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  1. Article ; Online: COVID-19 amidst Ebola's retreat.

    Ditekemena, John

    Science (New York, N.Y.)

    2020  Volume 368, Issue 6490, Page(s) 445

    MeSH term(s) Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Communicable Disease Control ; Coronavirus Infections/diagnosis ; Coronavirus Infections/economics ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Democratic Republic of the Congo/epidemiology ; Disease Outbreaks/prevention & control ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/prevention & control ; Humans ; Pandemics/economics ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/economics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Public-Private Sector Partnerships ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-30
    Publishing country United States
    Document type Editorial
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abc4859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 amidst Ebola's retreat

    Ditekemena, John

    Science

    2020  Volume 368, Issue 6490, Page(s) 445–445

    Keywords Multidisciplinary ; covid19
    Language English
    Publisher American Association for the Advancement of Science (AAAS)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abc4859
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Virological and care outcomes of community ART distribution: Experience with the PODI+ model in Kinshasa, Democratic Republic of the Congo.

    Gill, Michelle M / Bakebua, Winnie / Ditekemena, John / Gbomosa, Cady Nyombe / Tshishi, Dieudonné / Loando, Aimé / Giri, Abhigya / Ngantsui, Roger Beni / Hoffman, Heather J

    PLOS global public health

    2024  Volume 4, Issue 1, Page(s) e0002343

    Abstract: Introduction: Differentiated service delivery models for HIV treatment can minimize unnecessary burdens on health systems and promote efficient delivery of antiretroviral therapy (ART). Under the PODI+ (poste de distribution communautaire) model, ART ... ...

    Abstract Introduction: Differentiated service delivery models for HIV treatment can minimize unnecessary burdens on health systems and promote efficient delivery of antiretroviral therapy (ART). Under the PODI+ (poste de distribution communautaire) model, ART multi-month dispensation (MMD) was provided by lay workers (peers) in communities. We compared outcomes among clinically stable adults living with HIV receiving MMD via PODI+ or health facility (HF).
    Methods: Clients receiving MMD at nine HFs and two PODI+ sites in Kinshasa were followed prospectively for one year (2018-2020). Medication possession ratio (MPR) was measured as proportion of total days with medication during the study through record abstraction at 3-month intervals. Viral load was assessed at enrollment and 12 months. We compared MPR and viral load suppression by arm and examined associations and potential confounders using unadjusted and adjusted odds ratios (AOR). Likert-style client satisfaction was collected during 12-month interviews and described by arm.
    Results: Odds of maintaining viral load suppression at 12 months for PODI+ participants were two times that for HF participants. In adjusted models, PODI+ participants had 1.89 times the odds of being suppressed at 12 months compared to HF participants (95% CI: 1.10, 3.27). No significant differences in MPR were found between groups (OR: 0.86, 0.38-1.99). Older participants had significantly higher odds of MPR (AOR: 1.02, 95% CI: 1.01, 1.03) and viral suppression (AOR: 1.03, 95% CI: 1.00, 1.07). Satisfaction with services was ≥87% overall, but PODI+ participants rated time spent at site, provider attributes and other care aspects more favorably.
    Conclusions: Participants receiving MMD via peer-run community distribution points had similar MPR, but better virological outcomes and greater satisfaction with care than clinically similar participants receiving MMD through facilities. PODI+ could be a useful model for expansion to serve larger clinic populations from overburdened health facilities, particularly as policy shifts towards more inclusive MMD eligibility requirements.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0002343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19's final frontier: The central Africa region.

    Ditekemena, John / Doumbia, Seydou / Ebrahim, Shahul H

    Travel medicine and infectious disease

    2020  Volume 37, Page(s) 101694

    MeSH term(s) Africa, Central/epidemiology ; COVID-19/epidemiology ; Demography/statistics & numerical data ; Health Services Accessibility/statistics & numerical data ; Humans ; Poverty
    Keywords covid19
    Language English
    Publishing date 2020-04-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2020.101694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reversing the neglect of children and adolescents affected by tuberculosis.

