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Article ; Online: NEUROSCIENCE AND ART.

Tsamakis, Konstantinos / Karakis, Ioannis

2022 Volume 20, Issue 1, Page(s) 155–173

Abstract: https://doi.org/10.31952/amha.20.1.8 The objective of this article is to highlight the bidirectional relationship between neuroscience and art in the life and times of the most preeminent sculptor in modern Greek history, Yannoulis Chalepas. Analysis ... ...

Abstract	https://doi.org/10.31952/amha.20.1.8 The objective of this article is to highlight the bidirectional relationship between neuroscience and art in the life and times of the most preeminent sculptor in modern Greek history, Yannoulis Chalepas. Analysis of biographical sources and testimonies on the life and works of Yannoulis Chalepas was performed. Findings are discussed in relation to the neuropsychiatric maladies that he faced in his lifespan and their impact on his art. Yannoulis Chalepas' life and art are trichotomized in a charismatic, premorbid era (1851-1877), a prolonged, medieval, morbid period (1878-1917), and a transfigurative, post morbid era (1918-1938). The amalgamate of medical evidence suggests that Yannoulis Chalepas suffered from schizophrenia. That was reflected in his art through two distinct periods of artistic productivity and stylistic creativity. The bidirectional relationship between neuroscience and art in the history of humanity is also exemplified in the legacy of Yannoulis Chalepas. The borderland of artistic ingenuity with aberrant behavior, the misconceptions of neurocognitive disorders with psychosis along with their associated social stigma, the effect of artistic expression in the manifestation of psychiatric disease, as well as its healing and often transformative power are concepts that still tantalize equally scientists and artists around the globe.
MeSH term(s)	Male ; Humans ; Psychotic Disorders ; Humanities ; Physicians
Language	English
Publishing date	2022-05-31
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	2195042-8
ISSN	1334-6253 ; 1334-6253
ISSN (online)	1334-6253
ISSN	1334-6253
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Article ; Online: Challenges in Predicting Cognitive Decline in Dementia with Lewy Bodies.

Tsamakis, Konstantinos / Mueller, Christoph

Dementia and geriatric cognitive disorders

2021 Volume 50, Issue 1, Page(s) 1–8

Abstract: Despite being the second most common form of neurodegenerative dementia, dementia with Lewy bodies (DLB) is under-recognized and carries a worse prognosis than other subtypes of the condition. Cognitive impairment is a cardinal feature of all types of ... ...

Abstract	Despite being the second most common form of neurodegenerative dementia, dementia with Lewy bodies (DLB) is under-recognized and carries a worse prognosis than other subtypes of the condition. Cognitive impairment is a cardinal feature of all types of dementia and DLB presents with a distinct profile with deficits in attention, executive function, and visuoperceptual abilities. This difference from Alzheimer's disease and the common presence of neuropsychiatric symptoms may lead to challenges in predicting cognitive decline in this patient population. Firstly, the diagnosis of DLB is often delayed in clinical practice leading to variability from which time point in the disease course cognitive decline is measured. Secondly, the most frequently used measurement tools for cognitive difficulties focus on memory and naming rather than the domains affected by DLB. While there is now largely a consensus which tools are useful in diagnosing DLB, their validity in assessing deteriorating cognition is less clear. Thirdly, the presence of fluctuating cognition, the propensity to develop delirium episodes, as well as difficulties in distinguishing the two entities in clinical practice make it difficult to predict the disease course. Sleep disturbances are likely to influence cognitive decline but require further study in patients within established DLB. Fourthly, as in most cases of dementia, neuropathological comorbidities are frequently present in DLB. While the influence of Alzheimer's pathology on cognitive decline in DLB is comparatively well understood, the impact of other pathologies remains unclear. The recent definition of research criteria for mild cognitive impairment in DLB could facilitate earlier diagnosis and more structured follow-up. Assessment tools measuring cognitive domains predominantly affected in DLB need to be more consistently used in longitudinal studies and clinical practice, as well as concurrent measures of fluctuations in cognition. Greater availability of biomarkers and digital healthcare solutions can play an important role in enabling more accurate monitoring and prediction of cognitive decline in DLB.
MeSH term(s)	Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/psychology ; Disease Progression ; Humans ; Lewy Body Disease/complications ; Lewy Body Disease/psychology ; Longitudinal Studies ; Prognosis
Language	English
Publishing date	2021-03-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1026007-9
ISSN	1421-9824 ; 1013-7424
ISSN (online)	1421-9824
ISSN	1013-7424
DOI	10.1159/000515008
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Article ; Online: Early Onset of Tardive Dyskinesia in an Antipsychotic-Naive Patient Treated With Low-Dose Cariprazine.

