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Article ; Online: Essential Oils from Some Lamiaceae Plants: Antioxidant and Anticancer Potentials besides Thermal Properties.

Kilinç, Büşra Özlem / Gödelek, Duygu / Süfer, Özge / Saygideğer Demir, Burcu / Sezan, Aycan / Saygideğer, Yasemin / Bozok, Fuat

Chemistry & biodiversity

2022 Volume 19, Issue 10, Page(s) e202200418

Abstract: The purpose of this study was to determine the chemical compositions, antioxidant and anticancer activities and thermal behavior of essential oils (EOs) obtained by a microwave assisted Clevenger apparatus from Mentha longifolia subsp. typhoides var. ... ...

Abstract	The purpose of this study was to determine the chemical compositions, antioxidant and anticancer activities and thermal behavior of essential oils (EOs) obtained by a microwave assisted Clevenger apparatus from Mentha longifolia subsp. typhoides var. typhoides (ML), Thymus kotschyanus var. glabrescens (TK), Calamintha nepeta subsp. nepeta (CN) and Satureja cuneifolia (SC) in Osmaniye, Turkey. Nepetalactone (34.23 %), thymol (37.40 %), piperitone oxide (27.25 %), and carvacrol (28.34 %) were major compounds in the EOs of ML, TK, CN, and SC. Total phenolic content and antioxidant activity (by FRAP assay) were in the range of 0.27-3.01 mg gallic acid equivalents and 0.62-171.14 μmol trolox equivalent per g EO, respectively. IC
MeSH term(s)	Antioxidants/pharmacology ; Antioxidants/chemistry ; Gallic Acid ; Lamiaceae/chemistry ; Oils, Volatile/pharmacology ; Oils, Volatile/chemistry ; Oxides ; Plant Oils/chemistry ; Plants ; Satureja ; Thymol
Chemical Substances	Antioxidants ; Gallic Acid (632XD903SP) ; Oils, Volatile ; Oxides ; Plant Oils ; Thymol (3J50XA376E) ; piperitone oxide
Language	English
Publishing date	2022-09-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202200418
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Article ; Online: Adulthood asthma as a consequence of childhood adversity: a systematic review of epigenetically affected genes.

Saygideger, Yasemin / Özkan, Hakan / Baydar, Oya / Yilmaz, Ozge

Journal of developmental origins of health and disease

2022 Volume 13, Issue 6, Page(s) 674–682

Abstract: There is an accumulating data that shows relation between childhood adversity and vulnerability to chronic diseases as well as epigenetic influences that in turn give rise to these diseases. Asthma is one of the chronic diseases that is influenced from ... ...

Abstract	There is an accumulating data that shows relation between childhood adversity and vulnerability to chronic diseases as well as epigenetic influences that in turn give rise to these diseases. Asthma is one of the chronic diseases that is influenced from genetic regulation of the inflammatory biomolecules and therefore the hypothesis in this research was childhood adversity might have caused epigenetic differentiation in the asthma-related genes in the population who had childhood trauma. To test this hypothesis, the literature was systematically reviewed to extract epigenetically modified gene data of the adults who had childhood adversity, and affected genes were further evaluated for their association with asthma. PRISMA guidelines were adopted and PubMed and Google Scholar were included in the searched databases, to evaluate epigenetic modifications in asthma-related genes of physically, emotionally or sexually abused children. After retrieving a total of 5245 articles, 36 of them were included in the study. Several genes and pathways that may contribute to pathogenesis of asthma development, increased inflammation, or response to asthma treatment were found epigenetically affected by childhood traumas. Childhood adversity, causing epigenetic changes in DNA, may lead to asthma development or influence the course of the disease and therefore should be taken into account for the prolonged health consequences.
MeSH term(s)	Child ; Adult ; Humans ; Adverse Childhood Experiences ; Asthma/genetics ; Epigenesis, Genetic ; Inflammation
Language	English
Publishing date	2022-03-08
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	2554780-X
ISSN	2040-1752 ; 2040-1744
ISSN (online)	2040-1752
ISSN	2040-1744
DOI	10.1017/S2040174422000083
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Article: DNA Binding and Anticancer Properties of New Pd(II)-Phosphorus Schiff Base Metal Complexes.

Saygıdeğer Demir, Burcu / İnce, Simay / Yilmaz, Mustafa Kemal / Sezan, Aycan / Derinöz, Ezgi / Taskin-Tok, Tugba / Saygideger, Yasemin

Pharmaceutics

2022 Volume 14, Issue 11

Abstract: DNA has become the target of metal complexes in cancer drug discovery. Due to the side effects of widely known cisplatin and its derivative compounds, alternative metal-based drug discovery studies are still ongoing. In this study, the DNA-binding ... ...

