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Article ; Online: Primary plasma cell leukaemia presenting as unilateral proptosis.

Schrijver, Irene T / Kalikmanov-Mikhaylovskaya, Esta / Sandberg, Yorick

EJHaem

2023 Volume 4, Issue 4, Page(s) 1172–1173

Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article
ISSN	2688-6146
ISSN (online)	2688-6146
DOI	10.1002/jha2.809
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Article ; Online: Modes of action and diagnostic value of miRNAs in sepsis.

Antonakos, Nikolaos / Gilbert, Charly / Théroude, Charlotte / Schrijver, Irene T / Roger, Thierry

Frontiers in immunology

2022 Volume 13, Page(s) 951798

Abstract: Sepsis is a clinical syndrome defined as a dysregulated host response to infection resulting in life-threatening organ dysfunction. Sepsis is a major public health concern associated with one in five deaths worldwide. Sepsis is characterized by ... ...

Abstract	Sepsis is a clinical syndrome defined as a dysregulated host response to infection resulting in life-threatening organ dysfunction. Sepsis is a major public health concern associated with one in five deaths worldwide. Sepsis is characterized by unbalanced inflammation and profound and sustained immunosuppression, increasing patient susceptibility to secondary infections and mortality. microRNAs (miRNAs) play a central role in the control of many biological processes, and deregulation of their expression has been linked to the development of oncological, cardiovascular, neurodegenerative and metabolic diseases. In this review, we discuss the role of miRNAs in sepsis pathophysiology. Overall, miRNAs are seen as promising biomarkers, and it has been proposed to develop miRNA-based therapies for sepsis. Yet, the picture is not so straightforward because of the versatile and dynamic features of miRNAs. Clearly, more research is needed to clarify the expression and role of miRNAs in sepsis, and to promote the use of miRNAs for sepsis management.
MeSH term(s)	Biomarkers/metabolism ; Humans ; Immune Tolerance ; Inflammation ; MicroRNAs/metabolism ; Sepsis/diagnosis ; Sepsis/drug therapy ; Sepsis/genetics
Chemical Substances	Biomarkers ; MicroRNAs
Language	English
Publishing date	2022-08-05
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.951798
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Article ; Online: Impact of the timeliness of antibiotic therapy on the outcome of patients with sepsis and septic shock.

Asner, Sandra A / Desgranges, Florian / Schrijver, Irene T / Calandra, Thierry

The Journal of infection

2021 Volume 82, Issue 5, Page(s) 125–134

Abstract: Objectives: To review the impact of the timeliness of antibiotic therapy on the outcome of patients with sepsis or septic shock.: Methods: We searched MEDLINE, EMBASE, the Cochrane Library, Web of Science, Open-SIGLE databases, ClinicalTrials.gov and ...

Abstract	Objectives: To review the impact of the timeliness of antibiotic therapy on the outcome of patients with sepsis or septic shock. Methods: We searched MEDLINE, EMBASE, the Cochrane Library, Web of Science, Open-SIGLE databases, ClinicalTrials.gov and the metaRegister of Controlled Trials on July 27, 2020 for relevant studies on the timing of antibiotic therapy in adult patients with sepsis or septic shock. The primary outcome measure was all-cause crude or adjusted mortality at reported time points. Results: We included 35 sepsis studies involving 154,330 patients. Nineteen studies (54%) provided information on the appropriateness of antibiotic therapy in 20,062 patients of whom 16,652 patients (83%) received appropriate antibiotics. Twenty-four studies (68.6%) reported an association between time-to-antibiotics and mortality. Time thresholds associated with patient's outcome varied considerably between studies consisting of a wide range of time cutoffs (1 h, 125 min, 3 h or 6 h) in 14 studies, hourly delays (derived from the analyses of time intervals ranging from to 1 to 24 h) in 8 studies or time-to-antibiotic in 2 studies. Analyses of subsets of studies that focused on patients with septic shock (11 studies, 12,756 patients) or with sepsis (6 studies, 24,281 patients) yielded similar results. Conclusions: While two-thirds of sepsis studies reported an association between early administration of antibiotic therapy and patient outcome, the time-to-antibitiocs metrics varied significantly across studies and no robust time thresholds emerged.
MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Humans ; Sepsis/drug therapy ; Shock, Septic/drug therapy
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-03-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2021.03.003
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Article ; Online: Myeloid-Derived Suppressor-like Cells as a Prognostic Marker in Critically Ill Patients: Insights from Experimental Endotoxemia and Intensive Care Patients.

