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Article ; Online: Correction to "Radicals as Exceptional Electron-Withdrawing Groups: Nucleophilic Aromatic Substitution of Halophenols Via Homolysis-Enabled Electronic Activation".

Shin, Nick Y / Tsui, Elaine / Reinhold, Adam / Scholes, Gregory D / Bird, Matthew J / Knowles, Robert R

Journal of the American Chemical Society

2024 Volume 146, Issue 3, Page(s) 2286–2287

Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Published Erratum
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c13005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Pluronic F127 "nanoarmor" for stabilization of Cowpea mosaic virus immunotherapy.

Shin, Matthew D / Jung, Eunkyeong / Moreno-Gonzalez, Miguel A / Ortega-Rivera, Oscar A / Steinmetz, Nicole F

Bioengineering & translational medicine

2023 Volume 9, Issue 1, Page(s) e10574

Abstract: Our lab demonstrated that intratumoral Cowpea mosaic virus (CPMV) is a potent antitumor immunotherapy when used as in situ vaccine. As we pave the way for human clinical translation, formulation chemistry needs to be optimized for long-term storage of ... ...

Abstract	Our lab demonstrated that intratumoral Cowpea mosaic virus (CPMV) is a potent antitumor immunotherapy when used as in situ vaccine. As we pave the way for human clinical translation, formulation chemistry needs to be optimized for long-term storage of the drug candidate. In this work, CPMV was nanoengineered with Pluronic F127 to realize liquid and gel formulations which mitigate structural changes and RNA release during long-term storage. We evaluated the CPMV-F127 formulations for their stability and biological activity through a combination of in vitro assays and efficacy in vivo using a B16F10 murine melanoma model. Results demonstrate that both F127 liquid and gel formulations preserve CPMV structure and function following extended periods of thermal incubation at 4°C, 25°C, and 37°C. Heat-incubated CPMV without formulation resulted in structural changes and inferior in vivo efficacy. In stark contrast, in vivo efficacy was preserved when CPMV was formulated and protected with the F127 "nanoarmor."
Language	English
Publishing date	2023-07-14
Publishing country	United States
Document type	Journal Article
ISSN	2380-6761
ISSN	2380-6761
DOI	10.1002/btm2.10574
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Multivalent Display of ApoAI Peptides on the Surface of Tobacco Mosaic Virus Nanotubes Improves Cholesterol Efflux.

Shin, Matthew D / Ortega-Rivera, Oscar A / Steinmetz, Nicole F

Bioconjugate chemistry

2022 Volume 33, Issue 10, Page(s) 1922–1933

Abstract: Atherosclerosis is a progressive cardiovascular disease in which cholesterol-rich plaques build up within arteries, increasing the risk of thrombosis, myocardial infarction, and stroke. One promising therapeutic approach is the use of high-density ... ...

Abstract	Atherosclerosis is a progressive cardiovascular disease in which cholesterol-rich plaques build up within arteries, increasing the risk of thrombosis, myocardial infarction, and stroke. One promising therapeutic approach is the use of high-density lipoprotein (HDL) biomimetic formulations based on ApoAI peptides that promote cholesterol efflux from plaques, ultimately leading to cholesterol excretion. Here, we describe the multivalent display of ApoAI peptides on the surface of protein nanotubes derived from the plant virus tobacco mosaic virus (TMV) and protein nanoparticles using virus-like particles from bacteriophage Qβ. Bioconjugation yielded ApoAI conjugates varying in size and morphology. We tested ABCA1-mediated cholesterol efflux using macrophage foam cells, the mitigation of reactive oxygen species in endothelial cells, and wound healing in endothelial cells. We found that the multivalent ApoAI platform, in particular the TMV-based nanotube, significantly improved the efficacy of cholesterol efflux compared to free peptides, Qβ nanoparticle formulations, and traditional HDL therapy. Finally, to better understand the mechanistic basis of enhanced cholesterol efflux, we used confocal microscopy to show that while native TMV was taken up by cells, TMV-ApoAI remained at the exterior of foam cell membranes and efflux was documented using fluorescent cholesterol. Together, these data highlight that high aspect ratio materials with multivalent display of ApoAI peptides offer unique capabilities promoting efficient cholesterol efflux and may find applications in cardiovascular therapy.
MeSH term(s)	Humans ; Tobacco Mosaic Virus/metabolism ; Endothelial Cells/metabolism ; Reactive Oxygen Species ; Lipoproteins, HDL/metabolism ; Cholesterol/metabolism ; Atherosclerosis ; Plaque, Atherosclerotic ; Peptides/pharmacology ; Nanotubes
Chemical Substances	Reactive Oxygen Species ; Lipoproteins, HDL ; Cholesterol (97C5T2UQ7J) ; Peptides
Language	English
Publishing date	2022-10-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1024041-x
ISSN	1520-4812 ; 1043-1802
ISSN (online)	1520-4812
ISSN	1043-1802
DOI	10.1021/acs.bioconjchem.2c00371
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Article ; Online: Bioconjugation of Active Ingredients to Plant Viral Nanoparticles Is Enhanced by Preincubation with a Pluronic F127 Polymer Scaffold.

