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Article ; Online: Evo-Devo: Tinkering with the Stem Cell Niche to Produce Thorns.

Airoldi, Chiara A / Glover, Beverley J

2020 Volume 30, Issue 15, Page(s) R873–R875

Abstract: A new study shows that the defensive thorns of Citrus plants are produced when a TCP transcription factor is expressed in axillary meristems and binds to the promoter of WUSCHEL, repressing the maintenance of cell proliferation. ...

Abstract	A new study shows that the defensive thorns of Citrus plants are produced when a TCP transcription factor is expressed in axillary meristems and binds to the promoter of WUSCHEL, repressing the maintenance of cell proliferation.
MeSH term(s)	Gene Expression Regulation ; Meristem/metabolism ; Stem Cell Niche ; Stem Cells/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	Transcription Factors
Language	English
Publishing date	2020-08-04
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2020.06.019
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Article: Sizing Milking Groups in Small Cow Dairies of Mediterranean Countries.

Calvo, Angela / Airoldi, Gianfranco

Animals : an open access journal from MDPI

2020 Volume 10, Issue 5

Abstract: A dairy farmer chooses the number of milking groups in function of the herd size, stall type and milking system also in small cow dairies (number of animals lower than 100-120). In these dairies, there are different milking systems (bucket, trolley, ... ...

Abstract	A dairy farmer chooses the number of milking groups in function of the herd size, stall type and milking system also in small cow dairies (number of animals lower than 100-120). In these dairies, there are different milking systems (bucket, trolley, pipeline, little autotandem, herringbone or parallel parlors) and each of them has a different work routine. The knowledge of the routine is the starting point for assessing the milking installation, because it determines the number of milked cows per hour. Different milking systems have common tasks (as pre-dipping, inspecting foremilk, udder preparation, attaching teat cups, post-dipping), but in the meantime there are different operations that characterize each specific routine (e.g., animal entry and exit if there is a parlor, bucket, trolley or milking group positioning if tie-stall). For this reason, we surveyed twenty small dairy farms located in the Piedmont Region (Italy) with different milking systems to correctly acquire the specific milking routines. Different models were therefore studied using the observed routines in in the examined farms. These models were then used to calculate the number of milked cows per hour and the number of milking groups. The main findings were simple equations, specific for each milking system, easily accessible by the farmer to correctly size his milking system.
Language	English
Publishing date	2020-05-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani10050795
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Article: Lynch Syndrome: From Multidisciplinary Management to Precision Prevention.

Dal Buono, Arianna / Puccini, Alberto / Franchellucci, Gianluca / Airoldi, Marco / Bartolini, Michela / Bianchi, Paolo / Santoro, Armando / Repici, Alessandro / Hassan, Cesare

Cancers

2024 Volume 16, Issue 5

Abstract: Background and aims: Lynch syndrome (LS) is currently one of the most prevalent hereditary cancer conditions, accounting for 3% of all colorectal cancers and for up to 15% of those with DNA mismatch repair (MMR) deficiency, and it was one of the first ... ...

Abstract	Background and aims: Lynch syndrome (LS) is currently one of the most prevalent hereditary cancer conditions, accounting for 3% of all colorectal cancers and for up to 15% of those with DNA mismatch repair (MMR) deficiency, and it was one of the first historically identified. The understanding of the molecular carcinogenesis of LS tumors has progressed significantly in recent years. We aim to review the most recent advances in LS research and explore genotype-based approaches in surveillance, personalized cancer prevention, and treatment strategies. Methods: PubMed was searched to identify relevant studies, conducted up to December 2023, investigating molecular carcinogenesis in LS, surveillance strategies, cancer prevention, and treatment in LS tumors. Results: Multigene panel sequencing is becoming the benchmark in the diagnosis of LS, allowing for the detection of a pathogenic constitutional variant in one of the MMR genes. Emerging data from randomized controlled trials suggest possible preventive roles of resistant starch and/or aspirin in LS. Vaccination with immunogenic frameshift peptides appears to be a promising approach for both the treatment and prevention of LS-associated cancers, as evidenced by pre-clinical and preliminary phase 1/2a studies. Conclusions: Although robust diagnostic algorithms, including prompt testing of tumor tissue for MMR defects and referral for genetic counselling, currently exist for suspected LS in CRC patients, the indications for LS screening in cancer-free individuals still need to be refined and standardized. Investigation into additional genetic and non-genetic factors that may explain residual rates of interval cancers, even in properly screened populations, would allow for more tailored preventive strategies.
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16050849
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Article ; Online: The Survival of Salmonella typhimurium in Propylene Glycol/Water Mixtures.

