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Article ; Online: Bone marrow Tfr2 deletion improves the therapeutic efficacy of the activin-receptor ligand trap RAP-536 in β-thalassemic mice.

Tanzi, Emanuele / Di Modica, Simona Maria / Bordini, Jessica / Olivari, Violante / Pagani, Alessia / Furiosi, Valeria / Silvestri, Laura / Campanella, Alessandro / Nai, Antonella

American journal of hematology

2024

Abstract: β-thalassemia is a disorder characterized by anemia, ineffective erythropoiesis (IE), and iron overload, whose treatment still requires improvement. The activin receptor-ligand trap Luspatercept, a novel therapeutic option for β-thalassemia, stimulates ... ...

Abstract	β-thalassemia is a disorder characterized by anemia, ineffective erythropoiesis (IE), and iron overload, whose treatment still requires improvement. The activin receptor-ligand trap Luspatercept, a novel therapeutic option for β-thalassemia, stimulates erythroid differentiation inhibiting the transforming growth factor β pathway. However, its exact mechanism of action and the possible connection with erythropoietin (Epo), the erythropoiesis governing cytokine, remain to be clarified. Moreover, Luspatercept does not correct all the features of the disease, calling for the identification of strategies that enhance its efficacy. Transferrin receptor 2 (TFR2) regulates systemic iron homeostasis in the liver and modulates the response to Epo of erythroid cells, thus balancing red blood cells production with iron availability. Stimulating Epo signaling, hematopoietic Tfr2 deletion ameliorates anemia and IE in Hbb
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.27336
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Article: FAPi-Based Agents in Thyroid Cancer: A New Step towards Diagnosis and Therapy? A Systematic Review of the Literature.

Cancers

2024 Volume 16, Issue 4

Abstract: 1) Background: Thyroid cancer (TC) is often treated with surgery followed by iodine-131. Up to 50% of the instances of TC lose their avidity ... ...

Abstract	(1) Background: Thyroid cancer (TC) is often treated with surgery followed by iodine-131. Up to 50% of the instances of TC lose their avidity to
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16040839
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Article ; Online: Gout, hyperuricemia and cardio-vascular risk

Laura Morbidoni / Diletta Olivari

Italian Journal of Medicine, Vol

2018 Volume 12

Abstract: Concern about gout-related increase in risk of hypertension and cardiovascular diseases has been raising in recent years. A similar relationship has been postulated even for asymptomatic hyperuricemia. The aims of this review are to appraise the ... ...

Abstract	Concern about gout-related increase in risk of hypertension and cardiovascular diseases has been raising in recent years. A similar relationship has been postulated even for asymptomatic hyperuricemia. The aims of this review are to appraise the available evidence about: 1. the relationship between hyperuricemia itself and/or gout and cardiovascular diseases; 2. the effect of decreasing serum acid uric level on the rate of cardiovascular events. To meet this purpose, we did an extensive analysis of literature, limiting the search to articles in English, indexed in Medline and published in the last 17 years. Most of the retrieved studies were conducted on surrogate outcomes, whereas randomized trials on clinically relevant outcomes are few and of questionable quality. Based on the available data, we may conclude that hyperuricemia itself is a probable, although weak, risk factor for hypertension and increases the risk of nephropathy in patients with type 2 diabetes mellitus. Moreover, symptomatic gout significantly increases the risk of cardiovascular events, particularly of myocardial infarction and mainly in young-adult and people without other risk factors. Regarding the effectiveness of urate-lowering drugs in the prevention of myocardial infarction, the strongest evidence supports their use in subjects affected by gout. A probable efficacy in controlling hypertension, especially in young subjects and women, as well as in preventing nephropathy in type 2 diabetic patients has also been reported. Interestingly, allopurinol administered at doses ≤300 mg/day seems to protect from myocardial infarction, hypertension, total and serious cardiovascular events; preliminary evidences suggest a protective effect of febuxostat on major adverse cardiovascular events in high-risk gouty patients.
Keywords	Gout ; hyperuricemia ; cardiovascular risk ; cardiovascular diseases ; uratelowering therapy ; Medicine ; R
Subject code	610
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	PAGEPress Publications
Document type	Article ; Online
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Article: Adenoid cystic carcinoma: focus on heavy ion therapy and molecular imaging.

