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Article: ATP-Binding Cassette Subfamily G Member 2 in Acute Myeloid Leukemia: A New Molecular Target?

Damiani, Daniela / Tiribelli, Mario

2024 Volume 12, Issue 1

Abstract: Despite the progress in the knowledge of disease pathogenesis and the identification of many molecular markers as potential targets of new therapies, the cure of acute myeloid leukemia remains challenging. Disease recurrence after an initial response and ...

Abstract	Despite the progress in the knowledge of disease pathogenesis and the identification of many molecular markers as potential targets of new therapies, the cure of acute myeloid leukemia remains challenging. Disease recurrence after an initial response and the development of resistance to old and new therapies account for the poor survival rate and still make allogeneic stem cell transplantation the only curative option. Multidrug resistance (MDR) is a multifactorial phenomenon resulting from host-related characteristics and leukemia factors. Among these, the overexpression of membrane drug transporter proteins belonging to the ABC (ATP-Binding Cassette)-protein superfamily, which diverts drugs from their cellular targets, plays an important role. Moreover, a better understanding of leukemia biology has highlighted that, at least in cancer, ABC protein's role goes beyond simple drug transport and affects many other cell functions. In this paper, we summarized the current knowledge of ABCG2 (formerly Breast Cancer Resistance Protein, BCRP) in acute myeloid leukemia and discuss the potential ways to overcome its efflux function and to revert its ability to confer stemness to leukemia cells, favoring the persistence of leukemia progenitors in the bone marrow niche and justifying relapse also after therapy intensification with allogeneic stem cell transplantation.
Language	English
Publishing date	2024-01-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12010111
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Article ; Online: Human immunoglobulin G responses to Cimex lectularius L. saliva.

Sheele, Johnathan M / Ferrari, Brian / Goddard, Jerome / Schlatzer, Danie / Lundberg, Kathleen C / Guinto, Katirina / Embers, Monica E / Young, Andrew B / Ridge, Gale E / Damiani, Giovanni / McCormick, Thomas S

Parasite immunology

2020 Volume 42, Issue 12, Page(s) e12764

Abstract: Aims: To investigate the immunoglobulin (Ig) G response after being fed upon by Cimex lectularius ... against bed bug salivary gland extract, with antihuman Immunoglobulin G (IgG) secondary antibodies. No ...

Abstract	Aims: To investigate the immunoglobulin (Ig) G response after being fed upon by Cimex lectularius L. Methods and results: Participants were fed upon by three male C lectularius insects weekly for a month. Blood was obtained before the feeding and at the last feeding, which was used for immunoblots against bed bug salivary gland extract, with antihuman Immunoglobulin G (IgG) secondary antibodies. No consistent IgG changes developed in 11 humans serially fed upon by C lectularius. Two participants had new IgG responses to proteins at molecular weights of approximately 12-13 kDa, and one had an IgG response to a protein at approximately 40 kDa. At the last study visit, more intense IgG bands to proteins at molecular weights of 12-13 kDa had developed in 55% of participants (6/11) and at molecular weights of ≈30, ≈40 and ≈70 kDa in 45% (5/11) compared with the first study visit. Nitrophorin and apyrase were the most common C lectularius proteins identified with liquid chromatography-tandem mass spectrometry in both crushed bed bug salivary gland extract and post-bed bug feeding extract. Conclusions: Human participants did not have consistent IgG responses to crushed C lectularius salivary gland extract.
MeSH term(s)	Adolescent ; Adult ; Animals ; Bedbugs/immunology ; Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Insect Bites and Stings/blood ; Insect Bites and Stings/immunology ; Male ; Middle Aged ; Saliva/chemistry ; Saliva/immunology ; Salivary Glands/chemistry ; Salivary Proteins and Peptides/analysis ; Salivary Proteins and Peptides/immunology ; Young Adult
Chemical Substances	Immunoglobulin G ; Salivary Proteins and Peptides
Language	English
Publishing date	2020-06-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	424444-8
ISSN	1365-3024 ; 0141-9838
ISSN (online)	1365-3024
ISSN	0141-9838
DOI	10.1111/pim.12764
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Article ; Online: Pharmacogenetics in critical care: association between CYP3A5 rs776746 A/G genotype and acetaminophen response in sepsis and septic shock.

Scorcella, C / Domizi, R / Amoroso, S / Carsetti, A / Casarotta, E / Castaldo, P / D'angelo, C / Damiani, E / Gasparri, F / Donati, A / Adrario, E

BMC anesthesiology

2023 Volume 23, Issue 1, Page(s) 55

Abstract: ... carried CYP3A5 rs776746 A/G genotypes and showed significantly higher plasma levels of ACT than GG wild ... type patients, and than patients with UGT1A1 rs8330 C/G genotypes.: Conclusions: Identifying ...

