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  1. Article ; Online: Emerging immunotherapeutics for immune activation and tolerance.

    Pearson, Ryan M / Acharya, Abhinav P / Moon, James J

    Drug delivery and translational research

    2023  Volume 13, Issue 7, Page(s) 1857–1858

    MeSH term(s) Immunotherapy
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 2590155-2
    ISSN 2190-3948 ; 2190-393X
    ISSN (online) 2190-3948
    ISSN 2190-393X
    DOI 10.1007/s13346-023-01352-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nanoparticle personalized biomolecular corona: implications of pre-existing conditions for immunomodulation and cancer.

    Shaw, Jacob / Pearson, Ryan M

    Biomaterials science

    2022  Volume 10, Issue 10, Page(s) 2540–2549

    Abstract: Nanoparticles (NPs) have demonstrated great promise as immunotherapies for applications ranging from cancer, autoimmunity, and infectious disease. Upon encountering biological fluids, NPs rapidly adsorb biomolecules, forming the "biomolecular corona" (BC) ...

    Abstract Nanoparticles (NPs) have demonstrated great promise as immunotherapies for applications ranging from cancer, autoimmunity, and infectious disease. Upon encountering biological fluids, NPs rapidly adsorb biomolecules, forming the "biomolecular corona" (BC), and the altered character of NPs due to their newly acquired biological identity can impact their
    MeSH term(s) Humans ; Immunomodulation ; Nanoparticles ; Neoplasms ; Preexisting Condition Coverage ; Protein Corona ; Tissue Distribution
    Chemical Substances Protein Corona
    Language English
    Publishing date 2022-05-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d2bm00315e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rural communities experience higher radon exposure versus urban areas, potentially due to drilled groundwater well annuli acting as unintended radon gas migration conduits.

    Khan, Selim M / Pearson, Dustin D / Eldridge, Evangeline L / Morais, Tiago A / Ahanonu, Marvit I C / Ryan, M Cathryn / Taron, Joshua M / Goodarzi, Aaron A

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3640

    Abstract: ... residential radon levels relative to urban equivalents, equating to an additional 26.7 Bq/m ...

    Abstract Repetitive, long-term inhalation of radioactive radon gas is one of the leading causes of lung cancer, with exposure differences being a function of geographic location, built environment, personal demographics, activity patterns, and decision-making. Here, we examine radon exposure disparities across the urban-to-rural landscape, based on 42,051 Canadian residential properties in 2034 distinct communities. People living in rural, lower population density communities experience as much as 31.2% greater average residential radon levels relative to urban equivalents, equating to an additional 26.7 Bq/m
    MeSH term(s) Humans ; Radon/adverse effects ; Radon/analysis ; Air Pollutants, Radioactive/analysis ; Air Pollution, Indoor/analysis ; Rural Population ; Housing ; Canada ; Groundwater ; Lung Neoplasms/epidemiology ; Lung Neoplasms/etiology ; Radiation Monitoring
    Chemical Substances Radon (Q74S4N8N1G) ; Air Pollutants, Radioactive
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53458-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Excipient-Free Ionizable Polyester Nanoparticles for Lung-Selective and Innate Immune Cell Plasmid DNA and mRNA Transfection.

    Chakraborty, Atanu / Dharmaraj, Shruti / Truong, Nhu / Pearson, Ryan M

    ACS applied materials & interfaces

    2022  Volume 14, Issue 51, Page(s) 56440–56453

    Abstract: Extrahepatic nucleic acid delivery using polymers typically requires the synthesis and purification of custom monomers, post-synthetic modifications, and incorporation of additional excipients to augment their stability, endosomal escape, and in vivo ... ...

    Abstract Extrahepatic nucleic acid delivery using polymers typically requires the synthesis and purification of custom monomers, post-synthetic modifications, and incorporation of additional excipients to augment their stability, endosomal escape, and in vivo effectiveness. Here, we report the development of a single-component and excipient-free, polyester-based nucleic acid delivery nanoparticle platform comprising ionizable
    MeSH term(s) Polyesters ; RNA, Messenger/genetics ; RNA, Messenger/chemistry ; Transfection ; Plasmids/genetics ; DNA/chemistry ; Polymers/chemistry ; Lung/metabolism ; Nanoparticles/chemistry ; Immunity, Innate
    Chemical Substances Polyesters ; RNA, Messenger ; DNA (9007-49-2) ; Polymers
    Language English
    Publishing date 2022-12-16
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c14424
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  5. Article ; Online: The National Institutes of Health INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project: Accelerating research discoveries for people with Down syndrome across the lifespan.