Tsamakis, Konstantinos / Pantazidi, Maria / Alevyzakis, Evangelos / Tsiptsios, Dimitrios / Mueller, Christoph / Smyrnis, Nikolaos / Rizos, Emmanouil N

Journal of clinical psychopharmacology

2024 Volume 44, Issue 2, Page(s) 189–191

MeSH term(s)	Humans ; Antipsychotic Agents/adverse effects ; Tardive Dyskinesia/chemically induced ; Piperazines/therapeutic use ; Dyskinesia, Drug-Induced/etiology
Chemical Substances	Antipsychotic Agents ; cariprazine (F6RJL8B278) ; Piperazines
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/JCP.0000000000001809
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Article ; Online: Idiopathic Spinal Accessory Neuropathy: A Case Report.

Tsiptsios, Dimitrios / Mueller, Christoph / Tsamakis, Konstantinos

Neurology India

2021 Volume 69, Issue 2, Page(s) 522–523

MeSH term(s)	Accessory Nerve Diseases ; Humans ; Peripheral Nervous System Diseases ; Spine
Language	English
Publishing date	2021-04-27
Publishing country	India
Document type	Letter ; Comment
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.314589
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Article: Probiotics' Effects in the Treatment of Anxiety and Depression: A Comprehensive Review of 2014-2023 Clinical Trials.

Merkouris, Ermis / Mavroudi, Theodora / Miliotas, Daniil / Tsiptsios, Dimitrios / Serdari, Aspasia / Christidi, Foteini / Doskas, Triantafyllos K / Mueller, Christoph / Tsamakis, Konstantinos

Microorganisms

2024 Volume 12, Issue 2

Abstract: Changes in the gut microbiome can affect cognitive and psychological functions via the microbiota-gut-brain (MGB) axis. Probiotic supplements are thought to have largely positive effects on mental health when taken in sufficient amounts; however, despite ...

Abstract	Changes in the gut microbiome can affect cognitive and psychological functions via the microbiota-gut-brain (MGB) axis. Probiotic supplements are thought to have largely positive effects on mental health when taken in sufficient amounts; however, despite extensive research having been conducted, there is a lack of consistent findings on the effects of probiotics on anxiety and depression and the associated microbiome alterations. The aim of our study is to systematically review the most recent literature of the last 10 years in order to clarify whether probiotics could actually improve depression and anxiety symptoms. Our results indicate that the majority of the most recent literature suggests a beneficial role of probiotics in the treatment of depression and anxiety, despite the existence of a substantial number of less positive findings. Given probiotics' potential to offer novel, personalized treatment options for mood disorders, further, better targeted research in psychiatric populations is needed to address concerns about the exact mechanisms of probiotics, dosing, timing of treatment, and possible differences in outcomes depending on the severity of anxiety and depression.
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12020411
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Article: Processing Speed and Attentional Shift/Mental Flexibility in Patients with Stroke: A Comprehensive Review on the Trail Making Test in Stroke Studies.

