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Article ; Online: Conserved reduction of m

Castro-Hernández, Ricardo / Berulava, Tea / Metelova, Maria / Epple, Robert / Peña Centeno, Tonatiuh / Richter, Julia / Kaurani, Lalit / Pradhan, Ranjit / Sakib, M Sadman / Burkhardt, Susanne / Ninov, Momchil / Bohnsack, Katherine E / Bohnsack, Markus T / Delalle, Ivana / Fischer, Andre

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 9, Page(s) e2204933120

Abstract: ... ...

Abstract	N
MeSH term(s)	Humans ; Mice ; Animals ; Aged ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Hippocampus/metabolism ; Alzheimer Disease/metabolism ; Aging/metabolism ; RNA/metabolism ; Mammals/genetics
Chemical Substances	Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; RNA (63231-63-0)
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2204933120
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Article ; Online: Structural basis of regulated m

Li, Jiazhi / Wang, Longfei / Hahn, Quentin / Nowak, Radosław P / Viennet, Thibault / Orellana, Esteban A / Roy Burman, Shourya S / Yue, Hong / Hunkeler, Moritz / Fontana, Pietro / Wu, Hao / Arthanari, Haribabu / Fischer, Eric S / Gregory, Richard I

Nature

2023 Volume 613, Issue 7943, Page(s) 391–397

Abstract: Chemical modifications of RNA have key roles in many biological ... ...

Abstract	Chemical modifications of RNA have key roles in many biological processes
MeSH term(s)	Humans ; Biocatalysis ; Catalytic Domain ; GTP-Binding Proteins/chemistry ; GTP-Binding Proteins/metabolism ; Methyltransferases/antagonists & inhibitors ; Methyltransferases/chemistry ; Methyltransferases/metabolism ; Phosphorylation ; RNA Processing, Post-Transcriptional ; RNA, Transfer/chemistry ; RNA, Transfer/metabolism ; Substrate Specificity
Chemical Substances	GTP-Binding Proteins (EC 3.6.1.-) ; Methyltransferases (EC 2.1.1.-) ; METTL1 protein, human (EC 2.1.1.-) ; RNA, Transfer (9014-25-9) ; WDR4 protein, human ; 7-methylguanosine (2140-77-4)
Language	English
Publishing date	2023-01-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-05566-4
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

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Article: Crystallization of Feline Coronavirus M

Lu, Jimmy / Chen, Sizhu Amelia / Khan, Muhammad Bashir / Brassard, Raelynn / Arutyunova, Elena / Lamer, Tess / Vuong, Wayne / Fischer, Conrad / Young, Howard S / Vederas, John C / Lemieux, M Joanne

Frontiers in chemistry

2022 Volume 10, Page(s) 852210

Abstract: Coronaviruses infect a variety of hosts in the animal kingdom, and while each virus is taxonomically different, they all infect their ... ...

Abstract	Coronaviruses infect a variety of hosts in the animal kingdom, and while each virus is taxonomically different, they all infect their host
Language	English
Publishing date	2022-02-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2022.852210
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Metal-Metal Bonding in Late Transition-Metal [M

Hornung, Julius / Muhr, Maximilian / Schütz, Max / Heiß, Patricia / Stephan, Johannes / Jandl, Christian / Gemel, Christian / Kahlal, Samia / Saillard, Jean-Yves / Fischer, Roland A

Inorganic chemistry

2023 Volume 62, Issue 29, Page(s) 11381–11389

Abstract: Late dinuclear transition-metal (especially group 10 and 11) homoleptic carbonyl complexes are elusive species and have so far not been isolated. A typical example is the 30-electron species [ ... ...

Abstract	Late dinuclear transition-metal (especially group 10 and 11) homoleptic carbonyl complexes are elusive species and have so far not been isolated. A typical example is the 30-electron species [Ni
Language	English
Publishing date	2023-07-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c00866
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Article ; Online: METTL1-mediated m

Molecular cell

2021 Volume 81, Issue 16, Page(s) 3323–3338.e14

Abstract: ... roles of different RNA modifications. The RNA methyltransferase METTL1 catalyzes N7-methylguanosine (m ...

