectively. The South East region of Nigeria recorded the overall highest full vaccination compliance while the least performing region was the North West zone. The mother or guardian literacy level, employment status, antenatal care attendance, and internet usage were strong predictors of full vaccination compliance (p < 0.05). Conclusions: The socio-cultural factors associated with achieving full vaccination coverage in Nigeria in this study should drive the implementation of policies that will be best suited to each geopolitical zone of Nigeria.
MeSH term(s)	Humans ; Child ; Female ; Pregnancy ; Infant ; Nigeria ; Tetanus ; BCG Vaccine ; Vaccination ; Immunization Programs ; Measles
Chemical Substances	BCG Vaccine
Language	English
Publishing date	2023-10-31
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.17886
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