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  1. Book ; Thesis: The role of toll-like receptors in the human adrenal gland

    Kanczkowski, Waldemar

    2009  

    Author's details vorgelegt von Waldemar Kanczkowski
    Language English
    Size VI, 106 Bl., Ill., graph. Darst., 31 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dresden, Techn. Univ., Diss., 2009
    HBZ-ID HT016217464
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2010 E 1183 order for loan Magazin

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  2. Article ; Online: Is there a role for the adrenal glands in long COVID?

    Kanczkowski, Waldemar / Beuschlein, Felix / Bornstein, Stefan R

    Nature reviews. Endocrinology

    2022  Volume 18, Issue 8, Page(s) 451–452

    MeSH term(s) Adrenal Glands ; COVID-19/complications ; Humans
    Language English
    Publishing date 2022-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-022-00700-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 93: Show issues

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  3. Article ; Online: Erratum zu: Praktische Empfehlungen zum Screening und Management von Funktionsstörungen der Nebennierenrinde bei einer akuten SARS-CoV-2-Infektion.

    Masjkur, Jimmy / Barthel, Andreas / Kanczkowski, Waldemar / Müller, Gregor / Bornstein, Stefan R

    Innere Medizin (Heidelberg, Germany)

    2022  Volume 64, Issue Suppl 2, Page(s) 149

    Title translation Erratum to: Practical recommendations for screening and management of functional disorders of the adrenal cortex in cases of SARS-CoV-2 infections.
    Language German
    Publishing date 2022-05-24
    Publishing country Germany
    Document type Published Erratum
    ISSN 2731-7099
    ISSN (online) 2731-7099
    DOI 10.1007/s00108-022-01337-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Praktische Empfehlungen zum Screening und Management von Funktionsstörungen der Nebennierenrinde bei einer akuten SARS-CoV-2-Infektion.

    Masjkur, Jimmy / Barthel, Andreas / Kanczkowski, Waldemar / Müller, Gregor / Bornstein, Stefan R

    Der Internist

    2021  Volume 63, Issue 1, Page(s) 4–11

    Abstract: Diseases of the adrenal cortex require particular attention during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Firstly, SARS-CoV‑2 infections can give rise to extrapulmonary manifestations and cause endocrine disorders, ... ...

    Title translation Practical recommendations for screening and management of functional disorders of the adrenal cortex in cases of SARS-CoV-2 infections.
    Abstract Diseases of the adrenal cortex require particular attention during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Firstly, SARS-CoV‑2 infections can give rise to extrapulmonary manifestations and cause endocrine disorders, particularly in the adrenal cortex. Furthermore, patients with pre-existing insufficiency of the adrenal cortex or hypercortisonism are particularly at risk from a severe infection such as SARS-CoV‑2, to suffer from additional complications or a more severe course of a SARS-CoV‑2 infection with a higher mortality. Especially in hemodynamically unstable patients with a SARS-CoV‑2 infection, diseases of the adrenal glands should also be considered in the differential diagnostics and if necessary clarified, if this is not already known. Prolonged treatment of patients with a SARS-CoV‑2 infection with regimens containing high doses of glucocorticoids can also result in a secondary adrenal insufficiency. In order to address these special aspects, some practical recommendations for the diagnostic and therapeutic management of functional disorders of the adrenal glands in patients with a SARS-CoV‑2 infection are therefore presented.
    MeSH term(s) Adrenal Cortex ; Adrenal Insufficiency/diagnosis ; Adrenal Insufficiency/drug therapy ; COVID-19 ; Humans ; Pandemics ; SARS-CoV-2
    Language German
    Publishing date 2021-12-20
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2913-0
    ISSN 1432-1289 ; 0020-9554
    ISSN (online) 1432-1289
    ISSN 0020-9554
    DOI 10.1007/s00108-021-01236-1
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  5. Article ; Online: Adrenal Gland Function and Dysfunction During COVID-19.

    Kanczkowski, Waldemar / Gaba, Waqar Haider / Krone, Nils / Varga, Zsuzsanna / Beuschlein, Felix / Hantel, Constanze / Andoniadou, Cynthia / Bornstein, Stefan R

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

    2022  Volume 54, Issue 8, Page(s) 532–539

    Abstract: The coronavirus disease 2019 (COVID-19) pandemic is currently one of the major health concerns worldwide accounting for many deaths and posing a great social and economic burden. Early activation of adrenal hormone secretion is pivotal to surviving ... ...