Abstract	The emerging "epitranscriptomics" field is providing insights into the biological and pathological roles of different RNA modifications. The RNA methyltransferase METTL1 catalyzes N7-methylguanosine (m
MeSH term(s)	Carcinogenesis/genetics ; Guanosine/analogs & derivatives ; Guanosine/genetics ; Humans ; Methylation ; Methyltransferases/genetics ; Neoplasms/genetics ; Neoplasms/pathology ; Oncogenes/genetics ; RNA Processing, Post-Transcriptional/genetics ; RNA, Messenger/genetics ; RNA, Transfer/genetics ; tRNA Methyltransferases/genetics
Chemical Substances	8-methylguanosine ; RNA, Messenger ; Guanosine (12133JR80S) ; RNA, Transfer (9014-25-9) ; METTL1 protein, human (EC 2.1.1.-) ; Methyltransferases (EC 2.1.1.-) ; tRNA Methyltransferases (EC 2.1.1.-)
Language	English
Publishing date	2021-08-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2021.06.031
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Zs.A 5055: Show issues

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Article ; Online: Improved SARS-CoV-2 M

Vuong, Wayne / Fischer, Conrad / Khan, Muhammad Bashir / van Belkum, Marco J / Lamer, Tess / Willoughby, Kurtis D / Lu, Jimmy / Arutyunova, Elena / Joyce, Michael A / Saffran, Holly A / Shields, Justin A / Young, Howard S / Nieman, James A / Tyrrell, D Lorne / Lemieux, M Joanne / Vederas, John C

European journal of medicinal chemistry

2021 Volume 222, Page(s) 113584

Abstract: Replication of SARS-CoV-2, the coronavirus causing COVID-19, requires a main protease (M ...

Abstract	Replication of SARS-CoV-2, the coronavirus causing COVID-19, requires a main protease (M
MeSH term(s)	Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Binding Sites ; Chlorocebus aethiops ; Coronavirus 3C Proteases/antagonists & inhibitors ; Coronavirus 3C Proteases/chemistry ; Coronavirus 3C Proteases/metabolism ; Crystallography, X-Ray ; Cysteine Proteinase Inhibitors/chemical synthesis ; Cysteine Proteinase Inhibitors/metabolism ; Cysteine Proteinase Inhibitors/pharmacology ; Humans ; Micelles ; Microbial Sensitivity Tests ; Molecular Structure ; Protein Binding ; Pyrrolidines/chemical synthesis ; Pyrrolidines/metabolism ; Pyrrolidines/pharmacology ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology ; Solubility ; Structure-Activity Relationship ; Sulfonic Acids/chemical synthesis ; Sulfonic Acids/metabolism ; Sulfonic Acids/pharmacology ; Vero Cells
Chemical Substances	Antiviral Agents ; Cysteine Proteinase Inhibitors ; Micelles ; Pyrrolidines ; Sulfonic Acids ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28) ; GC376 (H1NMJ5XDG5)
Language	English
Publishing date	2021-05-30
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2021.113584
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Zs.B 784: Show issues

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Article ; Online: Synthesis, Characterization, and Application of Muscarinergic M

Köckenberger, Johannes / Fischer, Oliver / Konopa, Andreas / Bergwinkl, Sebastian / Mühlich, Susanne / Gmeiner, Peter / Kutta, Roger Jan / Hübner, Harald / Keller, Max / Heinrich, Markus R

Journal of medicinal chemistry

2022

Abstract: Through the linkage of two muscarinergic M ...

Abstract	Through the linkage of two muscarinergic M
Language	English
Publishing date	2022-12-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.2c01376
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Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

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Article ; Online: Further Evidence for Shape Coexistence in ^{79}Zn^{m} near Doubly Magic ^{78}Ni.

Nies, L / Canete, L / Dao, D D / Giraud, S / Kankainen, A / Lunney, D / Nowacki, F / Bastin, B / Stryjczyk, M / Ascher, P / Blaum, K / Cakirli, R B / Eronen, T / Fischer, P / Flayol, M / Girard Alcindor, V / Herlert, A / Jokinen, A / Khanam, A /

Köster, U / Lange, D / Moore, I D / Müller, M / Mougeot, M / Nesterenko, D A / Penttilä, H / Petrone, C / Pohjalainen, I / de Roubin, A / Rubchenya, V / Schweiger, Ch / Schweikhard, L / Vilen, M / Äystö, J

Physical review letters

2023 Volume 131, Issue 22, Page(s) 222503

Abstract: Isomers close to doubly magic _{28}^{78}Ni_{50} provide essential information on the shell evolution and shape coexistence near the Z=28 and N=50 double shell closure. We report the excitation energy measurement of the 1/2^{+} isomer in _{30}^{79}Zn_{49} ...