Abstract	Background: Pharmacogenetics could represent a further resource to understand the interindividual heterogeneity of response of the host to sepsis and to provide a personalized approach to the critical care patient. Methods: Secondary analysis of data from the prospective observational study NCT02750163, in 50 adult septic and septic shock patients treated with Acetaminophen (ACT) for pyrexia. We investigated the presence of two polymorphisms, located respectively in the genes UGT1A1 and CYP3A5, that encode for proteins related to the hepatic metabolism of ACT. The main dependent variables explored were plasmatic concentration of ACT, body temperature and hepatic parameters. Results: 8% of the patients carried CYP3A5 rs776746 A/G genotypes and showed significantly higher plasma levels of ACT than GG wild type patients, and than patients with UGT1A1 rs8330 C/G genotypes. Conclusions: Identifying specific genotypes of response to ACT may be helpful to guide a more personalized titration of therapy in sepsis and septic shock. CYP3A5 might be a good biomarker for ACT metabolism; however further studies are needed to confirm this result. Trial registration: NCT02750163.
MeSH term(s)	Adult ; Humans ; Shock, Septic/drug therapy ; Shock, Septic/genetics ; Acetaminophen/therapeutic use ; Pharmacogenetics ; Cytochrome P-450 CYP3A/genetics ; Sepsis/drug therapy ; Sepsis/genetics ; Genotype ; Critical Care
Chemical Substances	Acetaminophen (362O9ITL9D) ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; CYP3A5 protein, human (EC 1.14.14.1)
Language	English
Publishing date	2023-02-16
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091252-3
ISSN	1471-2253 ; 1471-2253
ISSN (online)	1471-2253
ISSN	1471-2253
DOI	10.1186/s12871-023-02018-y
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Article ; Online: Equid herpesvirus type 3 infection produces membrane-associated and secreted forms of glycoprotein G that are not required for efficient cell-to-cell spread of the virus in vitro.

Losinno, Antonella / Vissani, María Aldana / Sanchez, Diego / Damiani, Armando Mario

Archives of virology

2023 Volume 168, Issue 4, Page(s) 122

Abstract: The ORF 70 gene of equid alphaherpesvirus type 3 (EHV-3) encodes glycoprotein G (gG), which is ...

Abstract	The ORF 70 gene of equid alphaherpesvirus type 3 (EHV-3) encodes glycoprotein G (gG), which is conserved in the majority of alphaherpesviruses. This glycoprotein is located in the viral envelope and has the characteristic of being secreted into the culture medium after proteolytic processing. It modulates the antiviral immune response of the host by interacting with chemokines. The aim of this study was to identify and characterize EHV-3 gG. By constructing viruses with HA-tagged gG, it was possible to detect gG in lysates of infected cells, their supernatants, and purified virions. A 100-, 60-, and 17-kDa form of the protein were detected in viral particles, while a 60-kDa form was identified in supernatants of infected cells. The role of EHV-3 gG in the viral infection cycle was assessed by the construction of a gG-minus EHV-3 mutant and its gG-positive revertant. When growth characteristics in an equine dermal fibroblast cell line were compared, the plaque size and the growth kinetics of the gG-minus mutant were similar to those of the revertant virus, suggesting that EHV-3 gG does not play a role in direct cell-to-cell transmission or virus proliferation of EHV-3 in tissue culture. The identification and characterization of EHV-3 gG described here provide a solid background for further studies to assess whether this glycoprotein has a function in modulating the host immune response.
MeSH term(s)	Animals ; Horses ; Viral Envelope Proteins/metabolism ; Herpesvirus 1, Equid/genetics ; Herpesvirus 3, Equid/metabolism ; Cell Line ; Glycoproteins/genetics ; Herpesviridae Infections
Chemical Substances	Viral Envelope Proteins ; Glycoproteins
Language	English
Publishing date	2023-03-28
Publishing country	Austria
Document type	Journal Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-023-05727-4
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Article ; Online: Molecular Proof of a Clinical Concept: Expression of Estrogen Alpha-, Beta-Receptors and G Protein-Coupled Estrogen Receptor 1 (GPER) in Histologically Assessed Common Nevi, Dysplastic Nevi and Melanomas.

