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Article ; Online: Clinical outcomes, quality of life, and costs evaluation of peritoneal dialysis management models in Shanghai Songjiang District: a multi-center and prospective cohort study.

Ma, Xiaoyan / Tao, Min / Hu, Yan / Tang, Lunxian / Lu, Jiasun / Shi, Yingfeng / Chen, Hui / Chen, Si / Wang, Yi / Cui, Binbin / Du, Lin / Liang, Weiwei / Huang, Guansen / Zhou, Xun / Qiu, Andong / Zhuang, Shougang / Zang, Xiujuan / Liu, Na

Renal failure

2021 Volume 43, Issue 1, Page(s) 754–765

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Aged ; China ; Female ; Hospitalization/economics ; Humans ; Kidney Failure, Chronic/economics ; Kidney Failure, Chronic/psychology ; Kidney Failure, Chronic/therapy ; Male ; Mental Health ; Middle Aged ; Peritoneal Dialysis/adverse effects ; Peritoneal Dialysis/economics ; Peritonitis/epidemiology ; Peritonitis/etiology ; Prospective Studies ; Quality of Life
Language	English
Publishing date	2021-04-28
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2021.1918164
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Article ; Online: Exploring the safety profile of tremelimumab: an analysis of the FDA adverse event reporting system.

Zhao, Yibei / Jiang, Huiming / Xue, Lifen / Zhou, Mi / Zhao, Xiaobing / Liu, Fei / Jiang, SongJiang / Huang, Jing / Meng, Long

International journal of clinical pharmacy

2024 Volume 46, Issue 2, Page(s) 480–487

Abstract: Background: Despite the approval of tremelimumab in 2022, there is a lack of pharmacovigilance studies investigating its safety profile in real-world settings using the FDA Adverse Event Reporting System (FAERS) database.: Aim: This pharmacovigilance ...

Abstract	Background: Despite the approval of tremelimumab in 2022, there is a lack of pharmacovigilance studies investigating its safety profile in real-world settings using the FDA Adverse Event Reporting System (FAERS) database. Aim: This pharmacovigilance study aimed to comprehensively explore the adverse events (AEs) associated with tremelimumab using data mining techniques on the FAERS database. Method: The study utilized data from the FAERS database, covering the period from the first quarter of 2004 to the third quarter of 2022. Disproportionality analysis, the Benjamini Hochberg adjustment method and volcano plots were used to identify and evaluate AE signals associated with tremelimumab. Results: The study uncovered 233 AE cases associated with tremelimumab. Among these cases, pyrexia (n = 39), biliary tract infection (n = 23), and sepsis (n = 21) were the three main AEs associated with tremelimumab use. The study also investigated the system organ classes associated with tremelimumab-related AEs. The top three classes were gastrointestinal disorders (17.9%), infections and infestations (16.6%), and general disorders and administration site infections (11.2%). Several AEs were identified that were not listed on the drug label of tremelimumab. These AEs included pyrexia, biliary tract infection, sepsis, dyspnea, infusion site infection, hiccup, appendicitis, hypotension, dehydration, localised oedema, presyncope, superficial thrombophlebitis and thrombotic microangiopathy. Conclusion: This pharmacovigilance study identified several potential adverse events signals related to tremelimumab including some adverse events not listed on the drug label. However, further basic and clinical research studies are needed to validate these results.
MeSH term(s)	Humans ; United States/epidemiology ; Adverse Drug Reaction Reporting Systems ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Pharmacovigilance ; Sepsis ; United States Food and Drug Administration ; Fever ; Antibodies, Monoclonal, Humanized
Chemical Substances	tremelimumab (QEN1X95CIX) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2024-01-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2601204-2
ISSN	2210-7711 ; 2210-7703 ; 0928-1231
ISSN (online)	2210-7711
ISSN	2210-7703 ; 0928-1231
DOI	10.1007/s11096-023-01678-7
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Article ; Online: Regulation of ferroptosis-related genes in CD8+ NKT cells and classical monocytes may affect the immunotherapy response after combined treatment in triple negative breast cancer.

Liu, Zheming / He, Songjiang / Huang, Zhou / Liu, Jiahui / Gong, Yiping / Yao, Yi / Zhang, Xue

Thoracic cancer

2023 Volume 14, Issue 34, Page(s) 3369–3380

Abstract: Background: Drug resistance has led to the failure of immunotherapy in triple negative breast cancer patients. Here we aimed to explore the mechanisms of drug resistance in patients in order to enhance their response to immunotherapy.: Methods: We ... ...

