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Article: Tiempo de demora prehospitalaria, la cara oculta de la isquemia coronaria.

Artaiz, M / Landecho, M F

2016 Volume 39, Issue 1, Page(s) 10–11

Title translation	Prehospital delay: the hidden face of coronary ischaemia.
MeSH term(s)	Coronary Artery Disease ; Emergency Medical Services ; Humans ; Patient Acceptance of Health Care ; Time Factors
Language	Spanish
Publishing date	2016-04-29
Publishing country	Spain
Document type	Comment ; Editorial
ZDB-ID	2141772-6
ISSN	1137-6627
ISSN	1137-6627
DOI	10.4321/S1137-6627/2016000100002
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Article ; Online: Obesity as an adipose tissue dysfunction disease and a risk factor for infections - Covid-19 as a case study.

Landecho, M F / Marin-Oto, M / Recalde-Zamacona, B / Bilbao, I / Frühbeck, Gema

European journal of internal medicine

2021 Volume 91, Page(s) 3–9

Abstract: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) disease (COVID-19) is a novel threat that hampers life expectancy especially in obese individuals. Though this association is clinically relevant, the underlying mechanisms are not fully ... ...

Abstract	Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) disease (COVID-19) is a novel threat that hampers life expectancy especially in obese individuals. Though this association is clinically relevant, the underlying mechanisms are not fully elucidated. SARS CoV2 enters host cells via the Angiotensin Converting Enzyme 2 receptor, that is also expressed in adipose tissue. Moreover, adipose tissue is also a source of many proinflammatory mediators and adipokines that might enhance the characteristic COVID-19 cytokine storm due to a chronic low-grade inflammatory preconditioning. Further obesity-dependent thoracic mechanical constraints may also incise negatively into the prognosis of obese subjects with COVID-19. This review summarizes the current body of knowledge on the obesity-dependent circumstances triggering an increased risk for COVID-19 severity, and their clinical relevance.
MeSH term(s)	Adipose Tissue ; COVID-19 ; Humans ; Obesity/complications ; Obesity/epidemiology ; Risk Factors ; SARS-CoV-2
Language	English
Publishing date	2021-04-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2021.03.031
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Zs.A 2608: Show issues

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Article ; Online: Evaluation of the quality of multiple-choice questions according to the students' academic level.

Iñarrairaegui, Mercedes / Fernández-Ros, Nerea / Lucena, Felipe / Landecho, Manuel F / García, Nicolás / Quiroga, Jorge / Herrero, Jose Ignacio

BMC medical education

2022 Volume 22, Issue 1, Page(s) 779

Abstract: Background: One of the most important challenges in medical education is the preparation of multiple-choice questions able to discriminate between students with different academic level. Average questions may be very easy for students with good ... ...

Abstract	Background: One of the most important challenges in medical education is the preparation of multiple-choice questions able to discriminate between students with different academic level. Average questions may be very easy for students with good performance, reducing their discriminant power in this group of students. The aim of this study was to analyze if the discriminative power of multiple-choice questions is different according to the students' academic performance. Methods: We retrospectively analyzed the difficulty and discrimination indices of 257 multiple-choice questions used for the end of course examination of pathophysiology and analyzed whether the discrimination indices were lower in students with good academic performance (group 1) than in students with moderate/poor academic performance (group 2). We also evaluated whether case-based questions maintained their discriminant power better than factual questions in both groups of students or not. Comparison of the difficulty and discrimination indices between both groups was based on the Wilcoxon test. Results: Difficulty index was significantly higher in group 1 (median: 0.78 versus 0.56; P < 0.001) and discrimination index was significantly higher in group 2 (median: 0.21 versus 0.28; P < 0.001). Factual questions had higher discriminative indices in group 2 than in group 1 (median: 0.28 versus 0.20; P < 0.001), but discriminative indices of case-based questions did not differ significantly between groups (median: 0.30 versus 0.24; P = 0.296). Conclusions: Multiple-choice question exams have lower discriminative power in the group of students with high scores. The use of clinical vignettes may allow to maintain the discriminative power of multiple-choice questions.
MeSH term(s)	Humans ; Educational Measurement ; Retrospective Studies ; Students, Medical ; Academic Performance ; Education, Medical
Language	English
Publishing date	2022-11-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-022-03844-3
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Article ; Online: Common variable immunodeficiency-associated granulomatous and lymphocytic interstitial lung disease successfully treated with a combination regimen of rituximab and azathioprine.

