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Article ; Online: COVID-19 vaccine as a cause for unilateral lymphadenopathy detected by 18F-FDG PET/CT in a patient affected by melanoma.

Avner, Mordechai / Orevi, Marina / Caplan, Nadia / Popovtzer, Aron / Lotem, Michal / Cohen, Jonathan E

European journal of nuclear medicine and molecular imaging

2021 Volume 48, Issue 8, Page(s) 2659–2660

MeSH term(s)	COVID-19 ; COVID-19 Vaccines ; Fluorodeoxyglucose F18 ; Humans ; Lymphadenopathy/diagnostic imaging ; Melanoma/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Radiopharmaceuticals ; SARS-CoV-2
Chemical Substances	COVID-19 Vaccines ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-03-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-021-05278-3
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Zs.A 1227: Show issues

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Article: R869C mutation in molecular motor

Goldstein, Orly / Gana-Weisz, Mali / Shiner, Tamara / Attar, Reut / Mordechai, Yael / Waldman, Yedael Y / Bar-Shira, Anat / Thaler, Avner / Gurevich, Tanya / Mirelman, Anat / Giladi, Nir / Orr-Urtreger, Avi

Alzheimer's & dementia (Amsterdam, Netherlands)

2021 Volume 13, Issue 1, Page(s) e12143

Abstract: Introduction the: GBA: Methods: Whole-genome sequencing of 95 Ashkenazi-N370S-carriers affected with either DLB (n = 19) or PD (n = 76) was performed, and 564 genes related to dementia and PD analyzed.: Results: We identified enrichment of linked ... ...

Abstract	Introduction the: GBA Methods: Whole-genome sequencing of 95 Ashkenazi-N370S-carriers affected with either DLB (n = 19) or PD (n = 76) was performed, and 564 genes related to dementia and PD analyzed. Results: We identified enrichment of linked alleles in Discussion: Because
Language	English
Publishing date	2021-06-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832898-X
ISSN	2352-8729
ISSN	2352-8729
DOI	10.1002/dad2.12143
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Article ; Online: Lymphocyte counts may predict a good response to mesenchymal stromal cells therapy in graft versus host disease patients.

Hinden, Liad / Avner, Mordechai / Stepensky, Polina / Or, Reuven / Almogi-Hazan, Osnat

PloS one

2019 Volume 14, Issue 6, Page(s) e0217572

Abstract: Steroid-resistant GvHD is one of the most significant causes of mortality following allogeneic Hematopoietic Stem Cell Transplantation (HSCT). Treatment with mesenchymal stromal cells (MSC) seems to be a promising solution, however the results from ... ...

Abstract	Steroid-resistant GvHD is one of the most significant causes of mortality following allogeneic Hematopoietic Stem Cell Transplantation (HSCT). Treatment with mesenchymal stromal cells (MSC) seems to be a promising solution, however the results from clinical studies are still equivocal. Better selection of candidate patients and improving monitoring of patients following MSC administration can increase treatment effectiveness. In order to determine which characteristics can be used to predict a good response and better monitoring of patients, blood samples were taken prior to therapy, one week and one month after therapy, from 26 allogeneic HSCT patients whom contracted GvHD and were treated with MSCs. Samples were examined for differential blood counts, bilirubin levels and cell surface markers. Serum cytokine levels were also measured. We found that the level of lymphocytes, in particular T and NK cells, may predict a good response to therapy. A better response was observed among patients who expressed low levels of IL-6 and IL-22, Th17 related cytokines, prior to therapy. Patients with high levels of bilirubin prior to therapy showed a poorer response. The results of this study may facilitate early prediction of success or failure of the treatment, and subsequently, will improve selection of patients for MSC therapy.
MeSH term(s)	Adolescent ; Adult ; Anemia, Aplastic/immunology ; Anemia, Aplastic/mortality ; Anemia, Aplastic/pathology ; Anemia, Aplastic/therapy ; Antineoplastic Agents/therapeutic use ; Bilirubin ; Biomarkers/blood ; Female ; Graft vs Host Disease/diagnosis ; Graft vs Host Disease/immunology ; Graft vs Host Disease/mortality ; Graft vs Host Disease/pathology ; Hematologic Neoplasms/immunology ; Hematologic Neoplasms/mortality ; Hematologic Neoplasms/pathology ; Hematologic Neoplasms/therapy ; Humans ; Interleukin-6/blood ; Interleukins ; Killer Cells, Natural/immunology ; Killer Cells, Natural/pathology ; Lymphocyte Count ; Male ; Mesenchymal Stem Cell Transplantation ; Middle Aged ; Prognosis ; Severity of Illness Index ; Survival Analysis ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology ; Thalassemia/immunology ; Thalassemia/mortality ; Thalassemia/pathology ; Thalassemia/therapy ; Transplantation, Homologous ; Treatment Outcome ; Interleukin-22
Chemical Substances	Antineoplastic Agents ; Biomarkers ; IL6 protein, human ; Interleukin-6 ; Interleukins ; Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2019-06-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0217572
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Article ; Online: Lymphocyte counts may predict a good response to mesenchymal stromal cells therapy in graft versus host disease patients.

