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  1. Article: Rhizopus stolonifer

    Liu, Qianqian / Chen, Qingmin / Liu, Hu / Du, Yamin / Jiao, Wenxiao / Sun, Fei / Fu, Maorun

    Heliyon

    2024  Volume 10, Issue 8, Page(s) e29522

    Abstract: ... Rhizopus ... ...

    Abstract Rhizopus stolonifer
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e29522
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  2. Article: Potential antidepressant effects of Traditional Chinese botanical drug formula Chaihu-Shugan-San and its active ingredients.

    Guo, Ziyi / Long, Tianjian / Yao, Jianping / Li, Yamin / Xiao, Lu / Chen, Min

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1337876

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-04-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1337876
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  3. Article ; Online: Therapeutic progress in relapsed/refractory multiple myeloma.

    Chen, Qi / Zhang, Min / Zheng, Shan / Tong, Yuxin / Tan, Yamin

    Annals of hematology

    2024  

    Abstract: Improvement in the therapeutics for multiple myeloma (MM) has been continuously developed owing to the application of novel drugs and technologies in the last 20 years. The standard first-line therapy for MM consists of a three-drug induction regimen ... ...

    Abstract Improvement in the therapeutics for multiple myeloma (MM) has been continuously developed owing to the application of novel drugs and technologies in the last 20 years. The standard first-line therapy for MM consists of a three-drug induction regimen based on immunomodulatory drugs and proteasome inhibitors combined with autologous stem cell transplantation. However, MM remains incurable; therefore, therapies for relapsed/refractory MM (RRMM) are emerging and evolving rapidly. This study aimed to summarize and review the results of RRMM trials over the past 5 years to provide a holistic overview and insights for practitioners in related fields and to provide additional ideas for clinical trialists. This study shows that daratumumab and isatuximab continue to significantly advance as treatment options. Additionally, novel antibody drugs, such as elotuzumab and selinexor, as well as bispecific antibodies, teclistamab and talquetamab, are currently undergoing clinical research with promising outcomes. However, chimeric antigen receptor-T cell therapy targeting B-cell maturation antigen remains the optimal approach for MM treatment.
    Language English
    Publishing date 2024-04-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-024-05730-y
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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Author Correction: Developing a prognosis and chemotherapy evaluating model for colon adenocarcinoma based on mitotic catastrophe-related genes.

    Liu, Yinglei / Zhao, Yamin / Zhang, Siming / Rong, Shen / He, Songnian / Hua, Liqi / Wang, Xingdan / Chen, Hongjian

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 4770

    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-54131-8
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  5. Article: PDX1 Methylation, NGN3 and Pax6 Expression Levels in Pregnant Women with Gestational Diabetes Mellitus and their association with neonatal blood sugars and birth weight.

    Su, Yuanyuan / Li, Jingjing / Chen, Limin / Lian, Hongnan / Qie, Yamin

    Pakistan journal of medical sciences

    2024  Volume 40, Issue 3Part-II, Page(s) 509–513

    Abstract: Objective: To investigate the correlation of maternal PDX1 methylation, NGN3 and Pax6 expression levels with neonatal blood sugars and birth weight in pregnant women with GDM and non GDM.: Methods: This was a prospective cohort study. Total 80 ... ...

    Abstract Objective: To investigate the correlation of maternal PDX1 methylation, NGN3 and Pax6 expression levels with neonatal blood sugars and birth weight in pregnant women with GDM and non GDM.
    Methods: This was a prospective cohort study. Total 80 pregnant women who were examined and delivered in the Department of Obstetrics of Affiliated Hospital of Hebei University from January 2019 to June 2022 were recruited and divided into two groups according to the results of oral glucose tolerance test (OGTT): the control group and the observation group, with 40 cases in each group. PDXl methylation rate was measured by the methylation-specific PCR method, whereas gene expression levels of PDX1, NGN3 and Pax6 were measured by RT-PCR meanwhile, neonatal blood glucose and hemoglobin A1c (HbA1c) levels were also measured.
    Results: In comparison with the control group, the observation group had higher levels of FBG, 2-hour postprandial blood glucose (2hPBG) and HbA1c (P<0.05). Neonatal birth weight and insulin levels in the observation group were significantly higher than those in the control group, while Apgar scores and blood glucose were lower than those in the control group(P<0.05). Moreover, the observation group had significantly lower gene expression levels of PDX1, NGN3 and Pax6, and a higher PDX1 methylation rate than the control group (P<0.05). Correlation analysis revealed a negative correlation between neonatal blood glucose levels and PDX1, NGN3 and Pax6 levels in the observation group, with statistical significance (P<0.05).
    Conclusion: Changes in maternal PDX1 methylation, NGN3 and Pax6 expression levels may lead to abnormal glucose metabolism in neonates, which has a close bearing on neonatal hypoglycemia and blood glucose levels caused by GDM.
    Language English
    Publishing date 2024-01-29
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2032827-8
    ISSN 1681-715X ; 1682-024X ; 1017-4699
    ISSN (online) 1681-715X
    ISSN 1682-024X ; 1017-4699
    DOI 10.12669/pjms.40.3.7700
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3948: Show issues Location:
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  6. Article ; Online: A dynamic approach to support outbreak management using reinforcement learning and semi-connected SEIQR models.