Abstract	Background: Drug resistance has led to the failure of immunotherapy in triple negative breast cancer patients. Here we aimed to explore the mechanisms of drug resistance in patients in order to enhance their response to immunotherapy. Methods: We downloaded publicly available single-cell RNA-sequencing data of peripheral blood mononuclear cells from patients after treatment to investigate the possible mechanisms of drug resistance. The publicly available TCGA transcriptomic data and somatic mutation data were used for further validation. In this study, a series of bioinformatics and machine learning methods were employed. Results: We identified the vital roles of CD8+ NKT cells and classical monocytes in the immunotherapy response of triple-negative breast cancer patients. The proportion of these cell types was significantly increased in group partial response. We also found that downregulation of ferroptosis-related genes regulates the immune pathway. The analysis of scRNA data and TCGA transcriptomic data presented that DUSP1 may play a crucial role in immunotherapy resistance. Conclusion: Overall, the composition of the tumor microenvironment affects the immunotherapy response of patients, and DUSP1 may be a potential target for overcoming drug resistance.
MeSH term(s)	Humans ; Monocytes ; Triple Negative Breast Neoplasms/drug therapy ; Triple Negative Breast Neoplasms/genetics ; Ferroptosis/genetics ; Natural Killer T-Cells ; Immunotherapy ; CD8-Positive T-Lymphocytes ; Tumor Microenvironment
Language	English
Publishing date	2023-10-13
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2625856-0
ISSN	1759-7714 ; 1759-7706
ISSN (online)	1759-7714
ISSN	1759-7706
DOI	10.1111/1759-7714.15128
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Zs.A 6921: Show issues

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Article ; Online: Macrophage pyroptosis promotes synovial fibrosis through the HMGB1/TGF- β1 axis: an in vivo and in vitro study.

Wu, Peng / Liao, Taiyang / Ma, Zhenyuan / Wei, Yibao / Yin, Songjiang / Huang, Zhengquan / Mao, Jun

In vitro cellular & developmental biology. Animal

2023 Volume 59, Issue 4, Page(s) 289–299

Abstract: Macrophages and fibroblasts are the main effector cells in synovial tissue in the knee joint. Our previous studies showed that there was synovial macrophage pyroptosis in knee osteoarthritis (KOA) and that inhibiting this pyroptosis could alleviate ... ...

Abstract	Macrophages and fibroblasts are the main effector cells in synovial tissue in the knee joint. Our previous studies showed that there was synovial macrophage pyroptosis in knee osteoarthritis (KOA) and that inhibiting this pyroptosis could alleviate synovial fibrosis. In the present study, we aimed to elucidate the mechanism by which macrophage pyroptosis affects synovial fibrosis. We established an LPS/ATP-induced model in macrophages that mimicked the inflammatory environment of KOA and induced macrophage pyroptosis. The TGF-β1, SMAD3, and P-SMAD3, and the synovial fibrosis markers (Collagen I, TIMP1, Vimentin, and TGF-β1) were significantly decreased after fibroblasts were cultured with RAGE inhibitors and SMAD3 inhibitors. Moreover, ELISA and immunofluorescence analysis showed that macrophage pyroptosis induced the release of IL-1β, IL-18, and HMGB1 and caused the translocation of HMGB1 from the fibroblast nucleus to the cell membrane, where it could bind with RAGE. Subsequently, in the synovial tissue of KOA model rats, we observed that inhibiting HMGB1, RAGE, and SMAD3 could alleviate the expression of synovial fibrosis markers (Collagen I, TIMP1, Vimentin, and TGF-β1) at both the mRNA and protein levels. Besides, HE and Sirius Red staining were used to observe the transverse diameter of the right knee. In conclusion, macrophage pyroptosis induced IL-1β, IL-18, and HMGB1, which could be caused HMGB1 to translocate from the fibroblast nucleus and bind with RAGE, activating the TGF-β1/SMAD3 signaling pathway and affecting synovial fibrosis.
MeSH term(s)	Rats ; Animals ; Transforming Growth Factor beta1 ; Interleukin-18/metabolism ; Vimentin/metabolism ; HMGB1 Protein/metabolism ; Pyroptosis ; Fibrosis ; Collagen Type I/genetics ; Macrophages/metabolism
Chemical Substances	Transforming Growth Factor beta1 ; Interleukin-18 ; Vimentin ; HMGB1 Protein ; Collagen Type I
Language	English
Publishing date	2023-05-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1077810-x
ISSN	1543-706X ; 0883-8364 ; 1071-2690
ISSN (online)	1543-706X
ISSN	0883-8364 ; 1071-2690
DOI	10.1007/s11626-023-00769-z
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Zs.A 851: Show issues

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Article ; Online: TIPS placement as the first-line therapy to prevent variceal rebleeding in patients with cirrhosis and sarcopenia.

