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  1. Article ; Online: WHO Growth Charts Should be Used to Make Indian Children Reach Their Highest Growth Potential.

    Phadke, Mrudula / Menon, Pramila

    Indian pediatrics

    2024  Volume 61, Issue 3, Page(s) 289–290

    MeSH term(s) Child ; Humans ; Asian People ; Body Height ; Body Mass Index ; Body Weight ; Growth Charts ; World Health Organization
    Language English
    Publishing date 2024-03-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
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  2. Article ; Online: COVID-19 treatment by repurposing drugs until the vaccine is in sight.

    Phadke, Mrudula / Saunik, Sujata

    Drug development research

    2020  Volume 81, Issue 5, Page(s) 541–543

    Abstract: Corona virus disease (COVID-19) has created pandemic in the world as declared by WHO on March 12, 2020. It is a viral disease caused by SARS-CoV 2 virus and has affected large populations in over 120 countries. There is no specific treatment available ... ...

    Abstract Corona virus disease (COVID-19) has created pandemic in the world as declared by WHO on March 12, 2020. It is a viral disease caused by SARS-CoV 2 virus and has affected large populations in over 120 countries. There is no specific treatment available and management is empirical. Until such time that an effective vaccine is available for COVID-19 viral infection, one can repurpose known therapeutic drug molecules such as angiotensin receptor 2 blocker, a commonly used antihypertensive drug, to control COVID-19 virus from gaining entry into the host cell by blocking the angiotensin receptor. Clinical trials should also be undertaken to use statins, which are lipid-lowering drugs but have anti-inflammatory and immunomodulatory properties to prevent acute lung injury in COVID-19 infection.
    MeSH term(s) Angiotensin II Type 1 Receptor Blockers/administration & dosage ; Angiotensin II Type 1 Receptor Blockers/pharmacology ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Drug Repositioning ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology
    Chemical Substances Angiotensin II Type 1 Receptor Blockers ; Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Keywords covid19
    Language English
    Publishing date 2020-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604587-x
    ISSN 1098-2299 ; 0272-4391
    ISSN (online) 1098-2299
    ISSN 0272-4391
    DOI 10.1002/ddr.21666
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  3. Article ; Online: COVID ‐19 treatment by repurposing drugs until the vaccine is in sight

    Phadke, Mrudula / Saunik, Sujata

    Drug Development Research

    2020  Volume 81, Issue 5, Page(s) 541–543

    Keywords Drug Discovery ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 604587-x
    ISSN 1098-2299 ; 0272-4391
    ISSN (online) 1098-2299
    ISSN 0272-4391
    DOI 10.1002/ddr.21666
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: COVID-19 treatment by repurposing drugs until the vaccine is in sight

    Phadke, Mrudula / Saunik, Sujata

    Drug Dev Res

    Abstract: Corona virus disease (COVID-19) has created pandemic in the world as declared by WHO on March 12, 2020. It is a viral disease caused by SARS-CoV 2 virus and has affected large populations in over 120 countries. There is no specific treatment available ... ...

    Abstract Corona virus disease (COVID-19) has created pandemic in the world as declared by WHO on March 12, 2020. It is a viral disease caused by SARS-CoV 2 virus and has affected large populations in over 120 countries. There is no specific treatment available and management is empirical. Until such time that an effective vaccine is available for COVID-19 viral infection, one can repurpose known therapeutic drug molecules such as angiotensin receptor 2 blocker, a commonly used antihypertensive drug, to control COVID-19 virus from gaining entry into the host cell by blocking the angiotensin receptor. Clinical trials should also be undertaken to use statins, which are lipid-lowering drugs but have anti-inflammatory and immunomodulatory properties to prevent acute lung injury in COVID-19 infection.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #23356
    Database COVID19

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  5. Article ; Online: Trends in Urban Immunization Coverage in India: A Meta-Analysis and Meta-Regression.

    Kulkarni, Shashwat / Thampi, Varun / Deshmukh, Devika / Gadhari, Mangesh / Chandrasekar, Rajeshwari / Phadke, Mrudula

    Indian journal of pediatrics

    2021  Volume 90, Issue 1, Page(s) 38–48

    Abstract: Objectives: To assess the gaps and trends in child immunization coverage among urban and rural areas in India, and compare the success of immunisation program in each.: Methods: PubMed, Scopus, and Crossref, and Google Scholar electronic databases ... ...