    Bardhan, Sujata / Li, Huiqing / Tarver, Erika / Schramm, Charlene / Brown, Marishka / Garcia, Linda / Schwartz, Bryanna / Mazzucco, Anna / Natarajan, Nikila / Walsh, Elizabeth / Ryan, Laurie / Pearson, Gail / Parisi, Melissa A

    American journal of medical genetics. Part C, Seminars in medical genetics

    2024  Volume 196, Issue 1, Page(s) e32081

    Abstract: ... over its first 5 years, INCLUDE has invested $258 M in over 250 new research projects. INCLUDE also ...

    Abstract The National Institutes of Health (NIH) has a long-standing history of support for research in Down syndrome (DS). In response to a 2018 congressional directive for a trans-NIH initiative to address medical issues in DS, NIH launched the INCLUDE Project (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE). Reflecting the three INCLUDE components of basic science research, cohort development, and clinical trials, the Project has published funding opportunities to address conditions such as immune disorders and Alzheimer's disease. Due to a steady expansion in dedicated funding over its first 5 years, INCLUDE has invested $258 M in over 250 new research projects. INCLUDE also supports training initiatives to expand the number and diversity of investigators studying DS. NIH has funded an INCLUDE Data Coordinating Center that is collecting de-identified clinical information and multi-omics data from research participants for broad data sharing and secondary analyses. Through the DS-Connect® registry, INCLUDE investigators can access recruitment support. The INCLUDE Research Plan articulates research goals for the program, with an emphasis on diversity of research participants and investigators. Finally, a new Cohort Development Program is poised to increase the impact of the INCLUDE Project by recruiting a large DS cohort across the lifespan.
    MeSH term(s) United States/epidemiology ; Humans ; Down Syndrome ; Biomedical Research ; Longevity ; Alzheimer Disease ; National Institutes of Health (U.S.)
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2108622-9
    ISSN 1552-4876 ; 0148-7299 ; 1552-4868
    ISSN (online) 1552-4876
    ISSN 0148-7299 ; 1552-4868
    DOI 10.1002/ajmg.c.32081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1376/C: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Can we save Australia's endangered wildlife by increasing species recognition?

    Pearson, Elissa L. / Mellish, Sarah / McLeod, Emily M. / Sanders, Ben / Ryan, Jillian C.

    Journal for nature conservation

    2022  Volume 69, Issue -, Page(s) 126257

    Language English
    Document type Article
    ZDB-ID 2077553-2
    ISSN 1617-1381
    Database Current Contents Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Z 6016: Show issues

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  7. Article ; Online: Modified Suberoylanilide Hydroxamic Acid Reduced Drug-Associated Immune Cell Death and Organ Damage under Lipopolysaccharide Inflammatory Challenge.

    Truong, Nhu / Goodis, Christopher C / Cottingham, Andrea L / Shaw, Jacob R / Fletcher, Steven / Pearson, Ryan M

    ACS pharmacology & translational science

    2022  Volume 5, Issue 11, Page(s) 1128–1141

    Abstract: Histone deacetylase inhibitors (HDACi) induce potent anti-inflammatory responses when used to treat inflammatory diseases. Suberoylanilide hydroxamic acid (SAHA), a pan-HDACi, decreases pro-inflammatory cytokine levels and attenuates cytokine storm in ... ...

    Abstract Histone deacetylase inhibitors (HDACi) induce potent anti-inflammatory responses when used to treat inflammatory diseases. Suberoylanilide hydroxamic acid (SAHA), a pan-HDACi, decreases pro-inflammatory cytokine levels and attenuates cytokine storm in sepsis; however, its toxicity profile toward immune cells has limited its use as a sepsis therapeutic. Here, we developed a modification to SAHA by
    Language English
    Publishing date 2022-10-10
    Publishing country United States
    Document type Journal Article
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.2c00119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Decreasing surface albedo signifies a growing importance of clouds for Greenland Ice Sheet meltwater production.

    Ryan, J C / Smith, L C / Cooley, S W / Pearson, B / Wever, N / Keenan, E / Lenaerts, J T M

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 4205

    Abstract: ... that a 1% change in cloudiness has little effect (±0.16 W m ...