    Abstract The coronavirus disease 2019 (COVID-19) pandemic is currently one of the major health concerns worldwide accounting for many deaths and posing a great social and economic burden. Early activation of adrenal hormone secretion is pivotal to surviving systemic microbial infections. In addition, clinical studies demonstrated that glucocorticoids might also be beneficial in reducing disease progression and life deterioration in certain patients with COVID-19. Recent studies demonstrated that SARS-CoV-2 might target the adrenal glands, raising the possibility that at least some COVID-19 complications may be associated with adrenal dysfunction. Whether SARS-CoV-2 infection might cause adrenal dysfunction remains unknown. Histopathological examinations provided evidence that SARS-CoV-2 infection might indeed cause certain structural damage to the adrenal glands, especially concerning its vascular system. However, since no widespread cellular damage to cortical cells was observed, it is less likely that those changes could lead to an immediate adrenal crisis. This assumption is supported by the limited number of studies reporting rather adequate cortisol levels in patients with acute COVID-19. Those studies, however, could not exclude a potential late-onset or milder form of adrenal insufficiency. Although structural damage to adrenal glands is a rarely reported complication of COVID-19, some patients might develop a critical illness-related corticosteroid insufficiency (CIRCI), or iatrogenic adrenal insufficiency resulting from prolonged treatment with synthetic glucocorticoids. In this mini-review article, we aimed at describing and discussing factors involved in the adrenal gland function and possible dysfunction during COVID-19.
    MeSH term(s) Adrenal Glands ; Adrenal Insufficiency/drug therapy ; Adrenal Insufficiency/etiology ; COVID-19/complications ; COVID-19/drug therapy ; Glucocorticoids/therapeutic use ; Humans ; Pandemics ; SARS-CoV-2
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2022-08-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-1873-2150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Transcriptional Analysis of Sepsis-Induced Activation and Damage of the Adrenal Endothelial Microvascular Cells.

    Chen, Lan-Sun / Singh, Sumeet P / Müller, Gregor / Bornstein, Stefan R / Kanczkowski, Waldemar

    Frontiers in endocrinology

    2020  Volume 10, Page(s) 944

    Abstract: Bacterial sepsis is a serious threat to the body homeostasis and is often associated with high mortality in non-coronary intensive stations. In order to survive sepsis, rapid activation of the hypothalamus-pituitary-adrenal gland axis and ... ...

    Abstract Bacterial sepsis is a serious threat to the body homeostasis and is often associated with high mortality in non-coronary intensive stations. In order to survive sepsis, rapid activation of the hypothalamus-pituitary-adrenal gland axis and sympathomedullary system is necessary. In many patients with sepsis, the function of those two arms of the stress system is dysregulated with underlying mechanisms remaining unknown. In our previous experimental studies, we have demonstrated that LPS-induced systemic inflammation and CLP-induced peritonitis can result in adrenal gland damage. Histological and transcriptomic analysis revealed a potential involvement of the adrenal microvascular endothelium in this process. However, our knowledge about the function of adrenal microvascular cells during sepsis is scarce. In the present study, we have characterized transcriptomic alterations in isolated mouse adrenal microvascular endothelial cells induced by systemic administration of bacterial LPS. Our results revealed that LPS induced a distinct transcriptomic profile in the adrenal microvascular cells, including multiple genes regulating inflammation, activation of the coagulation cascade and vascular permeability. Activation of those genes may be potentially involved in the damage to the microvascular endothelium and altogether contribute to the sepsis-mediated adrenal dysregulation.
    Language English
    Publishing date 2020-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2019.00944
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  7. Article ; Online: The adrenal gland microenvironment in health, disease and during regeneration.

    Kanczkowski, Waldemar / Sue, Mariko / Bornstein, Stefan R

    Hormones (Athens, Greece)

    2017  Volume 16, Issue 3, Page(s) 251–265

    Abstract: The adrenal gland is a key component of the stress system in the human body. Multiple direct and paracrine interactions between different cell types and their progenitors take place within the adrenal gland microenvironment. These unique interactions are ...

