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  1. Article ; Online: Progression from palindromic rheumatism to rheumatoid arthritis after COVID-19 vaccination.

    Bansal, Pankaj / Sonani, Bhavin / Aslam, Fawad

    ARP rheumatology

    2022  Volume 1, Issue 1, Page(s) 100–101

    Abstract: Infections including COVID-19 infection are associated with immune overactivation and hyperinflammation, and cases of incident inflammatory arthritis after COVID-19 and other respiratory viral infections have been reported. Theoretical concerns of ... ...

    Title translation Progression from palindromic rheumatism to rheumatoid arthritis after COVID-19 vaccination.
    Abstract Infections including COVID-19 infection are associated with immune overactivation and hyperinflammation, and cases of incident inflammatory arthritis after COVID-19 and other respiratory viral infections have been reported. Theoretical concerns of autoimmunity due to molecular mimicry exist with vaccines including vaccines for COVID-19, and rare cases of flares of underlying chronic inflammatory disorders such as systemic lupus erythematosus have been reported after COVID-19 vaccination. Here we present the case of a patient with a 7-year history of well-controlled palindromic rheumatism who developed rheumatoid arthritis 2 weeks after vaccination for COVID-19. This is the first such case to our knowledge, and further studies can elaborate on the risk of autoimmunity due to COVID-19 vaccines if one exists. Given the overall safety and efficacy of COVID-19 vaccines, the proven benefits of vaccinating vulnerable patients with autoimmune disorders outweigh this potential theoretical risk of autoimmune disease flare, and vaccinations in this at-risk population shall be strongly encouraged.
    MeSH term(s) Arthritis, Rheumatoid ; Autoimmune Diseases/etiology ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Humans ; Vaccination/adverse effects ; Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2022-05-21
    Publishing country Portugal
    Document type Case Reports ; Journal Article
    ISSN 2795-4552
    ISSN (online) 2795-4552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: COVID-19 vaccination in immunocompromised patients.

    Sonani, Bhavin / Aslam, Fawad / Goyal, Amandeep / Patel, Janki / Bansal, Pankaj

    Clinical rheumatology

    2021  Volume 40, Issue 2, Page(s) 797–798

    MeSH term(s) COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Clinical Trials as Topic ; Humans ; Immunocompromised Host/immunology ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-01-11
    Publishing country Germany
    Document type Letter
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-020-05547-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Urgent Issues Facing Immigrant Physicians in the United States in the COVID-19 Era.

    Tiwari, Vivekanand / Bhardwaj, Abhishek / Sonani, Bhavin / Mehta, Atul C

    Annals of internal medicine

    2020  Volume 173, Issue 10, Page(s) 838–839

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Emigrants and Immigrants/legislation & jurisprudence ; Foreign Medical Graduates/legislation & jurisprudence ; Humans ; Pandemics ; Physicians/supply & distribution ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M20-4103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hydroxychloroquine

    Pankaj Bansal / Amandeep Goyal / Austin Cusick / Shubham Lahan / Harpal S. Dhaliwal / Poonam Bhyan / Pradnya Brijmohan Bhattad / Fawad Aslam / Sagar Ranka / Tarun Dalia / Lovely Chhabra / Devang Sanghavi / Bhavin Sonani / John M. Davis

    Annals of Medicine, Vol 53, Iss 1, Pp 117-

    a comprehensive review and its controversial role in coronavirus disease 2019

    2021  Volume 134

    Abstract: AbstractHydroxychloroquine, initially used as an antimalarial, is used as an immunomodulatory and anti-inflammatory agent for the management of autoimmune and rheumatic diseases such as systemic lupus erythematosus. Lately, there has been interest in its ...

