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  1. Article ; Online: Paclitaxel-loaded niosomes in combination with metformin: development, characterization and anticancer potentials.

    Al-Kofahi, Taqwa / Altrad, Bahaa / Amawi, Haneen / Aljabali, Alaa A / Abul-Haija, Yousef M / Obeid, Mohammad A

    Therapeutic delivery

    2024  Volume 15, Issue 2, Page(s) 109–118

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Paclitaxel/pharmacology ; Liposomes ; Metformin ; Drug Compounding ; Cell Line, Tumor
    Chemical Substances Paclitaxel (P88XT4IS4D) ; Liposomes ; Metformin (9100L32L2N)
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article
    ISSN 2041-6008
    ISSN (online) 2041-6008
    DOI 10.4155/tde-2023-0089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Monkeypox: Emerging virus of concern; antivirals and vaccines therapeutic options.

    Obeid, Mohammad A / Amawi, Haneen / Alshehri, Ahmed / Adesokan, Adedapo

    Microbial pathogenesis

    2022  Volume 173, Issue Pt A, Page(s) 105799

    Abstract: The detection of >400 Monkeypox virus cases in the month of May 2022 and increase to 57,527. confirmed cases by September ... ...

    Abstract The detection of >400 Monkeypox virus cases in the month of May 2022 and increase to 57,527. confirmed cases by September 9th
    MeSH term(s) Male ; Humans ; Mpox (monkeypox)/drug therapy ; Mpox (monkeypox)/epidemiology ; Mpox (monkeypox)/prevention & control ; Antiviral Agents/therapeutic use ; Homosexuality, Male ; Sexual and Gender Minorities ; Vaccines
    Chemical Substances Antiviral Agents ; Vaccines
    Language English
    Publishing date 2022-09-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632772-2
    ISSN 1096-1208 ; 0882-4010
    ISSN (online) 1096-1208
    ISSN 0882-4010
    DOI 10.1016/j.micpath.2022.105799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2136: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article: Acetylsalicylic acid reduces cigarette smoke withdrawal-induced anxiety in rats

    Hammad, Alaa M / Alzaghari, Lujain F / Alfaraj, Malek / Al-Qerem, Walid / Talib, Wamidh H / Alasmari, Fawaz / Amawi, Haneen / Hall, F Scott

    Frontiers in pharmacology

    2023  Volume 13, Page(s) 1047236

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-01-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.1047236
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  4. Article ; Online: The Length of Hospital Stay of Patients with Venous Thromboembolism: A Cross-Sectional Study from Jordan.

    Amawi, Haneen / Arabyat, Rasha M / Al-Azzam, Sayer / AlZu'bi, Toqa / U'wais, Hamza Tayseer / Hammad, Alaa M / Amawi, Ruba / Nusair, Mohammad B

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 4

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Aged ; Female ; Humans ; Male ; Middle Aged ; Anticoagulants/therapeutic use ; Cross-Sectional Studies ; Hypertension ; Jordan/epidemiology ; Length of Stay ; Pulmonary Embolism/therapy ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/prevention & control ; Venous Thrombosis/drug therapy ; Venous Thrombosis/epidemiology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2023-04-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59040727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6270: Show issues Location:
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  5. Article ; Online: Correlation Between BCL2 and Mcl1 Single Nucleotide Polymorphisms and Chemotherapy Response in Jordanian Patients with Colorectal Cancer.

    Mhaidat, Nizar M / Amawi, Haneen / Alzoubi, Karem H

    Current pharmaceutical biotechnology

    2020  Volume 22, Issue 5, Page(s) 646–653

    Abstract: Background: Colorectal cancer is one of the most common types of cancer worldwide and a leading cause of death in Jordan. BCL-2 and MCL-1 are anti-apoptotic proteins that inhibit programmed cell death and their over-expression has been shown to be ... ...