Spałkowska, Magdalena / Dyduch, Grzegorz / Broniatowska, Elżbieta / Damiani, Giovanni / Wojas-Pelc, Anna

Medicina (Kaunas, Lithuania)

2021 Volume 57, Issue 11

Abstract: Background and Objectives: ...

Abstract	Background and Objectives:
MeSH term(s)	Cross-Sectional Studies ; Dysplastic Nevus Syndrome/metabolism ; Dysplastic Nevus Syndrome/pathology ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/metabolism ; Humans ; Melanoma/metabolism ; Melanoma/pathology ; Receptors, Estrogen/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology
Chemical Substances	ESR1 protein, human ; ESR2 protein, human ; Estrogen Receptor alpha ; Estrogen Receptor beta ; GPER1 protein, human ; Receptors, Estrogen ; Receptors, G-Protein-Coupled
Language	English
Publishing date	2021-11-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina57111228
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Article ; Online: Equid herpesvirus type 3 infection produces membrane-associated and secreted forms of glycoprotein G that are not required for efficient cell-to-cell spread of the virus in vitro

Losinno, Antonella / Vissani, María Aldana / Sánchez González, Diego / Damiani, Armando Mario

Arch Virol. 2023 Apr., v. 168, no. 4 p.122-122

2023

Abstract: The ORF 70 gene of equid alphaherpesvirus type 3 (EHV-3) encodes glycoprotein G (gG), which is ...

Abstract	The ORF 70 gene of equid alphaherpesvirus type 3 (EHV-3) encodes glycoprotein G (gG), which is conserved in the majority of alphaherpesviruses. This glycoprotein is located in the viral envelope and has the characteristic of being secreted into the culture medium after proteolytic processing. It modulates the antiviral immune response of the host by interacting with chemokines. The aim of this study was to identify and characterize EHV-3 gG. By constructing viruses with HA-tagged gG, it was possible to detect gG in lysates of infected cells, their supernatants, and purified virions. A 100-, 60-, and 17-kDa form of the protein were detected in viral particles, while a 60-kDa form was identified in supernatants of infected cells. The role of EHV-3 gG in the viral infection cycle was assessed by the construction of a gG-minus EHV-3 mutant and its gG-positive revertant. When growth characteristics in an equine dermal fibroblast cell line were compared, the plaque size and the growth kinetics of the gG-minus mutant were similar to those of the revertant virus, suggesting that EHV-3 gG does not play a role in direct cell-to-cell transmission or virus proliferation of EHV-3 in tissue culture. The identification and characterization of EHV-3 gG described here provide a solid background for further studies to assess whether this glycoprotein has a function in modulating the host immune response.
Keywords	Alphaherpesvirinae ; cell lines ; chemokines ; culture media ; fibroblasts ; genes ; glycoproteins ; growth models ; horses ; immune response ; mutants ; proteolysis ; tissue culture ; viruses
Language	English
Dates of publication	2023-04
Size	p. 122.
Publishing place	Springer Vienna
Document type	Article ; Online
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-023-05727-4
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Article ; Online: New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part 2: [g]-fused and hetero-fused systems.

Micheli, Fabrizio / Bonanomi, Giorgio / Braggio, Simone / Capelli, Anna Maria / Damiani, Federica / Di Fabio, Romano / Donati, Daniele / Gentile, Gabriella / Hamprecht, Dieter / Perini, Ornella / Petrone, Marcella / Tedesco, Giovanna / Terreni, Silvia / Worby, Angela / Heidbreder, Christian

Bioorganic & medicinal chemistry letters

2008 Volume 18, Issue 3, Page(s) 908–912

Abstract: ... antagonists is reported. The new scaffolds of the [g]-fused and the hetero-fused tricyclic benzazepine are ...

Abstract	The synthesis and the SAR of a new series of potent and selective dopamine D(3) receptor antagonists is reported. The new scaffolds of the [g]-fused and the hetero-fused tricyclic benzazepine are here reported together with their pharmacokinetic profile.
MeSH term(s)	Animals ; Benzazepines/chemical synthesis ; Benzazepines/chemistry ; Benzazepines/pharmacology ; Combinatorial Chemistry Techniques ; Dopamine Antagonists/chemical synthesis ; Dopamine Antagonists/chemistry ; Dopamine Antagonists/pharmacology ; Drug Design ; Molecular Structure ; Rats ; Receptors, Dopamine D3/antagonists & inhibitors ; Structure-Activity Relationship
Chemical Substances	Benzazepines ; Dopamine Antagonists ; Receptors, Dopamine D3
Language	English
Publishing date	2008-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2007.12.042
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Article: Involvement of heterotrimeric G proteins in phagocytosis and recycling from the phagosomal compartment.