Liad Hinden / Mordechai Avner / Polina Stepensky / Reuven Or / Osnat Almogi-Hazan

PLoS ONE, Vol 14, Iss 6, p e

2019 Volume 0217572

Abstract	Steroid-resistant GvHD is one of the most significant causes of mortality following allogeneic Hematopoietic Stem Cell Transplantation (HSCT). Treatment with mesenchymal stromal cells (MSC) seems to be a promising solution, however the results from clinical studies are still equivocal. Better selection of candidate patients and improving monitoring of patients following MSC administration can increase treatment effectiveness. In order to determine which characteristics can be used to predict a good response and better monitoring of patients, blood samples were taken prior to therapy, one week and one month after therapy, from 26 allogeneic HSCT patients whom contracted GvHD and were treated with MSCs. Samples were examined for differential blood counts, bilirubin levels and cell surface markers. Serum cytokine levels were also measured. We found that the level of lymphocytes, in particular T and NK cells, may predict a good response to therapy. A better response was observed among patients who expressed low levels of IL-6 and IL-22, Th17 related cytokines, prior to therapy. Patients with high levels of bilirubin prior to therapy showed a poorer response. The results of this study may facilitate early prediction of success or failure of the treatment, and subsequently, will improve selection of patients for MSC therapy.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article: PARK16 locus: Differential effects of the non-coding rs823114 on Parkinson's disease risk, RNA expression, and DNA methylation.

Goldstein, Orly / Gana-Weisz, Mali / Casey, Fergal / Meltzer-Fridrich, Hila / Yaacov, Or / Waldman, Yedael Y / Lin, Dongdong / Mordechai, Yael / Zhu, Jing / Cullen, Patrick F / Omer, Nurit / Shiner, Tamara / Thaler, Avner / Bar-Shira, Anat / Mirelman, Anat / John, Sally / Giladi, Nir / Orr-Urtreger, Avi

Journal of genetics and genomics = Yi chuan xue bao

2021 Volume 48, Issue 4, Page(s) 341–345

MeSH term(s)	Amidohydrolases/genetics ; Cation Transport Proteins/genetics ; DNA Methylation/genetics ; Genetic Predisposition to Disease ; Humans ; Monosaccharide Transport Proteins/genetics ; Nuclear Proteins/genetics ; Parkinson Disease/genetics ; Parkinson Disease/pathology ; Phosphoproteins/genetics ; RNA/genetics ; Risk Factors ; rab GTP-Binding Proteins/genetics
Chemical Substances	Cation Transport Proteins ; Monosaccharide Transport Proteins ; NUCKS1 protein, human ; Nuclear Proteins ; Phosphoproteins ; Rab29 protein, human ; SLC41A1 protein, human ; SLC45a3 protein, human ; RNA (63231-63-0) ; Amidohydrolases (EC 3.5.-) ; PM20D1 protein, human (EC 3.5.-) ; rab GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2021-01-29
Publishing country	China
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2374568-X
ISSN	1873-5533 ; 1673-8527
ISSN (online)	1873-5533
ISSN	1673-8527
DOI	10.1016/j.jgg.2020.10.010
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Article ; Online: Surgically induced weight loss results in a rapid and consistent improvement of female pelvic floor symptoms.

Leshem, Avner / Groutz, Asnat / Amir, Hadar / Gordon, David / Shimonov, Mordechai

Scandinavian journal of urology

2018 Volume 52, Issue 3, Page(s) 219–224

Abstract: Objective: The aim of this study was to evaluate the effect over time of bariatric surgery on female pelvic floor symptoms.: Methods: In total, 160 consecutive adult women were requested to complete four anonymous questionnaires [International ... ...