    Abstract Background: Colorectal cancer is one of the most common types of cancer worldwide and a leading cause of death in Jordan. BCL-2 and MCL-1 are anti-apoptotic proteins that inhibit programmed cell death and their over-expression has been shown to be associated with reduced sensitivity to chemotherapy and poor survival in cancer patients.
    Objectives: In the present study, three SNPs in the promoter region of antiapoptotic genes were investigated in an effort to inspect the occurrences of SNPs (rs2279115, rs4987852) in the promoter region of BCL2 and SNP (rs9803935) in the promoter region of MCL1 in Jordanian patients with CRC, and investigate correlations between BCL2 and MCL1 SNPs and clinical outcomes.
    Methods: PCR-restriction fragment length polymorphism (RFLP)-based analysis was used for samples genotyping.
    Results: The BCL2 rs2279115 and MCL1 rs9803935 SNPs showed significant distribution where mutant and hetero genotypes are more prominent in CRC patients. Additionally, the rs2279115 genotypes and alleles were associated with stages of disease, its recurrence and metastasis. The MCL1 rs9803935 genotypes were associated disease metastasis. However, for BCL2 rs4987852 SNP, there was no association of genotypes or alleles with any of the disease variables.
    Conclusion: The BCL2 SNPs (rs2279115) and MCL1 SNP (rs9803935) present as important determinants of the progress of CRC in Jordanian patients.
    MeSH term(s) Aged ; Alleles ; Apoptosis Regulatory Proteins/genetics ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Female ; Genotype ; Humans ; Jordan ; Male ; Middle Aged ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Polymorphism, Single Nucleotide/genetics ; Proto-Oncogene Proteins c-bcl-2/genetics
    Chemical Substances Apoptosis Regulatory Proteins ; BCL2 protein, human ; MCL1 protein, human ; Myeloid Cell Leukemia Sequence 1 Protein ; Proto-Oncogene Proteins c-bcl-2
    Language English
    Publishing date 2020-07-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/1389201021666200703200126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6212: Show issues Location:
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  6. Article ; Online: Nanomaterials as a Potential Target for Infectious Parasitic Agents.

    Alsharedeh, Rawan H / Rezigue, Meriem / Bashatwah, Rasha M / Amawi, Haneen / Aljabali, Alaa A A / Obeid, Mohammad A / Tambuwala, Murtaza M

    Current drug delivery

    2023  

    Abstract: Despite the technological advancement in the era of personalized medicine and therapeutics development, infectious parasitic causative agents remain one of the most challenging areas of research and development. The disadvantages of conventional ... ...

    Abstract Despite the technological advancement in the era of personalized medicine and therapeutics development, infectious parasitic causative agents remain one of the most challenging areas of research and development. The disadvantages of conventional parasitic prevention and control are the emergence of multiple drug resistance as well as the non-specific targeting of intracellular parasites, which results in high dose concentration needs and subsequently intolerable cytotoxicity. Nanotechnology has attracted extensive interest to reduce medication therapy adverse effects including poor bioavailability and drug selectivity. Numerous nanomaterials-based delivery systems have previously been shown in animal models to be effective in the treatment of various parasitic infections. This review discusses a variety of nanomaterials-based antiparasitic procedures and techniques as well as the processes that allow them to be targeted to different parasitic infections. This review focuses on the key prerequisites for creating novel nanotechnology-based carriers as a potential option in parasite management, specifically in the context of human-related pathogenic parasitic agents.
    Language English
    Publishing date 2023-02-23
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2185284-4
    ISSN 1875-5704 ; 1567-2018
    ISSN (online) 1875-5704
    ISSN 1567-2018
    DOI 10.2174/1567201820666230223085403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6415: Show issues Location:
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  7. Article ; Online: Characterisation of niosome nanoparticles prepared by microfluidic mixing for drug delivery.

    Obeid, Mohammad A / Khadra, Ibrahim / Aljabali, Alaa A A / Amawi, Haneen / Ferro, Valerie A

    International journal of pharmaceutics: X

    2022  Volume 4, Page(s) 100137

    Abstract: Lipid nanoparticles have gained much attention due to their potential as drug delivery systems. They are safe, effective, and be targeted to particular tissues to deliver their payload. Niosomes are one type of lipid nanoparticles that comprise non-ionic ...

    Abstract Lipid nanoparticles have gained much attention due to their potential as drug delivery systems. They are safe, effective, and be targeted to particular tissues to deliver their payload. Niosomes are one type of lipid nanoparticles that comprise non-ionic surfactants which have proven to be effective due to their stability and biocompatibility. Different manufacturing processes have been reported for niosome preparation, but many of them are not scalable or reproducible for pharmaceutical use. In this study, microfluidic mixing was used to prepare niosomes with different lipid compositions by changing the type of non-ionic surfactant. Niosomes were evaluated for their physicochemical characteristics, morphology, encapsulation efficacy, release profiles of atenolol as a model hydrophilic compound, and cytotoxic activities. Microfluidic mixing allows for particle self-assembly and drug loading in a single step, without the need for post-preparation size reduction. Depending on the lipid composition, the empty particles were <90 nm in size with a uniform distribution. A slight but not significant increase in these values was observed when loading atenolol in most of the prepared formulations. All formulations were spherical and achieved variable levels of atenolol encapsulation. Atenolol release was slow and followed the Korsmeyer-Peppas model regardless of the surfactant type or the percentage of cholesterol used.
    Language English
    Publishing date 2022-11-01
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2590-1567
    ISSN (online) 2590-1567
    DOI 10.1016/j.ijpx.2022.100137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Erratum to: Cancer chemoprevention through dietary flavonoids: what's limiting?

