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Article: “Tong Guan Li Qiao” Acupuncture Therapy on Post-Stroke Dysphagia

Huang, Hongwen / Shi, Huiyan / Ren, Xuesong / Shi, Xuemin

Chinese medicine and natural products

2022 Volume 02, Issue 04, Page(s) e174–e178

Abstract: The differences between the “Tong Guan Li Qiao” acupuncture therapy and the conventional and ... idea of “Xing Nao Kai Qiao” acupuncture therapy in selecting and combining acupoints, centers ...

Abstract	The differences between the “Tong Guan Li Qiao” acupuncture therapy and the conventional and current other acupuncture methods for poststroke dysphagia are as follows: first, it adheres to the basic idea of “Xing Nao Kai Qiao” acupuncture therapy in selecting and combining acupoints, centers on the brain, and combines the dysphagia symptoms of the mouth, tongue, and throat-related orifices with the root cause of “brain”; second, there are strict and standard requirements in the acupuncture operation, that is, manipulation quantification. In addition to standardized twirling, lifting, and thrusting, the techniques of deep needling on the acupoints in the neck region, blood-letting puncturing at the posterior wall of the pharynx, and the needling sensation of “like a fishbone getting stuck in the throat” are all unique.
Keywords	dysphagia ; poststroke ; “Tong Guan Li Qiao” acupuncture therapy ; regulating spirit ; manipulation quantification ; brain
Language	English
Publishing date	2022-12-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	2749-568X ; 2096-918X
ISSN (online)	2749-568X
ISSN	2096-918X
DOI	10.1055/s-0042-1759766
Database	Thieme publisher's database

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Article ; Online: Tong-Qiao-Huo-Xue decoction activates PI3K/Akt/mTOR pathway to reduce BMECs autophagy after cerebral ischemia/reperfusion injury.

Hua, Yaping / Zhai, Yan / Wang, Guangyun / Wang, Ning / Wu, Qian / Huang, Qi / Seto, Saiwang / Wang, Yan

Journal of ethnopharmacology

2022 Volume 298, Page(s) 115585

Abstract: Ethnopharmacological relevance: Tong-Qiao-Huo-Xue Decoction (TQHXD) is a traditional classic ...

Abstract	Ethnopharmacological relevance: Tong-Qiao-Huo-Xue Decoction (TQHXD) is a traditional classic Chinese Medicinal Formula (CMF) used for clinical treatment of ischemic stroke. TQHXD leads to improvement in the symptoms of the acute period of cerebral infarction and recovery period after stroke. Our previous studies also showed that TQHXD produced a significant protective effect on the brain after cerebral ischemia-reperfusion (I/R) injury. It is reported that autophagy is closely related to ischemic brain injury; however, the functional contribution of TQHXD to brain microvascular endothelial cell (BMEC) autophagy and its underlying mechanism remains unclear. Aim of the study: The purpose of this study was to investigate the effects and mechanism of TQHXD in inhibiting cerebral ischemia-induced endothelial autophagy. Materials and methods: The high-performance liquid chromatography (HPLC) fingerprint of the chemical constituents from TQHXD was established for the quality control, and the Longa method was used to evaluate the efficacy of TQHXD in rats with middle cerebral artery occlusion (MCAO). The expression of LC3 was determined by immunofluorescence double staining. To evaluate the protective effects of TQHXD-containing cerebrospinal fluid (CSF) on BMECs injured by oxygen-glucose deprivation and reperfusion, cell survival rate was determined using the CCK-8 assay and cell apoptosis was determined by fluorescein isothiocyanate (FITC)-Annexin V/PI. Autophagy was detected using transmission electron microscopy. Results: The results showed that TQHXD-CSF significantly ameliorated oxygen-glucose deprivation/reperfusion (OGD/R)-induced injury in BMECs. Confocal microscopy and Western blot results showed that TQHXD-CSF reduced autophagy-related protein expression and autophagosome number. The results of the western blotting indicated that TQHXD-CSF caused a marked increase in the phosphorylation of protein kinase B and phosphoinsotide-3 kinase (Akt/p-Akt and PI3K/p-PI3K, respectively) and their expression levels were down-regulated after treatment with pathway inhibitor, ZSTK474. Furthermore, in a MCAO model in rats, TQHXD markedly increased p-PI3K, p-Akt and p-mTOR, whereas the autophagy related proteins decreased. Conclusions: Taken together, these findings demonstrate that TQHXD protects against ischemic insult by inhibiting autophagy through the regulation of the PI3K/Akt/mammalian target of rapamycin (mTOR) pathway and that TQHXD may have therapeutic value for protecting BMECs from cerebral ischemia.
MeSH term(s)	Animals ; Autophagy ; Brain Ischemia/drug therapy ; Drugs, Chinese Herbal ; Glucose/metabolism ; Infarction, Middle Cerebral Artery/drug therapy ; Oxygen/metabolism ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Reperfusion Injury/metabolism ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Drugs, Chinese Herbal ; tong-qiao-huo-xue ; mTOR protein, rat (EC 2.7.1.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Glucose (IY9XDZ35W2) ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-07-31
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115585
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Tong-Qiao-Huo-Xue decoction activates PI3K/Akt/mTOR pathway to reduce BMECs autophagy after cerebral ischemia/reperfusion injury