    Deborggraeve, Stijn / Casenghi, Martina / Hewison, Catherine / Ditekemena, John / Ditiu, Lucica / Amanullah, Farhana / Marais, Ben J

    The Lancet. Child & adolescent health

    2023  Volume 7, Issue 10, Page(s) 675–677

    MeSH term(s) Adolescent ; Child ; Humans ; Tuberculosis/epidemiology
    Language English
    Publishing date 2023-09-12
    Publishing country England
    Document type Editorial
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(23)00217-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Advanced HIV Disease at Antiretroviral Therapy Initiation and Treatment Outcomes Among Children and Adolescents Compared to Adults Living With HIV in Kinshasa, Democratic Republic of the Congo.

    Chabikuli, Otto Nzapfurundi / Ditekemena, John D / Sigwadhi, Lovemore Nyasha / Mulenga, Astrid / Mboyo, Aimé / Bidashimwa, Dieudonne / Nachega, Jean B

    Journal of the International Association of Providers of AIDS Care

    2023  Volume 22, Page(s) 23259582231221955

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adult ; Child ; Humans ; Adolescent ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Democratic Republic of the Congo/epidemiology ; Retrospective Studies ; Cohort Studies ; Treatment Outcome
    Language English
    Publishing date 2023-12-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2709037-1
    ISSN 2325-9582 ; 2325-9574
    ISSN (online) 2325-9582
    ISSN 2325-9574
    DOI 10.1177/23259582231221955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Completion of isoniazid preventive therapy for latent tuberculosis infection among children and adolescents compared to adults living with HIV in Kinshasa, Democratic Republic of the Congo.

    Bidashimwa, Dieudonné / Ditekemena, John D / Sigwadhi, Lovemore Nyasha / Nkuta, Lievain Maluentesa / Engetele, Elodie / Kilundu, Apolinaire / Chabikuli, Otto N / Nachega, Jean B

    Tropical medicine & international health : TM & IH

    2023  Volume 29, Issue 2, Page(s) 88–95

    Abstract: Background: Little is known about isoniazid preventive therapy (IPT) completion rates among children or adolescents compared to adults living with HIV in Kinshasa, Democratic Republic of the Congo (DRC).: Methods: We conducted a retrospective cohort ... ...

    Abstract Background: Little is known about isoniazid preventive therapy (IPT) completion rates among children or adolescents compared to adults living with HIV in Kinshasa, Democratic Republic of the Congo (DRC).
    Methods: We conducted a retrospective cohort analysis including children, adolescents, and adults living with HIV who were treated at FHI360 and partners-implemented HIV care programs at six health zones in Kinshasa, DRC, from 2004 to 2020. The primary outcome was the proportion of children, adolescents versus adults who did complete 6 months of daily self-administered IPT. Log-binomial regression assessed independent predictors of IPT non-completion and Kaplan-Meier technique for survival analysis.
    Results: Of 11,691 eligible patients on ART who initiated IPT, 429 were children (<11 years), 804 adolescents (11-19 years), and 10,458 adults (≥20 years). The median age was 7 (IQR: 3-9) years for children, 15 (IQR: 13-17) years for adolescents, and 43 (35-51) years for adults. Among those who were initiated on IPT, 5625 out of 11,691 people living with HIV (PLHIV) had IPT completion outcome results, and an overall 3457/5625 (61.5%) completion rate was documented. Compared to adults, children and adolescents were less likely to complete IPT [104/199 (52.3%) and 268/525 (51.0%), respectively, vs. 3085/4901 (62.9%)]. After adjustment, the only independent predictors for IPT non-completion were health zone of residence and type of ART regimen. Kaplan-Meier analysis showed comparable poor survival among patients who completed IPT versus those who did not (p-value for log-rank test, 0.15).
    Conclusions: The overall sub-optimal IPT completion rate in adults as well as children/adolescents in this setting is of great concern. Prospective studies are needed to elucidate the specific barriers to IPT completion among children, adolescents, and adults in DRC as well as the scale-up of evidence-informed interventions to improve IPT completion, such as adoption of shorter TB preventive regimens.
    MeSH term(s) Adult ; Child ; Humans ; Adolescent ; Child, Preschool ; Isoniazid/therapeutic use ; Latent Tuberculosis ; Antitubercular Agents/therapeutic use ; Tuberculosis/drug therapy ; Tuberculosis/prevention & control ; Democratic Republic of the Congo/epidemiology ; Retrospective Studies ; HIV Infections/complications ; HIV Infections/drug therapy
    Chemical Substances Isoniazid (V83O1VOZ8L) ; Antitubercular Agents
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1314080-2
    ISSN 1365-3156 ; 1360-2276
    ISSN (online) 1365-3156
    ISSN 1360-2276
    DOI 10.1111/tmi.13952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Awareness of obstetric danger signs among pregnant women in the Democratic Republic of Congo: evidence from a nationwide cross-sectional study.

