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  1. Article ; Online: Abelacimab for Prevention of Venous Thromboembolism.

    Toom, Sudhamshi / Avula, Akshay

    The New England journal of medicine

    2021  Volume 385, Issue 19, Page(s) 1821–1822

    MeSH term(s) Anticoagulants/therapeutic use ; Humans ; Risk Factors ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2114895
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
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  2. Article: Cystic bronchiectasis in sarcoidosis.

    Jadav, Raja Shekar / Dadana, Sriharsha / Avula, Akshay

    Clinical case reports

    2023  Volume 11, Issue 10, Page(s) e8045

    Abstract: Pulmonary sarcoidosis can manifest in different radiologic patterns. Typical manifestations in high-resolution computed tomography are bilateral perihilar lymphadenopathy, micronodules, and fibrotic changes. Atypical manifestations are mass-like or ... ...

    Abstract Pulmonary sarcoidosis can manifest in different radiologic patterns. Typical manifestations in high-resolution computed tomography are bilateral perihilar lymphadenopathy, micronodules, and fibrotic changes. Atypical manifestations are mass-like or alveolar opacities, honeycomb-like cysts, miliary opacities, tracheobronchial involvement, and pleural disease. Cystic bronchiectasis in pulmonary sarcoidosis is rare, with only a few reported cases in the literature. We present another case of cystic bronchiectasis with a honeycomb-like pattern in pulmonary sarcoidosis and with cardiac involvement. This case was presented as an abstract poster at the American Thoracic Society conference in 2022.
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.8045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Familial thrombocytopenia flare-up following the first dose of mRNA-1273 Covid-19 vaccine.

    Toom, Sudhamshi / Wolf, Brian / Avula, Akshay / Peeke, Stephen / Becker, Kevin

    American journal of hematology

    2021  Volume 96, Issue 5, Page(s) E134–E135

    MeSH term(s) 2019-nCoV Vaccine mRNA-1273 ; Adult ; Analgesics, Non-Narcotic/therapeutic use ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; COVID-19 Vaccines/therapeutic use ; Chronic Disease ; Dexamethasone/therapeutic use ; Female ; Glucocorticoids/therapeutic use ; Headache/blood ; Headache/drug therapy ; Headache/etiology ; Humans ; Ibuprofen/therapeutic use ; Immunoglobulins, Intravenous/therapeutic use ; Platelet Count ; Purpura/blood ; Purpura/drug therapy ; Purpura/etiology ; Thrombocytopenia/blood ; Thrombocytopenia/drug therapy ; Thrombocytopenia/etiology
    Chemical Substances Analgesics, Non-Narcotic ; COVID-19 Vaccines ; Glucocorticoids ; Immunoglobulins, Intravenous ; Dexamethasone (7S5I7G3JQL) ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; Ibuprofen (WK2XYI10QM)
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1251: Show issues Location:
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  4. Article: Role of Saliva as a Non-Invasive Diagnostic Method for Detection of COVID-19.

    Ghosh, Supratim / Dhobley, Akshay / Avula, Kishan K / Joseph, Shali / Gavali, Neelam / Sinha, Shradha

    Cureus

    2022  Volume 14, Issue 7, Page(s) e27471

    Abstract: SARS coronavirus2 is the primary cause of new Coronavirus illness (COVID-19) (SARS- COV-2). Today, COVID-19 is a global epidemic. Coronavirus illness may be diagnosed using a variety of approaches. The gold standard is RT-PCR, which is used in all of ... ...

    Abstract SARS coronavirus2 is the primary cause of new Coronavirus illness (COVID-19) (SARS- COV-2). Today, COVID-19 is a global epidemic. Coronavirus illness may be diagnosed using a variety of approaches. The gold standard is RT-PCR, which is used in all of these assays. Swabs from the nose, pharynx, or mouth are the most often used sampling methods for coronavirus detection. For COVID-19 testing, saliva may be utilized as an alternate sample. When compared to a nasopharyngeal swab, saliva samples have a number of advantages and disadvantages. Saliva has also been reviewed as a non-invasive diagnostic tool for the detection of COVID-19. The affordability of the salivary diagnostic process makes it an effective process for detecting the COVID-19 viruses. The researchers have found that salivary diagnostic processes have greater chances of success than other processes of Coronavirus detection. However, healthcare professionals need to make positive changes to their working processes to ensure the sustainability of the salivary diagnosis processes.
    Language English
    Publishing date 2022-07-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.27471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Rhinovirus-induced Rapidly Progressing Acute Respiratory Distress Syndrome in an Immunocompetent Host.

    Ngu, Sam / Pervaiz, Sami / Avula, Akshay / Chalhoub, Michel

    Cureus

    2019  Volume 11, Issue 2, Page(s) e3997

    Abstract: A previously healthy, 59-year-old female presented with respiratory distress and dry cough for one week. Outpatient radiographic findings were suspicious for basilar pneumonia. Empiric broad-spectrum antibiotics were started; however, she continued to ... ...