Hua, Yaping / Zhai, Yan / Wang, Guangyun / Wang, Ning / Wu, Qian / Huang, Qi / Seto, Saiwang / Wang, Yan

Journal of ethnopharmacology. 2022 Nov. 15, v. 298

2022

Abstract: Tong-Qiao-Huo-Xue Decoction (TQHXD) is a traditional classic Chinese Medicinal Formula (CMF) used ...

Abstract	Tong-Qiao-Huo-Xue Decoction (TQHXD) is a traditional classic Chinese Medicinal Formula (CMF) used for clinical treatment of ischemic stroke. TQHXD leads to improvement in the symptoms of the acute period of cerebral infarction and recovery period after stroke. Our previous studies also showed that TQHXD produced a significant protective effect on the brain after cerebral ischemia-reperfusion (I/R) injury. It is reported that autophagy is closely related to ischemic brain injury; however, the functional contribution of TQHXD to brain microvascular endothelial cell (BMEC) autophagy and its underlying mechanism remains unclear. The purpose of this study was to investigate the effects and mechanism of TQHXD in inhibiting cerebral ischemia-induced endothelial autophagy. The high-performance liquid chromatography (HPLC) fingerprint of the chemical constituents from TQHXD was established for the quality control, and the Longa method was used to evaluate the efficacy of TQHXD in rats with middle cerebral artery occlusion (MCAO). The expression of LC3 was determined by immunofluorescence double staining. To evaluate the protective effects of TQHXD-containing cerebrospinal fluid (CSF) on BMECs injured by oxygen–glucose deprivation and reperfusion, cell survival rate was determined using the CCK-8 assay and cell apoptosis was determined by fluorescein isothiocyanate (FITC)-Annexin V/PI. Autophagy was detected using transmission electron microscopy. The results showed that TQHXD-CSF significantly ameliorated oxygen-glucose deprivation/reperfusion (OGD/R)-induced injury in BMECs. Confocal microscopy and Western blot results showed that TQHXD-CSF reduced autophagy-related protein expression and autophagosome number. The results of the western blotting indicated that TQHXD-CSF caused a marked increase in the phosphorylation of protein kinase B and phosphoinsotide-3 kinase (Akt/p-Akt and PI3K/p-PI3K, respectively) and their expression levels were down-regulated after treatment with pathway inhibitor, ZSTK474. Furthermore, in a MCAO model in rats, TQHXD markedly increased p-PI3K, p-Akt and p-mTOR, whereas the autophagy related proteins decreased. Taken together, these findings demonstrate that TQHXD protects against ischemic insult by inhibiting autophagy through the regulation of the PI3K/Akt/mammalian target of rapamycin (mTOR) pathway and that TQHXD may have therapeutic value for protecting BMECs from cerebral ischemia.
Keywords	Western blotting ; apoptosis ; autophagosomes ; autophagy ; brain ; brain damage ; cell viability ; cerebrospinal fluid ; confocal microscopy ; endothelial cells ; fluorescein ; fluorescent antibody technique ; high performance liquid chromatography ; infarction ; ischemia ; isothiocyanates ; models ; non-specific serine/threonine protein kinase ; protective effect ; protein phosphorylation ; protein synthesis ; quality control ; rapamycin ; reperfusion injury ; stroke ; survival rate ; therapeutics ; traditional medicine ; transmission electron microscopy
Language	English
Dates of publication	2022-1115
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115585
Database	NAL-Catalogue (AGRICOLA)