Xiong, Bin / Yang, Chongtu / Zhou, Chen / Wu, Xiaomei / Huang, Songjiang

European journal of radiology

2022 Volume 158, Page(s) 110630

Abstract: Purpose: Sarcopenia increases the risk of mortality and hepatic encephalopathy (HE) in cirrhosis, and is a potential indication for transjugular intrahepatic portosystemic shunt (TIPS). The aim was to investigate the prognostic effect of sarcopenia in ... ...

Abstract	Purpose: Sarcopenia increases the risk of mortality and hepatic encephalopathy (HE) in cirrhosis, and is a potential indication for transjugular intrahepatic portosystemic shunt (TIPS). The aim was to investigate the prognostic effect of sarcopenia in patients with cirrhosis who received TIPS for prevention of variceal rebleeding. Method: We retrospectively included 262 patients with cirrhosis receiving TIPS as the first-line treatment for prevention of rebleeding. L3 skeletal muscle index (SMI) was measured and sarcopenia was defined using sex-specific cutoffs. Incidence of post-TIPS mortality and overt HE, and changes of L3-SMI before and after TIPS were compared between the non-sarcopenia and sarcopenia group. Moreover, 21 patients with sarcopenia who received TIPS as the second-line treatment were included for additional comparison. Results: At admission, 99 (37.8 %) and 163 (62.2 %) patients were diagnosed as sarcopenia and non-sarcopenia, respectively. Compared with the non-sarcopenia group, the sarcopenia group had a similar risk of mortality (adjusted hazard ratio [HR] 1.04, 95 % confidence interval [CI]: 0.55-1.96, p = 0.900) and overt HE (adjusted HR 1.20, 95 %CI 0.72-2.00, p = 0.479). The sarcopenia group achieved higher extent of L3-SMI improvement after TIPS than the non-sarcopenia group (7.0 vs 2.4 cm Conclusions: For patients treated with TIPS as the first-line treatment for prevention of rebleeding, baseline sarcopenia did not increase the risk of post-TIPS mortality and overt HE.
Language	English
Publishing date	2022-11-28
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2022.110630
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Zs.A 1630: Show issues

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Article ; Online: Neighbor2Neighbor: A Self-Supervised Framework for Deep Image Denoising.

Huang, Tao / Li, Songjiang / Jia, Xu / Lu, Huchuan / Liu, Jianzhuang

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

2022 Volume 31, Page(s) 4023–4038

Abstract: In recent years, image denoising has benefited a lot from deep neural networks. However, these models need large amounts of noisy-clean image pairs for supervision. Although there have been attempts in training denoising networks with only noisy images, ... ...

Abstract	In recent years, image denoising has benefited a lot from deep neural networks. However, these models need large amounts of noisy-clean image pairs for supervision. Although there have been attempts in training denoising networks with only noisy images, existing self-supervised algorithms suffer from inefficient network training, heavy computational burden, or dependence on noise modeling. In this paper, we proposed a self-supervised framework named Neighbor2Neighbor for deep image denoising. We develop a theoretical motivation and prove that by designing specific samplers for training image pairs generation from only noisy images, we can train a self-supervised denoising network similar to the network trained with clean images supervision. Besides, we propose a regularizer in the perspective of optimization to narrow the optimization gap between the self-supervised denoiser and the supervised denoiser. We present a very simple yet effective self-supervised training scheme based on the theoretical understandings: training image pairs are generated by random neighbor sub-samplers, and denoising networks are trained with a regularized loss. Moreover, we propose a training strategy named BayerEnsemble to adapt the Neighbor2Neighbor framework in raw image denoising. The proposed Neighbor2Neighbor framework can enjoy the progress of state-of-the-art supervised denoising networks in network architecture design. It also avoids heavy dependence on the assumption of the noise distribution. We evaluate the Neighbor2Neighbor framework through extensive experiments, including synthetic experiments with different noise distributions and real-world experiments under various scenarios. The code is available online: https://github.com/TaoHuang2018/Neighbor2Neighbor.
Language	English
Publishing date	2022-06-14
Publishing country	United States
Document type	Journal Article
ISSN	1941-0042
ISSN (online)	1941-0042
DOI	10.1109/TIP.2022.3176533
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Article ; Online: Hypoxia-activated cascade nanovaccine for synergistic chemoembolization-immune therapy of hepatocellular carcinoma.

