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  1. Article ; Online: P

    Stubbing, Louise A / Hubert, Jonathan G / Bell-Tyrer, Joseph / Hermant, Yann O / Yang, Sung Hyun / McSweeney, Alice M / McKenzie-Goldsmith, Geena M / Ward, Vernon K / Furkert, Daniel P / Brimble, Margaret A

    RSC chemical biology

    2023  Volume 4, Issue 8, Page(s) 533–547

    Abstract: Viral infections are one of the leading causes of acute morbidity in humans and much endeavour has been made by the synthetic community for the development of drugs to treat associated diseases. Peptide-based enzyme inhibitors, usually short sequences of ...

    Abstract Viral infections are one of the leading causes of acute morbidity in humans and much endeavour has been made by the synthetic community for the development of drugs to treat associated diseases. Peptide-based enzyme inhibitors, usually short sequences of three or four residues, are one of the classes of compounds currently under development for enhancement of their activity and pharmaceutical properties. This review reports the advances made in the design of inhibitors targeting the family of highly conserved viral proteases 3C/3CL
    Language English
    Publishing date 2023-06-21
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2633-0679
    ISSN (online) 2633-0679
    DOI 10.1039/d3cb00075c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Improving in vitro continuous cultivation of Plasmodium cynomolgi, a model for P. vivax.

    Christensen, Peter / Racklyeft, Annie / Ward, Kurt E / Matheson, Jessica / Suwanarusk, Rossarin / Chua, Adeline C Y / Kaneko, Osamu / Aung, Htin Lin / Rénia, Laurent / Amanzougaghene, Nadia / Magneron, Victor / Lemaitre, Julien / Le Grand, Roger / Kyle, Dennis / Bifani, Pablo / Cook, Gregory M / Snounou, Georges / Russell, Bruce

    Parasitology international

    2022  Volume 89, Page(s) 102589

    Abstract: ... clinical sampling. Such a method has recently been developed for the Berok strain of P. cynomolgi ... a parasite of macaques that has long been used as a model for P. vivax, as these two parasites are nearly ... indistinguishable biologically and are genetically closely related. The availability of the P. cynomolgi Berok ...

    Abstract The absence of a routine continuous in vitro cultivation method for Plasmodium vivax, an important globally distributed parasite species causing malaria in humans, has restricted investigations to field and clinical sampling. Such a method has recently been developed for the Berok strain of P. cynomolgi, a parasite of macaques that has long been used as a model for P. vivax, as these two parasites are nearly indistinguishable biologically and are genetically closely related. The availability of the P. cynomolgi Berok in routine continuous culture provides for the first time an opportunity to conduct a plethora of functional studies. However, the initial cultivation protocol proved unsuited for investigations requiring extended cultivation times, such as reverse genetics and drug resistance. Here we have addressed some of the critical obstacles to this, and we propose a set of modifications that help overcome them.
    MeSH term(s) Animals ; Macaca/parasitology ; Malaria/parasitology ; Malaria, Vivax/parasitology ; Parasites ; Plasmodium cynomolgi ; Plasmodium vivax
    Language English
    Publishing date 2022-04-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1363151-2
    ISSN 1873-0329 ; 1383-5769
    ISSN (online) 1873-0329
    ISSN 1383-5769
    DOI 10.1016/j.parint.2022.102589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Measurement of the Prompt D^{0} Nuclear Modification Factor in p-Pb Collisions at sqrt[s_{NN}]=8.16  TeV.

