Article ; Online: Xi Lei San Attenuates Dextran Sulfate Sodium-Induced Colitis in Rats and TNF-
2021 Volume 2021, Page(s) 1610251
Abstract: ... advantage for treating IBD. However, the therapeutic effects and underlying mechanisms of Xi Lei San ... in treatment of IBD remain unknown. This study was designed to investigate whether Xi Lei San exerted ... model of TNF-: Results: Xi Lei San and indirubin were identified by HPLC analysis. We found that Xi ...
Abstract | Objective: Inflammatory bowel disease (IBD) is a chronic nonspecific inflammatory bowel disease with an unclear etiology. The active ingredients of traditional Chinese medicines (TCMs) exert anti-inflammatory, antitumor, and immunomodulatory effects, and their multitarget characteristics provide them with a unique advantage for treating IBD. However, the therapeutic effects and underlying mechanisms of Xi Lei San in treatment of IBD remain unknown. This study was designed to investigate whether Xi Lei San exerted an anti-inflammatory effect in IBD via a mechanism involving NLRP3 inflammasomes and autophagy. Methods: We successfully established a rat model of dextran sulfate sodium- (DSS-) induced colitis as well as a cellular model of TNF- Results: Xi Lei San and indirubin were identified by HPLC analysis. We found that Xi Lei San could significantly increase the weights of rats and improve the structure of the intestinal tissues in DSS-induced colitis model rats. We also found that Xi Lei San significantly inhibited NLRP3 inflammasome activity, reduced the levels of inflammatory cytokines, and suppressed autophagy in DSS-induced colitis model rats. Conclusions: Our findings showed that Xi Lei San significantly ameliorated IBD by inhibiting NLRP3 inflammasome, autophagy, and oxidative stress. |
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MeSH term(s) | Animals ; Autophagy/physiology ; Caco-2 Cells ; Cytokines/biosynthesis ; Dextran Sulfate ; Female ; Humans ; Indoles/pharmacology ; Inflammasomes/physiology ; Inflammatory Bowel Diseases/chemically induced ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/immunology ; Medicine, Chinese Traditional ; NLR Family, Pyrin Domain-Containing 3 Protein/physiology ; Rats ; Rats, Sprague-Dawley ; Tumor Necrosis Factor-alpha/pharmacology |
Chemical Substances | Cytokines ; Indoles ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, rat ; Tumor Necrosis Factor-alpha ; Dextran Sulfate (9042-14-2) ; indirubin (V86L8P74GI) |
Language | English |
Publishing date | 2021-04-21 |
Publishing country | United States |
Document type | Journal Article |
ZDB-ID | 1137605-3 |
ISSN | 1466-1861 ; 0962-9351 |
ISSN (online) | 1466-1861 |
ISSN | 0962-9351 |
DOI | 10.1155/2021/1610251 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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