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  1. Article ; Online: COVID-19 skin lesions are rarely positive at RT-PCR test: the macrophage activation with vascular impact and SARS-CoV-2-induced cytokine storm.

    Ionescu, Marius-Anton

    International journal of dermatology

    2021  Volume 61, Issue 1, Page(s) 3–6

    Abstract: Background: Several skin manifestations have been reported since the start of the COVID-19 pandemic: chilblains-like, livedoid lesions, urticaria-like, pseudo-Kawasaki disease, and others. Histopathologic images of these lesions most often show aspects ... ...

    Abstract Background: Several skin manifestations have been reported since the start of the COVID-19 pandemic: chilblains-like, livedoid lesions, urticaria-like, pseudo-Kawasaki disease, and others. Histopathologic images of these lesions most often show aspects of endothelitis, images similar to autoimmune vasculitis. Cutaneous lesions are often negative at RT-PCR for SARS-CoV-2 virus.
    Method and results: We reviewed recent articles on the mechanisms of COVID-19 and we synthesized main pathways of inflammatory cascade. After the penetration into the cells of the respiratory epithelium, SARS-CoV-2 virus initiates a "cytokine storm" well described in previous publications: the expression of interferon type I (IFN-I) is one of the key elements of the antiviral response in COVID-19 patients, IFN-I expression seems to play an important role in the induction of interleukin 6 (IL-6), chemotactic factors such as Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) and the consequent activation of monocyte-macrophage system followed by the expression of TNF-alpha, and finally by the induction of coagulation factors by both extrinsic and intrinsic pathways.
    Conclusions: The simplified synthesis of the main pathophysiological mechanisms of COVID-19 could help us to understand at least partially the importance of macrophage activation and its vascular involvement in many skin lesions that remain often negative at in situ tests for SARS-CoV-2.
    MeSH term(s) COVID-19 ; Cytokine Release Syndrome ; Humans ; Macrophage Activation ; Pandemics ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2
    Language English
    Publishing date 2021-07-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.15749
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  2. Article: Psoriasis Management Challenges Regarding Difficult-to-Treat Areas: Therapeutic Decision and Effectiveness.

    Nicolescu, Alin Codrut / Ionescu, Marius-Anton / Constantin, Maria Magdalena / Ancuta, Ioan / Ionescu, Sinziana / Niculet, Elena / Tatu, Alin Laurentiu / Zirpel, Henner / Thaçi, Diamant

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 12

    Abstract: Psoriasis is not optimally controlled in spite of newly developed treatments, possibly due to the difficulty of objectively quantifying the disease's severity, considering the limitations of the clinical scores used in clinical practice. A major ... ...

    Abstract Psoriasis is not optimally controlled in spite of newly developed treatments, possibly due to the difficulty of objectively quantifying the disease's severity, considering the limitations of the clinical scores used in clinical practice. A major challenge addresses difficult-to-treat areas, especially in the absence of significant body surface involvement. It is controversial whether the severity evaluation of patients with several affected areas (having at least one difficult-to-treat area) should be done differently from current methods. Scores used for special areas (PSSI, NAPSI and ESIF) allow an accurate assessment of disease severity in difficult-to-treat areas, but the issue of whether to integrate these scores into PASI, BSA or DLQI remains. The review's purpose resides in providing an overview of the main current issues in determining psoriasis severity in patients with psoriasis in difficult-to-treat areas and suggesting possible solutions for the optimal integration of the area assessment in current scores: severity can be either established according to the highest calculated score (PASI or PSSI or NAPSI or ESIF) or by adding a correction factor in the calculation of PASI for special areas.
    Language English
    Publishing date 2022-12-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12122050
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  3. Article ; Online: DRESS and Stevens–Johnson Syndrome Overlap Secondary to Allopurinol in a 50-Year-Old Man—A Diagnostic and Treatment Challenge

    José Dario Martínez / Rodolfo Franco / Luis Manuel Sáenz / Americo Guadalupe Alvarado / José Antonio García / Sergio Máximo Delgado / Marius-Anton Ionescu / Camelia Busilă / Alin Laurentiu Tatu

    Life, Vol 13, Iss 12, p

    Case Report

    2023  Volume 2251

    Abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a drug reaction commonly related to eosinophilia, from uncertain epidemiology, and without consensus for diagnosis and treatment globally. It presents a great challenge in its ... ...

    Abstract Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a drug reaction commonly related to eosinophilia, from uncertain epidemiology, and without consensus for diagnosis and treatment globally. It presents a great challenge in its management and is characterized by fever, lymphadenopathy, skin rash, and multisystemic involvement. An aggressive and difficult-to-manage clinical case is presented in a 50-year-old man with chronic kidney disease due to diabetes mellitus type 2 and systemic arterial hypertension, who developed an unusual variant similar to DRESS and Stevens–Johnson syndrome (SJS) overlap secondary to allopurinol, with skin manifestations without eosinophilia, but fulfilling clinical and laboratory criteria for DRESS and SJS syndrome.
    Keywords allopurinol ; eosinophilia ; chronic kidney disease ; DRESS syndrome ; SJS ; Science ; Q
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Role of Silver Nitrate Spray for Skin Wound Care in Patients with Toxic Epidermal Necrolysis

    Jose Dario Martinez / Jesus Alberto Cardenas / Manuel Soria / Luis Manuel Saenz / Kattya Estrada / Sergio Maximo Delgado / Marius-Anton Ionescu / Camelia Busila / Alin Laurentiu Tatu

    Life, Vol 13, Iss 12, p

    Our Experience in 4 Patients

    2023  Volume 2341

    Abstract: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of severe cutaneous adverse reactions to drugs (SCARs) with several international recommendations for global medical management, ranging from pharmacological systemic ... ...