Abstract	DNA has become the target of metal complexes in cancer drug discovery. Due to the side effects of widely known cisplatin and its derivative compounds, alternative metal-based drug discovery studies are still ongoing. In this study, the DNA-binding ability of Pd(II) and Pt(II) complexes of four phosphorus Schiff base ligands and four hydrazonoic-phosphines are investigated by using in silico analyses. Phosphorus Schiff base-Pd(II) complexes encoded as
Language	English
Publishing date	2022-11-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14112409
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Article ; Online: Exposure to COVID-19 among unvaccinated healthcare personnel and risk for infection: a single-center retrospective study.

Candevir, Aslıhan / Ertürk, Damla / Kuşcu, Ferit / Kömür, Süheyla / Saygideğer, Yasemin / Inal, A Seza / Özyilmaz, Ezgi / Kurtaran, Behice / Taşova, Yeşim

Journal of infection in developing countries

2023 Volume 17, Issue 8, Page(s) 1081–1087

Abstract: Introduction: Characteristics of exposure and infection risk, are important in strategy development for infection control among healthcare workers (HCWs). Our objective was to investigate the characteristics of exposure of HCWs to SARS-CoV-2 and ... ...

Abstract	Introduction: Characteristics of exposure and infection risk, are important in strategy development for infection control among healthcare workers (HCWs). Our objective was to investigate the characteristics of exposure of HCWs to SARS-CoV-2 and determine the risk of COVID-19 development. Methodology: This is a retrospective single-center cohort study, conducted between March and December 2020. Unvaccinated and exposed HCWs were asked to complete a standard form, including demographic data and characteristics of exposure(s). Exposures were stratified according to national guidelines. STROBE checklist was used. Results: Among a total of 4,385 healthcare workers, 1,483 HCWs (33.8%) with a total of 1,903 exposures to SARS-CoV-2 were identified. Median age was 31 (IQR: 26-40) years and 45.4% were male (N = 673). Following exposure, 78 HCWs became SARS-CoV-2-positive (attack rate: 3.9%) and secondary attack rate was 4/16. In terms of infection, exposure to SARS-CoV-2-positive HCWs posed a greater risk compared to contact with patients (8.9%, [n = 66] vs. 3.8% [n = 12], respectively, p = 0.003). PCR positivity rates were 11.5%, 6.3%, and 8.4% for low, medium, and high-risk contacts (p = 0.152). Median time to infection post-exposure was 7 (IQR: 4-13) days. Conclusions: Given the attack rates, there was no correlation between risk levels and PCR test positivity rates. There was no difference between HCWs with or without work restrictions, in terms of PCR positivity. Due to feasibility issues, prioritizing universally applied symptom screening and resource control strategies and suspending contact tracing and work restrictions, appear to be safe during high prevalence period.
MeSH term(s)	Humans ; Male ; Adult ; Female ; COVID-19/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; Cohort Studies ; Health Personnel ; Delivery of Health Care
Language	English
Publishing date	2023-08-31
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2394024-4
ISSN	1972-2680 ; 2036-6590
ISSN (online)	1972-2680
ISSN	2036-6590
DOI	10.3855/jidc.17798
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Article ; Online: Slug and Vimentin downregulation at the metastatic site is associated with Skip-N2 metastasis of lung adenocarcinoma.

Saygideger, Yasemin / Avci, Alper / Bagir, Emine / Saygıdeğer Demir, Burcu / Sezan, Aycan / Ekici, Mucahit / Baydar, Oya / Erkin, Özgür Cem

Discover. Oncology

2022 Volume 13, Issue 1, Page(s) 7

Abstract: Objective: Lung cancer displays heterogeneity both in the tumor itself and in its metastatic regions. One interesting behavior of the tumor is known as Skip N2 metastasis, which N2 lymph nodes contain tumor cells while N1 are clean. In this study, mRNA ... ...

