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  1. Article ; Online: Harnessing Generative AI for Glioma Diagnosis: A Step Forward in Neuro-Oncologic Imaging.

    Lee, Matthew D / Jain, Rajan

    Neuro-oncology

    2024  

    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noae043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5307: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Book: Brain tumor imaging

    Jain, Rajan / Essig, Marco

    2016  

    Author's details Rajan Jain ; Marco Essig
    Keywords Brain Neoplasms / diagnosis ; Brain Neoplasms / genetics ; Diagnostic Imaging / methods ; Molecular imaging / trends ; Neuroimaging
    Language English
    Size XVII, 259 S. : zahlr. Ill., graph. Darst.
    Publisher Thieme
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT018737175
    ISBN 978-1-60406-806-1 ; 1-60406-806-X ; 9781604068306 ; 1604068302
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 3072 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Editorial for "MRI-Based Radiomics Approach for Differentiating Juvenile Myoclonic Epilepsy From Epilepsy With Generalized Tonic-Clonic Seizures Alone".

    Lee, Matthew D / Jain, Rajan

    Journal of magnetic resonance imaging : JMRI

    2023  

    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.29030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3648: Show issues Location:
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    Zs.MO 236: Show issues

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  4. Article ; Online: Letter to the Editor. The T2-FLAIR-mismatch sign.

    Jain, Rajan

    Neurosurgical focus

    2020  Volume 48, Issue 5, Page(s) E9

    MeSH term(s) Bayes Theorem ; Biomarkers ; Diagnostic Tests, Routine ; Glioma ; Humans ; Magnetic Resonance Imaging
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-05-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2026589-X
    ISSN 1092-0684 ; 1092-0684
    ISSN (online) 1092-0684
    ISSN 1092-0684
    DOI 10.3171/2020.2.FOCUS2042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Radiogenomics identifying important biological pathways in gliomas.

    Jain, Rajan / Chi, Andrew S

    Neuro-oncology

    2021  Volume 23, Issue 2, Page(s) 177–178

    MeSH term(s) Diagnostic Imaging ; Diagnostic Tests, Routine ; Glioblastoma ; Glioma/genetics ; Humans ; Prognosis
    Language English
    Publishing date 2021-02-24
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noaa290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5307: Show issues Location:
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  6. Article ; Online: Not all stress is bad for your heart.

    Jain, Rajan / Epstein, Jonathan A

    Science (New York, N.Y.)

    2021  Volume 374, Issue 6565, Page(s) 264–265

    Abstract: Shear stress forces instruct valve formation during cardiac development. ...

    Abstract Shear stress forces instruct valve formation during cardiac development.
    MeSH term(s) Heart ; Heart Rate
    Language English
    Publishing date 2021-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abm1858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
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    Zs.MG 77: Show issues

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  7. Article ; Online: A social profile of deaths related to sickle cell disease in India: a case for an ethical policy response.

    Chattoo, Sangeeta / Jain, Dipty / Nashine, Nidhi / Singh, Rajan

    Frontiers in public health

    2023  Volume 11, Page(s) 1265313

    Abstract: India accounts for 14.5 percent of the global SCD newborns, roughly over 42,000 a year, second to sub-Saharan Africa. Despite the availability of cheap diagnostic and treatment options, SCD remains a largely neglected disease within healthcare policy and ...

    Abstract India accounts for 14.5 percent of the global SCD newborns, roughly over 42,000 a year, second to sub-Saharan Africa. Despite the availability of cheap diagnostic and treatment options, SCD remains a largely neglected disease within healthcare policy and practice. Epidemiological modeling based on small, often dated, regional studies (largely from sub-Saharan Africa) estimate that between 50 and 90 percent of affected children will/die before the age of 5 years. This premise, coupled with targets of reducing under 5 mortality (SDG 4), privileges public health interventions for screening and prevention of new births, undermining investments in long-term health and social care. This paper presents a retrospective, descriptive analysis of the socio-demographic profile of 447 patients diagnosed with sickle cell or sickle-beta thalassemia, who died following admission at a tertiary care entre in India. We used anonymized hospital records of 3,778 sickle cell patients, admitted in pediatric and adult/medical wards between January 2016 and February 2021. A majority of hospital deaths occurred in the second and third decades of life, following a hospital admission for a week. The overall mortality during 2016-2019 was 14% with little gender difference over time. Contrary to our expectations, the number of hospital deaths did not increase during the first year of the COVID-19 pandemic, between 2020 and 2021. The conclusion highlights the importance of longitudinal, socio-demo-graphic data on deaths as providing important insights for identifying ethical policy interventions focused on improving SCD outcomes over time, reducing inequities in access to care, and preventing what might be considered "excess" deaths.
    MeSH term(s) Adult ; Child ; Humans ; Infant, Newborn ; Child, Preschool ; Retrospective Studies ; Pandemics ; Anemia, Sickle Cell/epidemiology ; Anemia, Sickle Cell/diagnosis ; Health Policy ; Cause of Death
    Language English
    Publishing date 2023-12-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1265313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A social profile of deaths related to sickle cell disease in India

    Sangeeta Chattoo / Dipty Jain / Nidhi Nashine / Rajan Singh

    Frontiers in Public Health, Vol

    a case for an ethical policy response

    2023  Volume 11

    Abstract: India accounts for 14.5 percent of the global SCD newborns, roughly over 42,000 a year, second to sub-Saharan Africa. Despite the availability of cheap diagnostic and treatment options, SCD remains a largely neglected disease within healthcare policy and ...

