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  1. Article ; Online: A Roadmap for Computational Modelling of M/EEG.

    Franceschiello, Benedetta / Lefebvre, Jérémie / Murray, Micah M / Glomb, Katharina

    Brain topography

    2022  Volume 35, Issue 1, Page(s) 1–3

    MeSH term(s) Computer Simulation ; Electroencephalography ; Humans
    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1078442-1
    ISSN 1573-6792 ; 0896-0267
    ISSN (online) 1573-6792
    ISSN 0896-0267
    DOI 10.1007/s10548-022-00889-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3304: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Epidemiology and pathogenicity of M. equirhinis in equine respiratory disorders.

    Martineau, Matthieu / Kokabi, Elena / Taiebi, Anis / Lefebvre, Stéphanie / Pradier, Sophie / Jaÿ, Maryne / Tardy, Florence / Leon, Albertine

    Veterinary microbiology

    2023  Volume 287, Page(s) 109926

    Abstract: ... Mycoplasma (M.) equirhinis is the species most frequently detected in clinical respiratory specimens ... we screened 1948 clinical specimens for the presence of M. equirhinis. The samples were both tracheal washes ... and clinical information, such as horse age, breed, and living environment. M. equirhinis was detected ...

    Abstract Mycoplasmas are pathogens involved in respiratory disorders of various animal hosts. In horses, Mycoplasma (M.) equirhinis is the species most frequently detected in clinical respiratory specimens, with a prevalence of 12-16%, but its clinical implication in equine respiratory disorders remains unclear. Here we screened 1948 clinical specimens for the presence of M. equirhinis. The samples were both tracheal washes (TW) and bronchoalveolar lavages (BAL) collected by veterinarians in France in day-to-day work between 2020 and 2022. The samples were associated with a standardized form that served to collect key general and clinical information, such as horse age, breed, and living environment. M. equirhinis was detected using a combination of culture and post-enrichment PCR. Other diagnostic data included virology and bacteriology as well as neutrophil counts, when available. Prevalence of M. equirhinis was examined as a function of a clinical score based on four significant clinical signs (nasal discharge, cough, dyspnoea, and hyperthermia). Multivariate logistic regression analysis was run to identify risk factors for the presence of M. equirhinis, and comparative prevalence analysis was used to test for association with other bacteria and viruses. TW and BAL were analysed independently, as we found that TW samples were associated with a higher prevalence of M. equirhinis. As prevalence remained steady whatever the clinical score, M. equirhinis cannot be considered a primary pathogen. M. equirhinis was more frequently isolated in thoroughbreds and trotters and in horses living exclusively stabled compared to other horses or other living environments. M. equirhinis was never detected in BAL specimens with a 'normal' neutrophil count, i.e. 5%, suggesting it could be associated with an inflammatory response, similar to that observed in equine asthma. Prevalence of M. equirhinis was shown to increase in the presence of other bacteria such as Streptococcus equi subsp. zooepidemicus (S. zoo) or viruses, and S. zoo load was higher in M. equirhinis-positive samples, suggesting a potential increase of clinical signs in the event of co-infection.
    MeSH term(s) Horses ; Animals ; Virulence ; Respiratory Tract Diseases/epidemiology ; Respiratory Tract Diseases/veterinary ; Respiratory Tract Diseases/microbiology ; Trachea/microbiology ; Mycoplasma ; Polymerase Chain Reaction/veterinary ; Viruses ; Horse Diseases/epidemiology ; Horse Diseases/microbiology
    Language English
    Publishing date 2023-11-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 753154-0
    ISSN 1873-2542 ; 0378-1135
    ISSN (online) 1873-2542
    ISSN 0378-1135
    DOI 10.1016/j.vetmic.2023.109926
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2917: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: On a modified M/M/$m$/$n$ queueing model

    Mario Lefebvre

    Computer Science Journal of Moldova, Vol 29, Iss 1(85), Pp 29-

    2021  Volume 40

    Abstract: The classic M/M/$m$/$n$ queueing model is modified by allowing a given task to require up to $m$ ... priority disciplines are considered. The case when $m=2$ is treated: the state space needed to fully ...