    Abstract The adrenal gland is a key component of the stress system in the human body. Multiple direct and paracrine interactions between different cell types and their progenitors take place within the adrenal gland microenvironment. These unique interactions are supported by high vascularization and the adrenal cortex extracellular matrix. Alterations in the adrenal gland microenvironment are known to influence the progression of several pathological conditions, such as obesity and sepsis, and to be influenced by these disorders. For example, it has been suggested that activation of immune-adrenal crosstalk during sepsis induces elevated adrenal glucocorticoid levels, whereas crosstalk between adrenocortical cells and sonic hedgehog responsive stem cells was found to contribute to the increased size of the adrenal cortex during obesity. By contrast to sepsis, where activation of adrenal glucocorticoid production has protective effects, chronic exposure to high levels of glucocorticoids induces adverse effects, typically manifested in patients with Cushing syndrome, such as increased body weight, dyslipidemia, glucose intolerance, and hypertension. Therefore, a better understanding of factors involved in the regulation of the adrenal gland microenvironment is crucial. This review highlights bidirectional interactions occurring between the adrenal gland microenvironment and systemic responses during obesity and sepsis. Furthermore, it presents and discusses recent advancements and challenges in attempts to restore or regenerate adrenal gland function, including the use of oxygenated immune-isolating devices.
    MeSH term(s) Adrenal Gland Diseases/metabolism ; Adrenal Gland Diseases/physiopathology ; Adrenal Glands/metabolism ; Adrenal Glands/physiopathology ; Humans ; Hypothalamo-Hypophyseal System/metabolism ; Hypothalamo-Hypophyseal System/physiopathology ; Pituitary-Adrenal System/metabolism ; Pituitary-Adrenal System/physiopathology ; Regeneration/physiology
    Language English
    Publishing date 2017-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2581819-3
    ISSN 2520-8721 ; 1109-3099
    ISSN (online) 2520-8721
    ISSN 1109-3099
    DOI 10.14310/horm.2002.1744
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  8. Article: Absence of Type I Interferon Autoantibodies or Significant Interferon Signature Alterations in Adults With Post-COVID-19 Syndrome.

    Achleitner, Martin / Mair, Nina K / Dänhardt, Juliane / Kardashi, Romina / Puhan, Milo A / Abela, Irene A / Toepfner, Nicole / de With, Katja / Kanczkowski, Waldemar / Jarzebska, Natalia / Rodionov, Roman N / Wolf, Christine / Lee-Kirsch, Min Ae / Steenblock, Charlotte / Hale, Benjamin G / Bornstein, Stefan R

    Open forum infectious diseases

    2023  Volume 11, Issue 1, Page(s) ofad641

    Abstract: Genetic defects in the interferon (IFN) system or neutralizing autoantibodies against type I IFNs contribute to severe COVID-19. Such autoantibodies were proposed to affect post-COVID-19 syndrome (PCS), possibly causing persistent fatigue for >12 weeks ... ...

    Abstract Genetic defects in the interferon (IFN) system or neutralizing autoantibodies against type I IFNs contribute to severe COVID-19. Such autoantibodies were proposed to affect post-COVID-19 syndrome (PCS), possibly causing persistent fatigue for >12 weeks after confirmed SARS-CoV-2 infection. In the current study, we investigated 128 patients with PCS, 21 survivors of severe COVID-19, and 38 individuals who were asymptomatic. We checked for autoantibodies against IFN-α, IFN-β, and IFN-ω. Few patients with PCS had autoantibodies against IFNs but with no neutralizing activity, indicating a limited role of type I IFNs in PCS pathogenesis. In a subset consisting of 28 patients with PCS, we evaluated IFN-stimulated gene activity and showed that it did not correlate with fatigue. In conclusion, impairment of the type I IFN system is unlikely responsible for adult PCS.
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad641
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  9. Article ; Online: Succinate mediates inflammation-induced adrenocortical dysfunction.