    Kao, Yamin / Chu, Po-Jui / Chou, Pai-Chien / Chen, Chien-Chang

    BMC public health

    2024  Volume 24, Issue 1, Page(s) 751

    Abstract: Background: Containment measures slowed the spread of COVID-19 but led to a global economic crisis. We establish a reinforcement learning (RL) algorithm that balances disease control and economic activities.: Methods: To train the RL agent, we design ...

    Abstract Background: Containment measures slowed the spread of COVID-19 but led to a global economic crisis. We establish a reinforcement learning (RL) algorithm that balances disease control and economic activities.
    Methods: To train the RL agent, we design an RL environment with 4 semi-connected regions to represent the COVID-19 epidemic in Tokyo, Osaka, Okinawa, and Hokkaido, Japan. Every region is governed by a Susceptible-Exposed-Infected-Quarantined-Removed (SEIQR) model and has a transport hub to connect with other regions. The allocation of the synthetic population and inter-regional traveling is determined by population-weighted density. The agent learns the best policy from interacting with the RL environment, which involves obtaining daily observations, performing actions on individual movement and screening, and receiving feedback from the reward function. After training, we implement the agent into RL environments describing the actual epidemic waves of the four regions to observe the agent's performance.
    Results: For all epidemic waves covered by our study, the trained agent reduces the peak number of infectious cases and shortens the epidemics (from 165 to 35 cases and 148 to 131 days for the 5th wave). The agent is generally strict on screening but easy on movement, except for Okinawa, where the agent is easy on both actions. Action timing analyses indicate that restriction on movement is elevated when the number of exposed or infectious cases remains high or infectious cases increase rapidly, and stringency on screening is eased when the number of exposed or infectious cases drops quickly or to a regional low. For Okinawa, action on screening is tightened when the number of exposed or infectious cases increases rapidly.
    Conclusions: Our experiments exhibit the potential of the RL in assisting policy-making and how the semi-connected SEIQR models establish an interactive environment for imitating cross-regional human flows.
    MeSH term(s) Humans ; Reinforcement, Psychology ; Learning ; Reward ; COVID-19/epidemiology ; Communicable Diseases ; Epidemics
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-024-18251-0
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  7. Article ; Online: Erbium: YAG laser treatment efficacy and association with histologic features for giant congenital melanocytic nevi management.

    Zhao, Yifei / Zou, Yun / Chen, Hui / Rao, Yamin / Lin, Xiaoxi

    Lasers in surgery and medicine

    2024  Volume 56, Issue 4, Page(s) 361–370

    Abstract: Background: Limited research exists on laser treatment of giant congenital melanocytic nevus (GCMN).: Objective: We sought to elucidate the efficacy of the Erbium: YAG laser on GCMN and the histologic factors associated with a positive clinical ... ...

    Abstract Background: Limited research exists on laser treatment of giant congenital melanocytic nevus (GCMN).
    Objective: We sought to elucidate the efficacy of the Erbium: YAG laser on GCMN and the histologic factors associated with a positive clinical response.
    Methods and materials: Between 2019 and 2022, we enrolled 30 medium-to-giant CMN patients who underwent Er: YAG laser treatment. All patients received biopsies before and after laser treatments. Clinical efficacy outcomes were evaluated by the investigator's global assessment (IGA), 5-point scale of depigmentation, and Vancouver Scar Scale (VSS) scores at least 6 months after treatment.
    Results: Of the 30 cases, 18 (60.0%) showed improvement (IGA score ≥3). Eight (26.7%) patients showed repigmentation. Eight (26.7%) patients developed hypertrophic scars. The average IGA, depigmentation, and VSS scores were 2.93, 3.57, and 3.20. The IGA score was higher (3.24 ± 1.18 vs. 2.22 ± 0.97, p = 0.031) and a lower repigmentation rate (14.3% vs. 55.6%, p = 0.032) was observed in the cases with Grenz zone. The IGA score was higher (3.33 ± 1.24 vs. 2.13 ± 0.89, p = 0.023) and the repigmentation rate was lower (11.1% vs. 50.0%, p = 0.034) also in the cases with the melanocytes nests with aggregation of melanin. Lesions with superficial ablation resulted in less hypertrophic scar formation than those with deep ablation (5.9% vs. 53.8%, p < 0.05).
    Conclusion: The Er: YAG laser demonstrated effective clinical results for GCMNs. The grenz zone and the melanocytes nests with aggregation of melanin are promising predictors of laser efficacy.
    MeSH term(s) Humans ; Erbium ; Melanins ; Lasers, Solid-State/therapeutic use ; Laser Therapy/methods ; Treatment Outcome ; Nevus, Pigmented/radiotherapy ; Nevus, Pigmented/surgery ; Cicatrix, Hypertrophic/pathology ; Immunoglobulin A ; Skin Neoplasms
    Chemical Substances Erbium (77B218D3YE) ; Melanins ; Immunoglobulin A
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604493-1
    ISSN 1096-9101 ; 0196-8092
    ISSN (online) 1096-9101
    ISSN 0196-8092
    DOI 10.1002/lsm.23776
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    Zs.A 1603: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Isolated bile leak after hepatectomy in a 3-year-old child treated by the rendezvous procedure.