    Abstract India accounts for 14.5 percent of the global SCD newborns, roughly over 42,000 a year, second to sub-Saharan Africa. Despite the availability of cheap diagnostic and treatment options, SCD remains a largely neglected disease within healthcare policy and practice. Epidemiological modeling based on small, often dated, regional studies (largely from sub-Saharan Africa) estimate that between 50 and 90 percent of affected children will/die before the age of 5 years. This premise, coupled with targets of reducing under 5 mortality (SDG 4), privileges public health interventions for screening and prevention of new births, undermining investments in long-term health and social care. This paper presents a retrospective, descriptive analysis of the socio-demographic profile of 447 patients diagnosed with sickle cell or sickle-beta thalassemia, who died following admission at a tertiary care entre in India. We used anonymized hospital records of 3,778 sickle cell patients, admitted in pediatric and adult/medical wards between January 2016 and February 2021. A majority of hospital deaths occurred in the second and third decades of life, following a hospital admission for a week. The overall mortality during 2016–2019 was 14% with little gender difference over time. Contrary to our expectations, the number of hospital deaths did not increase during the first year of the COVID-19 pandemic, between 2020 and 2021. The conclusion highlights the importance of longitudinal, socio-demo-graphic data on deaths as providing important insights for identifying ethical policy interventions focused on improving SCD outcomes over time, reducing inequities in access to care, and preventing what might be considered “excess” deaths.
    Keywords sickle cell ; India ; mortality ; structural inequality ; ethical policy ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Somatosensory cortex of macaque monkeys is designed for opposable thumb.

    Lazar, Leslee / Chand, Prem / Rajan, Radhika / Mohammed, Hisham / Jain, Neeraj

    Cerebral cortex (New York, N.Y. : 1991)

    2022  Volume 33, Issue 1, Page(s) 195–206

    Abstract: The evolution of opposable thumb has enabled fine grasping ability and precision grip, therefore the ability to finely manipulate the objects and refined tool use. Since tactile inputs to an opposable thumb are often spatially and temporally out of sync ... ...

    Abstract The evolution of opposable thumb has enabled fine grasping ability and precision grip, therefore the ability to finely manipulate the objects and refined tool use. Since tactile inputs to an opposable thumb are often spatially and temporally out of sync with inputs from the fingers, we hypothesized that inputs from the opposable thumb would be processed in an independent module in the primary somatosensory cortex (area 3b). Here we show that in area 3b of macaque monkeys, most neurons in the thumb representation do not respond to tactile stimulation of other digits and receive few intrinsic cortical inputs from other digits. However, neurons in the representations of other 4 digits respond to touch on any of the 4 digits and interconnect significantly more. The thumb inputs are thus processed in an independent module, whereas there is a significantly more interdigital information exchange between the other digits. This cortical organization reflects behavioral use of a hand with an opposable thumb.
    MeSH term(s) Animals ; Somatosensory Cortex/physiology ; Thumb ; Macaca ; Haplorhini ; Brain Mapping
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077450-6
    ISSN 1460-2199 ; 1047-3211
    ISSN (online) 1460-2199
    ISSN 1047-3211
    DOI 10.1093/cercor/bhac061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3235: Show issues Location:
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  10. Article ; Online: Role of F-actin-mediated endocytosis and exercise in mitochondrial transplantation in an experimental Parkinson's disease mouse model.

    Jain, Rachit / Begum, Nusrat / Rajan, Shruti / Tryphena, Kamatham Pushpa / Khatri, Dharmendra Kumar

    Mitochondrion

    2023  Volume 74, Page(s) 101824

    Abstract: Dopaminergic neurons gradually deteriorate in Parkinson's Disease (PD), which is characterized by the intracellular accumulation of Lewy bodies that are enriched with α-synuclein protein. Mitochondrial dysfunction is one of the primary contributors to ... ...

    Abstract Dopaminergic neurons gradually deteriorate in Parkinson's Disease (PD), which is characterized by the intracellular accumulation of Lewy bodies that are enriched with α-synuclein protein. Mitochondrial dysfunction is one of the primary contributors to this and is considered as the central player in the pathogenesis of PD. Recently, improving mitochondrial function has been extensively explored as a therapeutic strategy in various preclinical PD models. Mitochondrial transplantation is one such naïve yet highly efficient technique that has been well explored in diseases like diabetes, NAFLD, and cardiac ischemia but not in PD. Here, we compared the effects of transplanting normal allogenic mitochondria to those of transplanting exercise-induced allogenic mitochondria isolated from the liver into the PD mouse model. It is already known that normal Mitochondrial Transplant (MT) reduces the PD pathology, but our research found out that exercise-induced mitochondria were more effective in treating the PD pathology because they had higher respiratory capacities. Additionally, compared to a standard transplant, this therapy significantly boosted the rate of mitochondrial biogenesis and the quantity of mitochondrial subunits in PD mice. Further, we also explored the mechanism of mitochondrial uptake into the cells and found that F-actin plays a key role in the internalization of mitochondria. This study is the first to demonstrate the relevance of exercise-induced allogenic MT and the function of F-actin in the internalization of mitochondria in PD mice.
    MeSH term(s) Animals ; Mice ; Parkinson Disease/therapy ; Parkinson Disease/pathology ; Actins/metabolism ; Mitochondria/metabolism ; Disease Models, Animal ; Endocytosis ; Dopaminergic Neurons
    Chemical Substances Actins
    Language English
    Publishing date 2023-11-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2056923-3
    ISSN 1872-8278 ; 1567-7249
    ISSN (online) 1872-8278
    ISSN 1567-7249
    DOI 10.1016/j.mito.2023.11.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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