    Aaij, R / Abdelmotteleb, A S W / Abellan Beteta, C / Abudinén, F / Ackernley, T / Adeva, B / Adinolfi, M / Afsharnia, H / Agapopoulou, C / Aidala, C A / Aiola, S / Ajaltouni, Z / Akar, S / Akiba, K / Albrecht, J / Alessio, F / Alexander, M / Alfonso Albero, A / Aliouche, Z /
    Alvarez Cartelle, P / Amato, S / Amey, J L / Amhis, Y / An, L / Anderlini, L / Andersson, M / Andreianov, A / Andreotti, M / Andreou, D / Ao, D / Archilli, F / Artamonov, A / Artuso, M / Aslanides, E / Atzeni, M / Audurier, B / Bachmann, S / Bachmayer, M / Back, J J / Bailly-Reyre, A / Baladron Rodriguez, P / Balagura, V / Baldini, W / Baptista de Souza Leite, J / Barbetti, M / Barlow, R J / Barsuk, S / Barter, W / Bartolini, M / Baryshnikov, F / Basels, J M / Bassi, G / Batsukh, B / Battig, A / Bay, A / Beck, A / Becker, M / Bedeschi, F / Bediaga, I B / Beiter, A / Belavin, V / Belin, S / Bellee, V / Belous, K / Belov, I / Belyaev, I / Bencivenni, G / Ben-Haim, E / Berezhnoy, A / Bernet, R / Berninghoff, D / Bernstein, H C / Bertella, C / Bertolin, A / Betancourt, C / Betti, F / Bezshyiko, Ia / Bhasin, S / Bhom, J / Bian, L / Bieker, M S / Biesuz, N V / Bifani, S / Billoir, P / Biolchini, A / Birch, M / Bishop, F C R / Bitadze, A / Bizzeti, A / Blago, M P / Blake, T / Blanc, F / Blusk, S / Bobulska, D / Boelhauve, J A / Boente Garcia, O / Boettcher, T / Boldyrev, A / Bondar, N / Borghi, S / Borsato, M / Borsuk, J T / Bouchiba, S A / Bowcock, T J V / Boyer, A / Bozzi, C / Bradley, M J / Braun, S / Brea Rodriguez, A / Brodzicka, J / Brossa Gonzalo, A / Brundu, D / Buonaura, A / Buonincontri, L / Burke, A T / Burr, C / Bursche, A / Butkevich, A / Butter, J S / Buytaert, J / Byczynski, W / Cadeddu, S / Cai, H / Calabrese, R / Calefice, L / Cali, S / Calladine, R / Calvi, M / Calvo Gomez, M / Camargo Magalhaes, P / Campana, P / Campora Perez, D H / Campoverde Quezada, A F / Capelli, S / Capriotti, L / Carbone, A / Carboni, G / Cardinale, R / Cardini, A / Carli, I / Carniti, P / Carus, L / Casais Vidal, A / Caspary, R / Casse, G / Cattaneo, M / Cavallero, G / Cavallini, V / Celani, S / Cerasoli, J / Cervenkov, D / Chadwick, A J / Chapman, M G / Charles, M / Charpentier, Ph / Chavez Barajas, C A / Chefdeville, M / Chen, C / Chen, S / Chernov, A / Chernyshenko, S / Chobanova, V / Cholak, S / Chrzaszcz, M / Chubykin, A / Chulikov, V / Ciambrone, P / Cicala, M F / Cid Vidal, X / Ciezarek, G / Ciullo, G / Clarke, P E L / Clemencic, M / Cliff, H V / Closier, J / Cobbledick, J L / Coco, V / Coelho, J A B / Cogan, J / Cogneras, E / Cojocariu, L / Collins, P / Colombo, T / Congedo, L / Contu, A / Cooke, N / Coombs, G / Corredoira, I / Corti, G / Couturier, B / Craik, D C / Crkovská, J / Cruz Torres, M / Currie, R / Da Silva, C L / Dadabaev, S / Dai, L / Dall'Occo, E / Dalseno, J / D'Ambrosio, C / Danilina, A / d'Argent, P / Davies, J E / Davis, A / De Aguiar Francisco, O / de Boer, J / De Bruyn, K / De Capua, S / De Cian, M / De Freitas Carneiro Da Graca, U / De Lucia, E / De Miranda, J M / De Paula, L / De Serio, M / De Simone, D / De Simone, P / De Vellis, F / de Vries, J A / Dean, C T / Debernardis, F / Decamp, D / Dedu, V / Del Buono, L / Delaney, B / Dembinski, H-P / Denysenko, V / Deschamps, O / Dettori, F / Dey, B / Di Cicco, A / Di Nezza, P / Didenko, S / Dieste Maronas, L / Ding, S / Dobishuk, V / Dolmatov, A / Dong, C / Donohoe, A M / Dordei, F / Dos Reis, A C / Douglas, L / Downes, A G / Dudek, M W / Dufour, L / Duk, V / Durante, P / Durham, J M / Dutta, D / Dziurda, A / Dzyuba, A / Easo, S / Egede, U / Egorychev, V / Eidelman, S / Eisenhardt, S / Ek-In, S / Eklund, L / Ely, S / Ene, A / Epple, E / Escher, S / Eschle, J / Esen, S / Evans, T / Falcao, L N / Fan, Y / Fang, B / Farry, S / Fazzini, D / Feo, M / Fernez, A D / Ferrari, F / Ferreira Lopes, L / Ferreira Rodrigues, F / Ferreres Sole, S / Ferrillo, M / Ferro-Luzzi, M / Filippov, S / Fini, R A / Fiorini, M / Firlej, M / Fischer, K M / Fitzgerald, D S / Fitzpatrick, C / Fiutowski, T / Fleuret, F / Fontana, M / Fontanelli, F / Forty, R / Foulds-Holt, D / Franco Lima, V / Franco Sevilla, M / Frank, M / Franzoso, E / Frau, G / Frei, C / Friday, D A / Fu, J / Fuehring, Q / Gabriel, E / Galati, G / Gallas Torreira, A / Galli, D / Gambetta, S / Gan, Y / Gandelman, M / Gandini, P / Gao, Y / Garau, M / Garcia Martin, L M / Garcia Moreno, P / García Pardiñas, J / Garcia Plana, B / Garcia Rosales, F A / Garrido, L / Gaspar, C / Geertsema, R E / Gerick, D / Gerken, L L / Gersabeck, E / Gersabeck, M / Gershon, T / Giambastiani, L / Gibson, V / Giemza, H K / Gilman, A L / Giovannetti, M / Gioventù, A / Gironella Gironell, P / Giugliano, C / Giza, M A / Gizdov, K / Gkougkousis, E L / Gligorov, V V / Göbel, C / Golobardes, E / Golubkov, D / Golutvin, A / Gomes, A / Gomez Fernandez, S / Goncalves Abrantes, F / Goncerz, M / Gong, G / Gorelov, I V / Gotti, C / Grabowski, J P / Grammatico, T / Granado Cardoso, L A / Graugés, E / Graverini, E / Graziani, G / Grecu, A T / Greeven, L M / Grieser, N A / Grillo, L / Gromov, S / Gruberg Cazon, B R / Gu, C / Guarise, M / Guittiere, M / Günther, P A / Gushchin, E / Guth, A / Guz, Y / Gys, T / Hadavizadeh, T / Haefeli, G / Haen, C / Haimberger, J / Haines, S C / Halewood-Leagas, T / Halvorsen, M M / Hamilton, P M / Hammerich, J / Han, Q / Han, X / Hansen, E B / Hansmann-Menzemer, S / Hao, L / Harnew, N / Harrison, T / Hasse, C / Hatch, M / He, J / Heijhoff, K / Heinicke, K / Henderson, R D L / Hennequin, A M / Hennessy, K / Henry, L / Heuel, J / Hicheur, A / Hill, D / Hilton, M / Hollitt, S E / Hou, R / Hou, Y / Hu, J / Hu, W / Hu, X / Huang, W / Huang, X / Hulsbergen, W / Hunter, R J / Hushchyn, M / Hutchcroft, D / Ibis, P / Idzik, M / Ilin, D / Ilten, P / Inglessi, A / Iniukhin, A / Ishteev, A / Ivshin, K / Jacobsson, R / Jage, H / Jaimes Elles, S J / Jakobsen, S / Jans, E / Jashal, B K / Jawahery, A / Jevtic, V / Jiang, X / John, M / Johnson, D / Jones, C R / Jones, T P / Jost, B / Jurik, N / Juszczak, I / Kandybei, S / Kang, Y / Karacson, M / Karpenkov, D / Karpov, M / Kautz, J W / Keizer, F / Keller, D M / Kenzie, M / Ketel, T / Khanji, B / Kharisova, A / Kholodenko, S / Kirn, T / Kirsebom, V S / Kitouni, O / Klaver, S / Kleijne, N / Klimaszewski, K / Kmiec, M R / Koliiev, S / Kondybayeva, A / Konoplyannikov, A / Kopciewicz, P / Kopecna, R / Koppenburg, P / Korolev, M / Kostiuk, I / Kot, O / Kotriakhova, S / Kozachuk, A / Kravchenko, P / Kravchuk, L / Krawczyk, R D / Kreps, M / Kretzschmar, S / Krokovny, P / Krupa, W / Krzemien, W / Kubat, J / Kucewicz, W / Kucharczyk, M / Kudryavtsev, V / Kunde, G J / Lacarrere, D / Lafferty, G / Lai, A / Lampis, A / Lancierini, D / Lane, J J / Lane, R / Lanfranchi, G / Langenbruch, C / Langer, J / Lantwin, O / Latham, T / Lazzari, F / Lazzaroni, M / Le Gac, R / Lee, S H / Lefèvre, R / Leflat, A / Legotin, S / Lenisa, P / Leroy, O / Lesiak, T / Leverington, B / Li, H / Li, K / Li, P / Li, S / Li, Y / Li, Z / Liang, X / Lin, C / Lin, T / Lindner, R / Lisovskyi, V / Litvinov, R / Liu, G / Liu, H / Liu, Q / Liu, S / Lobo Salvia, A / Loi, A / Lollini, R / Lomba Castro, J / Longstaff, I / Lopes, J H / López Soliño, S / Lovell, G H / Lu, Y / Lucarelli, C / Lucchesi, D / Luchuk, S / Lucio Martinez, M / Lukashenko, V / Luo, Y / Lupato, A / Luppi, E / Lusiani, A / Lynch, K / Lyu, X-R / Ma, L / Ma, R / Maccolini, S / Machefert, F / Maciuc, F / Macko, V / Mackowiak, P / Maddrell-Mander, S / Madhan Mohan, L R / Maevskiy, A / Maisuzenko, D / Majewski, M W / Malczewski, J J / Malde, S / Malecki, B / Malinin, A / Maltsev, T / Malygina, H / Manca, G / Mancinelli, G / Manuzzi, D / Manzari, C A / Marangotto, D / Marchand, J F / Marconi, U / Mariani, S / Marin Benito, C / Marinangeli, M / Marks, J / Marshall, A M / Marshall, P J / Martelli, G / Martellotti, G / Martinazzoli, L / Martinelli, M / Martinez Santos, D / Martinez Vidal, F / Massafferri, A / Materok, M / Matev, R / Mathad, A / Matiunin, V / Matteuzzi, C / Mattioli, K R / Mauri, A / Maurice, E / Mauricio, J / Mazurek, M / McCann, M / Mcconnell, L / McGrath, T H / McHugh, N T / McNab, A / McNulty, R / Mead, J V / Meadows, B / Meier, G / Melnychuk, D / Meloni, S / Merk, M / Merli, A / Meyer Garcia, L / Mikhasenko, M / Milanes, D A / Millard, E / Milovanovic, M / Minard, M-N / Minotti, A / Mitchell, S E / Mitreska, B / Mitzel, D S / Mödden, A / Mohammed, R A / Moise, R D / Mokhnenko, S / Mombächer, T / Monroy, I A / Monteil, S / Morandin, M / Morello, G / Morello, M J / Moron, J / Morris, A B / Morris, A G / Mountain, R / Mu, H / Muheim, F / Mulder, M / Müller, K / Murphy, C H / Murray, D / Murta, R / Muzzetto, P / Naik, P / Nakada, T / Nandakumar, R / Nanut, T / Nasteva, I / Needham, M / Neri, N / Neubert, S / Neufeld, N / Neustroev, P / Newcombe, R / Niel, E M / Nieswand, S / Nikitin, N / Nolte, N S / Normand, C / Nunez, C / Oblakowska-Mucha, A / Obraztsov, V / Oeser, T / O'Hanlon, D P / Okamura, S / Oldeman, R / Oliva, F / Olivares, M E / Onderwater, C J G / O'Neil, R H / Otalora Goicochea, J M / Ovsiannikova, T / Owen, P / Oyanguren, A / Ozcelik, O / Padeken, K O / Pagare, B / Pais, P R / Pajero, T / Palano, A / Palutan, M / Pan, Y / Panshin, G / Papanestis, A / Pappagallo, M / Pappalardo, L L / Pappenheimer, C / Parker, W / Parkes, C / Passalacqua, B / Passaleva, G / Pastore, A / Patel, M / Patrignani, C / Pawley, C J / Pearce, A / Pellegrino, A / Pepe Altarelli, M / Perazzini, S / Pereima, D / Pereiro Castro, A / Perret, P / Petric, M / Petridis, K / Petrolini, A / Petrov, A / Petrucci, S / Petruzzo, M / Pham, H / Philippov, A / Piandani, R / Pica, L / Piccini, M / Pietrzyk, B / Pietrzyk, G / Pili, M / Pinci, D / Pisani, F / Pizzichemi, M / Placinta, V / Plews, J / Plo Casasus, M / Polci, F / Poli Lener, M / Poliakova, M / Poluektov, A / Polukhina, N / Polyakov, I / Polycarpo, E / Ponce, S / Popov, D / Popov, S / Poslavskii, S / Prasanth, K / Promberger, L / Prouve, C / Pugatch, V / Puill, V / Punzi, G / Qi, H R / Qian, W / Qin, N / Qu, S / Quagliani, R / Raab, N V / Rabadan Trejo, R I / Rachwal, B / Rademacker, J H / Rajagopalan, R / Rama, M / Ramos Pernas, M / Rangel, M S / Ratnikov, F / Raven, G / Rebollo De Miguel, M / Redi, F / Reiss, F / Remon Alepuz, C / Ren, Z / Renaudin, V / Resmi, P K / Ribatti, R / Ricci, A M / Ricciardi, S / Rinnert, K / Robbe, P / Robertson, G / Rodrigues, A B / Rodrigues, E / Rodriguez Lopez, J A / Rodriguez Rodriguez, E / Rollings, A / Roloff, P / Romanovskiy, V / Romero Lamas, M / Romero Vidal, A / Roth, J D / Rotondo, M / Rudolph, M S / Ruf, T / Ruiz Fernandez, R A / Ruiz Vidal, J / Ryzhikov, A / Ryzka, J / Saborido Silva, J J / Sagidova, N / Sahoo, N / Saitta, B / Salomoni, M / Sanchez Gras, C / Sanderswood, I / Santacesaria, R / Santamarina Rios, C / Santimaria, M / Santovetti, E / Saranin, D / Sarpis, G / Sarpis, M / Sarti, A / Satriano, C / Satta, A / Saur, M / Savrina, D / Sazak, H / Scantlebury Smead, L G / Scarabotto, A / Schael, S / Scherl, S / Schiller, M / Schindler, H / Schmelling, M / Schmidt, B / Schmitt, S / Schneider, O / Schopper, A / Schubiger, M / Schulte, S / Schune, M H / Schwemmer, R / Sciascia, B / Sciuccati, A / Sellam, S / Semennikov, A / Senghi Soares, M / Sergi, A / Serra, N / Sestini, L / Seuthe, A / Shang, Y / Shangase, D M / Shapkin, M / Shchemerov, I / Shchutska, L / Shears, T / Shekhtman, L / Shen, Z / Sheng, S / Shevchenko, V / Shields, E B / Shimizu, Y / Shmanin, E / Shupperd, J D / Siddi, B G / Silva Coutinho, R / Simi, G / Simone, S / Singla, M / Skidmore, N / Skuza, R / Skwarnicki, T / Slater, M W / Slazyk, I / Smallwood, J C / Smeaton, J G / Smith, E / Smith, M / Snoch, A / Soares Lavra, L / Sokoloff, M D / Soler, F J P / Solomin, A / Solovev, A / Solovyev, I / Souza De Almeida, F L / Souza De Paula, B / Spaan, B / Spadaro Norella, E / Spiridenkov, E / Spradlin, P / Sriskaran, V / Stagni, F / Stahl, M / Stahl, S / Stanislaus, S / Steinkamp, O / Stenyakin, O / Stevens, H / Stone, S / Strekalina, D / Suljik, F / Sun, J / Sun, L / Sun, Y / Svihra, P / Swallow, P N / Swientek, K / Szabelski, A / Szumlak, T / Szymanski, M / Taneja, S / Tanner, A R / Tat, M D / Terentev, A / Teubert, F / Thomas, E / Thompson, D J D / Thomson, K A / Tilquin, H / Tisserand, V / T'Jampens, S / Tobin, M / Tomassetti, L / Tonani, G / Tong, X / Torres Machado, D / Tou, D Y / Trifonova, E / Trilov, S M / Trippl, C / Tuci, G / Tully, A / Tuning, N / Ukleja, A / Unverzagt, D J / Ursov, E / Usachov, A / Ustyuzhanin, A / Uwer, U / Vagner, A / Vagnoni, V / Valassi, A / Valenti, G / Valls Canudas, N / van Beuzekom, M / Van Dijk, M / Van Hecke, H / van Herwijnen, E / van Veghel, M / Vazquez Gomez, R / Vazquez Regueiro, P / Vázquez Sierra, C / Vecchi, S / Velthuis, J J / Veltri, M / Venkateswaran, A / Veronesi, M / Vesterinen, M / Vieira, D / Vieites Diaz, M / Vilasis-Cardona, X / Vilella Figueras, E / Villa, A / Vincent, P / Volle, F C / Vom Bruch, D / Vorobyev, A / Vorobyev, V / Voropaev, N / Vos, K / Waldi, R / Walsh, J / Wang, C / Wang, J / Wang, M / Wang, R / Wang, Y / Wang, Z / Ward, J A / Watson, N K / Websdale, D / Weisser, C / Westhenry, B D C / White, D J / Whitehead, M / Wiederhold, A R / Wiedner, D / Wilkinson, G / Wilkinson, M K / Williams, I / Williams, M / Williams, M R J / Williams, R / Wilson, F F / Wislicki, W / Witek, M / Witola, L / Wong, C P / Wormser, G / Wotton, S A / Wu, H / Wyllie, K / Xiang, Z / Xiao, D / Xie, Y / Xu, A / Xu, J / Xu, L / Xu, M / Xu, Q / Xu, Z / Yang, D / Yang, S / Yang, Y / Yang, Z / Yeomans, L E / Yin, H / Yu, J / Yuan, X / Zaffaroni, E / Zavertyaev, M / Zdybal, M / Zenaiev, O / Zeng, M / Zhang, D / Zhang, L / Zhang, S / Zhang, Y / Zharkova, A / Zhelezov, A / Zheng, Y / Zhou, T / Zhou, X / Zhou, Y / Zhovkovska, V / Zhu, X / Zhu, Z / Zhukov, V / Zou, Q / Zucchelli, S / Zuliani, D / Zunica, G