Shi, Qin / Zhang, Wen / Zhou, Yongjie / Huang, Songjiang / Yu, Jiaze / Yang, Minjie / Zhang, Zihan / Ma, Jingqin / Luo, Jianjun / Rao, Shengxiang / Lu, Daru / Peng, Shaojun / Cao, Yongbin / Liu, Lingxiao / Yan, Zhiping

Biomaterials

2024 Volume 306, Page(s) 122480

Abstract: In this work, a promising treatment strategy for triggering robust antitumor immune responses in transarterial chemoembolization of hepatocellular carcinoma (HCC) is presented. The zeolitic imidazolate framework nanoparticles loaded with hypoxia- ... ...

Abstract	In this work, a promising treatment strategy for triggering robust antitumor immune responses in transarterial chemoembolization of hepatocellular carcinoma (HCC) is presented. The zeolitic imidazolate framework nanoparticles loaded with hypoxia-activated prodrug tirapazamine and immune adjuvant resiquimod facilitated in situ generation of nanovaccine via a facile approach. The nanovaccine can strengthen the ability of killing the liver cancer cells under hypoxic environment, while was capable of improving immunogenic tumor microenvironment and triggering strong antitumor immune responses by increasing the primary and distant intratumoral infiltration of immune cells such as cytotoxic T cells. Moreover, a porous microcarrier, approved by FDA as pharmaceutical excipient, was designed to achieve safe and effective delivery of the nanovaccine via transarterial therapy in rabbit orthotopic VX2 liver cancer model. The microcarrier exhibited the characteristics of excellent drug loading and occlusion of peripheral artery. The collaborative delivery of the microcarrier and nanovaccine demonstrated an exciting inhibitory effect on solid tumors and tumor metastases, which provided a great potential as novel combination therapy for HCC interventional therapy.
MeSH term(s)	Animals ; Rabbits ; Carcinoma, Hepatocellular/drug therapy ; Liver Neoplasms/pathology ; Nanovaccines ; Chemoembolization, Therapeutic ; Hypoxia/drug therapy ; Tumor Microenvironment
Chemical Substances	Nanovaccines
Language	English
Publishing date	2024-01-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2024.122480
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Zs.B 2371: Show issues

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Article ; Online: Macrophage migration inhibitory factor mediates skin aging via CD74: Insights from single-cell and bulk RNA sequencing data.

Wu, Songjiang / Ouyang, Yujie / Hu, Yibo / Jiang, Ling / Fu, Chuhan / Lei, Li / Zhang, Yushan / Guo, Haoran / Huang, Jinhua / Chen, Jing / Zeng, Qinghai

Clinical immunology (Orlando, Fla.)

2024 Volume 263, Page(s) 110199

Abstract: Cell-cell communication is crucial for regulating signaling and cellular function. However, the precise cellular and molecular changes remain poorly understood in skin aging. Based on single-cell and bulk RNA data, we explored the role of cell-cell ... ...

Abstract	Cell-cell communication is crucial for regulating signaling and cellular function. However, the precise cellular and molecular changes remain poorly understood in skin aging. Based on single-cell and bulk RNA data, we explored the role of cell-cell ligand-receptor interaction in skin aging. We found that the macrophage migration inhibitory factor (MIF)/CD74 ligand-receptor complex was significantly upregulatedin aged skin, showing the predominant paracrine effect of keratinocytes on fibroblasts. Enrichment analysis and in vitro experiment revealed a close association of the activation of the MIF/CD74 with inflammatory pathways and immune response. Mechanistically, MIF/CD74 could significantly inhibit PPARγ protein, which thus significantly increased the degree of fibroblast senescence, and significantly up-regulated the expression of senescence-associated secretory phenotype (SASP) factors and FOS gene. Therefore, our study reveals that MIF/CD74 inhibits the activation of the PPAR signaling pathway, subsequently inducing the production of SASP factors and the upregulation of FOS expression, ultimately accelerating fibroblast senescence.
Language	English
Publishing date	2024-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1459903-x
ISSN	1521-7035 ; 1521-6616
ISSN (online)	1521-7035
ISSN	1521-6616
DOI	10.1016/j.clim.2024.110199
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Article ; Online: Crosstalk between G-quadruplex and ROS.