    Abstract The classic M/M/$m$/$n$ queueing model is modified by allowing a given task to require up to $m$ servers to be performed. Moreover, the maximum time that a task can wait in the queue before being executed is a random variable having an exponential distribution. Both FIFO (First In, First Out) and priority disciplines are considered. The case when $m=2$ is treated: the state space needed to fully describe the system is given, its size is calculated and the balance equations are presented when $n=1,2$ and 3. The queueing process can be used to model cluster-type multiprocessor computing systems.
    Keywords state space ; balance equations ; queue discipline ; priority ; cluster-type multiprocessor computing systems ; Electronic computers. Computer science ; QA75.5-76.95
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Vladimir Andrunachievici Institute of Mathematics and Computer Science
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Convection enhanced delivery of EGFR targeting antibody-drug conjugates Serclutamab talirine and Depatux-M in glioblastoma patient-derived xenografts.

    Porath, Kendra A / Regan, Michael S / Griffith, Jessica I / Jain, Sonia / Stopka, Sylwia A / Burgenske, Danielle M / Bakken, Katrina K / Carlson, Brett L / Decker, Paul A / Vaubel, Rachael A / Dragojevic, Sonja / Mladek, Ann C / Connors, Margaret A / Hu, Zeng / He, Lihong / Kitange, Gaspar J / Gupta, Shiv K / Feldsien, Thomas M / Lefebvre, Didier R /
    Agar, Nathalie Y R / Eckel-Passow, Jeanette E / Reilly, Edward B / Elmquist, William F / Sarkaria, Jann N

    Neuro-oncology advances

    2022  Volume 4, Issue 1, Page(s) vdac130

    Abstract: ... GBM.: Methods: The efficacy of the EGFR-targeted ADCs depatuxizumab mafodotin (Depatux-M) and ... single infusion of 2 μg Ser-T and 60 μg Depatux-M as safe and effective associated with extended survival ... of over 200 days. In contrast, four Depatux-M CED doses were well tolerated and significantly extended ...

    Abstract Background: EGFR targeting antibody-drug conjugates (ADCs) are highly effective against EGFR-amplified tumors, but poor distribution across the blood-brain barrier (BBB) limits their efficacy in glioblastoma (GBM) when administered systemically. We studied whether convection-enhanced delivery (CED) can be used to safely infuse ADCs into orthotopic patient-derived xenograft (PDX) models of EGFRvIII mutant GBM.
    Methods: The efficacy of the EGFR-targeted ADCs depatuxizumab mafodotin (Depatux-M) and Serclutamab talirine (Ser-T) was evaluated
    Results: Dose-finding studies in orthotopic GBM6 identified single infusion of 2 μg Ser-T and 60 μg Depatux-M as safe and effective associated with extended survival prolongation (>300 days and 95 days, respectively). However, with serial infusions every 21 days, four Ser-T doses controlled tumor growth but was associated with lethal toxicity approximately 7 days after the final infusion. Limiting dosing to two infusions in GBM108 provided profound median survival extension of over 200 days. In contrast, four Depatux-M CED doses were well tolerated and significantly extended survival in both GBM6 (158 days) and GBM108 (310 days). In a toxicity analysis, Ser-T resulted in a profound loss in NeuN+ cells and markedly elevated GFAP staining, while Depatux-M was associated only with modest elevation in GFAP staining.
    Conclusion: CED of Depatux-M is well tolerated and results in extended survival in orthotopic GBM PDXs. In contrast, CED of Ser-T was associated with a much narrower therapeutic window.
    Language English
    Publishing date 2022-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 3009682-0
    ISSN 2632-2498 ; 2632-2498
    ISSN (online) 2632-2498
    ISSN 2632-2498
    DOI 10.1093/noajnl/vdac130
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  5. Book: Glucagon / 3 / Contributors J. M. Amatruda ...

    Aoki, Thomas T. / Assan, Roger / Amatruda, John M. / Lefebvre, Pierre J.