Castello, Angelo / Olivari, Laura / Lopci, Egesta

American journal of nuclear medicine and molecular imaging

2018 Volume 8, Issue 1, Page(s) 1–14

Abstract: Surgery, radiation therapy and chemotherapy are the oldest modalities for cancer treatment. However, as part of a continuous research in medicine, in order to improve therapeutic precision and biological effectiveness, there is an increasing interest ... ...

Abstract	Surgery, radiation therapy and chemotherapy are the oldest modalities for cancer treatment. However, as part of a continuous research in medicine, in order to improve therapeutic precision and biological effectiveness, there is an increasing interest into the use of heavy particle (e.g. protons or heavy ions) in the treatment of solid tumors. However, the restricted availability of the technology has concentrated the expertise in highly specialized centers that take care and treat extreme cases and rare pathologies. One of the tumors that has mostly beneficiated from heavy ion therapy is represented by adenoid cystic carcinoma (ACC) of the head and neck. In the current review we will focus our attention on the role of heavy particle therapy in general, with particular interest on ACC. The article will also summarize recent clinical evidence comparing traditional radiotherapy with the new heavy particles. Moreover, molecular imaging features of this uncommon tumor with
Language	English
Publishing date	2018-02-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2623515-8
ISSN	2160-8407
ISSN	2160-8407
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Article ; Online: The role of F-18 FDG PET/CT in the prognosis of patients with hypoxic/anoxic brain injury after cardio-circulatory arrest.

Rossato, Elena / Avesani, Renato / Bonadiman, Silvia / Olivari, Laura / Silva, Ronaldo / Zanatta, Paolo / Lupi, Andrea / Salgarello, Matteo

Minerva anestesiologica

2022 Volume 88, Issue 11, Page(s) 910–917

Abstract: Background: Advances in resuscitation techniques have resulted in more patients surviving cardio-circulatory arrest (CA) and consequently developing hypoxic/anoxic brain damage. The aim of this study is to evaluate the role of PET/CT (Positron Emission ... ...

Abstract	Background: Advances in resuscitation techniques have resulted in more patients surviving cardio-circulatory arrest (CA) and consequently developing hypoxic/anoxic brain damage. The aim of this study is to evaluate the role of PET/CT (Positron Emission Tomography/Computerized Tomography scan) with F-18 FDG (F-18 fluorodeoxyglucose) during the early rehabilitative hospitalization phase in determining the V/C (Vermis/Cerebellar) ratio as a prognostic index to predict patient outcome, as defined by clinical evaluation scales. Methods: This is a single-center retrospective study of 37 consecutive adult patients admitted to the neurorehabilitation center between January 2011 and June 2019. Functional status was measured by the following clinical scales: FIM (Functional Indipendence Measure), LCFS (Levels of Cognitive Functioning Scale), GOS (Glasgow Outcome Scale) and CRS-R (Coma Recovery Scale-Revised). PET/CT with F-18 FDG as a functional imaging technique was used to calculate the V/C ratio as a ratio between the metabolism of the vermis and of the Cerebellar Hemisphere. Results: A statistically significant correlation was observed between the V/C ratio and the delta values (difference between discharge and admission value) for each clinical evaluation scale (Delta FIM: P=0.0014; Delta LCFS P=0.0003). A statistically significant difference was observed between the V/C ratio of patients with LCFS ≥4 that showed an improved outcome (defined as an improvement of at least two points in LCFS), and that of patients with LCFS <4 that did not improve (P=0.0011). A V/C ratio cut-off of 1.5 corresponded with a positive predictive power of 80% and a negative predictive power of 82%; a value <1.5 predicted a better outcome. Conclusions: Clinical evaluation scales when associated with F-18 FDG PET/CT measurement of metabolism, provide a more reliable prognosis. This allows for more focused rehabilitation treatment and better management of family members' expectation.
MeSH term(s)	Adult ; Humans ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography/methods ; Retrospective Studies ; Prognosis ; Hypoxia, Brain/diagnostic imaging ; Heart Arrest/diagnostic imaging ; Heart Arrest/therapy ; Brain Injuries
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2022-07-14
Publishing country	Italy
Document type	Journal Article
ZDB-ID	123584-9
ISSN	1827-1596 ; 0026-4717 ; 0375-9393
ISSN (online)	1827-1596
ISSN	0026-4717 ; 0375-9393
DOI	10.23736/S0375-9393.22.16104-3
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Zs.A 516: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: COVID-19 pneumonia: increased choline uptake with 18F-choline PET/CT.

