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  1. Article ; Online: Pharmacokinetics and pharmacogenetics of high-dosage tedizolid for disseminated nocardiosis in a lung transplant patient.

    Corcione, Silvia / Vita, Davide / De Nicolò, Amedeo / Scabini, Silvia / Mornese Pinna, Simone / Cusato, Jessica / Mangiapia, Mauro / D'Avolio, Antonio / De Rosa, Francesco Giuseppe

    The Journal of antimicrobial chemotherapy

    2024  Volume 78, Issue 12, Page(s) 3003–3004

    MeSH term(s) Humans ; Pharmacogenetics ; Nocardia Infections/diagnosis ; Nocardia Infections/drug therapy ; Oxazolidinones ; Lung Transplantation/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/pharmacokinetics
    Chemical Substances tedizolid (97HLQ82NGL) ; Oxazolidinones ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 124: Show issues

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  2. Article: Epidemiology and Risk Factors for Nosocomial Infections in Left Ventricular Assist Device Recipients.

    Mornese Pinna, Simone / Corcione, Silvia / Cavallone, Elena / Shbaklo, Nour / Vita, Davide / De Benedetto, Ilaria / Montrucchio, Giorgia / Pasero, Daniela / Trompeo, Anna Chiara / Costamagna, Andrea / Brazzi, Luca / Rinaldi, Mauro / Boffini, Massimo / De Rosa, Francesco Giuseppe

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: Left ventricular assist devices (LVADs) have been increasingly used as a valid option to improve the prognosis and reduce the symptoms of end-stage heart failure. However, long-term complications, mostly infections and coagulation disorders, are frequent. ...

    Abstract Left ventricular assist devices (LVADs) have been increasingly used as a valid option to improve the prognosis and reduce the symptoms of end-stage heart failure. However, long-term complications, mostly infections and coagulation disorders, are frequent. We described the epidemiology and risk factors for nosocomial infections (NIs) in a cohort of adult patients who underwent continuous-flow LVAD implant between January 2010 and December 2017 in Turin, Italy. Secondary outcomes were the prevalence of multidrug-resistant (MDR) bacteria and mortality. Results: Overall, 64 LVADs were implanted. A total of 32 (50%) patients experienced at least one episode of NI, with a total of 46 infectious events. VAD-related infections occurred in 22 patients (68.8%). Non VAD-related NIs occurred in 12 patients (37.5%), mainly low respiratory tract infections. Length of intensive care unit admission was a risk factor for NI (OR 1.224, 95%CI; 1.049, 1.429). Gram-negative bacilli were responsible for 58.8% of VAD-related infections and 79.5% of non-VAD related infections. In sixteen patients (50%), at least one episode of infection was related to an MDR strain. INTERMACS class and length of MV were independent risk factors for NIs by MDR strains (respectively, OR 2.12, 95%CI: 1.08, 6.80;
    Language English
    Publishing date 2024-02-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14020270
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  3. Article ; Online: JC virus DNA in cerebrospinal fluid: insight into clinical significance.

    Mornese Pinna, Simone / Trunfio, Mattia / Imperiale, Daniele / Calcagno, Andrea

    Diagnostic microbiology and infectious disease

    2020  Volume 97, Issue 2, Page(s) 115017

    MeSH term(s) Blood-Brain Barrier/virology ; DNA, Viral/analysis ; Humans ; JC Virus/isolation & purification ; Leukoencephalopathy, Progressive Multifocal/cerebrospinal fluid ; Leukoencephalopathy, Progressive Multifocal/diagnosis ; Molecular Diagnostic Techniques ; Mutation
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2020-02-13
    Publishing country United States
    Document type Letter
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2020.115017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1845: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Predictors of mortality in patients with COVID-19 infection in different health-care settings: A retrospective analysis from a CORACLE study group.

    Boglione, Lucio / Corcione, Silvia / Shbaklo, Nour / Lupia, Tommaso / Scabini, Silvia / Mornese Pinna, Simone / Borrè, Silvio / De Rosa, Francesco Giuseppe

    Infection, disease & health

    2022  Volume 28, Issue 1, Page(s) 3–9

    Abstract: Background: Despite the large number of hospitalized patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, few data are available about risk factors and mortality in subjects with nosocomially acquired respiratory ... ...

