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Article ; Online: Veno-venous extracorporeal membrane oxygenation in patients with SARS-CoV-2 pneumonia in Brazil: a case series.

Brasil, Lucas Mendes Cunha de Resende / Arruda, Gabriel Nóbrega de / Diniz, Gabriela Bezerra de Freitas / Ikeoka, Dimas Tadahiro / Saliba, Gustavo Niankowski / Camargo, Camila Riberto / Machado, David José de Barros / Duarte, Felipe Aires / Fernandes, Felipe Lourenço

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

2023 Volume 49, Issue 4, Page(s) e20230046

Abstract: Objective: The world has been suffering from the COVID-19 pandemic. Some COVID-19 patients develop severe viral pneumonia, requiring mechanical ventilation and measures to treat refractory hypoxemia, such as a protective ventilation strategy, prone ... ...

Abstract	Objective: The world has been suffering from the COVID-19 pandemic. Some COVID-19 patients develop severe viral pneumonia, requiring mechanical ventilation and measures to treat refractory hypoxemia, such as a protective ventilation strategy, prone positioning, and the use of veno-venous extracorporeal membrane oxygenation (VV-ECMO). We describe a case series of 30 COVID-19 patients who needed VV-ECMO at the Hospital Alemão Oswaldo Cruz, located in the city of São Paulo, Brazil. Methods: We included all patients who required VV-ECMO due to COVID-19 pneumonia between March of 2020 and June of 2021. Results: Prior to VV-ECMO, patients presented with the following median scores: SOFA score, 11; APPS score, 7; Respiratory ECMO Survival Prediction score, 2; and Murray score, 3.3. The 60-day-in-hospital mortality was 33.3% (n = 10). Conclusions: Although our patients had a highly severe profile, our results were similar to those of other cohort studies in the literature. This demonstrates that VV-ECMO can be a good tool even in a pandemic situation when it is managed in an experienced center.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/therapy ; Extracorporeal Membrane Oxygenation/methods ; Pandemics ; Brazil/epidemiology ; Retrospective Studies
Language	Portuguese
Publishing date	2023-08-07
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	2223157-2
ISSN	1806-3756 ; 1806-3713
ISSN (online)	1806-3756
ISSN	1806-3713
DOI	10.36416/1806-3756/e20230046
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Increasing transplantability in Brazil: time to discuss Kidney Paired Donation.

Bastos, Juliana / Machado, David José de Barros / David-Neto, Elias

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia

2022 Volume 44, Issue 3, Page(s) 417–422

Abstract: Introduction: Kidney transplantation (KT) is the best treatment for chronic kidney disease. In Brazil, there are currently more than 26 thousand patients on the waitlist. Kidney Paired Donation (KPD) offers an incompatible donor-recipient pair the ... ...

Abstract	Introduction: Kidney transplantation (KT) is the best treatment for chronic kidney disease. In Brazil, there are currently more than 26 thousand patients on the waitlist. Kidney Paired Donation (KPD) offers an incompatible donor-recipient pair the possibility to exchange with another pair in the same situation, it is a strategy to raise the number of KT. Discussion: KPD ceased being merely an idea over 20 years ago. It currently accounts for 16.2% of living donors KT (LDKT) in the USA and 8% in Europe. The results are similar to other LDKT. It is a promising alternative especially for highly sensitized recipients, who tend to accumulate on the waitlist. KPD is not limited to developed countries, as excellent results were already published in India in 2014. In Guatemala, the first LDKT through KPD was performed in 2011. However, the practice remains limited to isolated cases in Latin America. Conclusion: KPD programs with different dimensions, acceptance rules and allocation criteria are being developed and expanded worldwide to meet the demands of patients. The rise in transplantability brought about by KPD mostly meets the needs of highly sensitized patients. The Brazilian transplant program is mature enough to accept the challenge of starting its KPD program, intended primarily to benefit patients who have a low probability of receiving a transplant from a deceased donor.
MeSH term(s)	Brazil ; Humans ; Kidney ; Kidney Transplantation/methods ; Living Donors ; Tissue and Organ Procurement
Language	Portuguese
Publishing date	2022-02-03
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2057873-8
ISSN	2175-8239 ; 2175-8239
ISSN (online)	2175-8239
ISSN	2175-8239
DOI	10.1590/2175-8239-JBN-2021-0141
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Article ; Online: Pioneering Experience of First Kidney Paired Donation in Brazil.