Moctezuma, Sananda I / Panizo, Carlos M / Landecho, Manuel F

Medicina clinica

2017 Volume 149, Issue 7, Page(s) 312–313

Title translation	Inmunodeficiencia común variable asociada a enfermedad pulmonar intersticial granulomatosa-linfocítica tratada con un régimen combinado de rituximab y azatioprina.
MeSH term(s)	Azathioprine/therapeutic use ; Common Variable Immunodeficiency/complications ; Common Variable Immunodeficiency/drug therapy ; Drug Therapy, Combination ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Lung Diseases, Interstitial/drug therapy ; Lung Diseases, Interstitial/etiology ; Middle Aged ; Rituximab/therapeutic use
Chemical Substances	Immunosuppressive Agents ; Rituximab (4F4X42SYQ6) ; Azathioprine (MRK240IY2L)
Language	Spanish
Publishing date	2017-07-21
Publishing country	Spain
Document type	Case Reports ; Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2017.05.041
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Article ; Online: COVID-19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease?

Landecho, M F / Yuste, J R / Gándara, E / Sunsundegui, P / Quiroga, J / Alcaide, A B / García-Layana, A

Journal of internal medicine

2020 Volume 289, Issue 1, Page(s) 116–120

Abstract: Importance: COVID-19 is caused by SARS-CoV-2, a betacoronavirus that uses the angiotensin-converting enzyme-related carboxypeptidase (ACE2) receptor to gain entry into cells. ACE2 receptor is widely expressed in multiple organs, including the retina, an ...

Abstract	Importance: COVID-19 is caused by SARS-CoV-2, a betacoronavirus that uses the angiotensin-converting enzyme-related carboxypeptidase (ACE2) receptor to gain entry into cells. ACE2 receptor is widely expressed in multiple organs, including the retina, an extension of the central nervous system. The ACE2 receptor is involved in the diabetic and hypertensive retinopathy. Additionally, coronaviruses cause ocular infections in animals, including retinitis, and optic neuritis. Objective: To assess whether there is any retinal disease associated with COVID-19. Design: We have evaluated 27 asymptomatic subjects, with retinal fundoscopic, optical coherence tomography (OCT) and OCT angiography fourteen days after hospital discharge due to COVID-19 bilateral pneumonia. Results: Cotton wool exudates were evident in six out of 27 patients evaluated, a 22%. Cotton wool exudates are a marker vascular disease severity in other medical context, that is diabetes and hypertension, and are associated with increased risk for acute vascular events. Whether antiaggregation therapy may play a role on fundoscopic-selected patients with COVID-19 requires prospective trials.
MeSH term(s)	COVID-19/complications ; COVID-19/epidemiology ; Cardiovascular Diseases/epidemiology ; Comorbidity ; Female ; Fluorescein Angiography ; Follow-Up Studies ; Fundus Oculi ; Humans ; Male ; Middle Aged ; Pandemics ; Prospective Studies ; Retina/pathology ; Retinal Diseases/diagnosis ; Retinal Diseases/etiology ; SARS-CoV-2 ; Tomography, Optical Coherence
Keywords	covid19
Language	English
Publishing date	2020-07-30
Publishing country	England
Document type	Journal Article
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.13156
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Article ; Online: Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury.

Cross, Amy R / de Andrea, Carlos E / Villalba-Esparza, María / Landecho, Manuel F / Cerundolo, Lucia / Weeratunga, Praveen / Etherington, Rachel E / Denney, Laura / Ogg, Graham / Ho, Ling-Pei / Roberts, Ian Sd / Hester, Joanna / Klenerman, Paul / Melero, Ignacio / Sansom, Stephen N / Issa, Fadi

JCI insight

2023 Volume 8, Issue 2

Abstract: Severe lung damage resulting from COVID-19 involves complex interactions between diverse populations of immune and stromal cells. In this study, we used a spatial transcriptomics approach to delineate the cells, pathways, and genes present across the ... ...

Abstract	Severe lung damage resulting from COVID-19 involves complex interactions between diverse populations of immune and stromal cells. In this study, we used a spatial transcriptomics approach to delineate the cells, pathways, and genes present across the spectrum of histopathological damage in COVID-19-affected lung tissue. We applied correlation network-based approaches to deconvolve gene expression data from 46 areas of interest covering more than 62,000 cells within well-preserved lung samples from 3 patients. Despite substantial interpatient heterogeneity, we discovered evidence for a common immune-cell signaling circuit in areas of severe tissue that involves crosstalk between cytotoxic lymphocytes and pro-inflammatory macrophages. Expression of IFNG by cytotoxic lymphocytes was associated with induction of chemokines, including CXCL9, CXCL10, and CXCL11, which are known to promote the recruitment of CXCR3+ immune cells. The TNF superfamily members BAFF (TNFSF13B) and TRAIL (TNFSF10) were consistently upregulated in the areas with severe tissue damage. We used published spatial and single-cell SARS-CoV-2 data sets to validate our findings in the lung tissue from additional cohorts of patients with COVID-19. The resulting model of severe COVID-19 immune-mediated tissue pathology may inform future therapeutic strategies.
MeSH term(s)	Humans ; COVID-19 ; Transcriptome ; SARS-CoV-2 ; Pneumonia ; Lung
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.157837
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Article ; Online: Impact of Routine and Long-Term Follow-Up on Weight Loss after Bariatric Surgery.