Schrijver, Irene T / Herderschee, Jacobus / Théroude, Charlotte / Kritikos, Antonios / Leijte, Guus / Le Roy, Didier / Brochut, Maelick / Chiche, Jean-Daniel / Perreau, Matthieu / Pantaleo, Giuseppe / Guery, Benoit / Kox, Matthijs / Pickkers, Peter / Calandra, Thierry / Roger, Thierry

Cells

2024 Volume 13, Issue 4

Abstract: Patients admitted to the intensive care unit (ICU) often experience endotoxemia, nosocomial infections and sepsis. Polymorphonuclear and monocytic myeloid-derived suppressor cells (PMN-MDSCs and M-MDSCs) can have an important impact on the development of ...

Abstract	Patients admitted to the intensive care unit (ICU) often experience endotoxemia, nosocomial infections and sepsis. Polymorphonuclear and monocytic myeloid-derived suppressor cells (PMN-MDSCs and M-MDSCs) can have an important impact on the development of infectious diseases, but little is known about their potential predictive value in critically ill patients. Here, we used unsupervised flow cytometry analyses to quantify MDSC-like cells in healthy subjects challenged with endotoxin and in critically ill patients admitted to intensive care units and at risk of developing infections. Cells phenotypically similar to PMN-MDSCs and M-MDSCs increased after endotoxin challenge. Similar cells were elevated in patients at ICU admission and normalized at ICU discharge. A subpopulation of M-MDSC-like cells expressing intermediate levels of CD15 (CD15
MeSH term(s)	Humans ; Endotoxemia ; Critical Illness ; Prognosis ; Myeloid-Derived Suppressor Cells ; Critical Care ; Endotoxins
Chemical Substances	Endotoxins
Language	English
Publishing date	2024-02-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells13040314
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Article ; Online: Myeloid-Derived Suppressor Cells in Sepsis.

Schrijver, Irene T / Théroude, Charlotte / Roger, Thierry

Frontiers in immunology

2019 Volume 10, Page(s) 327

Abstract: Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells characterized by their immunosuppressive functions. MDSCs expand during chronic and acute inflammatory conditions, the best described being cancer. Recent studies uncovered an important ... ...

Abstract	Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells characterized by their immunosuppressive functions. MDSCs expand during chronic and acute inflammatory conditions, the best described being cancer. Recent studies uncovered an important role of MDSCs in the pathogenesis of infectious diseases along with sepsis. Here we discuss the mechanisms underlying the expansion and immunosuppressive functions of MDSCs, and the results of preclinical and clinical studies linking MDSCs to sepsis pathogenesis. Strikingly, all clinical studies to date suggest that high proportions of blood MDSCs are associated with clinical worsening, the incidence of nosocomial infections and/or mortality. Hence, MDSCs are attractive biomarkers and therapeutic targets for sepsis, especially because these cells are barely detectable in healthy subjects. Blocking MDSC-mediated immunosuppression and trafficking or depleting MDSCs might all improve sepsis outcome. While some key aspects of MDSCs biology need in depth investigations, exploring these avenues may participate to pave the way toward the implementation of personalized medicine and precision immunotherapy for patients suffering from sepsis.
MeSH term(s)	Biomarkers ; Disease Susceptibility ; Granulocytes/immunology ; Granulocytes/metabolism ; Host-Pathogen Interactions/immunology ; Humans ; Immune Tolerance ; Immunity, Innate ; Immunomodulation ; Myeloid-Derived Suppressor Cells/immunology ; Myeloid-Derived Suppressor Cells/metabolism ; Prognosis ; Sepsis/diagnosis ; Sepsis/etiology ; Sepsis/metabolism ; Sepsis/mortality
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-02-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.00327
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Article: High levels of monocytic myeloid-derived suppressor cells are associated with favorable outcome in patients with pneumonia and sepsis with multi-organ failure.