Machado, David José de Barros / Nahas, William Carlos / David Neto, Elias

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia

2022 Volume AOP, Page(s) 462–463

MeSH term(s)	Brazil ; Humans ; Kidney ; Living Donors ; Tissue and Organ Procurement
Language	Portuguese
Publishing date	2022-02-02
Publishing country	Brazil
Document type	Letter
ZDB-ID	2057873-8
ISSN	2175-8239 ; 2175-8239
ISSN (online)	2175-8239
ISSN	2175-8239
DOI	10.1590/2175-8239-JBN-2021-0259
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Article: Baseline characteristics and evolution of Brazilian patients with atypical hemolytic uremic syndrome: first report of the Brazilian aHUS Registry.

Vaisbich, Maria Helena / de Andrade, Luís Gustavo Modelli / de Menezes Neves, Precil Diego Miranda / Palma, Lílian Monteiro Pereira / de Castro, Maria Cristina Ribeiro / Silva, Cassiano Augusto Braga / de Holanda Barbosa, Maria Izabel Neves / Penido, Maria Goretti Moreira Guimarães / Neto, Oreste Ângelo Ferra / Sobral, Roberta Mendes Lima / Miranda, Silvana Maria Carvalho / de Almeida Araújo, Stanley / Pietrobom, Igor Gouveia / Takase, Henrique Mochida / Ribeiro, Cláudia / da Silva, Rafael Marques / de Carvalho, César Augusto Almeida / Machado, David José Barros / E Silva, Ana Mateus Simões Teixeira /

da Silva, Andreia Ribeiro / Russo, Enzo Ricardo / Barros, Flávio Henrique Soares / Nasserala, Jarinne Camilo Landim / de Oliveira, Luciana Schmitt Cardon / de Castro Sylvestre, Lucimary / Weissheimer, Rafael / Nascimento, Sueli Oliveira / Bianchini, Gilson / de Carvalho Barreto, Fellype / Veloso, Valéria Soares Pigozzi / Fortes, Patrícia Marques / Colares, Vinicius Sardão / Gomes, Jaelson Guilhem / Leite, André Falcão Pedrosa / Mesquita, Pablo Girardelli Mendonça / Vieira-Neto, Osvaldo Merege

Clinical kidney journal

2022 Volume 15, Issue 8, Page(s) 1601–1611

Abstract: Background: Atypical hemolytic uremic syndrome (aHUS) is an ultra-rare disease. Therefore, studies involving large samples are scarce, making registries powerful tools to evaluate cases. We present herein the first analysis of the Brazilian aHUS ... ...

Abstract	Background: Atypical hemolytic uremic syndrome (aHUS) is an ultra-rare disease. Therefore, studies involving large samples are scarce, making registries powerful tools to evaluate cases. We present herein the first analysis of the Brazilian aHUS Registry (BRaHUS). Methods: Analysis of clinical, laboratory, genetic and treatment data from patients inserted in the BRaHUS, from 2017 to 2020, as an initiative of the Rare Diseases Committee of the Brazilian Society of Nephrology. Results: The cohort consisted of 75 patients (40 adults and 35 pediatric). There was a predominance of women (56%), median age at diagnosis of 20.7 years and a positive family history in 8% of cases. Renal involvement was observed in all cases and 37% had low C3 levels. In the <2 years of age group, males were predominant. Children presented lower levels of hemoglobin ( Conclusions: The cohort of BRaHUS was predominantly composed of female young adults, with renal involvement in all cases. Pediatric patients had lower hemoglobin and platelet levels and higher LDH levels than adults, and the most common genetic variants were identified in
Language	English
Publishing date	2022-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfac097
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Article ; Online: COVID-19 pneumonia in kidney transplant recipients-Where we are?

Machado, David José de Barros / Ianhez, Luiz Estevam

Transplant infectious disease : an official journal of the Transplantation Society

2020 Volume 22, Issue 5, Page(s) e13306

Abstract: In late December 2019, China reported cases of respiratory illness in humans that involved a novel coronavirus SARS-CoV-2. On March 20, 2020, the first coronavirus disease 2019 (COVID-19) in Brazil was diagnosed, and by now, we present the report on the ... ...

Abstract	In late December 2019, China reported cases of respiratory illness in humans that involved a novel coronavirus SARS-CoV-2. On March 20, 2020, the first coronavirus disease 2019 (COVID-19) in Brazil was diagnosed, and by now, we present the report on the first case of COVID among transplant recipients in our country. A liver and kidney transplant patient with SARS-CoV-2 pneumonia without respiratory failure was treated in a clinical multimodal strategy consisting of symptomatic support therapy, immunosuppression reduction, use of anti-coronavirus drugs and heparin leading to a progressive improvement of patient symptoms till discharge. The authors also present a comprehensive review of published cases.
MeSH term(s)	Aged ; Antiviral Agents/therapeutic use ; Brazil ; COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19/immunology ; COVID-19/virology ; COVID-19 Nucleic Acid Testing ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/adverse effects ; Kidney Failure, Chronic/immunology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Lung/diagnostic imaging ; Male ; RNA, Viral/isolation & purification ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Tomography, X-Ray Computed ; Transplant Recipients ; Treatment Outcome
Chemical Substances	Antiviral Agents ; Immunosuppressive Agents ; RNA, Viral
Keywords	covid19
Language	English
Publishing date	2020-05-26
Publishing country	Denmark
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.13306
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Article: COVID-19 pneumonia in kidney transplant recipients-Where we are?