Abstract	Objective: The aim of this study was to evaluate the effect over time of bariatric surgery on female pelvic floor symptoms. Methods: In total, 160 consecutive adult women were requested to complete four anonymous questionnaires [International Consultation on Incontinence Questionnaire (ICIQ), Bristol Female Lower Urinary Tract Symptoms (BFLUTS), Pelvic Floor Distress Inventory (PFDI-20) and Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12)] before bariatric surgery and at 3-6 months and 12-24 months postoperatively. Strict criteria were used to define clinically significant urinary incontinence (UI), pelvic organ prolapse (POP) and colorectal-anal (CRA) symptoms. Statistical analyses were performed using paired, two-sided, Student's t test for continuous data, and Fisher's exact test for categorical data. Results: Altogether, 101 women (67%, mean age 41.6 ± 11.8 years, mean preoperative body mass index 41.6 ± 4.6 kg/m²) completed all questionnaires. In women who had preoperative UI (42.6%), mean ICIQ score decreased from 9.5 ± 4.0 at baseline to 3.0 ± 3.6 (p < .001) and 2.9 ± 3.9 (p < .001) at 3-6 and 12-24 months postoperatively, respectively. In women who had preoperative POP symptoms (17.8%), mean PFDI-20/POP score decreased from 23.8 ± 10.9 at baseline to 12.7 ± 12.9 (p = .010) and 13.7 ± 17.1 (p = .025) at 3-6 and 12-24 months postoperatively. In women who had preoperative CRA symptoms (35.6%), mean PFDI-20/CRA score decreased from 26.0 ± 14.9 at baseline to 15.4 ± 15.1 (p = .001) and 18.8 ± 15.4 (p = .045) at 3-6 and 12-24 months postoperatively. De novo postoperative POP and CRA symptoms were reported by up to 16% of patients. Conclusions: Surgically induced weight loss is associated with significant improvements in UI, POP and CRA symptoms. The maximal clinical effect was achieved within 3-6 months, and remained constant throughout the second postoperative year. Nevertheless, de novo POP and CRA symptoms are expected in up to 16% of patients.
MeSH term(s)	Adolescent ; Adult ; Aged ; Bariatric Surgery ; Body Mass Index ; Female ; Humans ; Middle Aged ; Obesity/complications ; Obesity/surgery ; Pelvic Organ Prolapse/complications ; Postoperative Period ; Prospective Studies ; Severity of Illness Index ; Sexual Dysfunction, Physiological/complications ; Surveys and Questionnaires ; Symptom Assessment ; Urinary Incontinence/complications ; Weight Loss ; Young Adult
Language	English
Publishing date	2018-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2701936-6
ISSN	2168-1813 ; 2168-1805
ISSN (online)	2168-1813
ISSN	2168-1805
DOI	10.1080/21681805.2018.1447600
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Article ; Online: Effects of Bariatric Surgery on Female Pelvic Floor Disorders.

Leshem, Avner / Shimonov, Mordechai / Amir, Hadar / Gordon, David / Groutz, Asnat

Urology

2017 Volume 105, Page(s) 42–47

Abstract: Objective: To assess the effect of weight loss on urinary incontinence (UI), pelvic organ prolapse, colorectal-anal complaints, and sexual dysfunction among obese women undergoing bariatric surgery.: Materials and methods: One hundred sixty ... ...

Abstract	Objective: To assess the effect of weight loss on urinary incontinence (UI), pelvic organ prolapse, colorectal-anal complaints, and sexual dysfunction among obese women undergoing bariatric surgery. Materials and methods: One hundred sixty consecutive women who underwent bariatric surgery were prospectively enrolled. Four validated questionnaires (International Consultation on Incontinence Questionnaire-UI [ICIQ-UI], Bristol Female Lower Urinary Tract Symptoms-SF [BFLUTS-SF], Pelvic Floor Distress Inventory-20 [PFDI-20], and Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire-12 [PISQ-12]) were used to evaluate pelvic floor disorders and sexual dysfunction before and 3-6 months after surgery. Results: One hundred fifty participants (mean age: 43 ± 12.8 years; mean preoperative body mass index: 42 ± 4.6 kg/m Conclusion: Surgically induced weight loss was associated with a significant improvement in pelvic floor disorders, including UI, pelvic organ prolapse, and colorectal-anal symptoms, as well as improved sexual performance.
MeSH term(s)	Adolescent ; Adult ; Aged ; Bariatric Surgery ; Fecal Incontinence/etiology ; Fecal Incontinence/prevention & control ; Female ; Flatulence/etiology ; Flatulence/prevention & control ; Humans ; Middle Aged ; Obesity/complications ; Obesity/surgery ; Pelvic Floor Disorders/complications ; Pelvic Floor Disorders/prevention & control ; Prospective Studies ; Quality of Life ; Sexual Behavior ; Sexual Dysfunction, Physiological/etiology ; Sexual Dysfunction, Physiological/prevention & control ; Surveys and Questionnaires ; Urinary Incontinence/etiology ; Urinary Incontinence/prevention & control ; Weight Loss ; Young Adult
Language	English
Publishing date	2017-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2017.03.003
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Article ; Online: Sparsity-based super-resolved coherent diffraction imaging of one-dimensional objects.