    Abstract Background: Despite the large number of hospitalized patients affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, few data are available about risk factors and mortality in subjects with nosocomially acquired respiratory infection of Coronavirus Disease 2019 (COVID-19).
    Methods: We retrospectively evaluated in a multicentric study -during the pre-vaccination era-all patients admitted with confirmed diagnosis of nosocomial COVID-19 (NC). Patients were classified according to provenance: hospital-acquired NC or long-term care (LTC) facilities.
    Results: Among overall 1047 patients evaluated with COVID-19, 137 had a confirmed diagnosis of NC (13%). 78 (56.9%) patients had hospital-acquired NC and 59 (43%) had LTC NC. Overall mortality was 35.8%, in hospital-acquired NC 24.4%, in LTC NC 50.8% (p < 0.001) (Log Rank test: p = 0.001). Timing of diagnosis was significantly different between hospital acquired and LTC NC (3.5 vs 10 days, p < 0.001). In multivariate analysis age, intensive-care unit admission, LTC provenance and sepsis were significant predictors of mortality in patients with NC infection.
    Conclusion: Patients with NC are at higher risk of mortality (especially for LTC NC) and required preventive strategies, early diagnosis, and treatment to avoid COVID-19 cluster.
    MeSH term(s) Humans ; COVID-19 ; Retrospective Studies ; SARS-CoV-2 ; Hospitalization ; Hospitals
    Language English
    Publishing date 2022-06-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2902143-1
    ISSN 2468-0869 ; 2468-0451
    ISSN (online) 2468-0869
    ISSN 2468-0451
    DOI 10.1016/j.idh.2022.05.006
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  5. Article: New cephalosporins for the treatment of pneumonia in internal medicine wards.

    Lupia, Tommaso / Corcione, Silvia / Mornese Pinna, Simone / De Rosa, Francesco Giuseppe

    Journal of thoracic disease

    2020  Volume 12, Issue 7, Page(s) 3747–3763

    Abstract: The burden of hospital admission for pneumonia in internal medicine wards may not be underestimated; otherwise, cases of pneumonia are a frequent indication for antimicrobial prescriptions. Community- and hospital-acquired pneumonia are characterized by ... ...

    Abstract The burden of hospital admission for pneumonia in internal medicine wards may not be underestimated; otherwise, cases of pneumonia are a frequent indication for antimicrobial prescriptions. Community- and hospital-acquired pneumonia are characterized by high healthcare costs, morbidity and non-negligible rates of fatality. The overcoming prevalence of resistant gram-negative and positive bacteria (e.g., methicillin-resistant
    Language English
    Publishing date 2020-07-31
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-20-417
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Temocillin: Applications in Antimicrobial Stewardship as a Potential Carbapenem-Sparing Antibiotic.

    Lupia, Tommaso / De Benedetto, Ilaria / Stroffolini, Giacomo / Di Bella, Stefano / Mornese Pinna, Simone / Zerbato, Verena / Rizzello, Barbara / Bosio, Roberta / Shbaklo, Nour / Corcione, Silvia / De Rosa, Francesco Giuseppe

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 4

    Abstract: Temocillin is an old antibiotic, but given its particular characteristics, it may be a suitable alternative to carbapenems for treating infections due to ESBL- ... ...

    Abstract Temocillin is an old antibiotic, but given its particular characteristics, it may be a suitable alternative to carbapenems for treating infections due to ESBL-producing
    Language English
    Publishing date 2022-04-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11040493
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  7. Article: Antibiotic De-escalation Experience in the Setting of Emergency Department: A Retrospective, Observational Study.

    Corcione, Silvia / Mornese Pinna, Simone / Lupia, Tommaso / Trentalange, Alice / Germanò, Erika / Cavallo, Rossana / Lupia, Enrico / De Rosa, Francesco Giuseppe

    Journal of clinical medicine

    2021  Volume 10, Issue 15

    Abstract: Background: Antimicrobial de-escalation (ADE) is a part of antimicrobial stewardship strategies aiming to minimize unnecessary or inappropriate antibiotic exposure to decrease the rate of antimicrobial resistance. Information regarding the effectiveness ...

    Abstract Background: Antimicrobial de-escalation (ADE) is a part of antimicrobial stewardship strategies aiming to minimize unnecessary or inappropriate antibiotic exposure to decrease the rate of antimicrobial resistance. Information regarding the effectiveness and safety of ADE in the setting of emergency medicine wards (EMW) is lacking.
    Methods: Adult patients admitted to EMW and receiving empiric antimicrobial treatment were retrospectively studied. The primary outcome was the rate and timing of ADE. Secondary outcomes included factors associated with early ADE, length of stay, and in-hospital mortality.
    Results: A total of 336 patients were studied. An initial regimen combining two agents was prescribed in 54.8%. Ureidopenicillins and carbapenems were the most frequently empiric treatment prescribed (25.1% and 13.6%). The rate of the appropriateness of prescribing was 58.3%. De-escalation was performed in 111 (33%) patients. Patients received a successful de-escalation on day 2 (21%), 3 (23%), and 5 (56%). The overall in-hospital mortality was 21%, and it was significantly lower among the de-escalation group than the continuation group (16% vs 25%
    Conclusions: ADE appears safe and effective in the setting of EMWs despite that further research is warranted to confirm these findings.
    Language English
    Publishing date 2021-07-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10153285
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  8. Article ; Online: COVID-19 pneumonia: do not leave the corticosteroids behind!

