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  1. Article: [Gynecologic Cancer].

    Fujiwara, Keiichi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Volume 51, Issue 2, Page(s) 132–133

    MeSH term(s) Female ; Humans ; Genital Neoplasms, Female/therapy
    Language Japanese
    Publishing date 2024-03-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: [Gynecologic Cancer Revisiting First-Line Chemotherapy for Advanced Ovarian Cancer].

    Fujiwara, Keiichi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2023  Volume 50, Issue 2, Page(s) 151–152

    MeSH term(s) Female ; Humans ; Carcinoma, Ovarian Epithelial/drug therapy ; Genital Neoplasms, Female/drug therapy ; Ovarian Neoplasms/drug therapy ; Antineoplastic Combined Chemotherapy Protocols
    Language Japanese
    Publishing date 2023-02-27
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Gynecologic Oncology Global Clinical Trial Initiatives, since 1997].

    Fujiwara, Keiichi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2023  Volume 50, Issue 1, Page(s) 35–38

    Abstract: International collaboration in clinical trials in the field of gynecologic oncology has a long history. The reason for this is that the number of patients with gynecological cancer is halfway small, making it difficult for a single country to ... ...

    Abstract International collaboration in clinical trials in the field of gynecologic oncology has a long history. The reason for this is that the number of patients with gynecological cancer is halfway small, making it difficult for a single country to expeditiously conduct phase Ⅲ comparative trials to generate evidences. In order to keep up with this trend, we have been participating in trials under a worldwide network, starting with a joint trial with the United States. In this paper, we introduce our experience and the interesting events we have encountered in the course of these trials.
    MeSH term(s) Female ; Humans ; Genital Neoplasms, Female/drug therapy ; United States ; Clinical Trials as Topic
    Language Japanese
    Publishing date 2023-02-09
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Treatment of Cervical Cancer: Past, Current, and Future].

    Fujiwara, Keiichi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2022  Volume 49, Issue 2, Page(s) 143–144

    MeSH term(s) Female ; Forecasting ; Humans ; Papillomavirus Infections ; Uterine Cervical Neoplasms/therapy
    Language Japanese
    Publishing date 2022-03-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: [Gynecologic Cancer 2021].

    Fujiwara, Keiichi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2021  Volume 48, Issue 2, Page(s) 190

    MeSH term(s) Female ; Genital Neoplasms, Female/diagnosis ; Genital Neoplasms, Female/therapy ; Humans
    Language Japanese
    Publishing date 2021-02-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article: [Gynecologic Cancer Chemotherapy for Gynecologic Cancer 2020].

    Fujiwara, Keiichi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2020  Volume 47, Issue 2, Page(s) 232

    MeSH term(s) Female ; Genital Neoplasms, Female ; Humans
    Language Japanese
    Publishing date 2020-05-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Gynecologic Cancer Controversies in Gynecologic Cancer Surgery].

    Fujiwara, Keiichi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2019  Volume 46, Issue 2, Page(s) 228–229

    MeSH term(s) Female ; Genital Neoplasms, Female/surgery ; Gynecologic Surgical Procedures ; Humans
    Language Japanese
    Publishing date 2019-04-29
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Adipose tissue area is a predictive biomarker for the efficacy of pegylated liposomal doxorubicin in platinum-refractory/resistant ovarian cancer.

    Yoshida, Hiroyuki / Fujiwara, Keiichi

    Cancer medicine

    2023  Volume 12, Issue 13, Page(s) 14196–14206

    Abstract: Background: Pegylated liposomal doxorubicin (PLD), an anthracycline agent, is widely used as a treatment option for platinum-refractory/resistant epithelial ovarian cancer (EOC). Although only a subset of patients with platinum-refractory/resistant EOC ... ...

    Abstract Background: Pegylated liposomal doxorubicin (PLD), an anthracycline agent, is widely used as a treatment option for platinum-refractory/resistant epithelial ovarian cancer (EOC). Although only a subset of patients with platinum-refractory/resistant EOC derive benefit from PLD, predictive biomarkers for patients who will respond to the drug have not yet been established. Here, we evaluated the relationship between adipose tissue status and PLD efficacy in patients with platinum-refractory/resistant EOC.
    Methods: Patients with platinum-refractory/resistant EOC who were treated with single-agent PLD were included in this retrospective cohort study. Adipose tissue areas including visceral adipose tissue area (VATA), subcutaneous adipose tissue area (SATA), and visceral to subcutaneous adipose tissue area ratio (VSR) were calculated prior to the initiation of PLD using computed tomography images. The associations of adipose tissue areas with objective response rate (ORR) and patient survival were evaluated.
    Results: Forty-four patients with platinum-refractory/resistant EOC who received single-agent PLD were included. Subjects were categorized into high and low groups according to the median VATA, SATA, and VSR values, and body mass index (BMI). The ORR of PLD was significantly lower in the VSR-high group than in the VSR-low group (p = 0.0089). Patients in the high VSR group showed significantly shorter progression-free survival (PFS) compared with patients in the low VSR group (median, 4.0 vs. 8.5 months; p = 0.020). In the multivariable analysis, high VSR was a significant prognostic factor for shorter PFS (hazard ratio, 2.07; 95% confidence interval, 1.05-4.19; p = 0.035). VATA, SATA, and BMI showed no significant association with ORR and survival of patients who received PLD.
    Conclusions: High VSR is associated with lower ORR and shorter PFS in patients with platinum-refractory/resistant EOC who received single-agent PLD. VSR is a robust predictive biomarker for the efficacy of PLD.
    MeSH term(s) Female ; Humans ; Adipose Tissue ; Antineoplastic Combined Chemotherapy Protocols ; Carcinoma, Ovarian Epithelial/drug therapy ; Doxorubicin/therapeutic use ; Drug Resistance, Neoplasm ; Ovarian Neoplasms/drug therapy ; Platinum/therapeutic use ; Polyethylene Glycols/therapeutic use ; Retrospective Studies
    Chemical Substances Doxorubicin (80168379AG) ; liposomal doxorubicin ; N-hydroxysuccinimide S-acetylthioacetate (76931-93-6) ; Platinum (49DFR088MY) ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.6086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Image of a thawed frozen specimen obtained using a cryoprobe floated with oil droplets in normal saline: An endobronchial lipomatous hamartoma image.

    Takigawa, Yuki / Sato, Ken / Inoue, Tomoyoshi / Takada, Masahiro / Fujiwara, Keiichi

    Respirology case reports

    2024  Volume 12, Issue 3, Page(s) e01318

    Abstract: Hereby, we present a rare case of a resected endobronchial tumour that floated or showed oil droplets in saline. In this study, we report an interesting image related to endobronchial lipomatous hamartoma cryotherapy. ...

    Abstract Hereby, we present a rare case of a resected endobronchial tumour that floated or showed oil droplets in saline. In this study, we report an interesting image related to endobronchial lipomatous hamartoma cryotherapy.
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2750180-2
    ISSN 2051-3380
    ISSN 2051-3380
    DOI 10.1002/rcr2.1318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: [Gynecologic Tumor Chemotherapy for Rare Tumors in Gynecologic Malignancies].

    Fujiwara, Keiichi

    Gan to kagaku ryoho. Cancer & chemotherapy

    2018  Volume 45, Issue 2, Page(s) 232–233

    MeSH term(s) Antineoplastic Agents/therapeutic use ; Female ; Genital Neoplasms, Female/drug therapy ; Humans ; Periodicals as Topic
    Chemical Substances Antineoplastic Agents
    Language Japanese
    Publishing date 2018-02
    Publishing country Japan
    Document type Introductory Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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