Abstract	Isomers close to doubly magic _{28}^{78}Ni_{50} provide essential information on the shell evolution and shape coexistence near the Z=28 and N=50 double shell closure. We report the excitation energy measurement of the 1/2^{+} isomer in _{30}^{79}Zn_{49} through independent high-precision mass measurements with the JYFLTRAP double Penning trap and with the ISOLTRAP multi-reflection time-of-flight mass spectrometer. We unambiguously place the 1/2^{+} isomer at 942(10) keV, slightly below the 5/2^{+} state at 983(3) keV. With the use of state-of-the-art shell-model diagonalizations, complemented with discrete nonorthogonal shell-model calculations which are used here for the first time to interpret shape coexistence, we find low-lying deformed intruder states, similar to other N=49 isotones. The 1/2^{+} isomer is interpreted as the bandhead of a low-lying deformed structure akin to a predicted low-lying deformed band in ^{80}Zn, and points to shape coexistence in ^{79,80}Zn similar to the one observed in ^{78}Ni. The results make a strong case for confirming the claim of shape coexistence in this key region of the nuclear chart.
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.222503
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Article ; Online: Oncostatin M promotes lipolysis in white adipocytes.

van Krieken, Pim P / Roos, Julian / Fischer-Posovszky, Pamela / Wueest, Stephan / Konrad, Daniel

Adipocyte

2022 Volume 11, Issue 1, Page(s) 315–324

Abstract: Oncostatin M (OSM) is a member of the glycoprotein 130 cytokine family that is involved in chronic ...

Abstract	Oncostatin M (OSM) is a member of the glycoprotein 130 cytokine family that is involved in chronic inflammation and increased in adipose tissue under obesity and insulin resistance. OSM was shown to inhibit adipogenesis, suppress browning, and contribute to insulin resistance in cultured white adipocytes. In contrast, OSM may have a metabolically favourable role on adipocytes in mouse models of obesity and insulin resistance. However, a putative role of OSM in modulating lipolysis has not been investigated in detail to date. To address this, cultured white adipocytes of mouse or human origin were exposed to 10 or 100 ng/ml of OSM for various time periods. In murine 3T3-L1 cells, OSM stimulation directly activated hormone-sensitive lipase (HSL) and other players of the lipolytic machinery, and dose-dependently increased free fatty acid and glycerol release. In parallel, OSM attenuated insulin-mediated suppression of lipolysis and induced phosphorylation of serine-residues on the insulin receptor substrate-1 (IRS1) protein. Key experiments were verified in a second murine and a human adipocyte cell line. Inhibiton of extracellular signal-regulated kinase (ERK)-1/2 activation, abolished OSM-mediated HSL phosphorylation and lipolysis. In conclusion, OSM signalling directly promotes lipolysis in white adipocytes in an ERK1/2-dependent manner.
MeSH term(s)	3T3-L1 Cells ; Adipocytes, White/drug effects ; Adipocytes, White/metabolism ; Animals ; Dose-Response Relationship, Drug ; Fatty Acids/metabolism ; Glycerol/metabolism ; Humans ; Insulin Receptor Substrate Proteins/metabolism ; Insulin Resistance ; Lipolysis ; Mice ; Obesity/metabolism ; Oncostatin M/pharmacology
Chemical Substances	Fatty Acids ; IRS1 protein, human ; Insulin Receptor Substrate Proteins ; Irs1 protein, mouse ; Oncostatin M (106956-32-5) ; Glycerol (PDC6A3C0OX)
Language	English
Publishing date	2022-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2681769-X
ISSN	2162-397X ; 2162-397X
ISSN (online)	2162-397X
ISSN	2162-397X
DOI	10.1080/21623945.2022.2075129
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Article ; Online: Fomitiporia mediterranea M. Fisch., the historical Esca agent

Moretti, Samuele / Pacetti, Andrea / Pierron, Romain / Kassemeyer, Hanns-Heinz / Fischer, Michael / Péros, Jean-Pierre / Perez-Gonzalez, Gabriel / Bieler, Evie / Schilling, Marion / Di Marco, Stefano / Gelhaye, Eric / Mugnai, Laura / Bertsch, Christophe / Farine, Sibylle

a comprehensive review on the main grapevine wood rot agent in Europe

2021

Abstract: Fomitiporia mediterranea M. Fisch. (Fmed) is a basidiomycete first described in 2002, and was ...

Abstract	Fomitiporia mediterranea M. Fisch. (Fmed) is a basidiomycete first described in 2002, and was considered up to then as part of Fomitiporia punctata (P. Karst) Murrill. This fungus can degrade lignocellulosic biomass, causing white rot and leaving bleached fibrous host residues. In Europe Fmed is considered the main grapevine wood rot (Esca) agent within the Esca disease complex, which includes some of the most economically important Grapevine Trunk Diseases (GTDs). This review summarises and evaluates published research on Fmed, on white rot elimination by curettage or management by treatments with specific products applied to diseased grapevines, and on the relationship between wood symptoms and Grapevine Leaf Stripe Disease (GLSD) in the Esca disease complex. Information is also reviewed on the fungus biology, mechanisms of pathogenicity, and their possible relationships with external foliar symptoms of the Esca disease complex. Information on Fmed control strategies is also reviewed.
Keywords	Text ; ddc:630 ; Fmed -- Basidiomycete -- white rot -- wood symptoms -- foliar symptoms
Language	English
Publisher	Firenze University Press
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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