Tsiakiri, Anna / Christidi, Foteini / Tsiptsios, Dimitrios / Vlotinou, Pinelopi / Kitmeridou, Sofia / Bebeletsi, Paschalina / Kokkotis, Christos / Serdari, Aspasia / Tsamakis, Konstantinos / Aggelousis, Nikolaos / Vadikolias, Konstantinos

Neurology international

2024 Volume 16, Issue 1, Page(s) 210–225

Abstract: The Trail Making Test (TMT) is one of the most commonly administered tests in clinical and research neuropsychological settings. The two parts of the test (part A (TMT-A) and part B (TMT-B)) enable the evaluation of visuoperceptual tracking and ... ...

Abstract	The Trail Making Test (TMT) is one of the most commonly administered tests in clinical and research neuropsychological settings. The two parts of the test (part A (TMT-A) and part B (TMT-B)) enable the evaluation of visuoperceptual tracking and processing speed (TMT-A), as well as divided attention, set-shifting and cognitive flexibility (TMT-B). The main cognitive processes that are assessed using TMT, i.e., processing speed, divided attention, and cognitive flexibility, are often affected in patients with stroke. Considering the wide use of TMT in research and clinical settings since its introduction in neuropsychological practice, the purpose of our review was to provide a comprehensive overview of the use of TMT in stroke patients. We present the most representative studies assessing processing speed and attentional shift/mental flexibility in stroke settings using TMT and applying scoring methods relying on conventional TMT scores (e.g., time-to-complete part A and part B), as well as derived measures (e.g., TMT-(B-A) difference score, TMT-(B/A) ratio score, errors in part A and part B). We summarize the cognitive processes commonly associated with TMT performance in stroke patients (e.g., executive functions), lesion characteristics and neuroanatomical underpinning of TMT performance post-stroke, the association between TMT performance and patients' instrumental activities of daily living, motor difficulties, speech difficulties, and mood statue, as well as their driving ability. We also highlight how TMT can serve as an objective marker of post-stroke cognitive recovery following the implementation of interventions. Our comprehensive review underscores that the TMT stands as an invaluable asset in the stroke assessment toolkit, contributing nuanced insights into diverse cognitive, functional, and emotional dimensions. As research progresses, continued exploration of the TMT potential across these domains is encouraged, fostering a deeper comprehension of post-stroke dynamics and enhancing patient-centered care across hospitals, rehabilitation centers, research institutions, and community health settings. Its integration into both research and clinical practice reaffirms TMT status as an indispensable instrument in stroke-related evaluations, enabling holistic insights that extend beyond traditional neurological assessments.
Language	English
Publishing date	2024-01-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2514727-4
ISSN	2035-8377 ; 2035-8385
ISSN (online)	2035-8377
ISSN	2035-8385
DOI	10.3390/neurolint16010014
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Article ; Online: Covid-19 pandemic: a public and global mental health opportunity for social transformation?

Ahmad, Ayesha / Mueller, Christoph / Tsamakis, Konstantinos

BMJ (Clinical research ed.)

2020 Volume 369, Page(s) m1383

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections/psychology ; Global Health ; Mental Health ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; United Kingdom
Keywords	covid19
Language	English
Publishing date	2020-04-06
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1362901-3
ISSN	1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
ISSN (online)	1756-1833
ISSN	0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
DOI	10.1136/bmj.m1383
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Article ; Online: Predictive association between immigration status and chronic pain in the general population: results from the SwePain cohort.

Dragioti, Elena / Tsamakis, Konstantinos / Larsson, Britt / Gerdle, Björn

BMC public health

2020 Volume 20, Issue 1, Page(s) 1462

Abstract: Background: Previous studies suggest that immigration may influence the experience of pain.: Objective: This population-based study examines whether immigration status is associated with chronic pain (CP), chronic widespread pain (CWSP), and severe ... ...

