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  1. Article ; Online: Exploring acetaminophen prodrugs and hybrids: a review.

    Kouznetsov, Vladimir V

    RSC advances

    2024  Volume 14, Issue 14, Page(s) 9691–9715

    Abstract: This critical review highlights the advances in developing new molecules for treating pain syndrome, an important issue for human health. Acetaminophen (APAP, known as paracetamol) and nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in ... ...

    Abstract This critical review highlights the advances in developing new molecules for treating pain syndrome, an important issue for human health. Acetaminophen (APAP, known as paracetamol) and nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in clinical practice despite their adverse effects. Research is being conducted to develop innovative drugs with improved pharmaceutical properties to mitigate these effects. A more practical way to achieve that is to study well-known and time-tested drugs in their molecular combinations. Accordingly, the present work explores APAP and their combined chemical entities,
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra00365a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 treatment: Much research and testing, but far, few magic bullets against SARS-CoV-2 coronavirus.

    Kouznetsov, Vladimir V

    European journal of medicinal chemistry

    2020  Volume 203, Page(s) 112647

    Abstract: The new virus of the of β-Coronaviruses genus, SARS-CoV-2, is the causative agent of coronavirus disease-2019 (COVID-19) and is winning a proverbial chess match against all players simultaneous, including physicians, clinicians, pathologists, doctors, ... ...

    Abstract The new virus of the of β-Coronaviruses genus, SARS-CoV-2, is the causative agent of coronavirus disease-2019 (COVID-19) and is winning a proverbial chess match against all players simultaneous, including physicians, clinicians, pathologists, doctors, scientists, economists, athletes and politicians. The COVID-19 outbreak has seriously threatened public health, killing the most vulnerable persons and causing general panic. To stop this disease, effective remedies (i.e., drugs, vaccines, personal protection elements, etc.) are urgently required. Unfortunately, no registered specific therapies (including antiviral therapies, immune-modulating agents and vaccines) are currently available to treat coronavirus infections, highlighting an urgent need for therapeutics targeting SARS-CoV-2. In this work, fourteen existing small molecule drugs or/and experimental drugs selected by experts and examined from the point of view of bioavailability via the Lipinski-Veber rules and assessment of their physicochemical descriptors. The aim of this study is to discover selected pattern similarities and peculiar characteristics that could be useful for antiviral drug optimization, drug combination or new antiviral agent design.
    MeSH term(s) Animals ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; Biological Availability ; COVID-19 ; COVID-19 Vaccines ; Coronavirus Infections/drug therapy ; Coronavirus Infections/prevention & control ; Drug Combinations ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2 ; Viral Vaccines ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; COVID-19 Vaccines ; Drug Combinations ; Viral Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2020.112647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Pyrrolo[2,1-

    García Maza, Leidy J / Salgado, Arturo Mendoza / Kouznetsov, Vladimir V / Meléndez, Carlos M

    RSC advances

    2024  Volume 14, Issue 3, Page(s) 1710–1728

    Abstract: Fused pyrrolo[2,1- ...

    Abstract Fused pyrrolo[2,1-
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra07047f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Nanostructured silicate catalysts for environmentally benign Strecker-type reactions:

    Kouznetsov, Vladimir V / Hernández, José G

    RSC advances

    2022  Volume 12, Issue 32, Page(s) 20807–20828

    Abstract: Chemical processes are usually catalytic transformations. The use of catalytic reagents can reduce the reaction temperature, decrease reagent-based waste, and enhance the selectivity of a reaction potentially avoiding unwanted side reactions leading to ... ...

