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  1. Book ; Online: Progress with new malaria vaccines / Daniel Webster and Adrian V. S. Hill ; Progrès dans la mise au point des vaccins antipaludiques

    Webster, Daniel / Hill, Adrian V. S

    résumé ; Progresos en el desarrollo de nuevas vacunas contra la malaria : resumen

    2003  

    Abstract: Summaries in English, French, Spanish and ... ...

    Abstract Summaries in English, French, Spanish and Arabic
    Keywords Malaria vaccines ; Vaccines ; Synthetic ; DNA ; Malaria ; Falciparum ; Plasmodium falciparum ; Antigens ; Protozoan ; Models ; Animal ; Humans ; Clinical trials ; Phase I ; Phase II ; Parasitic Diseases and their Control ; pharmacology ; immunology ; growth and development immunology
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Article ; Online: Progress with new malaria vaccines / Daniel Webster and Adrian V. S. Hill ; Progrès dans la mise au point des vaccins antipaludiques

    Webster, Daniel / Hill, Adrian V. S

    résumé ; Progresos en el desarrollo de nuevas vacunas contra la malaria : resumen

    2003  

    Abstract: Summaries in English, French, Spanish and ... ...

    Abstract Summaries in English, French, Spanish and Arabic
    Keywords Malaria Vaccines ; Vaccines ; Synthetic ; DNA ; Malaria ; Falciparum ; Plasmodium falciparum ; Antigens ; Protozoan ; Models ; Animal ; Humans ; Clinical Trial ; Phase I ; Phase II ; Parasitic Diseases and their Control ; pharmacology ; immunology ; growth and development immunology
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  3. Article ; Online: COVID-19 vaccines for rapid global impact.

    Hill, Adrian V S

    BJU international

    2021  Volume 127, Issue 2, Page(s) 137–139

    MeSH term(s) COVID-19/prevention & control ; COVID-19 Vaccines ; Global Health ; Humans
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-02-05
    Publishing country England
    Document type Editorial
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/bju.15339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 13: Show issues

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  4. Article ; Online: A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy.

    Chong, Amanda Y / Brenner, Nicole / Jimenez-Kaufmann, Andres / Cortes, Adrian / Hill, Michael / Littlejohns, Thomas J / Gilchrist, James J / Fairfax, Benjamin P / Knight, Julian C / Hodel, Flavia / Fellay, Jacques / McVean, Gil / Moreno-Estrada, Andres / Waterboer, Tim / Hill, Adrian V S / Mentzer, Alexander J

    American journal of human genetics

    2024  Volume 111, Issue 2, Page(s) 295–308

    Abstract: Infectious agents contribute significantly to the global burden of diseases through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From ... ...

    Abstract Infectious agents contribute significantly to the global burden of diseases through both acute infection and their chronic sequelae. We leveraged the UK Biobank to identify genetic loci that influence humoral immune response to multiple infections. From 45 genome-wide association studies in 9,611 participants from UK Biobank, we identified NFKB1 as a locus associated with quantitative antibody responses to multiple pathogens, including those from the herpes, retro-, and polyoma-virus families. An insertion-deletion variant thought to affect NFKB1 expression (rs28362491), was mapped as the likely causal variant and could play a key role in regulation of the immune response. Using 121 infection- and inflammation-related traits in 487,297 UK Biobank participants, we show that the deletion allele was associated with an increased risk of infection from diverse pathogens but had a protective effect against allergic disease. We propose that altered expression of NFKB1, as a result of the deletion, modulates hematopoietic pathways and likely impacts cell survival, antibody production, and inflammation. Taken together, we show that disruptions to the tightly regulated immune processes may tip the balance between exacerbated immune responses and allergy, or increased risk of infection and impaired resolution of inflammation.
    MeSH term(s) Humans ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Hypersensitivity/genetics ; Inflammation/genetics ; NF-kappa B p50 Subunit/genetics ; UK Biobank
    Chemical Substances NF-kappa B p50 Subunit ; NFKB1 protein, human
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219384-x
    ISSN 1537-6605 ; 0002-9297
    ISSN (online) 1537-6605
    ISSN 0002-9297
    DOI 10.1016/j.ajhg.2023.12.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: A VLP for validation of the Plasmodium falciparum circumsporozoite protein junctional epitope for vaccine development.

    Atcheson, Erwan / Hill, Adrian V S / Reyes-Sandoval, Arturo

    NPJ vaccines

    2021  Volume 6, Issue 1, Page(s) 46

    Abstract: ... this pathogen. The most advanced malaria vaccine, RTS,S, confers only 30% protective efficacy under field ...

    Abstract Malaria continues to be a pressing global health issue, causing nearly half a million deaths per year. An effective malaria vaccine could radically improve our ability to control and eliminate this pathogen. The most advanced malaria vaccine, RTS,S, confers only 30% protective efficacy under field conditions, and hence the search continues for improved vaccines. New antigens and formulations are always first developed at a pre-clinical level. This paper describes the development of a platform to supplement existing tools of pre-clinical malaria vaccine development, by displaying linear peptides on a virus-like particle (VLP). Peptides from PfCSP, particularly from outside the normal target of neutralizing antibodies, the central NANP repeat region, are screened for evidence of protective efficacy. One peptide, recently identified as a target of potent neutralizing antibodies and lying at the junction between the N-terminal domain and the central repeat region of PfCSP, is found to confer protective efficacy against malaria sporozoite challenge in mice when presented on the Qβ VLP. The platform is also used to explore the effects of increasing numbers of NANP unit repeats, and including a universal CD4
    Language English
    Publishing date 2021-04-01
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-021-00302-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Order via subito

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    Inter-library loan at ZB MED

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  6. Article ; Online: Immunological considerations for SARS-CoV-2 human challenge studies.