    Pinna, Simone Mornese / Scabini, Silvia / Corcione, Silvia / Lupia, Tommaso / De Rosa, Francesco G

    Future microbiology

    2021  Volume 16, Page(s) 317–322

    Abstract: The host inflammatory response is critical in the progression of lung injuries in patients with SARS-CoV-2. Corticosteroids (CS) have been widely used as immunomodulating agents, but the right timing, dosage and type of molecule are unknown. In fact, the ...

    Abstract The host inflammatory response is critical in the progression of lung injuries in patients with SARS-CoV-2. Corticosteroids (CS) have been widely used as immunomodulating agents, but the right timing, dosage and type of molecule are unknown. In fact, the early use of CS could facilitate the viral replication but late administration may not prevent the alveolar damage. Nevertheless, a short administration of high doses of CS in the early stage of the inflammatory phase resulted in favorable outcomes. Noteworthy, some inhaled CS inhibited
    MeSH term(s) Administration, Inhalation ; Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/therapeutic use ; COVID-19/drug therapy ; Guidelines as Topic ; Humans ; Inflammation/drug therapy ; Inflammation/virology ; Meta-Analysis as Topic ; Randomized Controlled Trials as Topic ; Time Factors
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2021-03-12
    Publishing country England
    Document type Journal Article
    ISSN 1746-0921
    ISSN (online) 1746-0921
    DOI 10.2217/fmb-2020-0199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit.

    Mornese Pinna, Simone / Sousa Casasnovas, Iago / Olmedo, María / Machado, Marina / Juàrez Fernández, Miriam / Devesa-Cordero, Carolina / Galar, Alicia / Alvarez-Uria, Ana / Fernández-Avilés, Francisco / García Carreño, Jorge / Martínez-Sellés, Manuel / De Rosa, Francesco Giuseppe / Corcione, Silvia / Bouza, Emilio / Muñoz, Patricia / Valerio, Maricela

    Microorganisms

    2023  Volume 11, Issue 4

    Abstract: The use of venoarterial (VA) extracorporeal membrane oxygenation therapy (ECMO) in patients admitted to cardiac intensive care units (CICU) has increased. Data regarding infections in this population are scarce. In this retrospective study, we analyzed ... ...

    Abstract The use of venoarterial (VA) extracorporeal membrane oxygenation therapy (ECMO) in patients admitted to cardiac intensive care units (CICU) has increased. Data regarding infections in this population are scarce. In this retrospective study, we analyzed the risk factors, outcome, and predictors of in-hospital mortality due to nosocomial infections in patients with ECMO admitted to a single coronary intensive care unit between July 2013 and March 2019 treated with VA-ECMO for >48 h. From 69 patients treated with VA-ECMO >48 h, (median age 58 years), 29 (42.0%) patients developed 34 episodes of infections with an infection rate of 0.92/1000 ECMO days. The most frequent were ventilator-associated pneumonia (57.6%), tracheobronchitis (9.1%), bloodstream infections (9.1%), skin and soft tissue infections (9.1%), and cytomegalovirus reactivation (9.1%). In-hospital mortality was 47.8%, but no association with nosocomial infections was found (
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11041079
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  10. Article: Meropenem/Vaborbactam and Cefiderocol as Combination or Monotherapy to Treat Multi-Drug Resistant Gram-Negative Infections: A Regional Cross-Sectional Survey from Piedmont Infectious Disease Unit Network (PIDUN).

    Lupia, Tommaso / Corcione, Silvia / Shbaklo, Nour / Montrucchio, Giorgia / De Benedetto, Ilaria / Fornari, Valentina / Bosio, Roberta / Rizzello, Barbara / Mornese Pinna, Simone / Brazzi, Luca / De Rosa, Francesco Giuseppe

    Journal of functional biomaterials

    2022  Volume 13, Issue 4

    Abstract: Meropenem/vaborbactam (MV) and cefiderocol were recently approved by the Food and Drug Administration and European Medicines Agency and are among the most promising antibacterial in treatment regimens against multi-drug resistant (MDR) gram-negative ... ...

    Abstract Meropenem/vaborbactam (MV) and cefiderocol were recently approved by the Food and Drug Administration and European Medicines Agency and are among the most promising antibacterial in treatment regimens against multi-drug resistant (MDR) gram-negative bacilli. A survey with close-ended questions was proposed to infectious disease (ID) and intensive care unit (ICU) physicians of Piedmont and Valle d'Aosta Region's hospitals. The aim was to collect data about habits and prescriptions of cefiderocol and MV. Twenty-three physicians (11 ID specialists and 12 anesthesiologists) in 13 Italian hospitals took part in the survey. Both cefiderocol and MV were mostly used as target therapy after a previous treatment failure and after ID specialist consult. The most frequent MDR pathogen in hospitals was
    Language English
    Publishing date 2022-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2648525-4
    ISSN 2079-4983
    ISSN 2079-4983
    DOI 10.3390/jfb13040174
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