    Abstract AbstractHydroxychloroquine, initially used as an antimalarial, is used as an immunomodulatory and anti-inflammatory agent for the management of autoimmune and rheumatic diseases such as systemic lupus erythematosus. Lately, there has been interest in its potential efficacy against severe acute respiratory syndrome coronavirus 2, with several speculated mechanisms. The purpose of this review is to elaborate on the mechanisms surrounding hydroxychloroquine. The review is an in-depth analysis of the antimalarial, immunomodulatory, and antiviral mechanisms of hydroxychloroquine, with detailed and novel pictorial explanations. The mechanisms of hydroxychloroquine are related to potential cardiotoxic manifestations and demonstrate potential adverse effects when used for coronavirus disease 2019 (COVID-19). Finally, current literature associated with hydroxychloroquine and COVID-19 has been analyzed to interrelate the mechanisms, adverse effects, and use of hydroxychloroquine in the current pandemic. Currently, there is insufficient evidence about the efficacy and safety of hydroxychloroquine in COVID-19.KEY MESSAGESHCQ, initially an antimalarial agent, is used as an immunomodulatory agent for managing several autoimmune diseases, for which its efficacy is linked to inhibiting lysosomal antigen processing, MHC-II antigen presentation, and TLR functions.HCQ is generally well-tolerated although severe life-threatening adverse effects including cardiomyopathy and conduction defects have been reported.HCQ use in COVID-19 should be discouraged outside clinical trials under strict medical supervision.
    Keywords Hydroxychloroquine ; COVID-19 ; cardiotoxicity ; mechanism of action ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Hydroxychloroquine: a comprehensive review and its controversial role in coronavirus disease 2019.

    Bansal, Pankaj / Goyal, Amandeep / Cusick, Austin / Lahan, Shubham / Dhaliwal, Harpal S / Bhyan, Poonam / Bhattad, Pradnya Brijmohan / Aslam, Fawad / Ranka, Sagar / Dalia, Tarun / Chhabra, Lovely / Sanghavi, Devang / Sonani, Bhavin / Davis, John M

    Annals of medicine

    2020  Volume 53, Issue 1, Page(s) 117–134

    Abstract: Hydroxychloroquine, initially used as an antimalarial, is used as an immunomodulatory and anti-inflammatory agent for the management of autoimmune and rheumatic diseases such as systemic lupus erythematosus. Lately, there has been interest in its ... ...

    Abstract Hydroxychloroquine, initially used as an antimalarial, is used as an immunomodulatory and anti-inflammatory agent for the management of autoimmune and rheumatic diseases such as systemic lupus erythematosus. Lately, there has been interest in its potential efficacy against severe acute respiratory syndrome coronavirus 2, with several speculated mechanisms. The purpose of this review is to elaborate on the mechanisms surrounding hydroxychloroquine. The review is an in-depth analysis of the antimalarial, immunomodulatory, and antiviral mechanisms of hydroxychloroquine, with detailed and novel pictorial explanations. The mechanisms of hydroxychloroquine are related to potential cardiotoxic manifestations and demonstrate potential adverse effects when used for coronavirus disease 2019 (COVID-19). Finally, current literature associated with hydroxychloroquine and COVID-19 has been analyzed to interrelate the mechanisms, adverse effects, and use of hydroxychloroquine in the current pandemic. Currently, there is insufficient evidence about the efficacy and safety of hydroxychloroquine in COVID-19. KEY MESSAGES HCQ, initially an antimalarial agent, is used as an immunomodulatory agent for managing several autoimmune diseases, for which its efficacy is linked to inhibiting lysosomal antigen processing, MHC-II antigen presentation, and TLR functions. HCQ is generally well-tolerated although severe life-threatening adverse effects including cardiomyopathy and conduction defects have been reported. HCQ use in COVID-19 should be discouraged outside clinical trials under strict medical supervision.
    MeSH term(s) Antimalarials/pharmacology ; Antimalarials/therapeutic use ; COVID-19 ; Cardiotoxicity/etiology ; Clinical Trials as Topic ; Coronavirus Infections/drug therapy ; Humans ; Hydroxychloroquine/pharmacology ; Hydroxychloroquine/therapeutic use ; Pandemics ; Pneumonia, Viral/drug therapy ; COVID-19 Drug Treatment
    Chemical Substances Antimalarials ; Hydroxychloroquine (4QWG6N8QKH)
    Keywords covid19
    Language English
    Publishing date 2020-10-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2020.1839959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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