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Book: Xiang qi shi shang kai ju jue qiao

Huang, Shaolong

2008

Title translation	Letzte Kniffe zeitgemäßer Spieleröffnungen im chin. Schach <dt.>
Title variant	Xiangqi shishang kaiju jueqiao ; Hsiang-ch'i-shih-shang-k'ai-chü-chüeh-ch'iao / Huang Shao-lung pien-chu
Author's details	Huang Shaolong bianzhu
Keywords	Chinesisches Schach
Language	Chinese
Size	352 S., graph. Darst.
Publisher	Jin dun chu ban she
Publishing place	Beijing
Document type	Book
Note	In chines. Schr.
ISBN	9787508251783 ; 7508251784
Database	Former special subject collection: coastal and deep sea fishing

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Article: [Heavy metal accumulation during last hundred years and its assessment of potential ecological risk in the coastal wetland of Qi'ao Island, Pearl River Estuary of China].

Wang, Ai-jun / Ye, Xiang / Li, Tuan-jie / Huang, Cai-bin

Huan jing ke xue= Huanjing kexue

2011 Volume 32, Issue 5, Page(s) 1306–1314

Abstract: ... of Qi'ao Island in the Pearl River Estuary of China show that the sediment is mainly composed by clayey ...

Abstract	The processes of fine sediment transport and deposition can record some relative anthropogenic information in estuarine environments. Grain size analysis of the sediment core collected from coastal wetland of Qi'ao Island in the Pearl River Estuary of China show that the sediment is mainly composed by clayey silt, and the mean grain size, contents of clay and silt increase upward gradually. Chronology analysis show that the sedimentation rate above 59 cm is about 4.15 cm x a(-1), and 0.97 cm x a(-1) beneath 59 cm. Heavy metal analysis indicate that the contents of the each heavy metal increased slowly with a slight intensity of potential ecological risk; however, from 1966 to 1992, the heavy metal contents increased obviously because of the quick social-economy development around the Pearl River Estuary area, and the order of polluting degree of these heavy metals in core sediment is Cd > Ni > Pb > Cu > Cr > Zn. The potential ecological risk intensity of Cd increased from slight risk before 1966 to strong risk since 1992, and the potential ecological risk intensities other heavy metal are slight risk; the potential ecological risk index is weak level. The variations of core sediment heavy metal contents and its ecological risk assessments along the vertical profile reveal the interaction processes and intent of anthropogenic influences from the areas around the Pearl River Estuary and the catchments.
MeSH term(s)	China ; Ecology ; Environmental Monitoring/methods ; Environmental Pollutants/analysis ; Metals, Heavy/analysis ; Oceans and Seas ; Risk Assessment ; Rivers ; Water Pollutants, Chemical/analysis ; Wetlands
Chemical Substances	Environmental Pollutants ; Metals, Heavy ; Water Pollutants, Chemical
Language	Chinese
Publishing date	2011-05
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0250-3301
ISSN	0250-3301
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Treatment of mucous membrane diseases of the digestive tract with jing jie lian qiao tang--therapeutic effect in 168 cases.

Jiang, G T / Chen, B T / Kong, B Y / Huang, S / Yang, S F / Pan, J H / Lü, X O

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

1989 Volume 9, Issue 4, Page(s) 287–289

MeSH term(s)	Adult ; Colitis/drug therapy ; Drugs, Chinese Herbal/therapeutic use ; Duodenal Ulcer/drug therapy ; Gastritis/drug therapy ; Humans ; Middle Aged ; Stomach Ulcer/drug therapy ; Stomatitis, Aphthous/drug therapy
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	1989-12
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	603186-9
ISSN	0254-6272 ; 0255-2922
ISSN (online)	0254-6272
ISSN	0255-2922
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Article ; Online: ASO Author Reflections: Longitudinal Relief of Patient-Report Dysphagia in Esophageal Cancer.

