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  1. Article ; Online: Role of the Sodium-Dependent Organic Anion Transporter (SOAT/SLC10A6) in Physiology and Pathophysiology.

    Wannowius, Marie / Karakus, Emre / Aktürk, Zekeriya / Breuer, Janina / Geyer, Joachim

    International journal of molecular sciences

    2023  Volume 24, Issue 12

    Abstract: The sodium-dependent organic anion transporter (SOAT, gene ... ...

    Abstract The sodium-dependent organic anion transporter (SOAT, gene symbol
    MeSH term(s) Organic Anion Transporters/genetics ; Organic Anion Transporters/metabolism ; Biological Transport ; Sodium/metabolism
    Chemical Substances Organic Anion Transporters ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24129926
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Conference proceedings: Der Einfluss von Gesetzesdekreten auf die akademische Leistung türkischer Physiologen

    Gumustekin, Kenan / Aktürk, Zekeriya

    2021  , Page(s) V–25–06

    Event/congress 55. Kongress für Allgemeinmedizin und Familienmedizin; Lübeck; Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin; 2021
    Keywords Medizin, Gesundheit
    Publishing date 2021-09-17
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21degam141
    Database German Medical Science

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  3. Conference proceedings: The aftereffects of mass dismissals and detentions of academics at Turkish universities

    Hosoglu, Salih / Aktürk, Zekeriya

    2021  , Page(s) V–25–05

    Event/congress 55. Kongress für Allgemeinmedizin und Familienmedizin; Lübeck; Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin; 2021
    Keywords Medizin, Gesundheit
    Publishing date 2021-09-17
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21degam140
    Database German Medical Science

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  4. Article ; Online: Role of the Sodium-Dependent Organic Anion Transporter (SOAT/SLC10A6) in Physiology and Pathophysiology

    Marie Wannowius / Emre Karakus / Zekeriya Aktürk / Janina Breuer / Joachim Geyer

    International Journal of Molecular Sciences, Vol 24, Iss 9926, p

    2023  Volume 9926

    Abstract: The sodium-dependent organic anion transporter (SOAT, gene symbol SLC10A6 ) specifically transports 3′- and 17′-monosulfated steroid hormones, such as estrone sulfate and dehydroepiandrosterone sulfate, into specific target cells. These biologically ... ...

    Abstract The sodium-dependent organic anion transporter (SOAT, gene symbol SLC10A6 ) specifically transports 3′- and 17′-monosulfated steroid hormones, such as estrone sulfate and dehydroepiandrosterone sulfate, into specific target cells. These biologically inactive sulfo-conjugated steroids occur in high concentrations in the blood circulation and serve as precursors for the intracrine formation of active estrogens and androgens that contribute to the overall regulation of steroids in many peripheral tissues. Although SOAT expression has been detected in several hormone-responsive peripheral tissues, its quantitative contribution to steroid sulfate uptake in different organs is still not completely clear. Given this fact, the present review provides a comprehensive overview of the current knowledge about the SOAT by summarizing all experimental findings obtained since its first cloning in 2004 and by processing SOAT/ SLC10A6 -related data from genome-wide protein and mRNA expression databases. In conclusion, despite a significantly increased understanding of the function and physiological significance of the SOAT over the past 20 years, further studies are needed to finally establish it as a potential drug target for endocrine-based therapy of steroid-responsive diseases such as hormone-dependent breast cancer.
    Keywords SOAT ; SLC10A6 ; sulfated steroids ; transport ; breast cancer ; inhibitor ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: EQUIP: recent quality-related developments in the Turkish health sector.

    Aktürk, Zekeriya

    The European journal of general practice

    2011  Volume 17, Issue 2, Page(s) 133–134

    MeSH term(s) Family Practice/education ; Family Practice/standards ; Health Care Reform ; Humans ; Internship and Residency/organization & administration ; Quality Assurance, Health Care ; Quality of Health Care ; Turkey
    Language English
    Publishing date 2011-06
    Publishing country England
    Document type News
    ZDB-ID 1281338-2
    ISSN 1751-1402 ; 1381-4788
    ISSN (online) 1751-1402
    ISSN 1381-4788
    DOI 10.3109/13814788.2010.550612
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4343: Show issues Location:
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  6. Article ; Online: COVID-19 vaccine hesitancy in people with migratory backgrounds: a cross-sectional study among Turkish- and German-speaking citizens in Munich.