Machado, David José de Barros / Ianhez, Luiz Estevam

Transpl Infect Dis

Abstract	In late December 2019, China reported cases of respiratory illness in humans that involved a novel coronavirus SARS-CoV-2. On March 20, 2020, the first coronavirus disease 2019 (COVID-19) in Brazil was diagnosed, and by now, we present the report on the first case of COVID among transplant recipients in our country. A liver and kidney transplant patient with SARS-CoV-2 pneumonia without respiratory failure was treated in a clinical multimodal strategy consisting of symptomatic support therapy, immunosuppression reduction, use of anti-coronavirus drugs and heparin leading to a progressive improvement of patient symptoms till discharge. The authors also present a comprehensive review of published cases.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #176101
Database	COVID19

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Article ; Online: COVID‐19 pneumonia in kidney transplant recipients—Where we are?

Machado, David José de Barros / Ianhez, Luiz Estevam

Transplant Infectious Disease ; ISSN 1398-2273 1399-3062

2020

Keywords	Transplantation ; Infectious Diseases ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
DOI	10.1111/tid.13306
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Brazilian Consortium for the Study on Renal Diseases Associated With COVID-19: A Multicentric Effort to Understand SARS-CoV-2-Related Nephropathy.

Teixeira Júnior, Antonio Augusto Lima / Neves, Precil Diego Miranda de Menezes / Lages, Joyce Santos / Cunha, Kaile de Araújo / Muniz, Monique Pereira Rêgo / Brito, Dyego José de Araújo / Watanabe, Andréia / Watanabe, Elieser Hitoshi / Onuchic, Luiz Fernando / Nunes, Lucas Lobato Acatauassu / Coutinho Filho, Antônio Fernando / Barcelos, Flávia Lara / Gatto, Giuseppe Cesare / Monteiro, Antonio / Polido, Diego do Amaral / Motta, Douglas Rafanelle Moura de Santana / Leite, Thaísa de Oliveira / Guedes, Felipe Leite / Gomes, Orlando Vieira /

Valente, Lucila Maria / Israel, Karla Cristina Silva Petruccelli / Ladchumananandasivam, Francisco Rasiah / de Farias, Lígia Cristina Lopes / Marques, Igor Denizarde Bacelar / Uliano, Gustavo Lemos / Maramaldo, Carlos Eduardo Campos / Neto, Lídio Gonçalves Lima / Luchi, Weverton Machado / Wanderley, David Campos / Araújo, Stanley de Almeida / Salgado Filho, Natalino / Silva, Gyl Eanes Barros

Frontiers in medicine

2020 Volume 7, Page(s) 584235

Abstract: Kidney involvement appears to be frequent in coronavirus disease 2019 (COVID-19). Despite this, information concerning renal involvement in COVID-19 is still scarce. Several mechanisms appear to be involved in the complex relationship between the virus ... ...

Abstract	Kidney involvement appears to be frequent in coronavirus disease 2019 (COVID-19). Despite this, information concerning renal involvement in COVID-19 is still scarce. Several mechanisms appear to be involved in the complex relationship between the virus and the kidney. Also, different morphological patterns have been described in the kidneys of patients with COVID-19. For some authors, however, this association may be just a coincidence. To investigate this issue, we propose assessing renal morphology associated with COVID-19 at the renal pathology reference center of federal university hospitals in Brazil. Data will come from a consortium involving 17 federal university hospitals belonging to
Keywords	covid19
Language	English
Publishing date	2020-10-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2020.584235
Database	MEDical Literature Analysis and Retrieval System OnLINE

EntomoBrasilis, Vol

Mandibulata: Pancrustacea) Brazil 2020: the first annual production survey of new Brazilian species

2022 Volume 15

Abstract: This paper provided a list of all new Brazilian Hexapoda species described in 2020. Furthermore, based on the information extracted by this list, we tackled additional questions regarding the taxa, the specialists involved in the species descriptions as ... ...