    Amawi, Haneen / Ashby, Charles R / Tiwari, Amit K

    Chinese journal of cancer

    2017  Volume 36, Issue 1, Page(s) 70

    Language English
    Publishing date 2017-08-30
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 1045160-2
    ISSN 1944-446X ; 1000-467X
    ISSN (online) 1944-446X
    ISSN 1000-467X
    DOI 10.1186/s40880-017-0237-0
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    Zs.A 6213: Show issues Location:
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  9. Article ; Online: The use of zebrafish model in prostate cancer therapeutic development and discovery.

    Amawi, Haneen / Aljabali, Alaa A A / Boddu, Sai H S / Amawi, Sadam / Obeid, Mohammad A / Ashby, Charles R / Tiwari, Amit K

    Cancer chemotherapy and pharmacology

    2021  Volume 87, Issue 3, Page(s) 311–325

    Abstract: Zebrafish is now among the leading in vivo model for cancer research, including prostate cancer. They are an alternative economic model being used to study cancer development, proliferation, and metastasis. They can also be effectively utilized for the ... ...

    Abstract Zebrafish is now among the leading in vivo model for cancer research, including prostate cancer. They are an alternative economic model being used to study cancer development, proliferation, and metastasis. They can also be effectively utilized for the development of cancer drugs at all levels, including target validation, and high-throughput screening for possible lead molecules. In this review, we provide a comprehensive overview of the role of zebrafish as an in vivo model in prostate cancer research. Globally, prostate cancer is a leading cause of death in men. Although many molecular mechanisms have been identified as playing a role in the pathogenesis of prostate cancer, there is still a significant need to understand the initial events of the disease. Furthermore, current treatments are limited by the emergence of severe toxicities and multidrug resistance. There is an essential need for economical and relevant research tools to improve our understanding and overcome these problems. This review provides a comprehensive summary of studies that utilized zebrafish for different aims in prostate cancer research. We discuss the use of zebrafish in prostate cancer cell proliferation and metastasis, defining signaling pathways, drug discovery and therapeutic development against prostate cancer, and toxicity studies. Finally, this review highlights limitations in this field and future directions to efficiently use zebrafish as a robust model for prostate cancer therapeutics development.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Cell Proliferation/physiology ; Disease Models, Animal ; Drug Development ; Drug Discovery/methods ; Humans ; Male ; Neoplasm Metastasis ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology ; Toxicity Tests/methods ; Zebrafish
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2021-01-03
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 6820-2
    ISSN 1432-0843 ; 0344-5704 ; 0943-9404
    ISSN (online) 1432-0843
    ISSN 0344-5704 ; 0943-9404
    DOI 10.1007/s00280-020-04211-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1420: Show issues Location:
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  10. Article: Knowledge about cervical cancer and awareness about human papillomavirus vaccination among medical students in Jordan.

    Alsous, Mervat M / Ali, Ahlam / Al-Azzam, Sayer / Karasneh, Reema / Amawi, Haneen

    PeerJ

    2021  Volume 9, Page(s) e11611

    Abstract: Objectives: To assess the knowledge about cervical cancer and HPV infection and the awareness towards and perceived barriers of HPV vaccination amid medical students in Jordan.: Methods: The present study is a cross-sectional survey that was ... ...

    Abstract Objectives: To assess the knowledge about cervical cancer and HPV infection and the awareness towards and perceived barriers of HPV vaccination amid medical students in Jordan.
    Methods: The present study is a cross-sectional survey that was conducted for a period of three months in the College of Medicine at six different universities in Jordan. Third-year to sixth-year students from these medical colleges in Jordan were invited to participate in the study.
    Results: There were 504 students that took part in the study with 42.3% being males and 57.7% females. The mean knowledge score of students in our survey was 21.4 ± 4.4 out of 34, which was categorized as a moderate level of knowledge regarding cervical cancer and HPV. Only 40.5% knew about the availability of the HPV vaccine in Jordan, and 65.9% accepted the idea that it is necessary to introduce the HPV vaccine for school girls in Jordan.
    Conclusions: This study highlights that there is inadequate knowledge about cervical cancer and its screening among medical students in Jordan. Despite the limited awareness about the HPV vaccine among the study's participants, there is a favorable opinion towards the introduction of the vaccine for school girls in Jordan. The data provide a benchmark on the level of knowledge about cervical cancer and awareness about HPV, which can be used to formulate an effective awareness program.
    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.11611
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