    Aktürk, Zekeriya / Linde, Klaus / Hapfelmeier, Alexander / Kunisch, Raphael / Schneider, Antonius

    BMC infectious diseases

    2021  Volume 21, Issue 1, Page(s) 1214

    Abstract: Background: This study aimed to investigate the knowledge, attitudes, behaviors, and COVID-19 vaccine hesitancy of people with migratory backgrounds among Turkish- and German-speaking patients in Munich.: Methods: Primary outcomes were the intention ... ...

    Abstract Background: This study aimed to investigate the knowledge, attitudes, behaviors, and COVID-19 vaccine hesitancy of people with migratory backgrounds among Turkish- and German-speaking patients in Munich.
    Methods: Primary outcomes were the intention to get vaccinated for COVID-19 and COVID-19 knowledge levels (25 true/false items). Other variables included demographics, attitudes to COVID-19 and vaccination (7 items), and behaviors regarding COVID-19 (7 items). The attitude and behavior questions had 5-point Likert scales. Of the 10 Turkish-speaking family physicians in Munich, six agreed to administer Turkish or German questionnaires to consecutive patients in February 2021. Furthermore, participants with either citizenship, country of origin, native language, or place of birth being non-German were categorized as "Having a migratory background." Data from 420 respondents were analyzed.
    Results: Women constituted 41.4% (n = 174), the mean age was 42.2 ± 15.5 years, 245 (58.3%) preferred the Turkish questionnaire, 348 (82.9%) had a migratory background, and 197 (47.9%) intended to be vaccinated. The mean knowledge, attitude, and behavioral scores were 21.5 ± 3.2 (max = 25), 3.7 ± 0.8 (max = 5), and 4.0 ± 0.5 (max = 5). While 42.3% (n = 145) of the participants with a migratory background considered getting vaccinated, this proportion was 76.5% (n = 52) for non-immigrant Germans (Chi-square = 26.818, p < 0.001). Non-migratory background (odds ratio (OR): 3.082), high attitude scores (OR: 2.877), male sex (OR: 2.185), years of schooling (OR: 1.064), and age (OR: 1.022) were positively associated with vaccination intention.
    Conclusions: We suggest initiating or supporting projects run by persons or groups with immigrant backgrounds to attempt to elaborate and change their vaccination attitudes.
    MeSH term(s) Adult ; COVID-19 ; COVID-19 Vaccines ; Citizenship ; Cross-Sectional Studies ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Language ; Male ; Middle Aged ; SARS-CoV-2 ; Vaccination Hesitancy
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-12-06
    Publishing country England
    Document type Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-021-06940-9
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  7. Article ; Online: Antibiotic prescription in primary care from the perspective of family physicians: a qualitative study.

    Hosoglu, Salih / Classen, Annika Yanina / Akturk, Zekeriya

    Journal of infection in developing countries

    2021  Volume 15, Issue 8, Page(s) 1117–1123

    Abstract: Introduction: Antibiotic consumption increases worldwide steadily. Turkey is now top on the list of global consumption and became a prototype of excessive use of antibiotics. In the last two decades, family physicians (FPs) have become key figures in ... ...