Olivari, Laura / Riccardi, Niccolò / Rodari, Paola / Angheben, Andrea / Artioli, Paolo / Salgarello, Matteo

European journal of nuclear medicine and molecular imaging

2020 Volume 47, Issue 10, Page(s) 2476–2477

MeSH term(s)	COVID-19 ; Choline/analogs & derivatives ; Choline/pharmacokinetics ; Coronavirus Infections/complications ; Coronavirus Infections/diagnostic imaging ; Disease Progression ; Humans ; Inflammation ; Lung/diagnostic imaging ; Macrophages/metabolism ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Prostatectomy ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/complications ; Prostatic Neoplasms/pathology
Chemical Substances	fluoromethylcholine ; Choline (N91BDP6H0X)
Keywords	covid19
Language	English
Publishing date	2020-06-04
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-020-04870-3
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Zs.A 1227: Show issues

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Article: PSMA-PET/CT-Based Stereotactic Body Radiotherapy (SBRT) in the Treatment of Uncomplicated Non-Spinal Bone Oligometastases from Prostate Cancer.

Pastorello, Edoardo / Nicosia, Luca / Cuccia, Francesco / Olivari, Laura / Fiorini, Matilde / Giaj Levra, Niccolò / Mazzola, Rosario / Ricchetti, Francesco / Rigo, Michele / Ravelli, Paolo / D'Alessandro, Salvatore / Salgarello, Matteo / Ruggieri, Ruggero / Alongi, Filippo

Cancers

2023 Volume 15, Issue 10

Abstract: Background and purpose: Stereotactic body radiotherapy (SBRT) has a consolidated role in the treatment of bone oligometastases from prostate cancer (PCa). While the evidence for spinal oligometastases SBRT was robust, its role in non-spinal-bone ... ...

Abstract	Background and purpose: Stereotactic body radiotherapy (SBRT) has a consolidated role in the treatment of bone oligometastases from prostate cancer (PCa). While the evidence for spinal oligometastases SBRT was robust, its role in non-spinal-bone metastases (NSBM) is not standardized. In fact, there was no clear consensus about dose and target definition in this setting. The aim of our study was to evaluate efficacy, toxicity, and the pattern of relapse in SBRT delivered to NSBM from PCa. Materials and methods: From 2016 to 2021, we treated a series of oligo-NSBM from PCa with Results: a total of 150 NSBM in 95 patients were treated with 30-35 Gy in five fractions. With a median follow-up of 26 months, 1- and 3 years LPFS was 96.3% and 89%, respectively. A biologically effective dose (BED) ≥ 198 Gy was correlated with improved LPFS ( Conclusion: SBRT is a safe and effective tool for NSBM from PCa in the oligometastatic setting. Intraosseous relapse was a relatively rare event. Predictive factors of the improved outcomes were defined.
Language	English
Publishing date	2023-05-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15102800
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Article: Head-to-Head Comparison of FDG and Radiolabeled FAPI PET: A Systematic Review of the Literature.

Life (Basel, Switzerland)

2023 Volume 13, Issue 9

Abstract: FAPI-based radiopharmaceuticals are a novel class of tracers, mainly used for PET imaging, which have demonstrated several advantages over [ ...

Abstract	FAPI-based radiopharmaceuticals are a novel class of tracers, mainly used for PET imaging, which have demonstrated several advantages over [
Language	English
Publishing date	2023-08-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13091821
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Article: VEGF-D Serum Level as a Potential Predictor of Lymph Node Metastasis and Prognosis in Vulvar Squamous Cell Carcinoma Patients.

Ravaggi, Antonella / Gambino, Angela / Ferrari, Federico / Olivari, Alessandro / Zanotti, Laura / Romani, Chiara / Ardighieri, Laura / Antonelli, Paolo / Garganese, Giorgia / Gallo, Daniela / Scambia, Giovanni / Bignotti, Eliana / Sartori, Enrico / Calza, Stefano / Odicino, Franco

Frontiers in oncology

2022 Volume 12, Page(s) 818613

Abstract: Background: Radical surgical resection of the primary tumor with mono/bilateral inguinofemoral lymph node dissection is the standard treatment for invasive vulvar squamous cell carcinoma (VSCC) and is frequently related to severe morbidity. Tailoring ... ...