    (Handbook of experimental pharmacology ; 123)

    1996  

    Author's details ed. Pierre J. Lefèbvre
    Series title Handbook of experimental pharmacology ; 123
    Glucagon
    Collection Glucagon
    Language English
    Size XX, 349 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin
    Document type Book
    HBZ-ID HT007279634
    ISBN 3-540-60989-X ; 978-3-540-60989-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 6639 order for loan Magazin
    1982 A 2146 -123- order for loan Magazin

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  6. Article ; Online: Reply to the letter by M.P. Wilson, P. Katlariwala, G. Low, L. Jacques, A.S. Jack.

    Hardy, Alexandre / Lefebvre, Guillaume

    Orthopaedics & traumatology, surgery & research : OTSR

    2020  Volume 106, Issue 5, Page(s) 993

    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Thoracic Outlet Syndrome
    Language English
    Publishing date 2020-06-02
    Publishing country France
    Document type Letter ; Comment
    ISSN 1877-0568
    ISSN (online) 1877-0568
    DOI 10.1016/j.otsr.2020.05.002
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  7. Article ; Online: CTX-M-15 type ESBL-producing Salmonella Havana associated with international adoption in Canada.

    Bekal, Sadjia / Lefebvre, Brigitte / Bergevin, Marco / Tremblay, Cécile

    Canadian journal of microbiology

    2013  Volume 59, Issue 1, Page(s) 57

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Canada/epidemiology ; Drug Resistance, Multiple, Bacterial/genetics ; Emigration and Immigration ; Humans ; Salmonella/drug effects ; Salmonella/genetics ; Salmonella Infections/epidemiology ; Salmonella Infections/microbiology ; Travel ; beta-Lactamases/genetics ; beta-Lactamases/metabolism
    Chemical Substances Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2013-01
    Publishing country Canada
    Document type Letter
    ZDB-ID 280534-0
    ISSN 1480-3275 ; 0008-4166
    ISSN (online) 1480-3275
    ISSN 0008-4166
    DOI 10.1139/cjm-2012-0667
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    Zs.B 85: Show issues Location:
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  8. Article ; Online: Vapochromic behaviour of M[Au(CN)2]2-based coordination polymers (M = Co, Ni).

    Lefebvre, Julie / Korčok, Jasmine L / Katz, Michael J / Leznoff, Daniel B

    Sensors (Basel, Switzerland)

    2012  Volume 12, Issue 3, Page(s) 3669–3692

    Abstract: A series of M[Au(CN)(2)](2)(analyte)(x) coordination polymers (M = Co, Ni; analyte ... Addition of analyte vapours to solid M(μ-OH(2))[Au(CN)(2)](2) yielded visible vapochromic responses for M ... Co but not M = Ni; the IR ν(CN) spectral region changed in every case. A single crystal structure ...

    Abstract A series of M[Au(CN)(2)](2)(analyte)(x) coordination polymers (M = Co, Ni; analyte = dimethylsulfoxide (DMSO), N,N-dimethylformamide (DMF), pyridine; x = 2 or 4) was prepared and characterized. Addition of analyte vapours to solid M(μ-OH(2))[Au(CN)(2)](2) yielded visible vapochromic responses for M = Co but not M = Ni; the IR ν(CN) spectral region changed in every case. A single crystal structure of Zn[Au(CN)(2)](2)(DMSO)(2) revealed a corrugated 2-D layer structure with cis-DMSO units. Reacting a Ni(II) salt and K[Au(CN)(2)] in DMSO yielded the isostructural Ni[Au(CN)(2)](2)(DMSO)(2) product. Co[Au(CN)(2)](2)(DMSO)(2) and M[Au(CN)(2)](2)(DMF)(2) (M = Co, Ni) complexes have flat 2-D square-grid layer structures with trans-bound DMSO or DMF units; they are formed via vapour absorption by solid M(μ-OH(2))[Au(CN)(2)](2) and from DMSO or DMF solution synthesis. Co[Au(CN)(2)](2)(pyridine)(4) is generated via vapour absorption by Co(μ-OH(2))[Au(CN)(2)](2); the analogous Ni complex is synthesized by immersion of Ni(μ-OH(2))[Au(CN)(2)](2) in 4% aqueous pyridine. Similar immersion of Co(μ-OH(2))[Au(CN)(2)](2) yielded Co[Au(CN)(2)](2)(pyridine)(2), which has a flat 2-D square-grid structure with trans-pyridine units. Absorption of pyridine vapour by solid Ni(μ-OH(2))[Au(CN)(2)](2) was incomplete, generating a mixture of pyridine-bound complexes. Analyte-free Co[Au(CN)(2)](2) was prepared by dehydration of Co(μ-OH(2))[Au(CN)(2)](2) at 145 °C; it has a 3-D diamondoid-type structure and absorbs DMSO, DMF and pyridine to give the same materials as by vapour absorption from the hydrate.
    Language English
    Publishing date 2012-03-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s120303669
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  9. Article ; Online: Within-day and between-day variability of transthoracic anatomic M-mode echocardiography in the awake bottlenose dolphin (Tursiops truncatus).