Abstract	Background: Previous studies suggest that immigration may influence the experience of pain. Objective: This population-based study examines whether immigration status is associated with chronic pain (CP), chronic widespread pain (CWSP), and severe CP at a two-year follow-up. We also tested mediation by mood status (i.e., anxiety and depression). Methods: 15, 563 participants from a representative stratified random sample of 34,000 individuals living in south-eastern Sweden completed a postal survey, during 2013-2015, that included the following data: immigration status; presence of CP (pain lasting at least 3 months) and CWSP (a modified classification of widespread pain for use in epidemiological studies); severity of CP based on a numeric rating scale; and depression, anxiety, economic situation, and sociodemographic information. We applied logistic regressions using the generalized estimating equations (GEE), with Swedish-born as the reference group and path analyses models. Results: Compared to the Swedish-born participants (n = 14,093;90%), the immigrants (n = 1470;10%) had an elevated risk of all pain outcomes (CP: odds ratio [OR] = 1.18; 95% confidence interval [CI = 1.04-1.33, CWSP: OR = 1.39; 95% CI: 1.15-1.69 and severe CP: 1.51; 95% CI: 1.23-1.87) after adjustments. Path analyses showed that baseline age, immigrant status, and financial hardship had a significant influence on chronic pain outcomes at follow-up with baseline mood status as the mediator. Immigration status was also associated with age and financial hardship. Conclusion: Immigrants may have increased risk of chronic pain, widespread pain, and severe pain and this risk is mediated by mood status. Targeted interventions better tailored to the socio-economic and psychological status of immigrants with chronic pain are warranted.
MeSH term(s)	Adult ; Anxiety/epidemiology ; Chronic Pain/epidemiology ; Cohort Studies ; Emigration and Immigration/statistics & numerical data ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Population Groups ; Surveys and Questionnaires ; Sweden
Language	English
Publishing date	2020-09-29
Publishing country	England
Document type	Journal Article
ISSN	1471-2458
ISSN (online)	1471-2458
DOI	10.1186/s12889-020-09546-z
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Article: Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis.

Tsamakis, Konstantinos / Galinaki, Sofia / Alevyzakis, Evangelos / Hortis, Ioannis / Tsiptsios, Dimitrios / Kollintza, Evangelia / Kympouropoulos, Stylianos / Triantafyllou, Konstantinos / Smyrnis, Nikolaos / Rizos, Emmanouil

Microorganisms

2022 Volume 10, Issue 6

Abstract: There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota-gut- ... ...

Abstract	There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota-gut-brain axis and implies an association between alterations in the gut microbiome and several psychiatric conditions, such as autism, depression, bipolar disorder and psychosis. The aim of this review is to summarise recent findings and provide concise updates on the latest progress of the role of gut microbiota in the development and maintenance of psychiatric symptoms in schizophrenia and the first episode of psychosis. Despite the lack of consistent findings in regard to specific microbiome changes related to psychosis, the emerging literature reports significant differences in the gut microbiome of schizophrenic subjects compared to healthy controls and increasingly outlines the significance of an altered microbiome composition in the pathogenesis, development, symptom severity and prognosis of psychosis. Further human studies are, however, required, which should focus on identifying the drivers of microbiota changes in psychosis and establish the direction of causality between psychosis and microbiome alterations.
Language	English
Publishing date	2022-05-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms10061121
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Article ; Online: Occult tethered cord syndrome: a reversible cause of paraparesis not to be missed.

Tsiptsios, Dimitrios / Sysoev, Kirill / Ouranidis, Andreas / Rizos, Emmanouil / Tsamakis, Konstantinos

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

2020 Volume 36, Issue 9, Page(s) 1833–1834

MeSH term(s)	Humans ; Neural Tube Defects/complications ; Neural Tube Defects/diagnostic imaging ; Paraparesis
Language	English
Publishing date	2020-06-28
Publishing country	Germany
Document type	Letter
ZDB-ID	605988-0
ISSN	1433-0350 ; 0302-2803 ; 0256-7040
ISSN (online)	1433-0350
ISSN	0302-2803 ; 0256-7040
DOI	10.1007/s00381-020-04768-3
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