Sidorenko, Pavel / Kfir, Ofer / Shechtman, Yoav / Fleischer, Avner / Eldar, Yonina C / Segev, Mordechai / Cohen, Oren

Nature communications

2015 Volume 6, Page(s) 8209

Abstract: Phase-retrieval problems of one-dimensional (1D) signals are known to suffer from ambiguity that hampers their recovery from measurements of their Fourier magnitude, even when their support (a region that confines the signal) is known. Here we ... ...

Abstract	Phase-retrieval problems of one-dimensional (1D) signals are known to suffer from ambiguity that hampers their recovery from measurements of their Fourier magnitude, even when their support (a region that confines the signal) is known. Here we demonstrate sparsity-based coherent diffraction imaging of 1D objects using extreme-ultraviolet radiation produced from high harmonic generation. Using sparsity as prior information removes the ambiguity in many cases and enhances the resolution beyond the physical limit of the microscope. Our approach may be used in a variety of problems, such as diagnostics of defects in microelectronic chips. Importantly, this is the first demonstration of sparsity-based 1D phase retrieval from actual experiments, hence it paves the way for greatly improving the performance of Fourier-based measurement systems where 1D signals are inherent, such as diagnostics of ultrashort laser pulses, deciphering the complex time-dependent response functions (for example, time-dependent permittivity and permeability) from spectral measurements and vice versa.
Language	English
Publishing date	2015-09-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2041-1723
ISSN (online)	2041-1723
DOI	10.1038/ncomms9209
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Article: [Reform in mental health services--from whence and to where].

Haver, Eitan / Shani, Mordechai / Kotler, Moshe / Fast, Dov / Elizur, Avner / Baruch, Yehuda

Harefuah

2005 Volume 144, Issue 5, Page(s) 327–31, 383, 382

Abstract: For years the subject of mental health has been neglected in Israel, and reform of mental health services is now of paramount importance. Psychiatric medicine has altered considerably over the years, and emphasis is shifting from treatment in mental ... ...

Abstract	For years the subject of mental health has been neglected in Israel, and reform of mental health services is now of paramount importance. Psychiatric medicine has altered considerably over the years, and emphasis is shifting from treatment in mental health institutions to treatment at the community level. This transition is the result of the awakening of groups in our society advocating civil rights for the mentally ill and their integration into the community. This process is also bolstered by the advent of new anti-psychotic drugs. However, the social and medical infrastructure set up to deal with these issues has been found lacking. Over the past few years the Minister of Health has appointed a number of committees to address this issue, and they have all recommended extensive reform of mental health services in Israel. The recommendations handed down by the committees are for: (1) Restructure of mental health services, with emphasis on community services and gradual reduction of psychiatric beds; (2) Allocation of additional funding specifically ear-marked for the mentally challenged, enabling transfer of stabilized patients out of the hospital setting and often lengthy and unnecessary hospitalization, into community rehabilitation centers; (3) Transfer of responsibility for health insurance for mentally ill people from the State to the Health Funds, enabling integration of psychiatric treatment into the general treatment framework. The reform has already been initiated. This body of work will review the stages, processes and the difficulties that preceded the reform.
MeSH term(s)	Community Mental Health Services ; Health Care Reform/trends ; Humans ; Israel ; Mental Health Services/standards ; Mental Health Services/trends ; Outpatients
Language	Hebrew
Publishing date	2005-05
Publishing country	Israel
Document type	Editorial ; English Abstract
ZDB-ID	953872-0
ISSN	0017-7768
ISSN	0017-7768
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