Schrijver, Irene T / Karakike, Eleni / Théroude, Charlotte / Baumgartner, Pétra / Harari, Alexandre / Giamarellos-Bourboulis, Evangelos J / Calandra, Thierry / Roger, Thierry

Intensive care medicine experimental

2022 Volume 10, Issue 1, Page(s) 5

Abstract: Background: Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells with immunosuppressive functions sub-classified into monocytic and polymorphonuclear MDSCs (M-MDSCs and PMN-MDSCs). Clinical studies reported increased levels of MDSCs that ... ...

Abstract	Background: Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells with immunosuppressive functions sub-classified into monocytic and polymorphonuclear MDSCs (M-MDSCs and PMN-MDSCs). Clinical studies reported increased levels of MDSCs that were associated with poor outcome in sepsis patients. Since sepsis patients exhibit signs of inflammation and immunosuppression, MDSCs may provide benefit by dampening deleterious inflammation in some patients. To test this hypothesis, we measured MDSCs in critically ill sepsis patients with pneumonia and multi-organ dysfunctions and a high likelihood of death. Methods: This was a prospective multicenter observational cohort study performed in eight ICUs in Athens and Thessaloniki, Greece, enrolling critically ill patients with pneumonia and sepsis with multi-organ dysfunctions. A flow cytometry approach using blood collected at study inclusion in tubes containing lyophilized antibodies combined to unsupervised clustering was developed to quantify M-MDSCs and PMN-MDSCs. Results: Forty-eight patients were included, of whom 34 died within 90 days. At study inclusion, M-MDSCs and PMN-MDSCs were increased in sepsis patients when compared to healthy subjects (3.07% vs 0.96% and 22% vs 2.1% of leukocytes, respectively; p < 10 Conclusion: This is the first study to associate high levels of M-MDSCs with improved survival in sepsis patients.
Language	English
Publishing date	2022-02-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2740385-3
ISSN	2197-425X
ISSN	2197-425X
DOI	10.1186/s40635-022-00431-0
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Article ; Online: Beta-2-glycoprotein I as a biomarker for sepsis in critically ill patients in the intensive care unit: a prospective cohort study.

Schrijver, Irene T / Kemperman, Hans / Roest, Mark / Kesecioglu, Jozef / de Lange, Dylan W

Critical care (London, England)

2020 Volume 24, Issue 1, Page(s) 341

MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biomarkers/analysis ; Biomarkers/blood ; Cohort Studies ; Critical Illness ; Female ; Humans ; Intensive Care Units/organization & administration ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Prospective Studies ; Sepsis/blood ; Sepsis/diagnosis ; beta 2-Glycoprotein I/analysis ; beta 2-Glycoprotein I/blood
Chemical Substances	Biomarkers ; beta 2-Glycoprotein I
Language	English
Publishing date	2020-06-15
Publishing country	England
Document type	Letter
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-020-03066-3
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Article ; Online: COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions.

Schrijver, Irene T / Théroude, Charlotte / Antonakos, Nikolaos / Regina, Jean / Le Roy, Didier / Bart, Pierre-Alexandre / Chiche, Jean-Daniel / Perreau, Matthieu / Pantaleo, Giuseppe / Calandra, Thierry / Roger, Thierry

European journal of immunology

2022 Volume 52, Issue 10, Page(s) 1676–1679

Abstract: We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) ... ...