    Abstract Objectives: To assess the gaps and trends in child immunization coverage among urban and rural areas in India, and compare the success of immunisation program in each.
    Methods: PubMed, Scopus, and Crossref, and Google Scholar electronic databases were searched on October 9, 2019, and March 21, 2020, for studies that measured and reported immunization coverage indicators in India. Random-effects meta-analyses and meta-regressions were conducted.
    Results: The authors' search identified 545 studies, and 2 were obtained by expert suggestion. Among these 68 studies and 6 surveys were included. They found that full immunization coverage has grown yearly at 2.65% and 0.82% in rural and urban areas, respectively whereas partial immunization coverage declined by -2.44% and -0.69%, respectively. Percentage of nonimmunized children did not show a statistically significant trend in either.
    Conclusion: While rural immunization coverage has seen a large increase over the past two decades, the progress in urban areas is weak and negligible. This was largely attributable to a focus on minimizing dropouts in rural areas. However, a lack of significant reduction in unimmunized children may indicate left-out children or pockets in both rural and urban areas. The poor performance of immunization programs in urban areas, coupled with a larger impact of COVID-19, warrants that India urgently adopts urban-sensitive and urban-focused policies and programs.
    MeSH term(s) Child ; Humans ; Infant ; Vaccination Coverage ; COVID-19 ; Immunization ; Vaccination ; Immunization Programs ; India ; Rural Population ; Urban Population
    Language English
    Publishing date 2021-09-16
    Publishing country India
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-021-03843-0
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    Zs.A 826: Show issues Location:
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  6. Article ; Online: Assessment, outcomes and implications of multiple anthropometric deficits in children.

    Kundan, Idzes / Nair, Rajalakshmi / Kulkarni, Shashwat / Deshpande, Aparna / Jotkar, Raju / Phadke, Mrudula

    BMJ nutrition, prevention & health

    2021  Volume 4, Issue 1, Page(s) 267–274

    Abstract: Background: Malnutrition in children is widely prevalent around the world. It has been observed that malnourished children with multiple anthropometric deficits have higher mortality. However, adequate studies are not available on the outcome and ... ...

    Abstract Background: Malnutrition in children is widely prevalent around the world. It has been observed that malnourished children with multiple anthropometric deficits have higher mortality. However, adequate studies are not available on the outcome and recovery of these children.Nandurbar, a tribal district from Maharashtra, India, shows high prevalence of all three forms of malnutrition, often occurring simultaneously. A project previously undertaken in Nandurbar from July 2014 to June 2016 studied the effect of various therapeutic feeds in treatment of children with uncomplicated severe acute malnutrition (SAM). In this study, we analyse secondary data from it to correlate effects of stunting, wasting and underweight on treatment recovery.
    Methods: Analysis was done on 5979 children with SAM using linear and logistic regression on R software for recovery rates and weight gain in children with SAM with single versus multiple anthropometric deficits, their relation to age, sex, and recovery from severe stunting by gain in height.
    Results: The mean age of children was 35 months and 53.1% of the children were males. 2346 (39.2%) children recovered at the end of the 8-week treatment. 454 (7.6%) had single anthropometric deficit (SAM only), 3164 (52.9%) had two anthropometric deficits (SAM and severe underweight (SUW)) and 2355 (39.4%) children had three anthropometric deficits (SAM, SUW and severe stunting). Out of the 5979 children with SAM, only 52 (0.9%) of children were not underweight (severe or moderate).44.94% of children with SAM who were severely stunted recovered, compared with 35.52% of children who were not (p<0.001). After controlling for confounders, severe stunting was found to increase the odds of recovery by 1.49. Severely stunted children with SAM also showed faster recovery and weight gain by 1.93 days (p<0.012) and 0.29 g/kg/day (p<0.001), respectively. Recovery was higher in females and younger age group. Recovery was also found to depend on the therapeutic feed, with children receiving medical nutrition therapy showing better recovery for severely stunted children.
    Conclusion: Our findings corroborate previous literature that stunting is a way for the body to deal with chronic stress of nutritional deprivation and provides a survival advantage to a child.
    Language English
    Publishing date 2021-06-07
    Publishing country England
    Document type Journal Article
    ISSN 2516-5542
    ISSN (online) 2516-5542
    DOI 10.1136/bmjnph-2021-000233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Task shifting in health care: the risks of integrated medicine in India.