    Abstract Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of severe cutaneous adverse reactions to drugs (SCARs) with several international recommendations for global medical management, ranging from pharmacological systemic therapy to skin wound care. There is no defined best management of the skin wounds in SJS/TEN. The care of wounds is essential to initiate re-epithelialization. Our objective is to improve the cicatrization process, avoiding scarring due to deepening of the wounds, as well as prevent infections, achieve pain control, and avoid loss of serum proteins, fluids, and electrolytes. In this retrospective case series, we highlight the value of systemic therapy and the use of silver nitrate for wound management in four patients with TEN.
    Keywords toxic epidermal necrolysis ; Stevens–Johnson syndrome ; silver nitrate ; wound care ; Science ; Q
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: DRESS and Stevens-Johnson Syndrome Overlap Secondary to Allopurinol in a 50-Year-Old Man-A Diagnostic and Treatment Challenge: Case Report.

    Martínez, José Dario / Franco, Rodolfo / Sáenz, Luis Manuel / Alvarado, Americo Guadalupe / García, José Antonio / Delgado, Sergio Máximo / Ionescu, Marius-Anton / Busilă, Camelia / Tatu, Alin Laurentiu

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 12

    Abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a drug reaction commonly related to eosinophilia, from uncertain epidemiology, and without consensus for diagnosis and treatment globally. It presents a great challenge in its ... ...

    Abstract Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a drug reaction commonly related to eosinophilia, from uncertain epidemiology, and without consensus for diagnosis and treatment globally. It presents a great challenge in its management and is characterized by fever, lymphadenopathy, skin rash, and multisystemic involvement. An aggressive and difficult-to-manage clinical case is presented in a 50-year-old man with chronic kidney disease due to diabetes mellitus type 2 and systemic arterial hypertension, who developed an unusual variant similar to DRESS and Stevens-Johnson syndrome (SJS) overlap secondary to allopurinol, with skin manifestations without eosinophilia, but fulfilling clinical and laboratory criteria for DRESS and SJS syndrome.
    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13122251
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  6. Article: Role of Silver Nitrate Spray for Skin Wound Care in Patients with Toxic Epidermal Necrolysis: Our Experience in 4 Patients.

    Martinez, Jose Dario / Cardenas, Jesus Alberto / Soria, Manuel / Saenz, Luis Manuel / Estrada, Kattya / Delgado, Sergio Maximo / Ionescu, Marius-Anton / Busila, Camelia / Tatu, Alin Laurentiu

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 12

    Abstract: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of severe cutaneous adverse reactions to drugs (SCARs) with several international recommendations for global medical management, ranging from pharmacological systemic ... ...

    Abstract Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of severe cutaneous adverse reactions to drugs (SCARs) with several international recommendations for global medical management, ranging from pharmacological systemic therapy to skin wound care. There is no defined best management of the skin wounds in SJS/TEN. The care of wounds is essential to initiate re-epithelialization. Our objective is to improve the cicatrization process, avoiding scarring due to deepening of the wounds, as well as prevent infections, achieve pain control, and avoid loss of serum proteins, fluids, and electrolytes. In this retrospective case series, we highlight the value of systemic therapy and the use of silver nitrate for wound management in four patients with TEN.
    Language English
    Publishing date 2023-12-14
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13122341
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  7. Article ; Online: Chilblains is a common cutaneous finding during the COVID-19 pandemic: A retrospective nationwide study from France.

    de Masson, Adèle / Bouaziz, Jean-David / Sulimovic, Luc / Cassius, Charles / Jachiet, Marie / Ionescu, Marius-Anton / Rybojad, Michel / Bagot, Martine / Duong, Tu-Anh

    Journal of the American Academy of Dermatology

    2020  Volume 83, Issue 2, Page(s) 667–670

    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Betacoronavirus/isolation & purification ; Betacoronavirus/pathogenicity ; COVID-19 ; Chilblains/diagnosis ; Chilblains/epidemiology ; Chilblains/virology ; Child ; Child, Preschool ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Female ; France/epidemiology ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Retrospective Studies ; SARS-CoV-2 ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-05-04
    Publishing country United States
    Document type Letter
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2020.04.161
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    Zs.A 1540: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Topical non-occlusive polymers in hand-foot syndrome.

    Fabbrocini, Gabriella / Cristaudo, Antonio / Ionescu, Marius-Anton / Panariello, Luigia / Robert, Geraldine / Pellicano, Marcello / Ayala, Fabio

    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia

    2018  Volume 153, Issue 2, Page(s) 165–171

    Abstract: Background: Many cytotoxic and biological drugs are cause of severe dermatological side effects, such as hand-foot syndrome (HFS) and hand-foot skin reaction (HFSR). Oncologic patients with HFS or HFSR presents relevant symptoms that interferes with ... ...