Wu, Songjiang / Jiang, Ling / Lei, Li / Fu, Chuhan / Huang, Jinhua / Hu, Yibo / Dong, Yumeng / Chen, Jing / Zeng, Qinghai

Cell death & disease

2023 Volume 14, Issue 1, Page(s) 37

Abstract: The excessive production of reactive oxygen species (ROS) can lead to single nucleic acid base damage, DNA strand breakage, inter- and intra-strand cross-linking of nucleic acids, and protein-DNA cross-linking involved in the pathogenesis of cancer, ... ...

Abstract	The excessive production of reactive oxygen species (ROS) can lead to single nucleic acid base damage, DNA strand breakage, inter- and intra-strand cross-linking of nucleic acids, and protein-DNA cross-linking involved in the pathogenesis of cancer, neurodegenerative diseases, and aging. G-quadruplex (G4) is a stacked nucleic acid structure that is ubiquitous across regulatory regions of multiple genes. Abnormal formation and destruction of G4s due to multiple factors, including cations, helicases, transcription factors (TFs), G4-binding proteins, and epigenetic modifications, affect gene replication, transcription, translation, and epigenetic regulation. Due to the lower redox potential of G-rich sequences and unique structural characteristics, G4s are highly susceptible to oxidative damage. Additionally, the formation, stability, and biological regulatory role of G4s are affected by ROS. G4s are involved in regulating gene transcription, translation, and telomere length maintenance, and are therefore key players in age-related degeneration. Furthermore, G4s also mediate the antioxidant process by forming stress granules and activating Nrf2, which is suggestive of their involvement in developing ROS-related diseases. In this review, we have summarized the crosstalk between ROS and G4s, and the possible regulatory mechanisms through which G4s play roles in aging and age-related diseases.
MeSH term(s)	Reactive Oxygen Species/metabolism ; Epigenesis, Genetic ; G-Quadruplexes ; DNA/metabolism ; Regulatory Sequences, Nucleic Acid
Chemical Substances	Reactive Oxygen Species ; DNA (9007-49-2)
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-023-05562-0
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Article: The impact of the COVID-19 pandemic on undergraduate and postgraduate students: A cross-sectional survey.

Zhu, Lu / Zhou, Ying / Huang, Yiyue / Lei, Xinxin / Guo, Haoran / Hu, Yibo / Wu, Songjiang / Lei, Li / Guo, Aiyuan

Frontiers in psychiatry

2023 Volume 14, Page(s) 1074597

Abstract: Background: The COVID-19 pandemic has impacted many facets of life. This study focuses on undergraduate and postgraduate students in China to explore how the pandemic has affected health status, daily life, learning situations, graduation-related ... ...

Abstract	Background: The COVID-19 pandemic has impacted many facets of life. This study focuses on undergraduate and postgraduate students in China to explore how the pandemic has affected health status, daily life, learning situations, graduation-related situations, and their studies or work planning. Methods: This study sent online questionnaires to 2,395 participants to investigate the extent to which they were affected by the epidemic in the various aspects mentioned above and to understand what help they tend to get in the face of these effects. Results: A total of 2,000 valid questionnaires were collected. The physical health of 82.90% of the respondents was affected to varying degrees, with male students, non-medical students, and graduates being more affected than female students, students with medical majors, and non-graduates, respectively. The proportion of students affected by mental health, the total amount of physical exercise, emotional life, and interpersonal communication was 86.35, 88.65, 80.15, and 90.15%, respectively. Compared with medical students and non-graduates, non-medical students and graduates were more affected. In addition, students' learning and graduation conditions have also been affected to a certain extent: 13.07% of students may not be able to graduate on time, and the proportion of postgraduate students' graduations affected was higher than that of undergraduate students. Conclusion: The COVID-19 pandemic has affected the health status of students, their daily lives, learning situations, and so on to varying degrees. We need to pay attention to the issues, provide practical solutions, and provide a basis for better responses to similar epidemics in the future.
Language	English
Publishing date	2023-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1074597
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