    Abstract Chemical processes are usually catalytic transformations. The use of catalytic reagents can reduce the reaction temperature, decrease reagent-based waste, and enhance the selectivity of a reaction potentially avoiding unwanted side reactions leading to green technology. Chemical processes are also frequently based on multicomponent reactions (MCRs) that possess evident improvements over multistep processes. Both MCRs and catalysis tools are the most valuable principles of green chemistry. Among diverse MCRs, the three-component Strecker reaction (S-3-CR) is a particular transformation conducive to the formation of valuable bifunctional building blocks (α-amino nitriles) in organic synthesis, medicinal chemistry, drug research, and organic materials science. To be a practical synthetic tool, the S-3-CR must be achieved using alternative energy input systems, safe reaction media, and effective catalysts. These latter reagents are now deeply associated with nanoscience and nanocatalysis. Continuously developed, nanostructured silicate catalysts symbolize green pathways in our quest to attain sustainability. Studying and developing nanocatalyzed S-3-CR condensations as an important model will be suitable for achieving the current green mission. This critical review aims to highlight the advances in the development of nanostructured catalysts for technologically important Strecker-type reactions and to analyze this progress from the viewpoint of green and sustainable chemistry.
    Language English
    Publishing date 2022-07-20
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra03102g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Diastereoselective multicomponent synthesis of dihydroisoindolo[2,1-

    Sanabria-Sánchez, Carlos M / Kouznetsov, Vladimir V / Ochoa-Puentes, Cristian

    RSC advances

    2023  Volume 13, Issue 37, Page(s) 26189–26195

    Abstract: In this contribution, a series of dihydroisoindolo[2,1- ...

    Abstract In this contribution, a series of dihydroisoindolo[2,1-
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra05561b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: COVID-19 treatment

    Kouznetsov, Vladimir V.

    European Journal of Medicinal Chemistry

    Much research and testing, but far, few magic bullets against SARS-CoV-2 coronavirus

    2020  Volume 203, Page(s) 112647

    Keywords Organic Chemistry ; Pharmacology ; Drug Discovery ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2020.112647
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: COVID-19 treatment: Much research and testing, but far, few magic bullets against SARS-CoV-2 coronavirus

    Kouznetsov, Vladimir V

    Eur J Med Chem

    Abstract: The new virus of the of ß-Coronaviruses genus, SARS-CoV-2, is the causative agent of coronavirus disease-2019 (COVID-19) and is winning a proverbial chess match against all players simultaneous, including physicians, clinicians, pathologists, doctors, ... ...

    Abstract The new virus of the of ß-Coronaviruses genus, SARS-CoV-2, is the causative agent of coronavirus disease-2019 (COVID-19) and is winning a proverbial chess match against all players simultaneous, including physicians, clinicians, pathologists, doctors, scientists, economists, athletes and politicians. The COVID-19 outbreak has seriously threatened public health, killing the most vulnerable persons and causing general panic. To stop this disease, effective remedies (i.e., drugs, vaccines, personal protection elements, etc.) are urgently required. Unfortunately, no registered specific therapies (including antiviral therapies, immune-modulating agents and vaccines) are currently available to treat coronavirus infections, highlighting an urgent need for therapeutics targeting SARS-CoV-2. In this work, fourteen existing small molecule drugs or/and experimental drugs selected by experts and examined from the point of view of bioavailability via the Lipinski-Veber rules and assessment of their physicochemical descriptors. The aim of this study is to discover selected pattern similarities and peculiar characteristics that could be useful for antiviral drug optimization, drug combination or new antiviral agent design.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #644945
    Database COVID19

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  8. Article: Microwave-assisted Synthesis of Pharmacologically Active 4-Phenoxyquinolines and their Benzazole-quinoline Hybrids Through S

    Rodríguez Enciso, Duván A / Puerto Galvis, Carlos E / Kouznetsov, Vladimir V

    Current organic synthesis

    2023  Volume 20, Issue 5, Page(s) 546–559

    Abstract: Background: Quinoline and its derivatives have been shown to display a wide spectrum of biological properties, especially anticancer activity. Particularly, diverse potent anticancer drugs are based on the 4-phenoxyquinoline skeleton, acting as small- ... ...