    Abstract A previously healthy, 59-year-old female presented with respiratory distress and dry cough for one week. Outpatient radiographic findings were suspicious for basilar pneumonia. Empiric broad-spectrum antibiotics were started; however, she continued to deteriorate rapidly over the next 48 hours, with chest X-ray showing diffuse bilateral multifocal airspace opacities consistent with acute respiratory distress syndrome. The ratio of partial pressure arterial oxygen to fraction of inspired oxygen was 225. She required a high-flow nasal cannula with a subsequent upgrade to the intensive care unit (ICU) for increasing respiratory compromise. Polymerase chain reaction (PCR) of the nasopharyngeal aspirate confirmed human rhinovirus (hRV). High-dose intravenous steroids were started as adjuvant therapy due to the rapid decline, presumably due to a dysregulated host immune response. After 10 days in the ICU, she was discharged with tiotropium and steroid taper. Historically thought to be limited to pandemic viruses, improved detection of hRV has led to its implication in serious respiratory disorders extending beyond the oropharynx in immunocompetent hosts. We report a rare case of hRV-induced severe acute respiratory distress syndrome (ARDS) in an immunocompetent host. This case highlights the need for the early identification of viral culprits, which can minimize the use of invasive diagnostic testing and antibiotic usage.
    Keywords covid19
    Language English
    Publishing date 2019-02-01
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.3997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A case of hemothorax secondary to intrapleural fibrinolytic therapy: Considerations for use of fibrinolytics in high-risk patients.

    Narula, Naureen / Katyal, Nakul / Salem, Mohammed / Avula, Akshay / Siddiqui, Abdulhassan / Maroun, Rabih / Chalhoub, Michel

    Respiratory medicine case reports

    2021  Volume 34, Page(s) 101420

    Abstract: Indwelling Pleural Catheters (IPC) are increasingly being used for management of recurrent pleural effusions (RPEs). Use of IPC for management of both malignant and non-malignant recurrent pleural effusions has been associated with complications such as ... ...

    Abstract Indwelling Pleural Catheters (IPC) are increasingly being used for management of recurrent pleural effusions (RPEs). Use of IPC for management of both malignant and non-malignant recurrent pleural effusions has been associated with complications such as dysfunctional or nonfunctioning IPCs. Alteplase, a tissue plasminogen activator (tPA) is often used to restore flow of non-draining IPC in symptomatic patients. We present a case of a sixty-eight-year old patient with life-threatening pleural hemorrhage following intrapleural catheter instillation of tPA that was managed successfully by thoracotomy. Our case describe the importance of individualizing the fibrinolytic dose, frequency and the indwelling time in high risk patients. We have reviewed the current literature and recommendations for use of fibrinolytic therapy for IPC in high risk patients on anticoagulation.
    Language English
    Publishing date 2021-05-01
    Publishing country England
    Document type Case Reports
    ZDB-ID 2666110-X
    ISSN 2213-0071
    ISSN 2213-0071
    DOI 10.1016/j.rmcr.2021.101420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A Case of Laryngeal Tuberculosis, Endobronchial Tuberculosis and Pulmonary Tuberculosis Coexistent in an Immunocompetent Host.

    Avula, Akshay / Ngu, Sam / Mansour, Wissam / Gurala, Dhineshreddy / Maroun, Rabih

    Cureus

    2020  Volume 12, Issue 9, Page(s) e10713

    Abstract: Historically associated with poor prognosis seen in advanced disease, laryngeal tuberculosis (LTB) now represents only 1% of all cases of tuberculosis (TB). The incidence of LTB has decreased drastically with the introduction of anti-tubercular drugs. ... ...

    Abstract Historically associated with poor prognosis seen in advanced disease, laryngeal tuberculosis (LTB) now represents only 1% of all cases of tuberculosis (TB). The incidence of LTB has decreased drastically with the introduction of anti-tubercular drugs. LTB can be primary or secondary to pulmonary tuberculosis. LTB can mimic laryngeal cancer. We present a case of primary laryngeal TB with descending tracheobronchial spread in an immunocompetent 71-year-old female who developed progressive dysphonia over several months with unintentional weight loss and non-productive cough. Non-contrast enhanced computed tomography (CT) revealed clustering of subcentimeter stellate nodules in the right upper lung field with an enlarging ground-glass opacity in the right lower lung but did not show structural abnormalities within the neck. Positron emission tomography (PET) showed pathologic fluorodeoxyglucose (FDG) uptake within the larynx and trachea with extension into the left mainstream bronchus as well as the proximal left upper and lower lobe bronchi. Diffuse standardized uptake value (SUV) was greatest in the larynx (20.5). Polymerase chain reaction (PCR) on bronchoscope sputum specimen confirmed Mycobacterium tuberculosis. Findings were consistent with primary laryngeal TB with endobronchial extension. She was started on a four-drug regimen comprising of isoniazid, rifampin, ethambutol, and pyrazinamide with a good response. Her close contacts were treated as well. This case highlights the unusual spread of primary laryngeal TB in an immunocompetent host. Early diagnosis can limit adverse complications and unnecessary exposure to healthcare workers. To our knowledge, this is the first case of primary LTB with proximal spread to the tracheobronchial and pulmonary tuberculosis.
    Language English
    Publishing date 2020-09-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.10713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Immune Modulation Effect of Locoregional Therapies and Its Potential Synergy with Immunotherapy in Hepatocellular Carcinoma.