    Nkamba, Dalau Mukadi / Wembodinga, Gilbert / Bernard, Pierre / Ditekemena, John / Robert, Annie

    BMC women's health

    2021  Volume 21, Issue 1, Page(s) 82

    Abstract: Background: Poor awareness of obstetric danger signs is a major contributing factor to delays in seeking obstetric care and hence to high maternal mortality and morbidity worldwide. We conducted the current study to assess the level of agreement on ... ...

    Abstract Background: Poor awareness of obstetric danger signs is a major contributing factor to delays in seeking obstetric care and hence to high maternal mortality and morbidity worldwide. We conducted the current study to assess the level of agreement on receipt of counseling on obstetric danger signs between direct observations of antenatal care (ANC) consultation and women's recall in the exit interview. We also identified factors associated with pregnant women's awareness of obstetric danger signs during pregnancy in the Democratic Republic of Congo (DRC) METHODS: We used data from the 2017-2018 DRC Service Provision Assessment survey. Agreement between the observation and woman's recall was measured using Cohen's kappa statistic and percent agreement. Multivariable Zero-Inflated Poisson (ZIP) regression was used to identify factors associated with the number of danger signs during pregnancy the woman knew.
    Results: On average, women were aware of 1.5 ± 1.34 danger signs in pregnancy (range: 0 to 8). Agreement between observation and woman's recall was 70.7%, with a positive agreement of 16.9% at the country level but ranging from 2.1% in Bandundu to 39.7% in Sud Kivu. Using multivariable ZIP analysis, the number of obstetric danger signs the women mentioned was significantly higher in multigravida women (Adj.IRR = 1.38; 95% CI: 1.23-1.55), in women attending a private facility (Adj.IRR = 1.15; 95% CI: 1.01-1.31), in women attending a subsequent ANC visit (Adj.IRR = 1.11; 95% CI: 1.01-1.21), and in women counseled on danger signs during the ANC visit (Adj.IRR = 1.19; 95% CI: 1.05-1.35). There was a regional variation in the awareness of danger signs, with the least mentioned signs in the middle and the most in the eastern provinces.
    Conclusions: Our findings indicated poor agreement between directly observed counseling and women's reports that counseling on obstetric danger signs occurred during the current ANC visit. We found that province of residence, provision of counseling on obstetric danger signs, facility ownership, gravidity and the number of ANC visits were predictors of the awareness of obstetric danger signs among pregnant women. These factors should be considered when developing strategies aim at improving women's awareness about obstetric danger signs in the DRC.
    MeSH term(s) Cross-Sectional Studies ; Democratic Republic of the Congo/epidemiology ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Pregnancy ; Pregnant Women ; Prenatal Care
    Language English
    Publishing date 2021-02-26
    Publishing country England
    Document type Journal Article
    ISSN 1472-6874
    ISSN (online) 1472-6874
    DOI 10.1186/s12905-021-01234-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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