    Abstract Clouds regulate the Greenland Ice Sheet's surface energy balance through the competing effects of shortwave radiation shading and longwave radiation trapping. However, the relative importance of these effects within Greenland's narrow ablation zone, where nearly all meltwater runoff is produced, remains poorly quantified. Here we use machine learning to merge MODIS, CloudSat, and CALIPSO satellite observations to produce a high-resolution cloud radiative effect product. For the period 2003-2020, we find that a 1% change in cloudiness has little effect (±0.16 W m
    Language English
    Publishing date 2022-07-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-31434-w
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  9. Article ; Online: Nanoparticle-Based Delivery to Treat Spinal Cord Injury-a Mini-review.

    Chakraborty, Atanu / Ciciriello, Andrew J / Dumont, Courtney M / Pearson, Ryan M

    AAPS PharmSciTech

    2021  Volume 22, Issue 3, Page(s) 101

    Abstract: There is an increasing need to develop improved and non-invasive strategies to treat spinal cord injury (SCI). Nanoparticles (NPs) are an enabling technology to improve drug delivery, modulate inflammatory responses, and restore functional responses ... ...

    Abstract There is an increasing need to develop improved and non-invasive strategies to treat spinal cord injury (SCI). Nanoparticles (NPs) are an enabling technology to improve drug delivery, modulate inflammatory responses, and restore functional responses following SCI. However, the complex pathophysiology associated with SCI presents several distinct challenges that must be overcome for sufficient NP drug delivery to the spinal cord. The objective of this mini-review is to highlight the physiological challenges and cell types available for modulation and discuss several promising advancements using NPs to improve SCI treatment. We will focus our discussion on recent innovative approaches in NP drug delivery and how the implementation of multifactorial approaches to address the proinflammatory and complex immune dysfunction in SCI offers significant potential to improve outcomes in SCI.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/therapeutic use ; Drug Delivery Systems ; Humans ; Nanoparticles ; Spinal Cord Injuries/drug therapy
    Chemical Substances Anti-Inflammatory Agents
    Language English
    Publishing date 2021-03-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2052070-0
    ISSN 1530-9932 ; 1530-9932
    ISSN (online) 1530-9932
    ISSN 1530-9932
    DOI 10.1208/s12249-021-01975-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Challenges and successes to the implementation of a zoo conservation-education program.

    Mellish, Sarah / Ryan, Jillian C / McLeod, Emily M / Tuckey, Michelle R / Pearson, Elissa L

    Evaluation and program planning

    2021  Volume 88, Page(s) 101950

    Abstract: Zoo conservation-education programs have potential to address biodiversity loss, although evidence of their effectiveness to encourage social change is in its infancy. Moreover, how a program is implemented may influence program efficacy, yet there is ... ...

    Abstract Zoo conservation-education programs have potential to address biodiversity loss, although evidence of their effectiveness to encourage social change is in its infancy. Moreover, how a program is implemented may influence program efficacy, yet there is little evidence of the factors that shape this process in zoos. Accordingly, through a process evaluation of Zoos Victoria's 'When Balloons Fly" (WBF) conservation-education program against marine debris, we identified barriers and enablers to the implementation of the program which can be addressed to improve future initiatives. Between April-May 2018, 24 Zoos Victoria professionals completed an online survey focussed on identifying challenges and successes in implementing WBF. Four participants additionally completed a follow-up telephone interview. Themes were identified and organised according to the model of diffusion in service organisations (Greenhalgh, Robert, Macfarlane, Bate, & Kyriakidou, 2004). Our results illuminate that features of the organisation (e.g., structure, culture) rather than features of individuals (e.g., skills, motivation) or characteristics of the conservation-education program itself (e.g., messaging), were most influential to implementation success. Based on these findings, attention to the organisational context is critical for promoting and evaluating the success of conservation-education programs and must be given significant attention alongside program characteristics and staff capability to deliver them.
    MeSH term(s) Animals ; Animals, Zoo ; Conservation of Natural Resources ; Humans ; Motivation ; Program Evaluation ; Surveys and Questionnaires
    Language English
    Publishing date 2021-04-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2013444-7
    ISSN 1873-7870 ; 0149-7189
    ISSN (online) 1873-7870
    ISSN 0149-7189
    DOI 10.1016/j.evalprogplan.2021.101950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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