    Physical review letters

    2023  Volume 131, Issue 10, Page(s) 102301

    Abstract: ... of the transverse momentum p_{T}, and the rapidity in the nucleon-nucleon center-of-mass frame y^{*}. In the forward ... expectations is found in the kinematic region of p_{T}>6  GeV/c and -3.25

    Abstract The production of prompt D^{0} mesons in proton-lead collisions in both the forward and backward rapidity regions at a center-of-mass energy per nucleon pair of sqrt[s_{NN}]=8.16  TeV is measured by the LHCb experiment. The nuclear modification factor of prompt D^{0} mesons is determined as a function of the transverse momentum p_{T}, and the rapidity in the nucleon-nucleon center-of-mass frame y^{*}. In the forward rapidity region, significantly suppressed production with respect to pp collisions is measured, which provides significant constraints on models of nuclear parton distributions and hadron production down to the very low Bjorken-x region of ∼10^{-5}. In the backward rapidity region, a suppression with a significance of 2.0-3.8 standard deviations compared to parton distribution functions in a nuclear environment expectations is found in the kinematic region of p_{T}>6  GeV/c and -3.25<y^{*}<-2.5, corresponding to x∼0.01.<br />
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.131.102301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Nuclear Modification Factor of Neutral Pions in the Forward and Backward Regions in p-Pb Collisions.

    Aaij, R / Abdelmotteleb, A S W / Abellan Beteta, C / Abudinén, F / Ackernley, T / Adeva, B / Adinolfi, M / Afsharnia, H / Agapopoulou, C / Aidala, C A / Aiola, S / Ajaltouni, Z / Akar, S / Akiba, K / Albrecht, J / Alessio, F / Alexander, M / Alfonso Albero, A / Aliouche, Z /
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Blanc, F / Blusk, S / Bobulska, D / Boelhauve, J A / Boente Garcia, O / Boettcher, T / Boldyrev, A / Bondar, N / Borghi, S / Borisyak, M / Borsato, M / Borsuk, J T / Bouchiba, S A / Bowcock, T J V / Boyer, A / Bozzi, C / Bradley, M J / Braun, S / Brea Rodriguez, A / Brodzicka, J / Brossa Gonzalo, A / Brundu, D / Buonaura, A / Buonincontri, L / Burke, A T / Burr, C / Bursche, A / Butkevich, A / Butter, J S / Buytaert, J / Byczynski, W / Cadeddu, S / Cai, H / Calabrese, R / Calefice, L / Cali, S / Calladine, R / Calvi, M / Calvo Gomez, M / Camargo Magalhaes, P / Campana, P / Campora Perez, D H / Campoverde Quezada, A F / Capelli, S / Capriotti, L / Carbone, A / Carboni, G / Cardinale, R / Cardini, A / Carli, I / Carniti, P / Carus, L / Casais Vidal, A / Caspary, R / Casse, G / Cattaneo, M / Cavallero, G / Cavallini, V / Celani, S / Cerasoli, J / Cervenkov, D / Chadwick, A J / Chapman, M G / Charles, M / Charpentier, Ph / Chavez Barajas, C A / Chefdeville, M / Chen, C / Chen, S / Chernov, 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    Physical review letters

    2023  Volume 131, Issue 4, Page(s) 42302

    Abstract: ... is measured differentially in transverse momentum (p_{T}) for 1.5<p_{T}<10.0  GeV and in center ...

    Abstract The nuclear modification factor of neutral pions is measured in proton-lead collisions collected at a center-of-mass energy per nucleon of 8.16 TeV with the LHCb detector. The π^{0} production cross section is measured differentially in transverse momentum (p_{T}) for 1.5<p_{T}<10.0  GeV and in center-of-mass pseudorapidity (η_{c.m.}) regions 2.5<η_{c.m.}<3.5 (forward) and -4.0<η_{c.m.}<-3.0 (backward) defined relative to the proton beam direction. The forward measurement shows a sizable suppression of π^{0} production, while the backward measurement shows the first evidence of π^{0} enhancement in proton-lead collisions at the LHC. Together, these measurements provide precise constraints on models of nuclear structure and particle production in high-energy nuclear collisions.
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.131.042302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Observation of a Narrow Pentaquark State, P_{c}(4312)^{+}, and of the Two-Peak Structure of the P_{c}(4450)^{+}.