Abstract	Background: Radical surgical resection of the primary tumor with mono/bilateral inguinofemoral lymph node dissection is the standard treatment for invasive vulvar squamous cell carcinoma (VSCC) and is frequently related to severe morbidity. Tailoring surgical treatment is of paramount importance, and a comprehensive preoperative evaluation is mandatory. Vascular endothelial growth factor D (VEGF-D) is considered a regulator of lymphangiogenesis involved in tumor spread Methods: We analyzed the preoperative levels of serum VEGF-D (sVEGF-D) from two independent cohorts of patients with VSCC by enzyme-linked immunosorbent assay and its protein expression on tumor tissue by immunohistochemistry. Logistic regression was performed to identify the independent risk factors for lymph node metastasis, and Cox proportional hazard model was used for survival analysis. Results: High levels of sVEGF-D, but not tissue VEGF-D, significantly correlated with positive groin nodes and a more advanced International Federation of Gynecologists and Obstetricians (FIGO) stage. In multivariable analysis, a high sVEGF-D level was an independent predictor of lymph node metastasis and worse prognosis. A prediction model based on sVEGF-D, tumor grade assessed on biopsy, tumor diameter, and lymph node clinical evaluation was able to predict lymph node metastasis, reaching C-index values of 0.79 and 0.73 in the training and validation cohorts, respectively. Conclusions: The preoperative sVEGF-D level might be a reliable biomarker for the prediction of lymph node metastasis and prognosis in patients with VSCC, supporting better clinical/surgical decision. Multicenter prospective studies are required to confirm our findings.
Language	English
Publishing date	2022-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.818613
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Article ; Online: A single approach to targeting transferrin receptor 2 corrects iron and erythropoietic defects in murine models of anemia of inflammation and chronic kidney disease.

Olivari, Violante / Di Modica, Simona Maria / Lidonnici, Maria Rosa / Aghajan, Mariam / Cordero-Sanchez, Celia / Tanzi, Emanuele / Pettinato, Mariateresa / Pagani, Alessia / Tiboni, Francesca / Silvestri, Laura / Guo, Shuling / Ferrari, Giuliana / Nai, Antonella

Kidney international

2023 Volume 104, Issue 1, Page(s) 61–73

Abstract: Anemia is a common complication of systemic inflammation. Proinflammatory cytokines both decrease erythroblast sensitivity to erythropoietin (EPO) and increase the levels of the hepatic hormone hepcidin, sequestering iron in stores and causing functional ...

Abstract	Anemia is a common complication of systemic inflammation. Proinflammatory cytokines both decrease erythroblast sensitivity to erythropoietin (EPO) and increase the levels of the hepatic hormone hepcidin, sequestering iron in stores and causing functional iron deficiency. Anemia of chronic kidney disease (CKD) is a peculiar form of anemia of inflammation, characterized by impaired EPO production paralleling progressive kidney damage. Traditional therapy based on increased EPO (often in combination with iron) may have off-target effects due to EPO interaction with its non-erythroid receptors. Transferrin Receptor 2 (Tfr2) is a mediator of the iron-erythropoiesis crosstalk. Its deletion in the liver hampers hepcidin production, increasing iron absorption, whereas its deletion in the hematopoietic compartment increases erythroid EPO sensitivity and red blood cell production. Here, we show that selective hematopoietic Tfr2 deletion ameliorates anemia in mice with sterile inflammation in the presence of normal kidney function, promoting EPO responsiveness and erythropoiesis without increasing serum EPO levels. In mice with CKD, characterized by absolute rather than functional iron deficiency, Tfr2 hematopoietic deletion had a similar effect on erythropoiesis but anemia improvement was transient because of limited iron availability. Also, increasing iron levels by downregulating only hepatic Tfr2 had a minor effect on anemia. However, simultaneous deletion of hematopoietic and hepatic Tfr2, stimulating erythropoiesis and increased iron supply, was sufficient to ameliorate anemia for the entire protocol. Thus, our results suggest that combined targeting of hematopoietic and hepatic Tfr2 may be a therapeutic option to balance erythropoiesis stimulation and iron increase, without affecting EPO levels.
MeSH term(s)	Mice ; Animals ; Iron/metabolism ; Erythropoiesis/genetics ; Hepcidins/genetics ; Hepcidins/metabolism ; Disease Models, Animal ; Anemia/etiology ; Anemia/genetics ; Iron Deficiencies ; Erythropoietin/metabolism ; Inflammation/drug therapy ; Inflammation/complications ; Receptors, Transferrin/genetics ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/genetics
Chemical Substances	Iron (E1UOL152H7) ; Hepcidins ; Erythropoietin (11096-26-7) ; Receptors, Transferrin
Language	English
Publishing date	2023-03-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2023.03.012
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