Airoldi, A A / Zottola, E A

Journal of food protection

2019 Volume 52, Issue 4, Page(s) 256–258

Abstract: The effect of propylene glycol, a coolant used in dairy processing plants, on the growth and survival of Salmonella typhimurium was studied. Cultures were inoculated into 0.1% reconstituted nonfat dry milk with glycol concentrations ranging from 0 to 50% ...

Abstract	The effect of propylene glycol, a coolant used in dairy processing plants, on the growth and survival of Salmonella typhimurium was studied. Cultures were inoculated into 0.1% reconstituted nonfat dry milk with glycol concentrations ranging from 0 to 50% (A
Language	English
Publishing date	2019-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.4315/0362-028X-52.4.256
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Article ; Online: Fruquintinib as new treatment option in metastatic colorectal cancer patients: is there an optimal sequence?

Stucchi, Erika / Bartolini, Michela / Airoldi, Marco / Fazio, Roberta / Daprà, Valentina / Mondello, Giuseppe / Prete, Maria Giuseppina / Puccini, Alberto / Santoro, Armando

Expert opinion on pharmacotherapy

2024 , Page(s) 1–12

Abstract: Introduction: Available treatments for colorectal cancer are limited. However, in the last few years several advances and new treatment options became available and expanded the continuum of care in metastatic colorectal cancer (mCRC).: Areas covered!# ...

Abstract	Introduction: Available treatments for colorectal cancer are limited. However, in the last few years several advances and new treatment options became available and expanded the continuum of care in metastatic colorectal cancer (mCRC). Areas covered: Fruquintinib, a tyrosine kinase inhibitor, has been shown to be effective in heavily pretreated mCRC progressing to trifluridine-tipiracil (FTD/TPI) or regorafenib or both. Preclinical studies have shown that fruquintinib inhibits with high selectivity VEGFR 1-2-3, leading to a blockade in angiogenesis process, but also acts, with weak inhibition, on RET, FGFR-1, and c-kit kinases. Fruquintinib demonstrated good efficacy and tolerance in chemorefractory mCRC in two phase III trial: FRESCO and FRESCO 2. These results led to FDA approval of fruquintinib for pretreated mCRC patients who received prior fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy. Expert opinion: Fruquintinib is a valid therapeutic option for heavily pretreated mCRC patients. However, an optimal sequence of treatments is yet to be defined. In this review, we propose an algorithm for later lines of treatment to integrate fruquintinib as a standard of care together with the new therapeutic combinations that recently showed clinical benefit for chemorefractory mCRC, in both molecularly selected (e.g. KRAS
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2001535-5
ISSN	1744-7666 ; 1465-6566
ISSN (online)	1744-7666
ISSN	1465-6566
DOI	10.1080/14656566.2024.2336069
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Zs.A 5130: Show issues

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Article ; Online: "From All, To All": Implementing a collaborative online conference to reflect on the daily living of individuals with cerebral palsy.

Vieira, Beatriz S / Airoldi, Marina J / Chalfun, Deborah / Bonfim, Rafael G A S / Teplicky, Rachel / Rosenbaum, Peter / Mancini, Marisa C / Brandão, Marina B

Child: care, health and development

2024 Volume 50, Issue 2, Page(s) e13254

Abstract: Background: Translating knowledge to improve paediatric rehabilitation has become a research area of interest. This study describes the development and evaluation of an online conference that brought together perspectives of individuals with cerebral ... ...