    Aaij, R / Abellán Beteta, C / Adeva, B / Adinolfi, M / Aidala, C A / Ajaltouni, Z / Akar, S / Albicocco, P / Albrecht, J / Alessio, F / Alexander, M / Alfonso Albero, A / Alkhazov, G / Alvarez Cartelle, P / Alves, A A / Amato, S / Amhis, Y / An, L / Anderlini, L /
    Andreassi, G / Andreotti, M / Andrews, J E / Archilli, F / d'Argent, P / Arnau Romeu, J / Artamonov, A / Artuso, M / Arzymatov, K / Aslanides, E / Atzeni, M / Audurier, B / Bachmann, S / Back, J J / Baker, S / Balagura, V / Baldini, W / Baranov, A / Barlow, R J / Barsuk, S / Barter, W / Bartolini, M / Baryshnikov, F / Batozskaya, V / Batsukh, B / Battig, A / Battista, V / Bay, A / Bedeschi, F / Bediaga, I / Beiter, A / Bel, L J / Belavin, V / Belin, S / Beliy, N / Bellee, V / Belloli, N / Belous, K / Belyaev, I / Ben-Haim, E / Bencivenni, G / Benson, S / Beranek, S / Berezhnoy, A / Bernet, R / Berninghoff, D / Bertholet, E / Bertolin, A / Betancourt, C / Betti, F / Bettler, M O / van Beuzekom, M / Bezshyiko, Ia / Bhasin, S / Bhom, J / Bieker, M S / Bifani, S / Billoir, P / Birnkraut, A / Bizzeti, A / Bjørn, M / Blago, M P / Blake, T / Blanc, F / Blusk, S / Bobulska, D / Bocci, V / Boente Garcia, O / Boettcher, T / Bondar, A / Bondar, N / Borghi, S / Borisyak, M / Borsato, M / Boubdir, M / Bowcock, T J V / Bozzi, C / Braun, S / Brea Rodriguez, A / Brodski, M / Brodzicka, J / Brossa Gonzalo, A / Brundu, D / Buchanan, E / Buonaura, A / Burr, C / Bursche, A / Butter, J S / Buytaert, J / Byczynski, W / Cadeddu, S / Cai, H / Calabrese, R / Cali, S / Calladine, R / Calvi, M / Calvo Gomez, M / Camboni, A / Campana, P / Campora Perez, D H / Capriotti, L / Carbone, A / Carboni, G / Cardinale, R / Cardini, A / Carniti, P / Carvalho Akiba, K / Casais Vidal, A / Casse, G / Cattaneo, M / Cavallero, G / Cenci, R / Chapman, M G / Charles, M / Charpentier, Ph / Chatzikonstantinidis, G / Chefdeville, M / Chekalina, V / Chen, C / Chen, S / Chitic, S-G / Chobanova, V / Chrzaszcz, M / Chubykin, A / Ciambrone, P / Cid Vidal, X / Ciezarek, G / Cindolo, F / Clarke, P E L / Clemencic, M / Cliff, H V / Closier, J / Coco, V / Coelho, J A B / Cogan, J / Cogneras, E / Cojocariu, L / Collins, P / Colombo, T / Comerma-Montells, A / Contu, A / Coombs, G / Coquereau, S / Corti, G / Costa Sobral, C M / Couturier, B / Cowan, G A / Craik, D C / Crocombe, A / Cruz Torres, M / Currie, R / D'Ambrosio, C / Da Silva, C L / Dall'Occo, E / Dalseno, J / Danilina, A / Davis, A / De Aguiar Francisco, O / De Bruyn, K / De Capua, S / De Cian, M / De Miranda, J M / De Paula, L / De Serio, M / De Simone, P / Dean, C T / Dean, W / Decamp, D / Del Buono, L / Delaney, B / Dembinski, H-P / Demmer, M / Dendek, A / Derkach, D / Deschamps, O / Desse, F / Dettori, F / Dey, B / Di Canto, A / Di Nezza, P / Didenko, S / Dijkstra, H / Dordei, F / Dorigo, M / Dosil Suárez, A / Douglas, L / Dovbnya, A / Dreimanis, K / Dufour, L / Dujany, G / Durante, P / Durham, J M / Dutta, D / Dzhelyadin, R / Dziewiecki, M / Dziurda, A / Dzyuba, A / Easo, S / Egede, U / Egorychev, V / Eidelman, S / Eisenhardt, S / Eitschberger, U / Ek-In, S / Ekelhof, R / Eklund, L / Ely, S / Ene, A / Escher, S / Esen, S / Evans, T / Falabella, A / Farley, N / Farry, S / Fazzini, D / Fernandez Declara, P / Fernandez Prieto, A / 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Ward, D R / Wark, H M / Watson, N K / Websdale, D / Weiden, A / Weisser, C / Whitehead, M / Wilkinson, G / Wilkinson, M / Williams, I / Williams, M R J / Williams, M / Williams, T / Wilson, F F / Winn, M / Wislicki, W / Witek, M / Wormser, G / Wotton, S A / Wyllie, K / Xiao, D / Xie, Y / Xing, H / Xu, A / Xu, L / Xu, M / Xu, Q / Xu, Z / Yang, Z / Yao, Y / Yeomans, L E / Yin, H / Yu, J / Yuan, X / Yushchenko, O / Zarebski, K A / Zavertyaev, M / Zeng, M / Zhang, D / Zhang, L / Zhang, S / Zhang, W C / Zhang, Y / Zhelezov, A / Zheng, Y / Zhu, X / Zhukov, V / Zonneveld, J B / Zucchelli, S

    Physical review letters

    2019  Volume 122, Issue 22, Page(s) 222001

    Abstract: A narrow pentaquark state, P_{c}(4312)^{+}, decaying to J/ψp, is discovered with a statistical ... than that previously analyzed by the LHCb Collaboration. The P_{c}(4450)^{+} pentaquark structure formerly reported ... by LHCb is confirmed and observed to consist of two narrow overlapping peaks, P_{c}(4440)^{+} and P_{c ...

    Abstract A narrow pentaquark state, P_{c}(4312)^{+}, decaying to J/ψp, is discovered with a statistical significance of 7.3σ in a data sample of Λ_{b}^{0}→J/ψpK^{-} decays, which is an order of magnitude larger than that previously analyzed by the LHCb Collaboration. The P_{c}(4450)^{+} pentaquark structure formerly reported by LHCb is confirmed and observed to consist of two narrow overlapping peaks, P_{c}(4440)^{+} and P_{c}(4457)^{+}, where the statistical significance of this two-peak interpretation is 5.4σ. The proximity of the Σ_{c}^{+}D[over ¯]^{0} and Σ_{c}^{+}D[over ¯]^{*0} thresholds to the observed narrow peaks suggests that they play an important role in the dynamics of these states.
    Language English
    Publishing date 2019-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.122.222001
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  6. Article ; Online: Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein.