    Abstract Introduction: Antibiotic consumption increases worldwide steadily. Turkey is now top on the list of global consumption and became a prototype of excessive use of antibiotics. In the last two decades, family physicians (FPs) have become key figures in the healthcare system. This study aims to understand the reasons for inappropriate antibiotic prescribing and elicit suggestions for improving antibiotic use in primary care from doctors themselves.
    Methodology: This is a qualitative semi-structured interview study with research dialogues guided by the Vancouver School of interpretive phenomenology. Fourteen FPs from different parts of Turkey were questioned on inappropriate antibiotic prescriptions and their suggestions for improving antibiotic use.
    Results: The most important reasons for prescribing antibiotics without acceptable indications were patient expectations, defensive medical decision making, constraints due to workload, and limited access to laboratories. The most remarkable inference was the personal feeling of an insecure job environment of the FPs. The most potent suggestions for improving the quality of antibiotic prescription were public campaigns, improvements in the diagnostic infrastructures of primary care centers, and enhancing the social status of FPs. The FPs expressed strong concerns related to the complaints that patients make to administrative bodies.
    Conclusions: Primary care physicians work under immense pressure, stemming mainly from workload, patient expectations, and obstacles related to diagnostic processes. Improving the social status of physicians, increasing public awareness, and the facilitation of diagnostic procedures was the methods suggested for increasing antibiotic prescription accuracy.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Attitude of Health Personnel ; Humans ; Inappropriate Prescribing/prevention & control ; Inappropriate Prescribing/psychology ; Physician-Patient Relations ; Physicians, Family ; Practice Patterns, Physicians' ; Primary Health Care/methods ; Qualitative Research ; Turkey
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-08-31
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.13924
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Conference proceedings: Systematische Reviews mit Meta-Analyse von diagnostischen Studien verstehen und durchführen – Hands-on-Workshop

    Linde, Klaus / Aktürk, Zekeriya / Fomenko, Alexey / Eck, Stefanie / Teusen, Clara / von Schrottenberg, Victoria / Schneider, Antonius / Hapfelmeier, Alexander

    2023  , Page(s) WS–36–01

    Event/congress 57. Kongress für Allgemeinmedizin und Familienmedizin; Berlin; Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin; 2023
    Keywords Medizin, Gesundheit
    Publishing date 2023-09-27
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/23degam320
    Database German Medical Science

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  9. Conference proceedings: COVID-19 vaccine hesitancy in people with migratory backgrounds: a cross-sectional study among Turkish- and German-speaking citizens in Munich

    Aktürk, Zekeriya / Linde, Klaus / Hapfelmeier, Alexander / Kunisch, Raphael / Schneider, Antonius

    2021  , Page(s) V–15–01

    Event/congress 55. Kongress für Allgemeinmedizin und Familienmedizin; Lübeck; Deutsche Gesellschaft für Allgemeinmedizin und Familienmedizin; 2021
    Keywords Medizin, Gesundheit
    Publishing date 2021-09-17
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21degam082
    Database German Medical Science

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  10. Article ; Online: Urinary cortisol metabolites are reduced in MDR1 mutant dogs in a pilot targeted GC-MS urinary steroid hormone metabolome analysis.

    Gramer, Irina / Karakus, Emre / Hartmann, Michaela F / Wudy, Stefan A / Bauer, Natali / Moritz, Andreas / Aktürk, Zekeriya / Geyer, Joachim

    Journal of veterinary pharmacology and therapeutics

    2022  Volume 45, Issue 3, Page(s) 265–272

    Abstract: P-glycoprotein (P-gp) is the gene product of the multidrug resistance gene (MDR1, syn. ABCB1) that normally restricts the transfer of cortisol across the blood-brain barrier. In the absence of P-gp, cortisol access to the hypothalamus is increased and, ... ...

    Abstract P-glycoprotein (P-gp) is the gene product of the multidrug resistance gene (MDR1, syn. ABCB1) that normally restricts the transfer of cortisol across the blood-brain barrier. In the absence of P-gp, cortisol access to the hypothalamus is increased and, by feedback inhibition, this finally leads to lower endogenous plasma cortisol levels in dogs with homozygous nt230(del4) MDR1 mutation (MDR1
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics ; Animals ; Dogs ; Gas Chromatography-Mass Spectrometry/veterinary ; Hydrocortisone ; Hypothalamo-Hypophyseal System ; Metabolome ; Pituitary-Adrenal System ; Steroids
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Steroids ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2022-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 435216-6
    ISSN 1365-2885 ; 0140-7783
    ISSN (online) 1365-2885
    ISSN 0140-7783
    DOI 10.1111/jvp.13050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2226: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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