Abstract	Background: Translating knowledge to improve paediatric rehabilitation has become a research area of interest. This study describes the development and evaluation of an online conference that brought together perspectives of individuals with cerebral palsy (CP), families, health care professionals, and researchers to discuss the daily living of individuals with CP. Methods: We anchored the development and implementation of the online conference in the action cycle of the Knowledge to Action Framework. To develop the meeting, we included representatives from each stakeholder group in the programme committee. The conference programme was designed having the lifespan perspective of individuals with CP, from birth to adulthood, as its central core, with themes related to daily living (e.g., self-care, mobility, and continuing education). Participants' satisfaction with the conference was assessed using an anonymized online survey sent to all participants. Results: The conference had 1656 attendees, of whom 675 answered the online satisfaction survey. Most participants rated the structure of the conference (i.e., quality of the technical support, audio and video, and online platform) and discussed topics (i.e., relevance, content, discussion, speakers, and available time) positively. Conclusion: Collaborative conferences that include stakeholders throughout the planning and implementation are a viable, effective knowledge translation strategy that allows for sharing experiences and disseminating knowledge among families and individuals with CP, health care professionals, and researchers.
MeSH term(s)	Child ; Humans ; Cerebral Palsy/rehabilitation ; Health Personnel ; Self Care ; Education, Continuing
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	223039-2
ISSN	1365-2214 ; 0305-1862
ISSN (online)	1365-2214
ISSN	0305-1862
DOI	10.1111/cch.13254
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Article ; Online: Impact of the pandemic on surgical oncology in Piedmont, Italy: A retrospective observational study.

Lo Moro, Giuseppina / Ragusa, Paolo / Previti, Christian / Comandone, Alessandro / Airoldi, Mario / Aglietta, Massimo / Siliquini, Roberta

Journal of surgical oncology

2024 Volume 129, Issue 6, Page(s) 1165–1170

Abstract: Background and methods: This retrospective observational study analyzes how the COVID-19 pandemic affected surgical oncology healthcare in a large sample from Piedmont, Northern Italy. Patients admitted for regular hospitalization were included (n = 99 ... ...

Abstract	Background and methods: This retrospective observational study analyzes how the COVID-19 pandemic affected surgical oncology healthcare in a large sample from Piedmont, Northern Italy. Patients admitted for regular hospitalization were included (n = 99 651). Data from 2020 were compared to the averages from 2016 to 2019, stratified by tumor site, year, month, and admission method, using interrupted time series analysis post-March 2020. Results: In 2020, oncological surgeries decreased by 12.3% (n = 17 923) compared to the 2016-2019 average (n = 20 432), notably dropping post-March (incidence rate ratio = 0.858; p < 0.001). The greatest reduction was observed for breast (-19.2%), colon (-18.2%), bladder (-17.5%), kidney (-14.2%), and prostate (-14%) surgeries. There was a huge reduction in nonemergency admissions (-13.6%), especially for colon (-23.8%), breast (-19.4%), and bladder (-18.7%). The proportion of hospitalizations with emergency access increased (p < 0.001). Conclusions: The COVID-19 pandemic led to a significant decrease in cancer surgeries in Piedmont in 2020, with an increase in the proportion of admissions through emergency access. Discussion: The research provides valuable insights for comparing data with other regions and evaluating the effectiveness of efforts to recover lost surgical procedures. These findings can be useful to policymakers in developing coordinated measures and more efficient access strategies to healthcare services in any future emergency situations.
MeSH term(s)	Humans ; COVID-19/epidemiology ; Retrospective Studies ; Italy/epidemiology ; Surgical Oncology/statistics & numerical data ; Neoplasms/surgery ; Neoplasms/epidemiology ; Hospitalization/statistics & numerical data ; Male ; Female ; Pandemics ; SARS-CoV-2 ; Middle Aged
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	82063-5
ISSN	1096-9098 ; 0022-4790
ISSN (online)	1096-9098
ISSN	0022-4790
DOI	10.1002/jso.27606
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Zs.A 706: Show issues

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Article ; Online: Morphoelastic modelling of pattern development in the petal epidermal cell cuticle.

Lugo, Carlos A / Airoldi, Chiara / Chen, Chao / Crosby, Alfred J / Glover, Beverley J

Journal of the Royal Society, Interface

2023 Volume 20, Issue 204, Page(s) 20230001

Abstract: We use the model ... ...