Damiani, M T / Colombo, M I

Experimental cell research

2001 Volume 271, Issue 1, Page(s) 189–199

Abstract: ... of stimulatory and inhibitory trimeric G proteins. AlF(-)(4) inhibited both the uptake to and the recycling ... thereby assign a role for heterotrimeric G proteins in controlling traffic through the phagocytic pathway. ...

Abstract	Phagocytosis is a receptor-mediated process by which specialized cell types engulf large extracellular particles. Phagosome maturation involves a series of intracellular membrane fusion and budding events resulting in the delivery of particles to compartments enriched in lysosomal hydrolases where they are digested. Substantial amounts of plasma membrane and many phagosomal proteins, such as receptors, rapidly recycle to the plasma membrane following phagosome formation. Despite the importance of this recycling pathway in phagosome maturation and in the retrieval of immunogenic peptides from phagosomes, the molecular machinery involved is largely unknown. To assess the participation of GTPases in phagocytosis and recycling from phagosomes we used aluminum fluoride (AIF(-)(4)), which activates the GDP-bound form of stimulatory and inhibitory trimeric G proteins. AlF(-)(4) inhibited both the uptake to and the recycling from the phagosomal compartment. Cholera toxin, which activates Galphas, and pertussis toxin, which uncouples Gi and Go from receptors, were effective inhibitors of phagocytosis. However, both toxins stimulated recycling from phagosomes. These results suggest that more than one GTP-binding protein participates either directly or indirectly not only in phagocytosis, but also in maturation and recycling from phagosomes, and thereby assign a role for heterotrimeric G proteins in controlling traffic through the phagocytic pathway.
MeSH term(s)	Aluminum Compounds/pharmacology ; Animals ; Cell Line ; Cholera Toxin/pharmacology ; Fluorides/pharmacology ; Heterotrimeric GTP-Binding Proteins/metabolism ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/physiology ; Pertussis Toxin ; Phagocytosis/physiology ; Phagosomes/metabolism ; Staphylococcus aureus/cytology ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/metabolism ; Virulence Factors, Bordetella/pharmacology
Chemical Substances	Aluminum Compounds ; Virulence Factors, Bordetella ; Cholera Toxin (9012-63-9) ; Pertussis Toxin (EC 2.4.2.31) ; Heterotrimeric GTP-Binding Proteins (EC 3.6.5.1) ; Fluorides (Q80VPU408O) ; aluminum fluoride (Z77H3IKW94)
Language	English
Publishing date	2001-11-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1493-x
ISSN	1090-2422 ; 0014-4827
ISSN (online)	1090-2422
ISSN	0014-4827
DOI	10.1006/excr.2001.5354
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Article ; Online: Apremilast does not appear to outlast methotrexate.

Damiani, G

The British journal of dermatology

2019 Volume 182, Issue 3, Page(s) 534–535

MeSH term(s)	Humans ; Methotrexate ; National Health Programs ; Psoriasis ; Thalidomide/analogs & derivatives
Chemical Substances	Thalidomide (4Z8R6ORS6L) ; apremilast (UP7QBP99PN) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2019-08-19
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.18371
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Article: Rethinking Hidradenitis Suppurativa Management: Insights into Bacterial Interactions and Treatment Evolution.

Huynh, Faith D / Damiani, Giovanni / Bunick, Christopher G

Antibiotics (Basel, Switzerland)

2024 Volume 13, Issue 3

Abstract: Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory dermatological condition characterized by painful and recurrent nodules and purulent abscesses. HS can have a devastating impact on the quality of life of patients. This condition ... ...

Abstract	Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory dermatological condition characterized by painful and recurrent nodules and purulent abscesses. HS can have a devastating impact on the quality of life of patients. This condition is commonly localized to the axilla, groin, perineal, and inframammary regions, and can develop fistulas and sinus tracts over time. Its pathogenesis remains elusive and is best characterized at the moment as multi-factorial. Additionally, questions remain about the role of cutaneous dysbiosis as a primary HS trigger or as a secondary perturbation due to HS inflammation. This article features works in relation to HS and its interplay with bacterial microflora. We address current treatment approaches and their impact on HS-related bacteria, as well as areas of therapeutic innovation. In the future, disease-modifying or remittive therapy will likely combine an advanced/targeted anti-inflammatory approach with one that effectively modulates cutaneous and deep tissue dysbiosis.
Language	English
Publishing date	2024-03-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics13030268
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