    Balsari, Satchit / Simon, Greg / Nair, Rajalakshmi / Saunik, Sujata / Phadke, Mrudula

    The Lancet. Global health

    2017  Volume 5, Issue 10, Page(s) e963–e964

    Language English
    Publishing date 2017-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2723488-5
    ISSN 2214-109X ; 2214-109X
    ISSN (online) 2214-109X
    ISSN 2214-109X
    DOI 10.1016/S2214-109X(17)30322-4
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  8. Article ; Online: Task shifting in health care

    Satchit Balsari / Greg Simon / Rajalakshmi Nair / Sujata Saunik / Mrudula Phadke

    The Lancet Global Health, Vol 5, Iss 10, Pp e963-e

    the risks of integrated medicine in India

    2017  Volume 964

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2017-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  9. Article ; Online: Breastfeeding in Coronavirus Disease 2019 (COVID-19): Position Statement of Indian Academy of Pediatrics and Infant and Young Child Feeding Chapter.

    Bharadva, Ketan / Bellad, Roopa M / Tiwari, Satish / Somasekar, R / Phadke, Mrudula / Bodhankar, Uday / Bang, Akash / Kinikar, Aarti Avinash / Mallikarjuna, H B / Shah, Jayant / Khurana, Omesh / Gunasingh, D / Basavaraja, G V / Kumar, Remesh / Gupta, Piyush

    Indian pediatrics

    2021  Volume 59, Issue 1, Page(s) 58–62

    Abstract: Justification: Recent research has provided evidence for lack of transmission of SARS-CoV-2 through human milk and breastfeeding. Updating the practice guidelines will help in providing appropriate advice and support regarding breastfeeding during the ... ...

    Abstract Justification: Recent research has provided evidence for lack of transmission of SARS-CoV-2 through human milk and breastfeeding. Updating the practice guidelines will help in providing appropriate advice and support regarding breastfeeding during the coronavirus 2019 (COVID-19) pandemic.
    Objectives: To provide evidence-based guidelines to help the healthcare professionals to advise optimal breastfeeding practices during the COVID-19 pandemic.
    Process: Formulation of key questions was done under the chairmanship of President of the IAP. It was followed by review of literature and the recommendations of other international and national professional bodies. Through Infant and Young child (IYCF) focused WhatsApp group opinion of all members was taken. The final document was prepared after the consensus and approval by all members of the committee.
    Recommendations: The IYCF Chapter of IAP strongly recommends unabated promotion, protection and support to breastfeeding during the COVID-19 pandemic with due precautions.
    MeSH term(s) Breast Feeding ; COVID-19 ; Child ; Female ; Humans ; Infant ; Pandemics ; Pediatrics ; SARS-CoV-2
    Language English
    Publishing date 2021-11-22
    Publishing country India
    Document type Journal Article
    ZDB-ID 402594-5
    ISSN 0974-7559 ; 0019-6061
    ISSN (online) 0974-7559
    ISSN 0019-6061
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  10. Article ; Online: Is chromium from stainless steel utensils responsible for epidemic of type 2 diabetes?

    Gambhir, Prakash S / Phadke, Mrudula A

    Medical hypotheses

    2011  Volume 77, Issue 1, Page(s) 84–86

    Abstract: Type 2 diabetes prevalence is rising rapidly in developing world especially in India in last few decades. 'Thrifty phenotype' and 'westernization of lifestyle' is used to explain this epidemic. Chromium is an important modulator in insulin and glucose ... ...

    Abstract Type 2 diabetes prevalence is rising rapidly in developing world especially in India in last few decades. 'Thrifty phenotype' and 'westernization of lifestyle' is used to explain this epidemic. Chromium is an important modulator in insulin and glucose metabolism. Preconceptional chromium exposure has been demonstrated to raise the corticosterone and glucose levels in offspring of rodent model. Chromium is chelated when acidic food is stored in the stainless steel utensils. Chromium levels are shown to be high in Asian Indians. The hyperinsulinemia and insulin resistance is demonstrated in Indians from the newborn stage. We hypothesize that increased exposure to chromium in preconceptional and/or fetal stage leads to altered epigenetic control and altered endocrine and metabolic functioning. Increasing urbanization has led to increasing use of stainless steel and resultant exposure to chromium is at the least partly responsible for rising prevalence of type 2 diabetes. If proven avoiding or modifying the use of stainless steel utensils will halt the present epidemic of type 2 diabetes.
    MeSH term(s) Blood Glucose/analysis ; Chromium/toxicity ; Corticosterone/blood ; Diabetes Mellitus, Type 2/chemically induced ; Diabetes Mellitus, Type 2/epidemiology ; Humans ; India/epidemiology ; Insulin/blood ; Insulin Resistance ; Life Style ; Models, Theoretical ; Prevalence ; Stainless Steel/chemistry
    Chemical Substances Blood Glucose ; Insulin ; Chromium (0R0008Q3JB) ; Stainless Steel (12597-68-1) ; Corticosterone (W980KJ009P)
    Language English
    Publishing date 2011-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2011.03.032
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