Abstract	We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID-19 patients.
MeSH term(s)	Biomarkers ; COVID-19 ; Cytokines/pharmacology ; Humans ; Immune System Diseases ; Immunity, Innate ; Lipopolysaccharides ; Myeloid-Derived Suppressor Cells
Chemical Substances	Biomarkers ; Cytokines ; Lipopolysaccharides
Language	English
Publishing date	2022-06-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.202249827
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Article ; Online: Trained Immunity Confers Prolonged Protection From Listeriosis.

Théroude, Charlotte / Reverte, Marta / Heinonen, Tytti / Ciarlo, Eleonora / Schrijver, Irene T / Antonakos, Nikolaos / Maillard, Nicolas / Pralong, Florian / Le Roy, Didier / Roger, Thierry

Frontiers in immunology

2021 Volume 12, Page(s) 723393

Abstract: Trained immunity refers to the ability of the innate immune system exposed to a first challenge to provide an enhanced response to a secondary homologous or heterologous challenge. We reported that training induced with β-glucan one week before infection ...

Abstract	Trained immunity refers to the ability of the innate immune system exposed to a first challenge to provide an enhanced response to a secondary homologous or heterologous challenge. We reported that training induced with β-glucan one week before infection confers protection against a broad-spectrum of lethal bacterial infections. Whether this protection persists over time is unknown. To tackle this question, we analyzed the immune status and the response to
MeSH term(s)	Animals ; Bone Marrow ; Cytokines/metabolism ; Female ; Immunity, Innate ; Inflammation/immunology ; Listeria monocytogenes/immunology ; Listeriosis/immunology ; Listeriosis/microbiology ; Mice ; Mice, Inbred C57BL ; Monocytes/metabolism ; Neutrophils/metabolism
Chemical Substances	Cytokines
Language	English
Publishing date	2021-09-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.723393
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Article ; Online: High-dimensional immune phenotyping of blood cells by mass cytometry in patients infected with hepatitis C virus.

Herderschee, Jacobus / Heinonen, Tytti / Fenwick, Craig / Schrijver, Irene T / Ohmiti, Khalid / Moradpour, Darius / Cavassini, Matthias / Pantaleo, Giuseppe / Roger, Thierry / Calandra, Thierry

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2021 Volume 28, Issue 4, Page(s) 611.e1–611.e7

Abstract: Objectives: Chronic hepatitis C virus (HCV) infection affects the immune system. Whether elimination of HCV with direct-acting antivirals (DAA) restores immunity is unclear. We used mass cytometry to get a broad and in-depth assessment of blood cell ... ...

Abstract	Objectives: Chronic hepatitis C virus (HCV) infection affects the immune system. Whether elimination of HCV with direct-acting antivirals (DAA) restores immunity is unclear. We used mass cytometry to get a broad and in-depth assessment of blood cell populations of patients with chronic HCV before and after DAA therapy. Methods: Before and 12 weeks after sustained virological response (SVR12) to DAA therapy, 22 cell populations were analysed by mass cytometry in blood collected from ten healthy control individuals and 20 HCV-infected patients with (ten patients) or without (ten patients) human immunodeficiency virus (HIV) infection. Results: HCV infection altered the frequency of 14/22 (64%) blood cell populations. At baseline, the frequencies (median, interquartile range (IQR); control, HCV, HCV/HIV) of intermediate monocytes (1.2, IQR 0.47-1.46; 1.76, IQR 0.83-2.66; 0.78, IQR 0.28-1.77), non-classical monocytes (1.11, IQR 0.49-1.26; 0.9, IQR 0.18-0.99; 0.54, IQR 0.28-1.77), conventional dendritic cells type 2 (0.55, IQR 0.35-0.59; 0.31, IQR 0.16-0.38; 0.19, IQR 0.11-0.36) and CD56 Conclusions: Chronic HCV and HCV/HIV infections induce profound and durable perturbations of innate and adaptive immune homeostasis.
MeSH term(s)	Antiviral Agents/therapeutic use ; CD8-Positive T-Lymphocytes ; HIV Infections/complications ; HIV Infections/drug therapy ; Hepacivirus ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Hepatitis C, Chronic/drug therapy ; Humans
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2021.08.018
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