    Singh, Prabhsimranjot / Toom, Sudhamshi / Avula, Akshay / Kumar, Vivek / Rahma, Osama E

    Journal of hepatocellular carcinoma

    2020  Volume 7, Page(s) 11–17

    Abstract: Locoregional therapies (LRTs) including radiofrequency ablation, surgical resection, and TACE, play a pivotal role in the treatment of early stage/locally advanced hepatocellular carcinoma (HCC). Besides their direct effect on tumor cells, LRTs also play ...

    Abstract Locoregional therapies (LRTs) including radiofrequency ablation, surgical resection, and TACE, play a pivotal role in the treatment of early stage/locally advanced hepatocellular carcinoma (HCC). Besides their direct effect on tumor cells, LRTs also play an essential role in the immunomodulation of the tumor microenvironment which is of interest in the current era of cancer immunotherapy. In this review, we describe the HCC immune microenvironment and how it is affected by LRTs as described in multiple pre-clinical and clinical studies and provide the rationale for combining LRTs with immunotherapy.
    Language English
    Publishing date 2020-02-10
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2780784-8
    ISSN 2253-5969
    ISSN 2253-5969
    DOI 10.2147/JHC.S187121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Pneumopericardium, pneumomediastinum and air travel: A case report in a patient with Gardner syndrome.

    El Haj Chehade, Ahel / Debal, George / Mansour, Wissam / Avula, Akshay / Chalhoub, Michel

    Respiratory medicine case reports

    2020  Volume 31, Page(s) 101271

    Abstract: Onboard aircraft medical emergencies are on the rise as commercial air traffic is increasing. However, thoracic injury secondary to air travel is extremely rare and, most reported injuries are cases of pneumothoraces. Spontaneous pneumomediastinum and ... ...

    Abstract Onboard aircraft medical emergencies are on the rise as commercial air traffic is increasing. However, thoracic injury secondary to air travel is extremely rare and, most reported injuries are cases of pneumothoraces. Spontaneous pneumomediastinum and pneumopericardium have been barely reported in the medical literature as a complication of air travel. We are reporting a case of spontaneous pneumopericardium and pneumomediastinum in a patient with Gardner's Syndrome after a flight from Central America to New York City. The patient presented with chest discomfort. He was managed conservatively with oxygen therapy as he was hemodynamically stable throughout his stay in the hospital. A thorough work up in hospital including and esophagogram and a CT scan of the chest were none revealing of the cause. However, the patient was noted to have metastatic rectal cancer with lung involvement. The patient was discharged with instructions to avoid air travel.
    Language English
    Publishing date 2020-10-25
    Publishing country England
    Document type Case Reports
    ZDB-ID 2666110-X
    ISSN 2213-0071
    ISSN 2213-0071
    DOI 10.1016/j.rmcr.2020.101271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Seizure and COVID-19: Association and review of potential mechanism.

    Narula, Naureen / Joseph, Rudman / Katyal, Nakul / Daouk, Aref / Acharya, Sudeep / Avula, Akshay / Maroun, Rabih

    Neurology, psychiatry, and brain research

    2020  Volume 38, Page(s) 49–53

    Abstract: Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China, this highly transmissible virus has since spread rapidly around the world. Though respiratory complication is the primarily reported manifestation though ...

    Abstract Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China, this highly transmissible virus has since spread rapidly around the world. Though respiratory complication is the primarily reported manifestation though rare, yet serious neurological complications are being frequently reported in the literature. In selected coronavirus disease-2019 (COVID-19) cases neurologic complications may manifest as seizures. In this paper, we have reviewed current literature on seizures linked with SARS- COV 2 infection including published or pre-print original articles, review articles, and case reports. We have discussed the electroencephalogram (EEG), imaging, and Cerebrospinal fluid (CSF) findings in patients with COVID-19 presenting with seizure. We will be concluding the paper by briefly discussing the three mechanisms by which seizures can develop in patients infected with SARS- COV 2 - (a) Direct Mechanism (b) Indirect Mechanism and (c) Exacerbation of Seizure in Patients with Epilepsy (PWE). Our aim is to update the physicians working with COVID-19 patients about this potential complication and hope that understanding of these proposed mechanisms can provide an opportunity for the physicians for early diagnosis or even better, help prevent this complication.
    Keywords covid19
    Language English
    Publishing date 2020-10-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1128315-4
    ISSN 0941-9500
    ISSN 0941-9500
    DOI 10.1016/j.npbr.2020.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3592: Show issues Location:
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