    Yu, Jianfa / Shi, Rui / Chen, Guang / Zhang, Yamin

    Asian journal of surgery

    2022  Volume 45, Issue 11, Page(s) 2298–2299

    MeSH term(s) Bile ; Biliary Tract Diseases ; Child, Preschool ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Hepatectomy/methods ; Humans
    Language English
    Publishing date 2022-05-25
    Publishing country China
    Document type Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.05.018
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    Zs.B 2831: Show issues Location:
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  9. Article: [New progress in diagnosis and treatment of HPV-positive oropharyngeal carcinoma].

    Liu, Yamin / Chen, Huaihong

    Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

    2022  Volume 36, Issue 10, Page(s) 802–806

    Abstract: In recent years, the incidence of oropharyngeal carcinoma （OPC） is increasing, while the better prognosis of patients with Human papillomavirus （HPV） positive oropharyngeal carcinoma has been confirmed in a number of studies. There are a variety of ... ...

    Abstract In recent years, the incidence of oropharyngeal carcinoma （OPC） is increasing, while the better prognosis of patients with Human papillomavirus （HPV） positive oropharyngeal carcinoma has been confirmed in a number of studies. There are a variety of detection methods for HPV-associated oropharyngeal carcinoma. Including P16 immunohistochemistry, Polymerase Chain Reaction （PCR） or In situ hybridization （ISH） detection of HPV DNA, HPV RNA, Revers transcriptase Polymerase Chain Reaction （RT PCR） was used to detect HPV RNA. The better prognosis of patients with HPV-positive oropharyngeal carcinoma has led to the emergence of a large number of degraded treatment trials. The traditional P16 test has certain limitations in the diagnosis of patients with HPV-positive oropharyngeal carcinoma. It is necessary to combine with other detection methods to accurately screen out patients with HPV-positive oropharyngeal carcinoma and better apply to degraded therapy. In this article, we will briefly introduce the trend of HPV-associated oropharyngeal carcinoma, the detection methods and the new progress of degraded treatment trials.
    MeSH term(s) Carcinoma, Squamous Cell/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; DNA, Viral/analysis ; Humans ; Oropharyngeal Neoplasms/diagnosis ; Oropharyngeal Neoplasms/pathology ; Oropharyngeal Neoplasms/therapy ; Papillomaviridae/genetics ; Papillomavirus Infections/diagnosis ; RNA
    Chemical Substances Cyclin-Dependent Kinase Inhibitor p16 ; DNA, Viral ; RNA (63231-63-0)
    Language Chinese
    Publishing date 2022-10-11
    Publishing country China
    Document type Journal Article
    ISSN 2096-7993
    ISSN 2096-7993
    DOI 10.13201/j.issn.2096-7993.2022.10.015
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  10. Article ; Online: Industrial Distillation Fractions of Garlic Essential Oil, Design, Synthesis, and Antifungal Activity Evaluation of Aliphatic Substituted Trisulfide Derivatives.

    Chen, Yao / Wang, Hui / Wang, Haiyang / Gao, Jie / Huang, Yamin / Zhang, Yu / Lv, Xianhai

    Chemistry & biodiversity

    2024  , Page(s) e202400027

    Abstract: Garlic oil has a wide range of biological activities, and its broad-spectrum activity against phytopathogenic fungi still has the potential to be explored. In this study, enzymatic treatment of garlic resulted in an increase of approximately 50 % in the ... ...

    Abstract Garlic oil has a wide range of biological activities, and its broad-spectrum activity against phytopathogenic fungi still has the potential to be explored. In this study, enzymatic treatment of garlic resulted in an increase of approximately 50 % in the yield of essential oil, a feasible GC-MS analytical program for garlic oil was provided. Vacuum fractionation of the volatile oil and determination of its inhibitory activity against 10 fungi demonstrated that garlic oil has good antifungal activity. The antifungal activity levels were ranked as diallyl trisulfide (S-3)>diallyl disulfide (S-2)>diallyl monosulfide (S-1), with an EC
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202400027
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