Shin, Matthew D / Hochberg, Justin D / Pokorski, Jonathan K / Steinmetz, Nicole F

ACS applied materials & interfaces

2021 Volume 13, Issue 50, Page(s) 59618–59632

Abstract: Proteinaceous nanoparticles can be used to deliver large payloads of active ingredients, which is advantageous in medicine and agriculture. However, the conjugation of hydrophobic ligands to hydrophilic nanocarriers such as plant viral nanoparticles ( ... ...

Abstract	Proteinaceous nanoparticles can be used to deliver large payloads of active ingredients, which is advantageous in medicine and agriculture. However, the conjugation of hydrophobic ligands to hydrophilic nanocarriers such as plant viral nanoparticles (plant VNPs) can result in aggregation by reducing overall solubility. Given the benefits of hydrophilic nanocarrier platforms for targeted delivery and multivalent ligand display, coupled with the versatility of hydrophobic drugs, contrast agents, and peptides, this is an issue that must be addressed to realize their full potential. Here, we report two preincubation strategies that use a Pluronic F127 polymer scaffold to prevent the aggregation of conjugated plant VNPs: a plant VNP-polymer precoat (COAT) and an active ingredient formulation combined with a plant VNP-polymer precoat (FORMCOAT). The broad applications of these modified conjugation strategies were highlighted by testing their compatibility with three types of bioconjugation chemistry:
MeSH term(s)	Biocompatible Materials/chemistry ; Hydrophobic and Hydrophilic Interactions ; Ligands ; Materials Testing ; Molecular Structure ; Nanoparticles/chemistry ; Particle Size ; Poloxamer/chemistry
Chemical Substances	Biocompatible Materials ; Ligands ; Poloxamer (106392-12-5)
Language	English
Publishing date	2021-12-10
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c13183
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Authors' Reply to Letters to the Editors for "Integration of Pharmacy Students Into Family Medicine Residency Clinics".

Kostoff, Matthew D / Shin, Tiffany R

Family medicine

2017 Volume 49, Issue 5, Page(s) 403–404

Language	English
Publishing date	2017
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	639374-3
ISSN	1938-3800 ; 0742-3225
ISSN (online)	1938-3800
ISSN	0742-3225
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Radicals as Exceptional Electron-Withdrawing Groups: Nucleophilic Aromatic Substitution of Halophenols Via Homolysis-Enabled Electronic Activation.

Shin, Nick Y / Tsui, Elaine / Reinhold, Adam / Scholes, Gregory D / Bird, Matthew J / Knowles, Robert R

Journal of the American Chemical Society

2022 Volume 144, Issue 47, Page(s) 21783–21790

Abstract: While heteroatom-centered radicals are understood to be highly electrophilic, their ability to serve as transient electron-withdrawing groups and facilitate polar reactions at distal sites has not been extensively developed. Here, we report a new ... ...

Abstract	While heteroatom-centered radicals are understood to be highly electrophilic, their ability to serve as transient electron-withdrawing groups and facilitate polar reactions at distal sites has not been extensively developed. Here, we report a new strategy for the electronic activation of halophenols, wherein generation of a phenoxyl radical via formal homolysis of the aryl O-H bond enables direct nucleophilic aromatic substitution of the halide with carboxylate nucleophiles under mild conditions. Pulse radiolysis and transient absorption studies reveal that the neutral oxygen radical (O
MeSH term(s)	Electrons ; Electronics ; Carboxylic Acids ; Phenol ; Reactive Oxygen Species
Chemical Substances	Carboxylic Acids ; Phenol (339NCG44TV) ; Reactive Oxygen Species
Language	English
Publishing date	2022-11-17
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.2c10296
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Article ; Online: Contributions of Atrioventricular Delay Shortening and Ventricular Resynchronization to Hemodynamic Benefits of Biventricular Pacing.

Arnold, Ahran D / Shun-Shin, Matthew J / Ali, Nadine / Keene, Daniel / Howard, James P / Francis, Darrel P / Whinnett, Zachary I

JACC. Clinical electrophysiology

2022 Volume 9, Issue 1, Page(s) 117–119

MeSH term(s)	Humans ; Cardiac Resynchronization Therapy ; Hemodynamics ; Ventricular Function, Left
Language	English
Publishing date	2022-09-28
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2846739-5
ISSN	2405-5018 ; 2405-500X ; 2405-500X
ISSN (online)	2405-5018 ; 2405-500X
ISSN	2405-500X
DOI	10.1016/j.jacep.2022.07.024
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Article ; Online: Automated multi-beat tissue Doppler echocardiography analysis using deep neural networks.