    Chetboul, Valérie / Lichtenberger, Jonathan / Mellin, Mathieu / Mercera, Birgitta / Hoffmann, Anne-Cécile / Chaix, Gwendoline / Trehiou-Sechi, Emilie / Misbach, Charlotte / Petit, Amandine / Lefebvre, Hervé P / Gaide, Nicolas / Tissier, Renaud / Delfour, Fabienne

    Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology

    2012  Volume 14, Issue 4, Page(s) 511–518

    Abstract: ... and anatomical specificities. Anatomic M-mode (AMM) is a postprocessing echocardiographic technique ... generating M-mode studies from two-dimensional (2D) cineloops independently of the ultrasound beam ...

    Abstract The use of transthoracic echocardiography in dolphins has been limited so far owing to technical and anatomical specificities. Anatomic M-mode (AMM) is a postprocessing echocardiographic technique generating M-mode studies from two-dimensional (2D) cineloops independently of the ultrasound beam orientation. The aim of the present study was to determine the within-day (repeatability) and between-day (reproducibility) variability of AMM echocardiography in awake healthy bottlenose dolphins (BN, Tursiops truncatus). Four adult BN trained to lie in left recumbency at the water surface were involved in the protocol. A total of 96 echocardiographic examinations were performed on 4 different days by a trained observer examining each BN 6 times per day. Video clips of 2D left parasternal long-axis views showing the left ventricle (LV) ventrally and the aortic root dorsally were recorded at each examination and analyzed for AMM measurements in a random order. A general linear model was used to determine the within-day and between-day coefficients of variation (CV). All examinations were interpretable allowing calculation of 10 AMM variables (i.e., end-diastolic and end-systolic ventral and dorsal LV myocardial wall thicknesses as well as LV and aortic diameters, mean aortic diameter, and LV shortening fraction). Most within- and between-day CV values (18/20) were <15%, the lowest being observed for the end-diastolic LV diameter (1.6%). In conclusion, AMM provides a simple non-invasive evaluation of heart morphology and function in the awake BN with good repeatability and reproducibility of the measurements. Further studies are required to determine the corresponding reference intervals.
    MeSH term(s) Animals ; Aorta/anatomy & histology ; Aorta/diagnostic imaging ; Bottle-Nosed Dolphin/anatomy & histology ; Bottle-Nosed Dolphin/physiology ; Echocardiography/methods ; Echocardiography/veterinary ; Female ; Heart Ventricles/anatomy & histology ; Heart Ventricles/diagnostic imaging ; Male ; Reproducibility of Results ; Ventricular Function
    Language English
    Publishing date 2012-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2198278-8
    ISSN 1875-0834 ; 1760-2734
    ISSN (online) 1875-0834
    ISSN 1760-2734
    DOI 10.1016/j.jvc.2012.07.002
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  10. Book: Chondrocytes

    Haqqi, Tariq M. / Lefebvre, Véronique

    methods and protocols

    (Methods in molecular biology ; 2245 ; Springer protocols)

    2021  

    Author's details edited by Tariq M. Haqqi, Véronique Lefebvre
    Series title Methods in molecular biology ; 2245
    Springer protocols
    Collection
    Language English
    Size xiii, 229 Seiten, Illustrationen, Diagramme
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020685753
    ISBN 978-1-0716-1118-0 ; 9781071611197 ; 1-0716-1118-6 ; 1071611194
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -2245- verfügbar in Königswinter Königswinter

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