    Douglas, Alexander D / Hill, Adrian V S

    Nature reviews. Immunology

    2020  Volume 20, Issue 12, Page(s) 715–716

    MeSH term(s) COVID-19/immunology ; COVID-19 Vaccines/immunology ; Healthy Volunteers ; Humans ; Models, Biological ; Research Design ; SARS-CoV-2/immunology
    Chemical Substances COVID-19 Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-10-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-020-00472-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 34: Show issues

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  7. Article ; Online: Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture.

    Schurz, Haiko / Naranbhai, Vivek / Yates, Tom A / Gilchrist, James J / Parks, Tom / Dodd, Peter J / Möller, Marlo / Hoal, Eileen G / Morris, Andrew P / Hill, Adrian V S

    eLife

    2024  Volume 13

    Abstract: The heritability of susceptibility to tuberculosis (TB) disease has been well recognized. Over 100 genes have been studied as candidates for TB susceptibility, and several variants were identified by genome-wide association studies (GWAS), but few ... ...

    Abstract The heritability of susceptibility to tuberculosis (TB) disease has been well recognized. Over 100 genes have been studied as candidates for TB susceptibility, and several variants were identified by genome-wide association studies (GWAS), but few replicate. We established the International Tuberculosis Host Genetics Consortium to perform a multi-ancestry meta-analysis of GWAS, including 14,153 cases and 19,536 controls of African, Asian, and European ancestry. Our analyses demonstrate a substantial degree of heritability (pooled polygenic h
    MeSH term(s) Humans ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Polymorphism, Single Nucleotide ; Tuberculosis/genetics ; Racial Groups/genetics
    Language English
    Publishing date 2024-01-15
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.84394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: STING-pathway modulation to enhance the immunogenicity of adenoviral-vectored vaccines.

    Padron-Regalado, Eriko / Ulaszewska, Marta / Douglas, Alexander D / Hill, Adrian V S / Spencer, Alexandra J

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 14464

    Abstract: Traditional chemical adjuvants remain a practical means of enhancing the immunogenicity of vaccines. Nevertheless, it is recognized that increasing the immunogenicity of viral vectors is challenging. Recently, STING ligands have been shown to enhance the ...

    Abstract Traditional chemical adjuvants remain a practical means of enhancing the immunogenicity of vaccines. Nevertheless, it is recognized that increasing the immunogenicity of viral vectors is challenging. Recently, STING ligands have been shown to enhance the efficacy of different vaccine platforms, but their affectivity on viral-vectored vaccination has not been fully assessed. In this study we used a multi-pronged approach to shed light on the immunological properties and potential mechanisms of action of this type of adjuvant and focused our study on replication-deficient human adenovirus serotype 5 (AdHu5). When the STING ligand 2'3'-cGAMP was mixed with AdHu5, the adjuvant enhanced anti-vector immune responses while decreasing the transgene-specific CD8
    MeSH term(s) Adenoviruses, Human/genetics ; Adjuvants, Immunologic ; Animals ; CD8-Positive T-Lymphocytes ; Genetic Vectors/genetics ; Humans ; Mice ; Vaccination ; Viral Vaccines/genetics
    Chemical Substances Adjuvants, Immunologic ; Viral Vaccines
    Language English
    Publishing date 2022-08-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-18750-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Identification of host-pathogen-disease relationships using a scalable multiplex serology platform in UK Biobank.

    Mentzer, Alexander J / Brenner, Nicole / Allen, Naomi / Littlejohns, Thomas J / Chong, Amanda Y / Cortes, Adrian / Almond, Rachael / Hill, Michael / Sheard, Simon / McVean, Gil / Collins, Rory / Hill, Adrian V S / Waterboer, Tim

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 1818

    Abstract: Certain infectious agents are recognised causes of cancer and other chronic diseases. To understand the pathological mechanisms underlying such relationships, here we design a Multiplex Serology platform to measure quantitative antibody responses against ...

    Abstract Certain infectious agents are recognised causes of cancer and other chronic diseases. To understand the pathological mechanisms underlying such relationships, here we design a Multiplex Serology platform to measure quantitative antibody responses against 45 antigens from 20 infectious agents including human herpes, hepatitis, polyoma, papilloma, and retroviruses, as well as Chlamydia trachomatis, Helicobacter pylori and Toxoplasma gondii, then assayed a random subset of 9695 UK Biobank participants. We find seroprevalence estimates consistent with those expected from prior literature and confirm multiple associations of antibody responses with sociodemographic characteristics (e.g., lifetime sexual partners with C. trachomatis), HLA genetic variants (rs6927022 with Epstein-Barr virus (EBV) EBNA1 antibodies) and disease outcomes (human papillomavirus-16 seropositivity with cervical intraepithelial neoplasia, and EBV responses with multiple sclerosis). Our accessible dataset is one of the largest incorporating diverse infectious agents in a prospective UK cohort offering opportunities to improve our understanding of host-pathogen-disease relationships with significant clinical and public health implications.
    MeSH term(s) Biological Specimen Banks ; Epstein-Barr Virus Infections ; Female ; Herpesvirus 4, Human/genetics ; Humans ; Prospective Studies ; Seroepidemiologic Studies ; United Kingdom/epidemiology ; Uterine Cervical Neoplasms
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-29307-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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