    Nguyen, William / Boulet, Coralie / Dans, Madeline G / Loi, Katie / Jarman, Kate E / Watson, Gabrielle M / Tham, Wai-Hong / Fairhurst, Kate J / Yeo, Tomas / Fidock, David A / Wittlin, Sergio / Chowdury, Mrittika / de Koning-Ward, Tania F / Chen, Gong / Yan, Dandan / Charman, Susan A / Baud, Delphine / Brand, Stephen / Jackson, Paul F /
    Cowman, Alan F / Gilson, Paul R / Sleebs, Brad E

    European journal of medicinal chemistry

    2024  Volume 270, Page(s) 116354

    Abstract: Malaria is a devastating disease that causes significant morbidity worldwide. The development of new antimalarial chemotypes is urgently needed because of the emergence of resistance to frontline therapies. Independent phenotypic screening campaigns ... ...

    Abstract Malaria is a devastating disease that causes significant morbidity worldwide. The development of new antimalarial chemotypes is urgently needed because of the emergence of resistance to frontline therapies. Independent phenotypic screening campaigns against the Plasmodium asexual parasite, including our own, identified the aryl amino acetamide hit scaffold. In a prior study, we identified the STAR-related lipid transfer protein (PfSTART1) as the molecular target of this antimalarial chemotype. In this study, we combined structural elements from the different aryl acetamide hit subtypes and explored the structure-activity relationship. It was shown that the inclusion of an endocyclic nitrogen, to generate the tool compound WJM-715, improved aqueous solubility and modestly improved metabolic stability in rat hepatocytes. Metabolic stability in human liver microsomes remains a challenge for future development of the aryl acetamide class, which was underscored by modest systemic exposure and a short half-life in mice. The optimized aryl acetamide analogs were cross resistant to parasites with mutations in PfSTART1, but not to other drug-resistant mutations, and showed potent binding to recombinant PfSTART1 by biophysical analysis, further supporting PfSTART1 as the likely molecular target. The optimized aryl acetamide analogue, WJM-715 will be a useful tool for further investigating the druggability of PfSTART1 across the lifecycle of the malaria parasite.
    MeSH term(s) Rats ; Mice ; Humans ; Animals ; Antimalarials/chemistry ; Plasmodium falciparum ; Malaria, Falciparum/drug therapy ; Malaria/drug therapy ; Acetamides/pharmacology ; Lipids ; Carrier Proteins
    Chemical Substances Antimalarials ; lipid transfer protein ; acetamide (8XOE1JSO29) ; Acetamides ; Lipids ; Carrier Proteins
    Language English
    Publishing date 2024-03-25
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2024.116354
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  7. Article ; Online: Digenic Congenital Hypogonadotropic Hypogonadism Due to Heterozygous GNRH1 p.R31C and AMHR2 p.G445_L453del Variants

    Stuckey, Bronwyn G. A. / Jones, Timothy W. / Ward, Bryan K. / Wilson, Scott G.

    Genes (Basel). 2023 May 31, v. 14, no. 6

    2023  

    Abstract: ... for the GNRH1 p.R31C mutation, reported in the literature as pathogenic and dominant. The same mutation was ... a second variant, AMHR2 p.G445_L453del, in the heterozygous form, reported as pathogenic in the patient ...

    Abstract A 28-year-old man with congenital hypogonadotropic hypogonadism (CHH) was found to be heterozygous for the GNRH1 p.R31C mutation, reported in the literature as pathogenic and dominant. The same mutation was found in his son at birth, but the testing of the infant at 64 days confirmed the hormonal changes associated with minipuberty. This led to further genetic sequencing of the patient and his son, which found a second variant, AMHR2 p.G445_L453del, in the heterozygous form, reported as pathogenic in the patient but not in his son. This suggests a digenic cause of the patient’s CHH. Together, these mutations are postulated to contribute to CHH by the lack of anti-Müllerian hormone (AMH) signalling, leading to the impaired migration of gonadotrophin releasing hormone (GnRH) neurons, the lack of the AMH effect on GnRH secretion, and altered GnRH decapeptide with reduced binding to GnRH receptors. This led us to the conclusion that the observed GNRH1 mutation in the heterozygous state is not certain to be dominant or, at least, exhibits incomplete penetrance and variable expressivity. This report also emphasises the opportunity afforded by the time window of minipuberty in assessing the inherited genetic disorders of hypothalamic function.
    Keywords anti-Mullerian hormone ; gonadotropins ; heterozygosity ; mutation ; patients ; penetrance ; secretion
    Language English
    Dates of publication 2023-0531
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14061204
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Plasma p-tau181 associated with structural changes in mild cognitive impairment.

    Nabizadeh, Fardin / Balabandian, Mohammad / Rostami, Mohammad Reza / Ward, Richard T / Ahmadi, Niloufar / Pourhamzeh, Mahsa

    Aging clinical and experimental research

    2022  Volume 34, Issue 9, Page(s) 2139–2147

    Abstract: ... development. The increased plasma level of hyperphosphorylated tau 181 (p-tau181) has been recently considered ... In the current study, we examined the association of cerebrospinal fluid (CSF) and plasma levels of p-tau181 ... showed a significant negative correlation between the increased levels of plasma p-tau181, CSF total tau ...

    Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with dementia and is a serious concern for the health of individuals and government health care systems worldwide. Gray matter atrophy and white matter damage are major contributors to cognitive deficits in AD patients, as demonstrated by magnetic resonance imaging (MRI). Many of these brain changes associated with AD begin to occur about 15 years before the onset of initial clinical symptoms. Therefore, it is critical to find biomarkers reflective of these brain changes associated with AD to identify this disease and monitor its prognosis and development. The increased plasma level of hyperphosphorylated tau 181 (p-tau181) has been recently considered a novel biomarker for the diagnosis of AD, preclinical AD, and mild cognitive impairment (MCI). In the current study, we examined the association of cerebrospinal fluid (CSF) and plasma levels of p-tau181 with structural brain changes in cortical thickness, cortical volume, surface area, and subcortical volume in MCI patients. In this cross-sectional study, we included the information of 461 MCI patients from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. The results of voxel-wise partial correlation analyses showed a significant negative correlation between the increased levels of plasma p-tau181, CSF total tau, and CSF p-tau181 with structural changes in widespread brain regions. These results provide evidence for the use of plasma p-tau181 as a diagnostic marker for structural changes in the brain associated with the early stages of AD and neurodegeneration.
    MeSH term(s) Aged ; Alzheimer Disease/blood ; Alzheimer Disease/complications ; Biomarkers/blood ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/etiology ; Cross-Sectional Studies ; Female ; Humans ; tau Proteins/blood
    Chemical Substances Biomarkers ; MAPT protein, human ; tau Proteins
    Language English
    Publishing date 2022-06-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-022-02148-2
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  9. Article ; Online: Constraining the p-Mode-g-Mode Tidal Instability with GW170817.

    Abbott, B P / Abbott, R / Abbott, T D / Acernese, F / Ackley, K / Adams, C / Adams, T / Addesso, P / Adhikari, R X / Adya, V B / Affeldt, C / Agarwal, B / Agathos, M / Agatsuma, K / Aggarwal, N / Aguiar, O D / Aiello, L / Ain, A / Ajith, P /
    Allen, B / Allen, G / Allocca, A / Aloy, M A / Altin, P A / Amato, A / Ananyeva, A / Anderson, S B / Anderson, W G / Angelova, S V / Antier, S / Appert, S / Arai, K / Araya, M C / Areeda, J S / Arène, M / Arnaud, N / Arun, K G / Ascenzi, S / Ashton, G / Ast, M / Aston, S M / Astone, P / Atallah, D V / Aubin, F / Aufmuth, P / Aulbert, C / AultONeal, K / Austin, C / Avila-Alvarez, A / Babak, S / Bacon, P / Badaracco, F / Bader, M K M / Bae, S / Baker, P T / Baldaccini, F / Ballardin, G / Ballmer, S W / Banagiri, S / Barayoga, J C / Barclay, S E / Barish, B C / Barker, D / Barkett, K / Barnum, S / Barone, F / Barr, B / Barsotti, L / Barsuglia, M / Barta, D / Bartlett, J / Bartos, I / Bassiri, R / Basti, A / Batch, J C / Bawaj, M / Bayley, J C / Bazzan, M / Bécsy, B / Beer, C / Bejger, M / Belahcene, I / Bell, A S / Beniwal, D / Bensch, M / Berger, B K / Bergmann, G / Bernuzzi, S / Bero, J J / Berry, C P L / Bersanetti, D / Bertolini, A / Betzwieser, J / Bhandare, R / Bilenko, I A / 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    Physical review letters

    2019  Volume 122, Issue 6, Page(s) 61104

    Abstract: We analyze the impact of a proposed tidal instability coupling p modes and g modes within neutron ... we compute the Bayes factor (lnB_{!pg}^{pg}) comparing our p-g model to a standard one. We find ... that the observed signal is consistent with waveform models that neglect p-g effects, with lnB_{!pg}^{pg}=0.03_{-0 ...

    Abstract We analyze the impact of a proposed tidal instability coupling p modes and g modes within neutron stars on GW170817. This nonresonant instability transfers energy from the orbit of the binary to internal modes of the stars, accelerating the gravitational-wave driven inspiral. We model the impact of this instability on the phasing of the gravitational wave signal using three parameters per star: an overall amplitude, a saturation frequency, and a spectral index. Incorporating these additional parameters, we compute the Bayes factor (lnB_{!pg}^{pg}) comparing our p-g model to a standard one. We find that the observed signal is consistent with waveform models that neglect p-g effects, with lnB_{!pg}^{pg}=0.03_{-0.58}^{+0.70} (maximum a posteriori and 90% credible region). By injecting simulated signals that do not include p-g effects and recovering them with the p-g model, we show that there is a ≃50% probability of obtaining similar lnB_{!pg}^{pg} even when p-g effects are absent. We find that the p-g amplitude for 1.4  M_{⊙} neutron stars is constrained to less than a few tenths of the theoretical maximum, with maxima a posteriori near one-tenth this maximum and p-g saturation frequency ∼70  Hz. This suggests that there are less than a few hundred excited modes, assuming they all saturate by wave breaking. For comparison, theoretical upper bounds suggest ≲10^{3} modes saturate by wave breaking. Thus, the measured constraints only rule out extreme values of the p-g parameters. They also imply that the instability dissipates ≲10^{51}  erg over the entire inspiral, i.e., less than a few percent of the energy radiated as gravitational waves.
    Language English
    Publishing date 2019-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.122.061104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Measurement of Antiproton Production in p-He Collisions at sqrt[s_{NN}]=110  GeV.

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    Physical review letters

    2018  Volume 121, Issue 22, Page(s) 222001

    Abstract: ... section in p-He collisions, and impact the interpretation of recent results on antiproton cosmic rays ...

    Abstract The cross section for prompt antiproton production in collisions of protons with an energy of 6.5 TeV incident on helium nuclei at rest is measured with the LHCb experiment from a data set corresponding to an integrated luminosity of 0.5  nb^{-1}. The target is provided by injecting helium gas into the LHC beam line at the LHCb interaction point. The reported results, covering antiproton momenta between 12 and 110  GeV/c, represent the first direct determination of the antiproton production cross section in p-He collisions, and impact the interpretation of recent results on antiproton cosmic rays from space-borne experiments.
    Language English
    Publishing date 2018-10-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.121.222001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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