Abstract	This paper provided a list of all new Brazilian Hexapoda species described in 2020. Furthermore, based on the information extracted by this list, we tackled additional questions regarding the taxa, the specialists involved in the species descriptions as well as the journals in which those papers have been published. We recorded a total of 680 new Brazilian species of Hexapoda described in 2020, classified in 245 genera, 112 families and 18 orders. These 680 species were published in a total of 2019 articles comprising 423 different authors residing in 27 countries. Only 30% of these authors are women, which demonstrates an inequality regarding sexes. In relation to the number of authors by species, the majority of the new species had two authors and the maximum of authors by species was five. We also found inequalities in the production of described species regarding the regions of Brazil, with Southeast and South leading. The top 10 institutions regarding productions of new species have four in the Southeast, two at South and with one at North Region being the outlier of this pattern. Out of the total 219 published articles, Zootaxa dominated with 322 described species in 95 articles. The average impact factor was of 1.4 with only seven articles being published in Impact Factors above 3, indicating a hardship on publishing taxonomic articles in high-impact journals. The highlight of this paper is that it is unprecedent, as no annual record of Hexapoda species described was ever made in previous years to Brazil.
Keywords	Biodiversity ; insects ; neotropics ; taxonomist ; taxonomy ; Ecology ; QH540-549.5 ; Botany ; QK1-989 ; Zoology ; QL1-991
Subject code	590
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Entomologistas do Brasil
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Brazilian Consortium for the Study on Renal Diseases Associated With COVID-19

Antonio Augusto Lima Teixeira Júnior / Precil Diego Miranda de Menezes Neves / Joyce Santos Lages / Kaile de Araújo Cunha / Monique Pereira Rêgo Muniz / Dyego José de Araújo Brito / Andréia Watanabe / Elieser Hitoshi Watanabe / Luiz Fernando Onuchic / Lucas Lobato Acatauassu Nunes / Antônio Fernando Coutinho Filho / Flávia Lara Barcelos / Giuseppe Cesare Gatto / Antonio Monteiro / Diego do Amaral Polido / Douglas Rafanelle Moura de Santana Motta / Thaísa de Oliveira Leite / Felipe Leite Guedes / Orlando Vieira Gomes /

Lucila Maria Valente / Karla Cristina Silva Petruccelli Israel / Francisco Rasiah Ladchumananandasivam / Lígia Cristina Lopes de Farias / Igor Denizarde Bacelar Marques / Gustavo Lemos Uliano / Carlos Eduardo Campos Maramaldo / Lídio Gonçalves Lima Neto / Weverton Machado Luchi / David Campos Wanderley / Stanley de Almeida Araújo / Natalino Salgado Filho / Gyl Eanes Barros Silva

Frontiers in Medicine, Vol

A Multicentric Effort to Understand SARS-CoV-2-Related Nephropathy

2020 Volume 7

Abstract: ... from a consortium involving 17 federal university hospitals belonging to Empresa Brasileira de Serviços Hospitalares ...

Abstract	Kidney involvement appears to be frequent in coronavirus disease 2019 (COVID-19). Despite this, information concerning renal involvement in COVID-19 is still scarce. Several mechanisms appear to be involved in the complex relationship between the virus and the kidney. Also, different morphological patterns have been described in the kidneys of patients with COVID-19. For some authors, however, this association may be just a coincidence. To investigate this issue, we propose assessing renal morphology associated with COVID-19 at the renal pathology reference center of federal university hospitals in Brazil. Data will come from a consortium involving 17 federal university hospitals belonging to Empresa Brasileira de Serviços Hospitalares (EBSERH) network, as well as some state hospitals and an autopsy center. All biopsies will be sent to the referral center for renal pathology of the EBSERH network. The data will include patients who had coronavirus disease, both alive and deceased, with or without pre-existing kidney disease. Kidney biopsies will be analyzed by light, fluorescence, and electron microscopy. Furthermore, immunohistochemical (IHC) staining for various inflammatory cells (i.e., cells expressing CD3, CD20, CD4, CD8, CD138, CD68, and CD57) as well as angiotensin-converting enzyme 2 (ACE2) will be performed on paraffinized tissue sections. In addition to ultrastructural assays, in situ hybridization (ISH), IHC and reverse transcription-polymerase chain reaction (RT-PCR) will be used to detect Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) in renal tissue. For the patients diagnosed with Collapsing Glomerulopathy, peripheral blood will be collected for apolipoprotein L-1 (APOL1) genotyping. For patients with thrombotic microangiopathy, thrombospondin type 1 motif, member 13 (ADAMTS13), antiphospholipid, and complement panel will be performed. The setting of this study is Brazil, which is second behind the United States in highest confirmed cases and deaths. With this complete approach, we ...
Keywords	COVID-19 ; SARS-CoV-2 ; glomerulopathy ; kidney injury ; collapsing glomerulopathy ; thrombotic microangiopathy ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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