Abstract	We use the model system
MeSH term(s)	Flowers/metabolism ; Models, Biological ; Epidermal Cells
Language	English
Publishing date	2023-07-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2156283-0
ISSN	1742-5662 ; 1742-5689
ISSN (online)	1742-5662
ISSN	1742-5689
DOI	10.1098/rsif.2023.0001
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Article ; Online: Impact Response of Monolithic and Laminated Polycarbonate Panels: An Experimental and Numerical Investigation.

Ghavanini, Navid / Caporale, Antonio Maria / Astori, Paolo / Airoldi, Alessandro / Panichelli, Paolo

Polymers

2023 Volume 15, Issue 24

Abstract: This study aimed to investigate the impact resistance of monolithic and laminated polycarbonate plates for windshields in motorsport applications through a coupled experimental-numerical study. Both low- and high-velocity impact tests were performed by ... ...

Abstract	This study aimed to investigate the impact resistance of monolithic and laminated polycarbonate plates for windshields in motorsport applications through a coupled experimental-numerical study. Both low- and high-velocity impact tests were performed by using a drop tower and a gas gun, respectively, considering a sharp-edged projectile impacting on flat panels. The response of the polycarbonate plates was evaluated in terms of the failure mode, perforation velocity threshold, and energy absorption mechanism. The experiments allowed for the assessment and the generalization of a 3D finite element modeling approach originally developed for supersonic application based on different state-of-the-art constitutive theories, including temperature-dependent and rate-dependent von Mises plasticity coupled with ductile damage, Mie-Grüneisen equation of state, and temperature variation due to energy dissipation under adiabatic assumptions. The approach was completed with a cohesive zone model for a laminate plate and studies were performed to highlight the relevancy of different aspects of material characterization. The tests and numerical analyses performed at different velocity ranges highlight the importance of viscoplastic behavior in a polycarbonate windshield. The numerical approach showed its capability to model the different failure modes for monolithic and laminated panels and capture the perforation velocity thresholds with appreciable accuracy, which were actually found to be quite similar for the two types of panels in the test conditions considered. A numerical investigation suggests that the development of delaminations could lead to the improved energy absorption of laminated polycarbonate. To further assess the numerical model, it was used to successfully predict the penetration threshold velocity of a polycarbonate windshield subjected to a gas gun impact test.
Language	English
Publishing date	2023-12-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym15244677
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Article ; Online: Adjuvant Effect of Cinnamon Polyphenolic Components in Colorectal Cancer Cell Lines.

Palmioli, Alessandro / Forcella, Matilde / Oldani, Monica / Angotti, Irene / Sacco, Grazia / Fusi, Paola / Airoldi, Cristina

International journal of molecular sciences

2023 Volume 24, Issue 22

Abstract: Colorectal cancer (CRC) is the second-leading cause of cancer death, with a worldwide incidence rate constantly increasing; thus, new strategies for its prevention or treatment are needed. Here, we describe the adjuvant effect of the polyphenol-enriched ... ...

Abstract	Colorectal cancer (CRC) is the second-leading cause of cancer death, with a worldwide incidence rate constantly increasing; thus, new strategies for its prevention or treatment are needed. Here, we describe the adjuvant effect of the polyphenol-enriched fractions of cinnamon, from cinnamon bark and buds, when co-administered with a potent anticancer drug, cetuximab, used for CRC therapy. The co-administration significantly reduces the cetuximab dose required for the antiproliferative activity against colorectal cancer cell line E705, which is sensitive to EGFR-targeted therapy. The anticancer activity of these cinnamon-derived fractions, whose major components (as assessed by UPLC-HRMS analysis) are procyanidins and other flavonoids, strictly correlates with their ability to induce apoptosis in cancer cell lines through ERK activation and the mitochondrial membrane potential impairment. Due to the severe side effects of cetuximab administration, our results suggest the use of nutraceuticals based on the polyphenolic fractions of cinnamon extracts as adjuvants in the therapy of CRC.
MeSH term(s)	Humans ; Cetuximab/pharmacology ; Cetuximab/therapeutic use ; Cinnamomum zeylanicum ; Cell Proliferation ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/metabolism
Chemical Substances	Cetuximab (PQX0D8J21J) ; Antineoplastic Agents
Language	English
Publishing date	2023-11-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242216117
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