Lane, Elisabeth S / Jevsikov, Jevgeni / Shun-Shin, Matthew J / Dhutia, Niti / Matoorian, Nasser / Cole, Graham D / Francis, Darrel P / Zolgharni, Massoud

Medical & biological engineering & computing

2023 Volume 61, Issue 5, Page(s) 911–926

Abstract: Tissue Doppler imaging is an essential echocardiographic technique for the non-invasive assessment of myocardial blood velocity. Image acquisition and interpretation are performed by trained operators who visually localise landmarks representing Doppler ... ...

Abstract	Tissue Doppler imaging is an essential echocardiographic technique for the non-invasive assessment of myocardial blood velocity. Image acquisition and interpretation are performed by trained operators who visually localise landmarks representing Doppler peak velocities. Current clinical guidelines recommend averaging measurements over several heartbeats. However, this manual process is both time-consuming and disruptive to workflow. An automated system for accurate beat isolation and landmark identification would be highly desirable. A dataset of tissue Doppler images was annotated by three cardiologist experts, providing a gold standard and allowing for observer variability comparisons. Deep neural networks were trained for fully automated predictions on multiple heartbeats and tested on tissue Doppler strips of arbitrary length. Automated measurements of peak Doppler velocities show good Bland-Altman agreement (average standard deviation of 0.40 cm/s) with consensus expert values; less than the inter-observer variability (0.65 cm/s). Performance is akin to individual experts (standard deviation of 0.40 to 0.75 cm/s). Our approach allows for > 26 times as many heartbeats to be analysed, compared to a manual approach. The proposed automated models can accurately and reliably make measurements on tissue Doppler images spanning several heartbeats, with performance indistinguishable from that of human experts, but with significantly shorter processing time. HIGHLIGHTS: • Novel approach successfully identifies heartbeats from Tissue Doppler Images • Accurately measures peak velocities on several heartbeats • Framework is fast and can make predictions on arbitrary length images • Patient dataset and models made public for future benchmark studies.
MeSH term(s)	Humans ; Algorithms ; Echocardiography, Doppler/methods ; Neural Networks, Computer ; Echocardiography ; Myocardium
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	282327-5
ISSN	1741-0444 ; 0025-696X ; 0140-0118
ISSN (online)	1741-0444
ISSN	0025-696X ; 0140-0118
DOI	10.1007/s11517-022-02753-3
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Article ; Online: Evacuation of Hematomas Using the Inari Triever Aspiration Catheter (FlowTriever).

Chick, Jeffrey Forris Beecham / Abad-Santos, Matthew / Castle, Jordan C / Monroe, Eric J / Quezada, Maria D / Shin, David S

Cardiovascular and interventional radiology

2022 Volume 45, Issue 6, Page(s) 895–897

MeSH term(s)	Catheters ; Hematoma/diagnostic imaging ; Hematoma/therapy ; Humans ; Thrombectomy ; Treatment Outcome
Language	English
Publishing date	2022-03-11
Publishing country	United States
Document type	Letter
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-022-03110-5
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Article: Bioconjugation of Active Ingredients to Plant Viral Nanoparticles Is Enhanced by Preincubation with a Pluronic F127 Polymer Scaffold

Shin, Matthew D. / Hochberg, Justin D. / Pokorski, Jonathan K. / Steinmetz, Nicole F.

ACS applied materials & interfaces. 2021 Dec. 10, v. 13, no. 50

2021

Abstract	Proteinaceous nanoparticles can be used to deliver large payloads of active ingredients, which is advantageous in medicine and agriculture. However, the conjugation of hydrophobic ligands to hydrophilic nanocarriers such as plant viral nanoparticles (plant VNPs) can result in aggregation by reducing overall solubility. Given the benefits of hydrophilic nanocarrier platforms for targeted delivery and multivalent ligand display, coupled with the versatility of hydrophobic drugs, contrast agents, and peptides, this is an issue that must be addressed to realize their full potential. Here, we report two preincubation strategies that use a Pluronic F127 polymer scaffold to prevent the aggregation of conjugated plant VNPs: a plant VNP–polymer precoat (COAT) and an active ingredient formulation combined with a plant VNP–polymer precoat (FORMCOAT). The broad applications of these modified conjugation strategies were highlighted by testing their compatibility with three types of bioconjugation chemistry: N-hydroxysuccinimide ester–amine coupling, maleimide–thiol coupling, and copper(I)-catalyzed azide–alkyne cycloaddition (click chemistry). The COAT and FORMCOAT strategies promoted efficient bioconjugation and prevented the aggregation that accompanies conventional bioconjugation methods, thus improving the stability, homogeneity, and translational potential of plant VNP conjugates in medicine and agriculture.
Keywords	active ingredients ; chemical bonding ; copper ; cycloaddition reactions ; hydrophilicity ; hydrophobicity ; ligands ; medicine ; nanocarriers ; peptides ; polymers ; solubility
Language	English
Dates of publication	2021-1210
Size	p. 59618-59632.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.1c13183
Database	NAL-Catalogue (AGRICOLA)

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