Abstract	Objective: Lung cancer displays heterogeneity both in the tumor itself and in its metastatic regions. One interesting behavior of the tumor is known as Skip N2 metastasis, which N2 lymph nodes contain tumor cells while N1 are clean. In this study, mRNA levels of epithelial mesenchymal transition (EMT) related genes in skip N2 and normal N2 involvements of non-small cell lung cancer tissues were investigated to evaluate the possible molecular background that may contribute to the pathogenesis of Skip N2 metastasis. Materials and methods: Eighty-three surgically resected and paraffin embedded lymph node samples of lung cancer patients were analyzed in this study, which 40 of them were Skip N2. N2 tissues were sampled from 50% tumor containing areas and total RNA was extracted. mRNA levels for 18S, E-cadherin, Vimentin, ZEB1 and SLUG were analyzed via qPCR and E-cadherin and vimentin protein levels via immunohistochemistry (IHC). Bioinformatic analysis were adopted using online datasets to evaluate significantly co-expressed genes with SLUG in lung cancer tissue samples. Results: Skip-N2 patients who had adenocarcinoma subtype had better survival rates. Comparative analysis of PCR results indicated that Skip N2 tumor tissues had increased E-Cadherin/Vimentin ratio and ZEB1 mRNA expression, and significantly decreased levels of SLUG. E-cadherin IHC staining were higher in Skip N2 and Vimentin were in Non-Skip N2. TP63 had a strong correlation with SLUG expression in the bioinformatics analyses. Conclusion: The results indicate that, at molecular level, Skip N2 pathogenesis has different molecular background and regulation of SLUG expression may orchestrate the process.
Language	English
Publishing date	2022-01-22
Publishing country	United States
Document type	Journal Article
ISSN	2730-6011
ISSN (online)	2730-6011
DOI	10.1007/s12672-022-00467-4
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Article ; Online: Correction: YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model.

Minas, Tsion Zewdu / Han, Jenny / Javaheri, Tahereh / Hong, Sung-Hyeok / Schlederer, Michaela / Saygideğer-Kont, Yasemin / Çelik, Haydar / Mueller, Kristina M / Temel, Idil / Özdemirli, Metin / Kovar, Heinrich / Erkizan, Hayriye Verda / Toretsky, Jeffrey / Kenner, Lukas / Moriggl, Richard / Üren, Aykut

Oncotarget

2024 Volume 15, Page(s) 143

Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.28524
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Article ; Online: Evaluation of the antitumor activity of a series of the pincer-type metallocomplexes produced from isonicotinohydrazide derivative.

Saygıdeğer Demir, Burcu / Mahmoudi, Ghodrat / Sezan, Aycan / Derinöz, Ezgi / Nas, Eylem / Saygideger, Yasemin / Zubkov, Fedor I / Zangrando, Ennio / Safin, Damir A

Journal of inorganic biochemistry

2021 Volume 223, Page(s) 111525

Abstract: In this work we report on the antitumor properties of a series of pincer-type metallocomplexes [ ... ...

Abstract	In this work we report on the antitumor properties of a series of pincer-type metallocomplexes [Hg
MeSH term(s)	Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Coordination Complexes/chemical synthesis ; Coordination Complexes/pharmacology ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Drug Screening Assays, Antitumor ; Humans ; Isoniazid/analogs & derivatives ; Isoniazid/pharmacology ; Molecular Structure ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	Antineoplastic Agents ; CDKN1A protein, human ; Coordination Complexes ; Cyclin-Dependent Kinase Inhibitor p21 ; TP53 protein, human ; Tumor Suppressor Protein p53 ; Isoniazid (V83O1VOZ8L)
Language	English
Publishing date	2021-06-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2021.111525
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Article ; Online: Relationship between disease severity and prognostic indicators and matrix metallaproteinase in patients with stable idiopatic pulmonary fibrosis

Efraim Güzel / Yasemin Saygideger / Ezgi Özyılmaz / Oya Baydar Toprak

Cukurova Medical Journal, Vol 47, Iss 3, Pp 1273-

2022 Volume 1280

Abstract: Purpose: Blood-derived biomarkers have been extensively considered as possible prognostic indicators in idiopathic pulmonary fibrosis (IPF) recently. In order to assess the value of circulating biomarkers in common IPF clinical practice, the study ... ...

Abstract	Purpose: Blood-derived biomarkers have been extensively considered as possible prognostic indicators in idiopathic pulmonary fibrosis (IPF) recently. In order to assess the value of circulating biomarkers in common IPF clinical practice, the study intends to draw conclusions regarding the link between disease severity, prognostic indicators, and serum matrix metalloproteinase in patients with stable idiopathic pulmonary fibrosis. Materials and Methods: The study comprised 22 people with an IPF diagnosis that had been verified by a multidisciplinary approach. The sociodemographic details, clinical and radiologic symptoms, pulmonary function tests and the Gender-Age-Physiology (GAP) score were noted. ELISA has been used to research serum MMP concentrations. Results: There is no statistically significant correlation between the Matrix Metalloproteinase (MMP) 2, MMP 7, MMP 9, and MMP13 and the GAP index and, pulmonary function tests, or disease severity. GAP score was found to be higher in stage 3 in patients with severe disease, in stage 2 in patients with moderate disease, and in stage 1 in patients with mild disease. Conclusion: There are consistent findings in the literature, despite the fact that the association between MMP and IPF prognostic markers, pulmonary function tests, and disease severity could not be seen in this investigation. However, because they could open the door to a cutting-edge treatment strategy, these indicators should be investigated prospectively in larger series.
Keywords	idiopathic pulmonary fibrosis ; matrix metalloproteinases ; gap ; severity ; biomarkers ; idiopatik pulmoner fibrozis ; matrix metalloproteinaz ; ciddiyet ; biyomarker ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-09-01T00:00:00Z
Publisher	Cukurova University
Document type	Article ; Online
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Article ; Online: Differential Proteomics of