    Abstract Background: Quinoline and its derivatives have been shown to display a wide spectrum of biological properties, especially anticancer activity. Particularly, diverse potent anticancer drugs are based on the 4-phenoxyquinoline skeleton, acting as small-molecules VEGR2 and/or c-Met kinase inhibitors. However, the design of new drugs based on these quinoline derivatives remains a challenge. Up till now, all approaches to 4-phenoxyquinoline skeleton construction do not obey any green chemistry principles.
    Aims and objectives: Developing a new, and efficient protocol for the synthesis of potentially bioactive 4-phenoxyquinoline derivatives and benzazole-quinoline-quinoline hybrids from commercially available 4,7-dichloroquinoline and phenol derivatives using microwave energy (MW) in the presence of 1-methyl 3-butylimidazolium hexafluorophosphate.
    Methods: Neweco-efficient protocol for valuable 7-chloro-4-phenoxyquinolines and their hybrids, which is based on SNAr reaction of 4,7-dichloroquinoline with respective simple phenols and hydroxyaryl- benzazoles under MWenergy in green reaction media, is studied for the first time.
    Results: We found that among various solvents tested, the ionic liquid 1-methyl 3-butylimidazolium hexafluorophosphate ([bmim][PF
    Conclusion: We developed for the first time a new green, efficient method to prepare potentially bioactive functionalized 7-chloro-4-phenoxyquinolines and benzazole-quinoline molecules. Good to excellent yields of the quinoline products, use of MW irradiation in ([bmim] [PF
    Language English
    Publishing date 2023-02-12
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1570-1794
    ISSN 1570-1794
    DOI 10.2174/1570179419666220830090614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Nanostructured silicate catalysts for environmentally benign Strecker-type reactions: status quo and quo vadis

    Kouznetsov, Vladimir V. / Hernández, José G.

    RSC advances. 2022 July 20, v. 12, no. 32

    2022  

    Abstract: Chemical processes are usually catalytic transformations. The use of catalytic reagents can reduce the reaction temperature, decrease reagent-based waste, and enhance the selectivity of a reaction potentially avoiding unwanted side reactions leading to ... ...

    Abstract Chemical processes are usually catalytic transformations. The use of catalytic reagents can reduce the reaction temperature, decrease reagent-based waste, and enhance the selectivity of a reaction potentially avoiding unwanted side reactions leading to green technology. Chemical processes are also frequently based on multicomponent reactions (MCRs) that possess evident improvements over multistep processes. Both MCRs and catalysis tools are the most valuable principles of green chemistry. Among diverse MCRs, the three-component Strecker reaction (S-3-CR) is a particular transformation conducive to the formation of valuable bifunctional building blocks (α-amino nitriles) in organic synthesis, medicinal chemistry, drug research, and organic materials science. To be a practical synthetic tool, the S-3-CR must be achieved using alternative energy input systems, safe reaction media, and effective catalysts. These latter reagents are now deeply associated with nanoscience and nanocatalysis. Continuously developed, nanostructured silicate catalysts symbolize green pathways in our quest to attain sustainability. Studying and developing nanocatalyzed S-3-CR condensations as an important model will be suitable for achieving the current green mission. This critical review aims to highlight the advances in the development of nanostructured catalysts for technologically important Strecker-type reactions and to analyze this progress from the viewpoint of green and sustainable chemistry.
    Keywords catalytic activity ; drugs ; green chemistry ; models ; nitriles ; renewable energy sources ; silicates ; sustainable technology ; temperature ; wastes
    Language English
    Dates of publication 2022-0720
    Size p. 20807-20828.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/d2ra03102g
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: A Simple and Effective Protocol for the Pechmann Reaction to Obtain 4-Methylcoumarin Derivatives Using a High-Speed Mixer Ball Mill Process

    Silvia J. Becerra-Anaya / Diego R. Merchán Arenas / Vladimir V. Kouznetsov

    Chemistry, Vol 5, Iss 73, Pp 1077-

    2023  Volume 1088

    Abstract: We hereby report a simple and efficient method for the preparation of 4-methylcoumarins series, including Coumarin 120 (7-amino-4-methylcoumarin) from phenols (or naphthols) and ethyl acetoacetate in the presence of 3 mol% InCl 3. Coumarins were obtained ...

    Abstract We hereby report a simple and efficient method for the preparation of 4-methylcoumarins series, including Coumarin 120 (7-amino-4-methylcoumarin) from phenols (or naphthols) and ethyl acetoacetate in the presence of 3 mol% InCl 3. Coumarins were obtained in good yields (52–92%) through Pechmann condensation, under a rapid and environmentally friendly protocol using a high-speed ball mill mixer at room temperature, with short reaction times, under solvent-free conditions.
    Keywords Pechmann reaction ; 4-methylcoumarins ; 4-methyl-2 H -chromen-2-ones ; solvent-free condensation ; mechanochemical activation ; ball milling ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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