    Abstract Background: Many cytotoxic and biological drugs are cause of severe dermatological side effects, such as hand-foot syndrome (HFS) and hand-foot skin reaction (HFSR). Oncologic patients with HFS or HFSR presents relevant symptoms that interferes with daily activities and with adherence to anticancer treatment. The HFRS control and treatment are important goals to enhance the quality of life of oncologic patients. The aim of this study was to assess the efficacy and tolerability of a b.i.d. (bis in die) topical administration of an anhydric ointment based on topical non-occlusive polymers (TNOP) in patients with HFS on current anticancer drug regiments.
    Methods: A prospective, open, multicenter clinical study was conducted in oncologic patients with HFS attended two hospital-based Italian dermatological unit. A global-non-instrumental evaluation, based on different standardized tools (i.e., Sum Score System Index [SRRC] Score, Dermatology Life Qualiy Index [DLQI] and global efficacy) was conducted using measurements at baseline, at 4 and 8 weeks. Non-parametric test for two correlate samples, was used to assess changes in means of the different scores. The protocol was approved by ethical committee of both dermatology service pariticipating to the study.
    Results: Twenty-one oncologic patients were enrolled. Thirteen (61.9%) of participants were female. The median age was 63 years (range: 37-73). Seventeen (80.9%) patients presenting a HFS associated to capecitabine, and four patients (19.1%) associated to docetaxel. At the enrollment, 33.3% (7/21) of patients showed at level of the hands a HFS of grade 2 and 9.5% (2/21) of grade 3. At level of the feet, 28.6% (6/21) showed a HFS of grade 2, and 17.4% (4/21) of grade 3. The SRRC scores were significantly decreased after 8 weeks of treatment compared to baseline, for both sites. In particular, SRRC score decreased from 4.38 to 1.67 (Z=-3.60, P=0.00) and from 4.48 to 1.43 (Z=-3.87, P=0.00) for hands and feet, respectively. A consistent significant improvement in the perceived QoL of patients was also observed. From baseline to visit 3, the total mean score of DLQI decreased from 10.62 to 4.57 (Δ=-57%, Z=-4.020, P=0.000).
    Conclusions: In a sample of oncologic patients with HFS, the b.i.d. administration of TNOP for eight weeks, induced a progressive and significant decrease of the SRRC Score and a relevant improvement in the perceived quality of life.
    MeSH term(s) Administration, Cutaneous ; Adult ; Aged ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Capecitabine/administration & dosage ; Capecitabine/adverse effects ; Female ; Hand-Foot Syndrome/drug therapy ; Hand-Foot Syndrome/etiology ; Hand-Foot Syndrome/pathology ; Humans ; Italy ; Male ; Middle Aged ; Ointments ; Polymers/administration & dosage ; Prospective Studies ; Quality of Life ; Severity of Illness Index ; Taxoids/administration & dosage ; Taxoids/adverse effects ; Treatment Outcome
    Chemical Substances Antineoplastic Agents ; Ointments ; Polymers ; Taxoids ; docetaxel (15H5577CQD) ; Capecitabine (6804DJ8Z9U)
    Language English
    Publishing date 2018-03-21
    Publishing country Italy
    Document type Journal Article ; Multicenter Study
    ZDB-ID 604114-0
    ISSN 1827-1820 ; 0026-4741 ; 0392-0488
    ISSN (online) 1827-1820
    ISSN 0026-4741 ; 0392-0488
    DOI 10.23736/S0392-0488.17.05709-1
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    Zs.B 119: Show issues Location:
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  9. Article: Chilblains is a common cutaneous finding during the COVID-19 pandemic: A retrospective nationwide study from France

    de Masson, Adèle / Bouaziz, Jean-David / Sulimovic, Luc / Cassius, Charles / Jachiet, Marie / Ionescu, Marius-Anton / Rybojad, Michel / Bagot, Martine / Duong, Tu-Anh

    J Am Acad Dermatol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #165251
    Database COVID19

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  10. Article ; Online: Demodex folliculorum

    Tatu, Alin Laurentiu / Ionescu, Marius Anton / Cristea, Violeta Corina

    Indian journal of dermatology, venereology and leprology

    2017  Volume 83, Issue 5, Page(s) 610–611

    MeSH term(s) Animals ; Bacillus pumilus/isolation & purification ; Dermoscopy/methods ; Face/pathology ; Humans ; Male ; Mite Infestations/complications ; Mite Infestations/diagnosis ; Mites ; Rosacea/diagnosis ; Rosacea/etiology
    Language English
    Publishing date 2017-07-27
    Publishing country India
    Document type Case Reports ; Letter
    ZDB-ID 416068-x
    ISSN 0973-3922 ; 0019-5162 ; 0378-6323
    ISSN (online) 0973-3922
    ISSN 0019-5162 ; 0378-6323
    DOI 10.4103/ijdvl.IJDVL_921_16
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