Shah, Syed Ali Raza / Rahman, Hazir / Qasim, Muhammad / Akram, Muhammad Safwan / Saygideger, Yasemin / Puspita, Nanda / Saygıdeğer Demir, Burcu / Alzahrani, Khalid J / Rehman, Muhammad Fayyaz Ur / Alzahrani, Fuad M / Alblihd, Mohamed A

Medicina (Kaunas, Lithuania)

2022 Volume 58, Issue 9

Abstract: Background and ... ...

Abstract	Background and Objective
MeSH term(s)	Gastritis/microbiology ; Glycogen Synthase/metabolism ; Helicobacter Infections/microbiology ; Helicobacter pylori ; Humans ; Hydrogenase/metabolism ; Nucleoside-Diphosphate Kinase/metabolism ; Pakistan ; Peroxiredoxins/metabolism ; Proteome/metabolism ; Proteomics ; Stomach Neoplasms/pathology ; Tandem Mass Spectrometry ; Ulcer
Chemical Substances	Proteome ; Peroxiredoxins (EC 1.11.1.15) ; Hydrogenase (EC 1.12.7.2) ; Glycogen Synthase (EC 2.4.1.11) ; Nucleoside-Diphosphate Kinase (EC 2.7.4.6)
Language	English
Publishing date	2022-08-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina58091168
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Article ; Online: COVID-19 patients' sera induce epithelial mesenchymal transition in cancer cells.

Saygideger, Yasemin / Sezan, Aycan / Candevir, Aslihan / Saygıdeğer Demir, Burcu / Güzel, Efraim / Baydar, Oya / Derinoz, Ezgi / Komur, Suheyla / Kuscu, Ferit / Ozyılmaz, Ezgi / Kuleci, Sedat / Hanta, Ismail / Akkız, Hikmet / Tasova, Yesim

Cancer treatment and research communications

2021 Volume 28, Page(s) 100406

Abstract: Covid-19 Pneumonia of SARS-CoV-2 pandemic infection, persists to have high disease burden especially in cancer patients. Increased inflammation and thromboembolic processes are blamed to influence cancer patients more than the others but due to lack of ... ...

Abstract	Covid-19 Pneumonia of SARS-CoV-2 pandemic infection, persists to have high disease burden especially in cancer patients. Increased inflammation and thromboembolic processes are blamed to influence cancer patients more than the others but due to lack of knowledge regarding the pathophysiology of the both the virus itself and the response of the host, more basic and translational disease modeling research is needed to understand Cancer-Covid-19 interaction. In this study, serum samples from the patients, who were hospitalized due to Covid-19 pneumonia, applied to different cancer cells and cytotoxicity, motility, proliferation and gene expression analysis were performed. Serum samples derived from healthy volunteers and the fetal bovine serum that is used regularly in cell culture experiments used as controls. Hospitalized Covid-19 patients who had also cancer, were retrospectively screened, and their clinical course were recorded. Overall 12 Patient (PS) and 4 healthy serums (CS) were included in the experiments. PS applied cells showed increased motility in A549 cells as well as lost cell to cell connection in MCF7 and HCT116 cells, and induced expression of VIM, ZEB1 and SNAIL2 mRNA levels. Eight cancer diagnosed patients who were hospitalized due to Covid-19 between April and September 2020 were also reviewed retrospectively, which 5 of them were dead during SARS-CoV-2 infection. Thorax CT images of the 2 patients showed increased metastatic nodules in the lungs as of January 2021. The results of the study indicate that metastasis may be one of the prolonged consequences of COVID-19 pandemic in cancer sufferers.
MeSH term(s)	Adult ; Aged ; COVID-19/complications ; COVID-19/immunology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Cytotoxicity, Immunologic ; Epithelial-Mesenchymal Transition/physiology ; Female ; Humans ; Immune Sera/adverse effects ; Immune Sera/toxicity ; Lung Neoplasms/secondary ; Lung Neoplasms/virology ; Male ; Middle Aged ; Neoplasms/immunology ; Neoplasms/pathology
Chemical Substances	Immune Sera
Language	English
Publishing date	2021-05-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2468-2942
ISSN (online)	2468-2942
DOI	10.1016/j.ctarc.2021.100406
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