Lujan, J / Tuero, C / Landecho, M F / Moncada, R / A Cienfuegos, J / Rotellar, F / Silva, C / Lapuente, F / Martínez, P / Frühbeck, G / Valenti, Victor

Obesity surgery

2020 Volume 30, Issue 11, Page(s) 4293–4299

Abstract: Background: Weight loss after bariatric surgery varies among patients. Patients who do not complete long-term follow-up are considered to loose less weight than those with regular follow-up visits.: Objective: To evaluate the influence of patients' ... ...

Abstract	Background: Weight loss after bariatric surgery varies among patients. Patients who do not complete long-term follow-up are considered to loose less weight than those with regular follow-up visits. Objective: To evaluate the influence of patients' follow-up compliance on long-term excess weight loss (%EWL) and total weight loss (%TWL) after bariatric surgery, comparing results between gastric bypass (GB) and sleeve gastrectomy (SG). Methods: Patients with up to 5 years of follow-up data after bariatric surgery were included in this retrospective analysis. Patients were divided in 2 groups: those in group 1 who had attended every scheduled postoperative appointment and those in group 2 who had been lost to follow-up before 1 year and were later contacted by telephone. %EWL and %TWL were compared to determine the possible relationship between type of surgery and regularity of the follow-up. Results: A total of 385 patients were included. A significant difference in EWL was observed at 5 years in the SG group (78% for group 1 versus 39% for group 2; p = 0.02) and GB group (75% for group 1 versus 62% for group 2; p = 0.01). No significant differences between surgeries were found when comparing long-term EWL in group 1 patients 77% for SG versus 75% for GB. For group 2 patients, GB achieved greater EWL than SG; p = 0.005. %TWL patients in group 2 showed significant differences in all periods of study (p < 0.05). Conclusion: Bariatric surgery patients who attended all scheduled follow-up appointments experienced significantly greater long-term EWL and TWL than those who did not. GB has apparent increased benefits for weight loss in long-term follow-up when compared with SG for patients who did not attend long-term follow-up. Therefore, continued long-term follow-up of bariatric patients should be encouraged to increase postoperative weight loss results.
MeSH term(s)	Bariatric Surgery ; Follow-Up Studies ; Gastrectomy ; Gastric Bypass ; Humans ; Obesity, Morbid/surgery ; Retrospective Studies ; Treatment Outcome ; Weight Loss
Language	English
Publishing date	2020-06-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-020-04788-7
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Article ; Online: Chronic rhinosinusitis is associated with prolonged SARS-CoV-2 RNA shedding in upper respiratory tract samples: A case-control study.

Recalde-Zamacona, B / Tomás-Velázquez, A / Campo, A / Satrústegui-Alzugaray, B / Fernández-Alonso, M / Iñigo, M / Rodríguez-Mateos, M / Di Frisco, M / Felgueroso, C / Bertó, J / Marín-Oto, M / Alcaide, A B / Zulueta, J J / Seijo, L / Landecho, M F

Journal of internal medicine

2021 Volume 289, Issue 6, Page(s) 921–925

Abstract: Background: SARS-CoV-2, the COVID-19 causative agent, has infected millions of people and killed over 1.6 million worldwide. A small percentage of cases persist with prolonged positive RT-PCR on nasopharyngeal swabs. The aim of this study was to ... ...