Huang, Shujie / Qiao, Guibin

Annals of surgical oncology

2023 Volume 30, Issue 8, Page(s) 5182

MeSH term(s)	Humans ; Deglutition Disorders/etiology ; Deglutition Disorders/therapy ; Esophageal Neoplasms/complications ; Esophageal Neoplasms/surgery ; Esophagectomy
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-023-13505-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: COVID-19 spread prediction using socio-demographic and mobility-related data.

Qiao, Mengling / Huang, Bo

Cities (London, England)

2023 Volume 138, Page(s) 104360

Abstract: Studying the impacts of factors that may vary spatially and temporally as infectious disease progresses is critical for the prediction and intervention of COVID-19. This study aimed to quantitatively assess the spatiotemporal impacts of socio-demographic ...

Abstract	Studying the impacts of factors that may vary spatially and temporally as infectious disease progresses is critical for the prediction and intervention of COVID-19. This study aimed to quantitatively assess the spatiotemporal impacts of socio-demographic and mobility-related factors to predict the spread of COVID-19. We designed two different schemes that enhanced temporal and spatial features respectively, and both with the geographically and temporally weighted regression (GTWR) model adopted to consider the heterogeneity and non-stationarity problems, to reveal the spatiotemporal associations between the factors and the spread of COVID-19 pandemic. Results indicate that our two schemes are effective in facilitating the accuracy of predicting the spread of COVID-19. In particular, the temporally enhanced scheme quantifies the impacts of the factors on the temporal spreading trend of the epidemic at the city level. Simultaneously, the spatially enhanced scheme figures out how the spatial variances of the factors determine the spatial distribution of the COVID-19 cases among districts, particularly between the urban area and the surrounding suburbs. Findings provide potential policy implications in terms of dynamic and adaptive anti-epidemic.
Language	English
Publishing date	2023-05-04
Publishing country	England
Document type	Journal Article
ISSN	0264-2751
ISSN	0264-2751
DOI	10.1016/j.cities.2023.104360
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impacts of substituting magnesium with zinc on crystallization behaviors in an aluminosilicate glass.

Huang, Biwei / Zheng, Qingshuang / Cai, Muzhi / Qiao, Ang / Tao, Haizheng

Physical chemistry chemical physics : PCCP

2024

Abstract: A series of zinc-magnesium mixed aluminosilicate glasses with the molar composition (1- ...

Abstract	A series of zinc-magnesium mixed aluminosilicate glasses with the molar composition (1-
Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d4cp00668b
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ultrasound-Assisted Spinal Anesthesia in a Patient with a Preexisting Lumbar Interspinous Spacer: A Case Report.

Huang, Priscilla / Singleton, Michael N / Qiao, William P

A&A practice

2024 Volume 18, Issue 4, Page(s) e01772

Abstract: An interspinous spacer is a minimally invasive implantable device for the treatment of lumbar spinal stenosis. The in situ implant may prevent safe and successful spinal anesthesia because its position can obstruct the path of the spinal needle. Lumbar ... ...

Abstract	An interspinous spacer is a minimally invasive implantable device for the treatment of lumbar spinal stenosis. The in situ implant may prevent safe and successful spinal anesthesia because its position can obstruct the path of the spinal needle. Lumbar neuraxial ultrasonography has been shown to aid in performance of neuraxial anesthesia in patients with challenging anatomy. Currently, there are no reported cases of ultrasound-assisted spinal anesthesia in patients with interspinous spacers. We present a case in which ultrasonography assisted the successful administration of a spinal anesthetic by avoiding an indwelling lumbar interspinous spacer.
MeSH term(s)	Humans ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Anesthesia, Spinal ; Decompression, Surgical ; Prostheses and Implants ; Ultrasonography
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	2575-3126
ISSN (online)	2575-3126
DOI	10.1213/XAA.0000000000001772
Database	MEDical Literature Analysis and Retrieval System OnLINE

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