    Mateska, Ivona / Witt, Anke / Hagag, Eman / Sinha, Anupam / Yilmaz, Canelif / Thanou, Evangelia / Sun, Na / Kolliniati, Ourania / Patschin, Maria / Abdelmegeed, Heba / Henneicke, Holger / Kanczkowski, Waldemar / Wielockx, Ben / Tsatsanis, Christos / Dahl, Andreas / Walch, Axel Karl / Li, Ka Wan / Peitzsch, Mirko / Chavakis, Triantafyllos /
    Alexaki, Vasileia Ismini

    eLife

    2023  Volume 12

    Abstract: The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex, thereby representing an endogenous feedback loop. However, severe ... ...

    Abstract The hypothalamus-pituitary-adrenal (HPA) axis is activated in response to inflammation leading to increased production of anti-inflammatory glucocorticoids by the adrenal cortex, thereby representing an endogenous feedback loop. However, severe inflammation reduces the responsiveness of the adrenal gland to adrenocorticotropic hormone (ACTH), although the underlying mechanisms are poorly understood. Here, we show by transcriptomic, proteomic, and metabolomic analyses that LPS-induced systemic inflammation triggers profound metabolic changes in steroidogenic adrenocortical cells, including downregulation of the TCA cycle and oxidative phosphorylation, in mice. Inflammation disrupts the TCA cycle at the level of succinate dehydrogenase (SDH), leading to succinate accumulation and disturbed steroidogenesis. Mechanistically, IL-1β reduces SDHB expression through upregulation of DNA methyltransferase 1 (DNMT1) and methylation of the
    MeSH term(s) Mice ; Animals ; Succinic Acid ; Proteomics ; Glucocorticoids/metabolism ; Adrenocorticotropic Hormone/metabolism ; Inflammation/metabolism
    Chemical Substances Succinic Acid (AB6MNQ6J6L) ; Glucocorticoids ; Adrenocorticotropic Hormone (9002-60-2)
    Language English
    Publishing date 2023-07-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.83064
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  10. Article ; Online: Clinical improvement of Long-COVID is associated with reduction in autoantibodies, lipids, and inflammation following therapeutic apheresis.

    Achleitner, Martin / Steenblock, Charlotte / Dänhardt, Juliane / Jarzebska, Natalia / Kardashi, Romina / Kanczkowski, Waldemar / Straube, Richard / Rodionov, Roman N / Bornstein, Nitzan / Tselmin, Sergey / Kaiser, Frank / Bucher, Ronald / Barbir, Mahmoud / Wong, Ma-Li / Voit-Bak, Karin / Licinio, Julio / Bornstein, Stefan R

    Molecular psychiatry

    2023  Volume 28, Issue 7, Page(s) 2872–2877

    Abstract: In the aftermath of the COVID-19 pandemic, we are witnessing an unprecedented wave of post-infectious complications. Most prominently, millions of patients with Long-Covid complain about chronic fatigue and severe post-exertional malaise. Therapeutic ... ...

    Abstract In the aftermath of the COVID-19 pandemic, we are witnessing an unprecedented wave of post-infectious complications. Most prominently, millions of patients with Long-Covid complain about chronic fatigue and severe post-exertional malaise. Therapeutic apheresis has been suggested as an efficient treatment option for alleviating and mitigating symptoms in this desperate group of patients. However, little is known about the mechanisms and biomarkers correlating with treatment outcomes. Here, we have analyzed in different cohorts of Long-Covid patients specific biomarkers before and after therapeutic apheresis. In patients that reported a significant improvement following two cycles of therapeutic apheresis, there was a significant reduction in neurotransmitter autoantibodies, lipids, and inflammatory markers. Furthermore, we observed a 70% reduction in fibrinogen, and following apheresis, erythrocyte rouleaux formation and fibrin fibers largely disappeared as demonstrated by dark field microscopy. This is the first study demonstrating a pattern of specific biomarkers with clinical symptoms in this patient group. It may therefore form the basis for a more objective monitoring and a clinical score for the treatment of Long-Covid and other postinfectious syndromes.
    MeSH term(s) Humans ; Lipoproteins, LDL ; Autoantibodies ; Post-Acute COVID-19 Syndrome ; Pandemics ; COVID-19 ; Blood Component Removal ; Inflammation ; Biomarkers
    Chemical Substances Lipoproteins, LDL ; Autoantibodies ; Biomarkers
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-023-02084-1
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