Abstract	Background: SARS-CoV-2, the COVID-19 causative agent, has infected millions of people and killed over 1.6 million worldwide. A small percentage of cases persist with prolonged positive RT-PCR on nasopharyngeal swabs. The aim of this study was to determine risk factors for prolonged viral shedding amongst patient's basal clinical conditions. Methods: We have evaluated all 513 patients attended in our hospital between 1 March and 1 July. We have selected all 18 patients with prolonged viral shedding and compared them with 36 sex-matched randomly selected controls. Demographic, treatment and clinical data were systematically collected. Results: Global median duration of viral clearance was 25.5 days (n = 54; IQR, 22-39.3 days), 48.5 days in cases (IQR 38.7-54.9 days) and 23 days in controls (IQR 20.2-25.7), respectively. There were not observed differences in demographic, symptoms or treatment data between groups. Chronic rhinosinusitis and atopy were more common in patients with prolonged viral shedding (67%) compared with controls (11% and 25% respectively) (P < 0.001 and P = 0.003). The use of inhaled corticosteroids was also more frequent in case group (P = 0.007). Multivariate analysis indicated that CRS (odds ratio [OR], 18.78; 95% confidence interval [95%CI], 3.89-90.59; P < 0.001) was independently associated with prolonged SARS-CoV-2 RNA shedding in URT samples, after adjusting for initial PCR Ct values. Conclusion: We found that chronic rhinosinusitis and atopy might be associated with increased risk of prolonged viral shedding. If confirmed in prospective trials, this finding might have clinical implications for quarantine duration due to increased risk of pandemic spread.
MeSH term(s)	Aged ; COVID-19/complications ; COVID-19/virology ; Case-Control Studies ; Female ; Humans ; Male ; Middle Aged ; Nasopharynx/virology ; Rhinitis/complications ; Rhinitis/virology ; SARS-CoV-2/physiology ; Sinusitis/complications ; Sinusitis/virology ; Virus Shedding
Language	English
Publishing date	2021-02-09
Publishing country	England
Document type	Journal Article
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.13237
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Article ; Online: Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection.

Cells

2022 Volume 11, Issue 12

Abstract: People with pre-existing lung diseases such as chronic obstructive pulmonary disease (COPD) are more likely to get very sick from SARS-CoV-2 disease 2019 (COVID-19). Still, an interrogation of the immune response to COVID-19 infection, spatially ... ...

Abstract	People with pre-existing lung diseases such as chronic obstructive pulmonary disease (COPD) are more likely to get very sick from SARS-CoV-2 disease 2019 (COVID-19). Still, an interrogation of the immune response to COVID-19 infection, spatially throughout the lung structure, is lacking in patients with COPD. For this study, we characterized the immune microenvironment of the lung parenchyma, airways, and vessels of never- and ever-smokers with or without COPD, all of whom died of COVID-19, using spatial transcriptomic and proteomic profiling. The parenchyma, airways, and vessels of COPD patients, compared to control lungs had (1) significant enrichment for lung-resident CD45RO
MeSH term(s)	COVID-19 ; Humans ; Lung/metabolism ; Proteomics ; Pulmonary Disease, Chronic Obstructive/metabolism ; SARS-CoV-2
Language	English
Publishing date	2022-06-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11121864
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Article ; Online: Web-based formative assessment through clinical cases: role in pathophysiology teaching.

Fernández Ros, Nerea / Lucena, Felipe / Iñarrairaegui, Mercedes / Landecho, Manuel F / Sunsundegui, Patricia / Jordán-Iborra, Carlota / Pineda, Iñigo / Quiroga, Jorge / Herrero, Jose Ignacio

BMC medical education

2021 Volume 21, Issue 1, Page(s) 249

Abstract: Background: Active learning strategies such as formative assessment through clinical cases may help to get a deeper learning. We have studied the effect of this kind of online formative assessment in pathophysiology teaching.: Methods: Seven brief ... ...

Abstract	Background: Active learning strategies such as formative assessment through clinical cases may help to get a deeper learning. We have studied the effect of this kind of online formative assessment in pathophysiology teaching. Methods: Seven brief clinical cases were used to give formative assessment in the first semester of a pathophysiology course. To evaluate its effect on learning, we analyzed the proportion of students that passed the end of semester exam with a score above 60 over 100. We also analyzed the effect of the intervention according to the students' previous academic performance. Results: Ninety-six students participated in the study and sat the exam. Sixty-five of them passed it. Students that passed the exam had a higher previous academic performance and had done a higher number of exercises of formative assessment, both in univariate and multivariate analysis. The participants were divided in three groups, according to their previous academic performance. In the intermediate group, the number of cases done by the students who passed the exam was significantly higher than in those who did not pass it (median: 4 versus 0; P = 0.009). Conclusion: Formative assessment through web-based clinical cases was followed by an improvement of the academic results in pathophysiology, mainly in students with intermediate performance.
MeSH term(s)	Educational Measurement ; Humans ; Internet ; Problem-Based Learning ; Teaching
Language	English
Publishing date	2021-04-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-021-02691-y
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